Profile (CV) of the research teaching staff

Carrodeguas Villar, José Alberto
Department: Departamento de Bioquímica y Biología Molecular y Celular
Field: Biología Celular
Faculty: Facultad de Ciencias

Research Institutes: INSTITUTO DE BIOCOMPUTACIÓN Y FÍSICA DE SISTEMAS COMPLEJOS (BIFI)
INSTITUTO INVESTIGACIÓN SANITARIA DE ARAGÓN (IIS)
Group: B49_23R: NeuroBioSys - Molecular Neurobiology and Systems Biology

UNESCO codes
  • Biología molecular
  • Bioquímica
  • Cultivo celular
Academic position: Cated. Universidad

Academic position
  • Coordinador del Máster Universitario en Biología Molecular y Celular
Email: carrode@unizar.es
ORCID number: 0000-0003-0062-1029

Research interests
  • Biomedicina
  • Mecanismos moleculares de enfermedad
  • Cultivo celular
  • Biología molecular, celular y genética
  • Ciencias biológicas
  • Biología celular
  • Biología molecular
  • Demencias seniles (alzheimer, parkinson...)

University degrees
  • Doctor en Ciencias (Biológicas). Universidad Autónoma de Madrid. 1994
  • Licenciado en Ciencias Biológicas. Universidad de Santiago de Compostela. 1990
 
             

Journal articles

  • González, Cristina; Martínez-Sánchez, Lidia; Clemente, Paula; Toivonen, Janne Markus; Arredondo, Juan José; Fernández-Moreno, Miguel Ángel; Carrodeguas, José Alberto. Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development. FEBS OPENBIO. 2023. DOI: 10.1002/2211-5463.13742

  • Latorre-Muro, Pedro; Baeza, Josué; Hurtado-Guerrero, Ramón; Hicks, Thomas; Delso, Ignacio; Hernández-Ruiz, Cristina; Velazquez-Campoy, Adrián; Lawton, Alexis J.; Angulo, Jesús; Denu, John M.; Carrodeguas, José A. Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 2021. DOI: 10.1074/jbc.RA120.015103

  • Aragó, M.; Moreno-Felici, J.; Abás, S.; Rodríguez-Arévalo, S.; Hyroššová, P.; Figueras, A.; Viñals, F.; Pérez, B.; Loza, M.I.; Brea, J.; Latorre, Pedro; Carrodeguas, José A.; García-Rovés, P.M.; Galdeano, C.; Ginex, T.; Luque, F.J.; Escolano, C.; Perales, J.C. Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M. BIOMEDICINE & PHARMACOTHERAPY. 2020. DOI: 10.1016/j.biopha.2019.109601

  • Salillas, Sandra; Alías, Miriam; Michel, Valérie; Mahía, Alejandro; Lucía, Ainhoa; Rodrigues, Liliana; Bueno, Jessica; Galano-Frutos, Juan José; de Reuse, Hilde; Velázquez-Campoy, Adrián; Carrodeguas, José Alberto; Sostres, Carlos; Castillo, Javier; Aínsa. José Antonio; Díaz-De-Villegas, María Dolores; Lanas, Ángel; Touati, Eliette; Sancho, Javier. Design, synthesis, and efficacy testing of nitroethylene- and 7-nitrobenzoxadiazol-based flavodoxin inhibitors against helicobacter pylori drug-resistant clinical strains and in helicobacter pylori-infected mice. JOURNAL OF MEDICINAL CHEMISTRY. 2019. DOI: 10.1021/acs.jmedchem.9b00355

  • Latorre-Muro, Pedro; Baeza, J.; Armstrong, E.A.; Hurtado-Guerrero, Ramón; Corzana, F.; Wu, L.E.; Sinclair, D.A.; López-Buesa, Pascual; Carrodeguas, José A.; Denu, J.M. Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. MOLECULAR CELL. 2018. DOI: 10.1016/j.molcel.2018.07.031

  • Latorre, P.; Varona, L.; Burgos, C.; Carrodeguas, J.A.; López-Buesa, P. O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1a. PLOS ONE. 2017. DOI: 10.1371/journal.pone.0179988

