My research work focuses on the development of microdevices for the molecular recognition of traces: pre-concentration, orthogonal detection and identification using SERS Spectroscopy (Surface Enhanced Raman Spectroscopy). This line arises from the need to create multi-sensor platforms that are not only sensitive, robust, fast and low cost, but also highly selective, capable of discriminating the analyte of interest in complex mixtures.
Since 2008, my efforts have focused on the detection and identification in the gas phase of volatile organic compounds, industrial toxins, explosives and chemical warfare agents at concentration levels ranging from hundreds of ppmV to trace values ¿¿(sub-ppbV). The strategies have been articulated around three main axes:
1. Electronic nose approach where we combine the combinatorial selectivity of a set of microcantilevers-type mass sensors with integrated heating functionalized with different nanoporous solids with specific adsorption properties.
2. Preconcentration of the target analyte, in a stage prior to detection, by means of a preconcentrator microdevice that incorporates nanoporous adsorbents.
3. SERS spectroscopy for in-situ detection and identification of the analyte thanks to obtaining its vibrational Raman fingerprint.
For any of them, the synthesis and functionalization of nanomaterials and nanostructures with composition, size and shape control, as well as the use of micro and nanofabrication technologies are key and necessary elements to achieve molecular recognition at the interface.
With regard to research in the field of security and defense, this not only addresses the detection and identification of nerve agents, but also the potential decontamination of the affected areas through adsorption and hydrolysis through porous surfaces that incorporate MOF-type materials.
Currently, I am exploring the potential application of SERS technology to new fields such as: i) detection of bio-aerosols and airborne particles; ii) pesticides and pharmaceutical wastewater; iii) food control and product quality; and iv) early diagnosis of diseases in exhaled air.
In parallel, I am: i) reorienting micro and nanofabrication processes towards more sustainable routes based on 3D printing and soft lithography technologies; ii) incorporating non-noble plasmonic materials (Al, Cu); iii) and opening the study to materials such as perovskites, polyoxometalates and carbon nanostructures, which contribute to amplifying the SERS effect by chemical mechanism.
In the medium-long term, my goal is to develop a standard low-cost manufacturing process for a microfluidic SERS chip, as well as the SERS measurement methodology with portable Raman equipment to be able to undertake proofs of concept in field conditions.
• Number of six-year terms awarded: 4 (research)+ 1 (technology transfer)
• PhD thesis supervised: 12 finished + 4 currently in progress
• PhD thesis supervised from 2015 to Sept. 2021: 6 finished + 4 currently in progress
• Total citations in Scopus: 2007; 89 indexed documents in Dec 2024; Average Citations in 2018-2023: 131 citations/year;
• Index h: 26 (source: Scopus - Author ID: 7006376911); Google scholar h-index= 28 (Dec. 2024)
• Total Publications in the period 2018-2023: 25.
