Profile (CV) of the research teaching staff

Barrachina Porcar, Laura
Department: Departamento de Anatomía, Embriología y Genética Animal
Field: Genética
Faculty: Facultad de Veterinaria

Research Institutes: INSTITUTO INVESTIGACIÓN SANITARIA DE ARAGÓN (IIS)
INSTITUTO AGROALIMENTARIO DE ARAGÓN (IA2)
Group: A19_23R: LAGENBIO
Academic position: Investigador Doctor Senior
Email: lbarrach@unizar.es
ORCID number: 0000-0001-9818-508X

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Journal articles

  • Barrachina, Laura; Ivanovska, Ana; Eslami Arshaghi, Tarlan; O’brien, Aisling; Cequier, Alina; Murphy, Mary; Hollinshead, Fiona; Rodellar, Clementina; Barry, Frank. Generation of equine induced pluripotent stem cells from cells of embryonic, perinatal and adult tissues. STEM CELL RESEARCH & THERAPY. 2025. DOI: 10.1186/s13287-025-04671-1

  • Vitoria, Arantza; Barrachina, Laura; Romero, Antonio; Fuente, Sara; de Blas, Ignacio; Gil, Lydia; Vázquez, Francisco José. Laparoscopic Inguinal Hernioplasty with a Polyether Ether Ketone Anchoring Device in Intact Male Horses Does Not Compromise Testicular Perfusion, Sperm Production or Motility Characteristics. ANIMALS. 2025. DOI: 10.3390/ani15030402

  • Cequier, Alina; Serrano, Mª Belén; Soler-Monsó, Mª. Teresa; Bernad, Elvira; Vázquez, Francisco José; Vitoria, Arantza; Fuente, Sara; Zaragoza, Pilar; Romero, Antonio; Rodellar, Clementina; Barrachina, Laura. MHC compatibility influences the interaction between different types of equine mesenchymal stem/stromal cells and the local immune response. RESEARCH IN VETERINARY SCIENCE. 2025. DOI: 10.1016/j.rvsc.2025.105889

  • Pezzanite, Lynn; Barrachina, Laura; Schnabel, Lauren. Editorial: Links between regenerative medicine and immunotherapy: how cellular therapies modulate immune responses for improved outcomes. FRONTIERS IN VETERINARY SCIENCE. 2024. DOI: 10.3389/fvets.2024.1462218

  • Cequier, Alina; Vázquez, Francisco José; Vitoria, Arantza; Bernad, Elvira; Fuente, Sara; Serrano, María Belén; Zaragoza, María Pilar; Romero, Antonio; Rodellar, Clementina; Barrachina, Laura. The systemic cellular immune response against allogeneic mesenchymal stem cells is influenced by inflammation, differentiation and MHC compatibility: in vivo study in the horse. FRONTIERS IN VETERINARY SCIENCE. 2024. DOI: 10.3389/fvets.2024.1391872

  • Vázquez, Francisco José; Barrachina, Laura; Fuente, Sara; Manero, Cristina; Romero, Antonio; Vitoria, Arantza. Aprendiendo la palpación transrectal en caballos: comparación de dos metodologías de enseñanza. JOURNAL OF VETERINARY MEDICAL EDUCATION. 2024. DOI: 10.3138/jvme-2023-0010-es

  • Vázquez Bringas, Francisco José; Barrachina Porcar, Laura; Fuente Franco, Sara; Manero Martinez, Cristina; Romero Lasheras, Antonio; Vitoria Moraiz, Arantza Training of veterinary students in trans rectal palpation of equids: a comparison of live versus cadaver models. JOURNAL OF VETERINARY MEDICAL EDUCATION. 2024. DOI: 10.3138/jvme-2023-0010

  • Barrachina, Laura; Arshaghi Eslami, Tarlan; O'brien, Aisling; Ivanovska, Ana; Barry, Frank. Induced pluripotent stem cells in companion animals: how can we move the field forward?. FRONTIERS IN VETERINARY SCIENCE. 2023. DOI: 10.3389/fvets.2023.1176772

  • Vázquez, Francisco J.; Romero, Antonio; Fuente, Sara; Barrachina, Laura; Vitoria, Arantza. Laparoscopically assisted percutaneous inguinal ring closure for resolution of inguinal/scrotal hernias in rams: cadaveric study and three cases report. ANIMALS. 2023. DOI: 10.3390/ani13050836

  • Barrachina Porcar, Laura; Romero Lasheras, Antonio; Vitoria Moraiz, Arantzazu; Vázquez Bringas, Francisco José Actualización en el uso de células madre en patologías del aparato locomotor equino. EQUINUS (MADRID). 2023