  • Silva, C. G.; Monteiro, A.; Manahl, C.; Lostal, E.; Holocher-Ertl, T.; Andrade, N.; Brasileiro, F.; Mota, P. G.; Serrano Sanz, F.; Carrodeguas, J. A.; Brito, R. M. M. Cell spotting: Educational and motivational outcomes of cell biology citizen science project in the classroom. JCOM, JOURNAL OF SCIENCE COMMUNICATION. 2016

  • Latorre, P; Burgos, C; Hidalgo, J; Varona, L; Carrodeguas, Ja; López-Buesa, P. c.A2456C-substitution in Pck1 changes the enzyme kinetic and functional properties modifying fat distribution in pigs. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2016. DOI: 10.1038/srep19617

  • López, L.C.; Varea, O.; Navarro, S.; Carrodeguas, J.A.; de Groot, N.S.; Ventura, S.; Sancho, J. Benzbromarone, quercetin, and folic acid inhibit amylin aggregation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016. DOI: 10.3390/ijms17060964

  • Escós, M.; Latorre, P.; Hidalgo, J.; Hurtado-Guerrero, R.; Carrodeguas, J.A.; López-Buesa, P. Kinetic and functional properties of human mitochondrial phosphoenolpyruvate carboxykinase. BIOCHEMISTRY AND BIOPHYSICS REPORTS. 2016. DOI: 10.1016/j.bbrep.2016.06.007

  • Hidalgo, J.; Latorre, P.; Carrodeguas, J.A.; Velázquez-Campoy, A.; Sancho, J.; López-Buesa, P. Inhibition of pig phosphoenolpyruvate carboxykinase isoenzymes by 3-Mercaptopicolinic acid and novel inhibitors. PLOS ONE. 2016. DOI: 10.1371/journal.pone.0159002

  • Laurents, D. V.; Pantoja-Uceda, D.; López, L. C.; Carrodeguas, J. A.; Mompeán, M.; Jiménez, M. Á.; Sancho, J. DMSO affects Aß1-40's conformation and interactions with aggregation inhibitors as revealed by NMR. RSC ADVANCES. 2015. DOI: 10.1039/c5ra12100k

  • Nelo-Bazán, Ma; Latorre, P; Bolado-Carrancio, A; Pérez-Campo, Fm; Echenique-Robba, P; Rodríguez-Rey, Jc; Carrodeguas, Ja. Early growth response 1 (EGR-1) is a transcriptional regulator of mitochondrial carrier homolog 1 (MTCH 1)/presenilin 1-associated protein (PSAP). GENE. 2015. DOI: 10.1016/j.gene.2015.12.014

  • Monteiro, A.J.; Silva, C.G.; Carrodeguas Villar, J. Cell spotting – let’s fight cancer together!. SCIENCE IN SCHOOL. 2015

  • Martínez-Oliván, J; Arias-Moreno, X; Hurtado-Guerrero, R; Carrodeguas, Ja; Miguel-Romero, L; Marina, A; Bruscolini, P; Sancho, J. The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome. FEBS LETTERS. 2015. DOI: 10.1016/j.febslet.2015.10.014

  • Burgos, Carmen; Latorre, Pedro; Altarriba, Juan; Carrodeguas, José Alberto; Varona, Luis; López-Buesa, Pascual. Allelic frequencies of NR6A1 and VRTN, two genes that affect vertebrae number in diverse pig breeds: A study of the effects of the VRTN insertion on phenotypic traits of a Duroc x Landrace-Large White cross MEAT SCIENCE. 2015. DOI: 10.1016/j.meatsci.2014.09.143

  • Ansón-Casaos, Alejandro; González-Domínguez, José Miguel;Lafragüeta, Ignacio; Carrodeguas, José A.; Martínez, M.Teresa. Optical absorption response of chemically modified single-walled carbon nanotubes upon ultracentrifugation in various dispersants. CARBON. 2014. DOI: 10.1016/j.carbon.2013.08.048

  • Liggi, S; Drakakis, G; Koutsoukas, A; Cortes-Ciriano, I; Martínez-Alonso, P; Malliavin, Te; Velazquez-Campoy, A; Brewerton, Sc; Bodkin, Mj; Evans, Da; Glen, Rc; Carrodeguas, Ja; Bender, A. Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts. FUTURE MEDICINAL CHEMISTRY. 2014. DOI: 10.4155/fmc.14.137