Journal articles
- Malankowska, M.; Schlautmann, S.; Berenschot, E.J.W.; Tiggelaar, R.M.; Pina, M.P.; Mallada, R.; Tas, N.R.; Gardeniers, H. Three-dimensional fractal geometry for gas permeation in microchannels. MICROMACHINES. 2018. DOI: 10.3390/mi9020045
- Lafuente, M.; Berenschot, E.J.W.; Tiggelaar, R.M.; Mallada, R.; Tas, N.R.; Pina, M.P. 3D fractals as SERS active platforms: Preparation and evaluation for gas phase detection of G-nerve agents. MICROMACHINES. 2018. DOI: 10.3390/mi9020060
- Lafuente, M.; Pellejero, I.; Sebastián, V.; Urbiztondo, M.A.; Mallada, R.; Pina, M.P.; Santamaría, J. Highly sensitive SERS quantification of organophosphorous chemical warfare agents: A major step towards the real time sensing in the gas phase. SENSORS AND ACTUATORS B-CHEMICAL. 2018. DOI: 10.1016/j.snb.2018.04.058
- Malankowska, M.; Martins, C. F.; Rho, H. S.; Neves, L. A.; Tiggelaar, R. M.; Crespo, J. G.; Pina, M. P.; Mallada, R.; Gardeniers, H.; Coelhoso, I. M. Microfluidic devices as gas – Ionic liquid membrane contactors for CO2 removal from anaesthesia gases. JOURNAL OF MEMBRANE SCIENCE. 2018. DOI: 10.1016/j.memsci.2017.09.065
- Kallem, P.; Drobek, M.; Julbe, A.; Vriezekolk, E.J.; Mallada, R.; Pina, M.P. Hierarchical Porous Polybenzimidazole Microsieves: An Efficient Architecture for Anhydrous Proton Transport via Polyionic Liquids. ACS APPLIED MATERIALS & INTERFACES. 2017. DOI: 10.1021/acsami.7b01916
- Lafuente, M.; Martínez, E.; Pellejero, I.; Artal, M.del Carmen; Pina, M. del Pilar Wettability control on microstructured polypropylene surfaces by means of O2 plasma. PLASMA PROCESSES AND POLYMERS. 2017. DOI: 10.1002/ppap.201700019
- Gabal, M.; Arauzo, A.; Camón, A.; Castrillo, M.; Guerrero, E.; Lozano, M.P.; Pina, M.P.; Sesé, J.; Spagna, S.; Diederichs, J.; Rayner, G.; Sloan, J.; Galli, F.; Van, Der Geest; Haberstroh, C.; Dittmar, N.; Oca, A.; Grau, F.; Fernandes, A.; Rillo, C. Hydrogen-Free Liquid-Helium Recovery Plants: The Solution for Low-Temperature Flow Impedance Blocking. PHYSICAL REVIEW APPLIED. 2016. DOI: 10.1103/PhysRevApplied.6.024017
- Pina Iritia, M.P.; Almazán, F.; Eguizábal, A.; Pellejero, I.; Urbiztondo, M.; Sesé, J.; Santamaría, J.; García-Romeo, D.; Calvo, B.; Medrano, N. Explosives Detection by Array of Si µ -Cantilevers Coated with Titanosilicate-Type Nanoporous Materials. IEEE SENSORS JOURNAL. 2016. DOI: 10.1109/JSEN.2015.2451732
- Almazán, F.; Pellejero, I.; Morales, A.; Urbiztondo, M.A.; Sesé, J.; Pina, M.P.; Santamaría, J. Zeolite based microconcentrators for volatile organic compounds sensing at trace-level: fabrication and performance. JOURNAL OF MICROMECHANICS AND MICROENGINEERING. 2016. DOI: 10.1088/0960-1317/26/8/084010
- Kallem, P.;Eguizabal, A.;Mallada, R.;Pina, M. P. Constructing Straight Polyionic Liquid Microchannels for Fast Anhydrous Proton Transport. ACS APPLIED MATERIALS & INTERFACES. 2016. DOI: 10.1021/acsami.6b13315
- Gabal Lanau, Miguel; Lozano Bernal, Maria Pilar; Oca, Arancha; Pina Iritia, Maria Pilar; Sesé Monclús, Javier; Rillo Millán, Conrado. Helium contamination through polymeric walls. PHYSICS PROCEDIA. 2015. DOI: 10.1016/j.phpro.2015.06.025