  • Vázquez, Francisco José; Vitoria, Arantza; Gómez-Arrue, Javier; Fuente, Sara; Barrachina, Laura; de Blas, Ignacio; Romero, Antonio. Complications in laparoscopic access in standing horses using cannula and trocar units developed for human medicine. VETERINARY SCIENCES. 2023. DOI: 10.3390/vetsci10010061

  • Vitoria, Arantza; Romero, Antonio; Barrachina, Laura; Fuente, Sara; Gil, Lydia; de Blas, Ignacio; Vázquez Bringas, Francisco José. Development of a laparoscopic technique for inguinal hernioplasty in standing horses. VETERINARY RECORD. 2023. DOI: 10.1002/vetr.2584

  • Cequier, Alina; Romero, Antonio; Vázquez, Francisco J.; Vitoria, Arantza; Bernad, Elvira; Fuente, Sara; Zaragoza, Pilar; Rodellar, Clementina; Barrachina, Laura. Equine mesenchymal stem cells influence the proliferative response of lymphocytes: effect of inflammation, differentiation and MHC-compatibility. ANIMALS. 2022. DOI: 10.3390/ani12080984

  • Cequier, Alina; Vázquez, Francisco José; Romero, Antonio; Vitoria, Arantza; Bernad, Elvira; García-Martínez, Mirta; Gascón, Isabel; Barrachina, Laura; Rodellar, Clementina. The immunomodulation–immunogenicity balance of equine Mesenchymal Stem Cells (MSCs) is differentially affected by the immune cell response depending on inflammatory licensing and major histocompatibility complex (MHC) compatibility. FRONTIERS IN VETERINARY SCIENCE. 2022. DOI: 10.3389/fvets.2022.957153

  • Cequier, A.; Sanz, C.; Rodellar, C.; Barrachina, L. The usefulness of mesenchymal stem cells beyond the musculoskeletal system in horses. ANIMALS. 2021. DOI: 10.3390/ani11040931

  • Barrachina Porcar, Laura; Cequier Soler, Alina; Romero Lasheras, Antonio; Vitoria Moraiz, Arantza; Zaragoza Fernández, Pilar; Vázquez Bringas, Francisco José; Rodellar Penella, Clementina. Allo-antibody production after intraarticular administration of mesenchymal stem cells (MSCs) in an equine osteoarthritis model: effect of repeated administration, MSC inflammatory stimulation, and equine leukocyte antigen (ELA) compatibility. STEM CELL RESEARCH & THERAPY. 2020. DOI: 10.1186/s13287-020-1571-8

  • Fernandez-Pernas, P.; Barrachina, L.; Marquina, M.; Rodellar, C.; Arufe, M.C.; Costa, C. Mesenchymal stromal cells for articular cartilage repair: preclinical studies. EUROPEAN CELLS & MATERIALS. 2020. DOI: 10.22203/eCM.v040a06

  • Vitoria, Arantza; Romero, Antonio; Fuente, Sara; Barrachina, Laura; Vazquez, Francisco José. Application of a laparoscopic technique for vasectomy in standing horses. VETERINARY RECORD. 2019. DOI: 10.1136/vr.105396

  • Yaneselli, Kevin; Barrachina, Laura; Remacha, Ana Rosa; Algorta, Agustina; Vitoria, Arantza; Cequier, Alina; Romero, Antonio; Vázquez, Francisco José; Maisonnave, Jacqueline; Rodellar Clementina. Effect of allogeneic platelet lysate on equine bone marrow derived mesenchymal stem cell characteristics, including immunogenic and immunomodulatory gene expression profile. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 2019. DOI: 10.1016/j.vetimm.2019.109944

  • Cequier, A.; Barrachina, L.; Romero, A.; Vitoria, A.; Zaragoza, P.; Vazquez, F.J.; Rodellar, C. Humoral immune response against allogeneic equine mesenchymal stem cells (MSCs) mediated by the major histocompatibility complex (MHC): an issue to take into account for the safety and efficacy of treatment with MSCs. HUMAN GENE THERAPY. 2019

  • Barrachina, L.; Romero, A.; Zaragoza, P.; Rodellar, C.; Vázquez, F.J. Practical considerations for clinical use of mesenchymal stem cells: From the laboratory to the horse. VETERINARY JOURNAL. 2018. DOI: 10.1016/j.tvjl.2018.07.004

  • Barrachina, L.; Remacha, A.R.; Romero, A.; Vitoria, A.; Albareda, J.; Prades, M.; Roca, M.; Zaragoza, P.; Vázquez, F.J.; Rodellar, C. Assessment of effectiveness and safety of repeat administration of proinflammatory primed allogeneic mesenchymal stem cells in an equine model of chemically induced osteoarthritis. BMC VETERINARY RESEARCH. 2018. DOI: 10.1186/s12917-018-1556-3