  • Echenique-Robba, P.; Nelo-Bazán, M.A.; Carrodeguas, J.A. Reducing the standard deviation in multiple-assay experiments where the variation matters but the absolute value does not. PLOS ONE. 2013. DOI: 10.1371/journal.pone.0078205

  • Galve, A; Burgos, C; Varona, L; Carrodeguas, Ja; Cánovas, A; López-Buesa, P. Allelic frequencies of PRKAG3 in several pig breeds and its technological consequences on a Duroc × Landrace-Large White cross. JOURNAL OF ANIMAL BREEDING AND GENETICS. 2013. DOI: 10.1111/jbg.12042

  • Cánovas,A.;Varona,L.;Burgos,C.;Galve,A.;Carrodeguas,J. A.;Ibáñez-Escriche,N.;Martín-Burriel,I.;López-Buesa,P. Early postmortem gene expression and its relationship to composition and quality traits in pig longissimus dorsi muscle. JOURNAL OF ANIMAL SCIENCE. 2012. DOI: 10.2527/jas2011-4799

  • López, L.C.; Dos-Reis, S.; Espargaró, A.; Carrodeguas, J.A.; Maddelein, M.-L; Ventura, S.; Sancho, J. Discovery of novel inhibitors of amyloid ß-Peptide 1-42 Aggregation. JOURNAL OF MEDICINAL CHEMISTRY. 2012. DOI: 10.1021/jm301186p

  • Conesa, C.; Doss, M-X.; Antzelevitch,C.; Sachinidis, A.; Sancho, J.; Carrodeguas, J.A. Identification of Specific Pluripotent Stem Cell Death-inducing Small Molecules by Chemical Screening. STEM CELL REVIEWS. 2011. DOI: 10.1007/s12015-011-9248-4

  • Ospina, Angélica; Lagunas-Martínez, Alfredo; Pardo, Julián; Carrodeguas, José Alberto. Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL. FEBS LETTERS. 2011. DOI: 10.1016/j.febslet.2011.08.012

  • Burgos, C.; Moreno, C.; Carrodeguas, J. A.; Barcelona, J. A.; Tarrafeta, L.; López-Buesa, P. The effects of trimming on loin composition from pigs fed a modified diet. FLEISCHWIRTSCHAFT INTERNATIONAL. 2010

  • Burgos, C.; Moreno, C.; Carrodeguas, J.A.; Barcelona, J.A.; Tarrafeta, L.; López-Buesa, P. The influence of diet, sex, IGF2 and RYR1 genotypes, and anatomical location on pork loin composition. JOURNAL OF FOOD COMPOSITION AND ANALYSIS. 2010

  • Lamarca, V; Marzo, I; Sanzclemente, A; Carrodeguas, J. Exposure of any of two proapoptotic domains of presenilin 1-associated proteinmitochondrial carrier homolog 1 on the surface of mitochondria is sufficient for induction of apoptosis in a BaxBak-independent manner. EUROPEAN JOURNAL OF CELL BIOLOGY. 2008. DOI: 10.1016/j.ejcb.2008.02.004

  • Burgos, C.; Carrodeguas, J.A.; Tarrafeta, L.; López-Buesa, P. Genética molecular y selección porcina; el caso de IGF2 y MC4R. EUROCARNE (MADRID). 2008

  • Lamarca, V.;Sanz-Clemente, A.;Perez-Pe, R.;Martinez-Lorenzo, M. J.;Halaihel, N.;Muniesa, P.;Carrodeguas, J. A. Two Isoforms of PSAP/MTCH1 Share Two Proapoptotic Domains and Multiple Internal Signals for Import into the Mitochondrial Outer Membrane. AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2007

  • Lanaspa, M. A.;Giral, H.;Breusegem, S. Y.;Halaihel, N.;Baile, G.;Catalan, J.;Carrodeguas, J. A.;Barry, N. P.;Levi, M.;Sorribas, V. Interaction of MAP17 with NHERF3/4 Induces Translocation of the Renal Na/Pi IIa Transporter to the Trans-Golgi. AMERICAN JOURNAL OF PHYSIOLOGY. RENAL, FLUID AND ELECTROLYTE PHYSIOLOGY. 2007. DOI: 10.1152/ajprenal.00075.2006