- Eguizabal, Adela; Usón, Laura; Sebastián, Víctor; Hueso, José L.; Pina, M. Pilar. Efficient and facile tuning of Vulcan XC72 with ultra-small Pt nanoparticles for electrocatalytic applications. RSC ADVANCES. 2015. DOI: 10.1039/C5RA16698E
- Lemus, J.; Eguizábal, A.; Pina, M. P. UV polymerization of room temperature ionic liquids for high temperature PEMs: Study of ionic moieties and crosslinking effects. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY. 2015. DOI: 10.1016/j.ijhydene.2015.01.078
- Lozano Bernal, María Pilar; Gabal Lanau, Miguel; Sesé Monclús, Javier; Pina Iritia, Maria Pilar; Rillo Millan, Conrado. Purification of recovered helium with low level of impurities: evaluation of two different methods. PHYSICS PROCEDIA. 2015. DOI: 10.1016/j.phpro.2015.06.028
- Eguizábal, A.; Urbiztondo, M.A.; Pina, M.P. Pt based catalytic coatings on poly(benzimidazole) micromonoliths for indoor quality control. CATALYSIS TODAY. 2014. DOI: 10.1016/j.cattod.2014.07.042
- Pellejero, I.; Urbiztondo, M. A.; Pina, M. P.; Santamaría, J. Reinforced SIL-1 micromembranes integrated on chip: APPLICATION to CO2 separation. JOURNAL OF MEMBRANE SCIENCE. 2014. DOI: 10.1016/j.memsci.2014.02.007
- García-Romeo, D.; Pellejero, I.; Urbiztondo, M. A.; Sesé, J.; Pina, M. P.; Martínez, P. A.; Calvo, B.; Medrano, N. Portable low-power electronic interface for explosive detection using microcantilevers. SENSORS AND ACTUATORS B-CHEMICAL. 2014. DOI: 10.1016/j.snb.2014.04.038
- Eguizábal Alguacil, Adela; Sgroi, Mauro; Pullini, Daniele; Ferain, Etienne; Pina Iritia, Maria Pilar. Nanoporous PBI Membranes by Track-Etching for High Temperature PEMFC. JOURNAL OF MEMBRANE SCIENCE. 2014. DOI: 10.1016/j.memsci.2013.12.006
- Eguizábal, A.;Lemus, J.;Pina, M. P. On the incorporation of protic ionic liquids imbibed in large pore zeolites to polybenzimidazole membranes for high temperature proton exchange membrane fuel cells. JOURNAL OF POWER SOURCES. 2013. DOI: 10.1016/j.jpowsour.2012.07.094
Conference presentations
- García-Romeo, D.; Calvo, B.; Medrano, N.; Pina, M.P.; Almazán, F.; Pellejero, I.; Urbiztondo, M.; Sesé, J.; Santamaría, J;. Portable lock-in amplifier for microcantilever based sensor array. Application to explosives detection using Co-BEA type zeolites as sensing materials. PROCEEDINGS OF IEEE SENSORS ... 2014. DOI: 10.1109/ICSENS.2014.6985279
- Pina, M.P.; Almazán, F.; Eguizábal, A.; Pellejero, I.; Urbiztondo, M.; Sesé, J.; Santamaría, J.; García-Romeo, D.; Calvo, B.; Medrano, N.;. Explosives detection by array of Si µ-cantilevers coated with titanosilicate type nanoporous materials. PROCEEDINGS OF IEEE SENSORS ... 2014. DOI: 10.1109/ICSENS.2014.6985276
Scientific chapters
- Zeolite membranes: Synthesis, characterization, important applications, and recent advances. Pina, M.P.; Arruebo, M.; Mallada, R. HANDBOOK OF MEMBRANE SEPARATIONS: CHEMICAL, PHARMACEUTICAL, FOOD, AND BIOTECHNOLOGICAL APPLICATIONS, SECOND EDITION. 2015
- Protic Ionic Liquids Confinement in Macro, Meso and Microporous Materials for Proton Conduction. Eguizábal, A.; Pina, M.P. ENCAPSULATION NANOTECHNOLOGIES. 2013