  • Barrachina, L.; Remacha, A.R.; Romero, A.; Zaragoza, P.; Vázquez, F.J.; Rodellar, C. Differentiation of equine bone marrow derived mesenchymal stem cells increases the expression of immunogenic genes. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 2018. DOI: 10.1016/j.vetimm.2018.04.004

  • Barrachina Porcar, Laura; Remacha Gayán, Ana Rosa; Romero Lasheras, Antonio; Vázquez Bringas, Francisco José; Albareda, Jorge; Prades, Marta; Gosálvez, Jaime; Roy, Rosa; Zaragoza, Pilar; Martín Burriel, Inmaculada; Rodellar Penella, Clementina Priming equine bone marrow derived mesenchymal stem cells (eBM-MSCs) with pro-inflammatory cytokines: implications in immunomodulation-immunogenicity balance, cell viability and differentiation potential. STEM CELLS AND DEVELOPMENT. 2017. DOI: 10.1089/scd.2016.0209

  • Barrachina, L.; Remacha, A. R.; Romero, A.; Vázquez, F. J.; Albareda, J.; Prades, M.; Ranera, B.; Zaragoza, P.; Martín-Burriel, I.; Rodellar, C. Inflammation affects the viability and plasticity of equine mesenchymal stem cells: Possible implications in intra-articular treatments. JOURNAL OF VETERINARY SCIENCE. 2017. DOI: 10.4142/jvs.2017.18.1.39

  • Romero, A.; Barrachina, L.; Ranera, B.; Remacha, A.R.; Moreno, B.; de Blas, I.; Sanz, A.; Vázquez, F.J.; Vitoria, A.; Junquera, C.; Zaragoza, P.; Rodellar, C. Comparison of autologous bone marrow and adipose tissue derived mesenchymal stem cells, and platelet rich plasma, for treating surgically induced lesions of the equine superficial digital flexor tendon. VETERINARY JOURNAL. 2017. DOI: 10.1016/j.tvjl.2017.04.005

  • Barrachina Porcar, Laura; Remacha Gayán, Ana Rosa; Soler Baigorri, Lourdes; García, Natalia; Romero Lasheras, Antonio; Vázquez Bringas, Francisco José; Vitoria Moraiz, Arantza; Álava, María Ángeles; Lampreave, Fermín; Rodellar Penella, Clementina. Acute phase protein haptoglobin as inflammatory marker in serum and synovial fluid in an equine model of arthritis. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 2016. DOI: 10.1016/j.vetimm.2016.10.005

  • Barrachina, Laura; Remacha, Ana Rosa; Romero, Antonio; Vázquez, Francisco José; Albareda, Jorge; Prades, Marta; Ranera, Beatriz; Zaragoza, Pilar; Martín-Burriel, Inmaculada; Rodellar, Clementina. Effect of inflammatory environment on equine bone marrow derived mesenchymal stem cells immunogenicity and immunomodulatory properties. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 2016. DOI: 10.1016/j.vetimm.2016.02.007

  • Ardanaz, Nekane; Vázquez, Francisco José; Romero, Antonio; Remacha, Ana Rosa; Barrachina, Laura; Sanz, Arianne; Ranera, Beatriz; Vitoria, Arantza; Albareda, Jorge; Prades, Marta; Zaragoza, Pilar; Martín-Burriel, Inmaculada; Rodellar, Clementina. Inflammatory response to the administration of mesenchymal stem cells in an equine experimental model: effect of autologous, and single and repeat doses of pooled allogeneic cells in healthy joints. BMC VETERINARY RESEARCH. 2016. DOI: 10.1186/s12917-016-0692-x

  • Remacha, A.R.; Barrachina, L.; Álvarez-Arguedas, S.; Ranera, B.; Romero, A.; Vázquez, F.J.; Zaragoza, P.; Yañez, R.; Martín-Burriel, I.; Rodellar, C. Expression of genes involved in immune response and in vitro immunosuppressive effect of equine MSCs. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 2015. DOI: 10.1016/j.vetimm.2015.04.004

  • Vázquez, F.J.; Romero, A.; Vitoria, A.; Zalaya, J.; Blas, I. De; Fernández, A.; Gil, L.; Gironés, O.; Gracia, M.J.; Luján, L.L.; María, G.; Varona, L.; Vega, A. De; Gómez-Arrue, J.; Ardanaz, N.; Barrachina, L.; Rodellar, C. El modelo integrador y de innovación docente del Grado en Veterinaria de Zaragoza: integración en équidos. REVISTA COMPLUTENSE DE CIENCIAS VETERINARIAS. 2014