  • Burgos, Carmen;Carrodeguas, Jose Alberto;Moreno, Carlos;Altarriba, Juan;Tarrafeta, Luis;Barcelona, Jose Antonio;Lopez Buesa, Pascual. Allelic incidence in several pig breeds of a missense variant of pig melanocortin-4 receptor (MC4R) gene associated with carcass and productive traits; its relation to IGF2 genotype. MEAT SCIENCE. 2006

  • Yakubovskaya, E.; Chen, Z.; Carrodeguas, J.A.; Kisker, C.; Bogenhagen, D.F. Functional Human Mitochondrial DNA Polymerase  Forms a Heterotrimer*. JOURNAL OF BIOLOGICAL CHEMISTRY. 2006. DOI: 10.1074/jbc.M509730200

  • Carrodeguas, J.A;Burgos, C;Moreno, C;Sanchez, A.C;Ventanas, S;Tarrafeta, L;Barcelona, J.A;Lopez, M.O;Oria, R;Lopez Buesa, P. Incidence in Diverse Pig Populations of an Igf2 Mutation With Potential Influence on Meat Quality and Quantity: an Assay Based on Real Time Pcr (Rt-Pcr). MEAT SCIENCE. 2005

  • Burgos, C;Carrodeguas, J.A;Moreno, C;Sanchez, A.C;Tarrafeta, L;Barcelona, J.A;Lopez Buesa, P. A Real Time Pcr (Rt-Pcr) Alternative Assay to Detect the T/C Mutation in Position 1843 of the Ryanodine Receptor Gene. MEAT SCIENCE. 2005

  • Carrodeguas, J.A;Rodolosse, A;Garza, M.V;Sanz Clemente, A;Perez Pe, R;Lacosta, A.M;Dominguez, L;Monleon, O;Sanchez Diaz, R;Sorribas, V;Sarasa, M. The Chick Embryo Appears as a Natural Model for Research in Beta-Amyloid Precursor Protein Processing. NEUROSCIENCE. 2005

  • Carrodeguas, J.A.; Pinz, K.G.; Bogenhagen, D.F. DNA binding properties of human pol gammaB. JOURNAL OF BIOLOGICAL CHEMISTRY. 2002

  • Carrodeguas, J.A.; Theis, K.; Bogenhagen, D.F.; Kisker, C. Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer. MOLECULAR CELL. 2001

  • Carrodeguas, J.A.; Bogenhagen, D.F. Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase. NUCLEIC ACIDS RESEARCH. 2000

  • Carrodeguas, J.A.; Kobayashi, R.; Lim, S.E.; Copeland, W.C.; Bogenhagen, D.F. The accessory subunit of Xenopus laevis mitochondrial DNA polymerase gamma increases processivity of the catalytic subunit of human DNA polymerase gamma and is related to class II aminoacyl-tRNA synthetases. MOLECULAR AND CELLULAR BIOLOGY. 1999

  • Carrodeguas, J.A.; Vallejo, C.G. Mitochondrial transcription initiation in the crustacean Artemia franciscana. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1997

  • Garesse R.; Carrodeguas, J.A.; Santiago, J.; Pérez, M.L.; Marco, R.; Vallejo, C.G. Artemia mitochondrial genome: molecular biology and evolutive considerations. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY. 1997

  • Ye, F.; Carrodeguas, J.A.; Bogenhagen, D.F. The gamma subfamily of DNA polymerases: cloning of a developmentally regulated cDNA encoding Xenopus laevis mitochondrial DNA polymerase gamma. NUCLEIC ACIDS RESEARCH. 1996

  • Carrodeguas, J.A.; Yun, S.; Shadel, G.S.; Clayton, D.A.; Bogenhagen, D.F. Functional conservation of yeast mtTFB despite extensive sequence divergence. GENE EXPRESSION. 1996

Conference presentations

  • de la Fuente Herreruela, D.;Gracia, P.;Camino, J.D.;Carrodeguas, J.A.;Cremades, N. Assessment of a potential novel interaction between alpha-synuclein and p62. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2019



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