- Gas Sensing with Silicon-Based Nanoporous Solids. Urbiztondo, Miguel; Pina, Pilar; Santamaría, Jesús. ORDERED POROUS SOLIDS. 2009
- Zeolite Membranes: Synthesis, Characterization, Important Applications & Recent Advances. Arruebo, Manuel; Mallada, Reyes; Pina Iritia, María Pilar. HANDBOOK OF MEMBRANE SEPARATIONS. 2008
- Grace: Development of Pd-Zeolite Composite Membranes for Hydrogen Production by Membrane Reactor. Menéndez, M.; Pina, M.P.; Urbiztondo, M.A.; Casado, L.; Boutonnet, M.; Rojas, S.; Nassos, S. CARBON DIOXIDE CAPTURE FOR STORAGE IN DEEP GEOLOGIC FORMATIONS : RESULTS FROM THE CO² CAPTURE PROJECT 2005
- El reactor de membrana catalítica como eficiente contactor gas-sólido en la combustión de COVs. Pina Iritia, María Pilar; Irusta, Silvia; Menéndez, Miguel; Santamaría, Jesús. CATALIZADORES Y ADSORBENTES PARA LA PROTECCIÓN AMBIENTAL EN LA REGIÓN IBEROAMERICANA. 2001
- Eliminación de COVs mediante combustión catalítica. Pina Iritia, María Pilar; Irusta, Silvia; Menéndez, Miguel; Santamaría, Jesús. CATALIZADORES Y ADSORBENTES PARA LA PROTECCIÓN AMBIENTAL EN LA REGIÓN IBEROAMERICANA. 1998
Projects
- JIUZ-2019-CIE-05: Aplicación de nanocristales de perovskita de haluro en espectroscopía Raman amplificada en superficie (SERS). 01/01/20 - 31/12/20
- SENSOFT / SMART SENSING FOR RAPID RESPONSE TO CHEMICAL THREATS ON SOFT TARGETS (H2020 nº GA 823895). 01/01/19 - 31/12/23
- FCT-17-12128: LOS CINCO SENTIDOS Y LA NANOTECNOLOGÍA. 01/01/18 - 31/03/19
- CTQ2016-79419-R: TECNOLOGÍAS AVANZADAS DE ADSORCIÓN, DETECCIÓN SERS Y CATÁLISIS PARA GUERRA QUÍMICA. 30/12/16 - 31/12/20
- UZCUD2016-TEC-07: DESARROLLO DE MICRODISPOSITIVOS Y NANOMATERIALES PARA LA DETECCIÓN DE AGENTES QUÍMICOS PELIGROSOS. 01/11/16 - 30/09/17
- FCT-14-9143. AUDIOVISUALES CIENTÍFICOS UNIVERSIDAD DE ZARAGOZA:. 01/09/14 - 31/12/15
- CTQ2013-49068-C2-1-R: MICROSISTEMAS BASADOS EN NANOESTRUCTURAS CON PROPIEDADES ESPECÍFICAS DE ADSORCIÓN Y PLASMÓN SUPERFICIAL, PARA DETECCIÓN DE EXPLOSIVOS OCULTOS Y AGENTES DE GUERRA QUÍMICA. 01/01/14 - 30/09/17
PhD supervision
- Development of proton exchange membranes based on synergistic combination of polybenzimidazole, ionic liquids and zeolites/zeotypes for high temperature PEM fuel cells. Universidad de Zaragoza. Sobresaliente "Cum Laude". 10/02/16
- Fabricación de microdispositivos basados en zeolitas y su aplicación en sensores y membranas. Universidad de Zaragoza. Sobresaliente "Cum Laude". 10/02/12
- Microdispositivos basados en zeolitas: sensores y otras aplicaciones. Universidad de Zaragoza. Sobresaliente "Cum Laude". 18/06/08
- Desarrollo de las membranas catalíticas para la eliminación de fenol en corrientes acuosas. Universidad de Zaragoza. Sobresaliente "Cum Laude". 27/07/07
- Combustión de compuestos orgánicos volátiles en reactores de membrana catalítica mesoporosa basados en óxidos metálicos. Estudio cinético y simulación. Universidad de Zaragoza. Sobresaliente "Cum Laude". 14/01/05
Docencia UNIZAR de los últimos seis cursos
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