Conference presentations

  • Barrachina, Laura; O’brien, Aisling; Eslami Arshaghi, Tarlan; Ivanovska, Ana; Murphy, Mary; Barry, Frank. Development of reprogramming protocols for equine induced pluripotent stem cells (iPSCs): first steps towards a One Medicine strategy for osteoarthritis. CYTOTHERAPY. 2023. DOI: 10.1016/S1465-3249(23)00675-8

  • Vázquez, Fj; Vitoria, A; Barrachina, L; Fuente, S ; de Blas, I; Romero, A; Gil, L. Assessment of the effect of a new technique for laparoscopic partial closure of the inguinal canal on sperm production and testicular perfusion in stallions. REPRODUCTION IN DOMESTIC ANIMALS. 2016. DOI: 10.1111/rda.12801

  • Vitoria, Arantza; Vázquez, Francisco José; Barrachina, Laura; Fuente, Sara; Gil, Lydia; de Blas, Ignacio; Romero, Antonio. Standing laparoscopic partial closure of the inguinal canal in stallions. VETERINARY SURGERY. 2016. DOI: 10.1111/vsu.12500

  • Barrachina Porcar, Laura; Remacha, Ar; Ranera, B; Romero, A; Vazquez, Fj; Albareda, J; Prades, M; Zaragoza, P; Martín Burriel, I; Rodellar, C. Towards the development of more effective equine osteoarthritis treatments: potential benefit of stimulating the MSCs immunomodulatory ability. VETERINARY SURGERY. 2015. DOI: 10.1111/vsu.12345

  • Vázquez Bringas, Francisco José; Alonso de Diego, M.; Ardanaz, N.; Barrachina, L.; Cunilleras, E.J.; Blas, I. De; Vega, A. De; Valle, A. Del; Gil, L.; Gironés, O.; Gómez-Arrue, J.; Gómez-Lucas, R.; Gracia-Salinas, M.J.; López-San Román, J.; Luján, L.L.; Muniesa, A.; Prades, M.; Ribera, T.; Rodellar, C.; Rodríguez, I.; Romero, A.; Santiago, I.; Vitoria, A.; Viu, J.; Zalaya, J. Desarrollo de una aplicación informática para aprender clínica y producción equina jugando al Trivial. REVISTA COMPLUTENSE DE CIENCIAS VETERINARIAS. 2014. DOI: 10.5209/rev_RCCV.2014.v8.n1.44301

  • Barrachina, Laura; Remacha, Ana Rosa; Ranera, Beatriz; Romero, Antonio; Vazquez, Francisco Jose; Albareda, Jorge; Prades, Marta; Zaragoza, Pilar; Martin-Burriel, Inmaculada; Rodellar, Clementina;. Effect of inflammatory environment on equine bone marrow derived mesenchymal stem cell (BM-MSCs) proliferation, differentiation and immunomodulatory gene expression profile. HUMAN GENE THERAPY. 2014

  • Remacha, Ana Rosa; Barrachina, Laura; Romero, Antonio; Vazquez, Francisco José; Zaragoza, Pilar; Rodellar, Clementina. Role of mesenchymal stem cells in equine laminitis. HUMAN GENE THERAPY. 2013

  • Ardanaz Laguardia, Nekane; Vázquez Bringas, Francisco José; Romero Lasheras , Antonio; Remacha, Ana Rosa; Ranera, Beatriz; Vitoria Moraiz, Arantza; Barrachina Porcar, Laura; Martín-Burriel, Inmaculada; Zaragoza Fernández, Pilar; Rodellar Penella, Clementina. Intra-articular injection of autologous and allogeneic mesenchymal stem cells (MSCs) in horses: clinical and laboratorial findings. VETERINARY SURGERY. 2013. DOI: 10.1111/j.1532-950X.2013.12027.x

Scientific chapters

  • The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses. Cequier Soler, Alina. STEM CELLS IN DOMESTIC ANIMALS: APPLICATIONS IN HEALTH AND PRODUCTION. 2023

  • The immunomodulation–immunogenicity balance of equine Mesenchymal Stem Cells (MSCs) is differentially affected by the immune cell response depending on inflammatory licensing and major histocompatibility complex (MHC) compatibility. Cequier Soler, Alina. RISING STARS IN VETERINARY REGENERATIVE MEDICINE: 2022. 2023

  • Vázquez Bringas, F. J., de Blas Giral, I., Gracia Salinas, M. J., Romero Lasheras, A., Gil Huerta, L., Vitoria Moraiz, A., Zalaya Mugüerza, J., Barrachina Porcar, L., Fuente Franco, S. SIMPA : caricaturas didácticas como apoyo visual al aprendizaje de la patología equina. LA DIFUSIÓN DE LA INNOVACIÓN DOCENTE: RETOS Y REFLEXIONES. 2018



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