I am a 4th year PhD student in the Genetic Regulation and Physiology of Cyanobacteria Research Group (CYANOFUR) at the University of Zaragoza, under the supervision of Dr. María F. Fillat and Dr. Emma Sevilla. My research is focused on genetic regulation in cyanobacteria, specifically on the regulation mediated by Ferric Uptake Regulator (FUR) proteins. I have published 4 articles in scientific journals indexed in the JCR and I also visited the Pakrasi Lab (Washington University in St. Louis, Missouri, United States of America) as part of my PhD to learn about CRISPR/Cpf1 in cyanobacteria. I have also participated in the organization of congresses and have presented more than 60 communications, both poster as talks, in more than 30 national and international congresses, having presented 15 oral communications and having received 3 awards for best oral communication.
I hold a BSc in Biotechnology and a MSc in Molecular and Cellular Biology from the University of Zaragoza. In both cases I graduated with an Extraordinary Award and received the AGM Award for the best record of my faculty. Both my Final Degree and my Final Master's Projects were qualified with Honors and both were awarded by the ‘Chair of Cooperation for Development’. My Final Master's Project was also awarded by the ‘Royal Spanish Society of Chemistry’. I have completed several complementary training programs in Bioinformatics, I have a good command of English (Level C2, Certificate of Proficiency in English) and I have completed more than 500 hours of training in more than 50 certified courses on bioinformatics, teaching, communication skills or interpersonal skills.
I combine my research work with teaching tasks at the university. I have supervised 300 hours of extracurricular internships and I have taught subjects in the Degree in Biotechnology and the Master's Degree in Compulsory Secondary Education Teachers from the University of Zaragoza. I have also co-directed 7 Final Degree Projects (2 in progress) and 1 Master's Final Project (in progress), three of which have been awarded by the ‘Chair of Cooperation for Development’. I have a great commitment to teaching and education, and that is why I also belong to the board of directors of the ‘University Students with Childhood’ Association and I work as a volunteer in the 'El Cañar' Association, which provides school support to children at risk of social exclusion.
Journal articles
- Matarredona, Laura; García-Bonete, María José; Guío, Jorge; Camacho, Mónica; Fillat, María F.; Esclapez, Julia; Bonete, María José. Global Lrp regulator protein from Haloferax mediterranei: Transcriptional analysis and structural characterization. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2024. DOI: 10.1016/j.ijbiomac.2024.129541
- Fernández-Otal, Ángela; Guío, Jorge; Sarasa-Buisan, Cristina; Peleato, M. Luisa; Fillat, María F.; Lanas, Ángel; Bes, M. Teresa. Functional characterization of Fur from the strict anaerobe Clostridioides difficile provides insight into its redox-driven regulatory capacity. FEBS JOURNAL. 2024. DOI: 10.1111/febs.17156
- Guío, Jorge; Fillat, Maria F.; Peleato, Maria L.; Sevilla, Emma. Responses of Anabaena sp. PCC7120 to lindane: Physiological effects and differential expression of potential lin genes. MICROBIOLOGYOPEN. 2023. DOI: 10.1002/mbo3.1355
- Sarasa-Buisan, Cristina; Guío, Jorge; Peleato, M. Luisa; Fillat, María F.; Sevilla, Emma. Expanding the FurC (PerR) regulon in Anabaena (Nostoc) sp. PCC 7120: Genome-wide identification of novel direct targets uncovers FurC participation in central carbon metabolism regulation. PLOS ONE. 2023. DOI: 10.1371/journal.pone.0289761
- Olivan-Muro, Irene; Sarasa-Buisan, Cristina; Guio, Jorge; Arenas, Jesús; Sevilla, Emma; Fillat, Maria F. Unbalancing Zur (FurB)-mediated homeostasis in Anabaena sp. PCC7120: Consequences on metal trafficking, heterocyst development and biofilm formation. ENVIRONMENTAL MICROBIOLOGY. 2023. DOI: 10.1111/1462-2920.16434
- Sarasa-Buisán, C.; Guío, J.; Castro, C.; Bes, M. T.; Fillat, M. F.; Peleato, M. L.; Sevilla, E. Contributions on lindane degradation by Microcystis aeruginosa PCC 7806. WATER (SWITZERLAND). 2022. DOI: 10.3390/w14081219
- Guío, Jorge; Bes, Mª Teresa; Balsera, Mónica; Calvo-Beguería, L.; Sevilla, E.; Peleato, Mª Luisa; Fillat, Mª Francisca. Thioredoxin dependent changes in the redox states of FurA from Anabaena sp. PCC7120. ANTIOXIDANTS. 2021. DOI: 10.3390/antiox10060913
- Sarasa-Buisan, Cristina; Guio, Jorge; Broset, Esther; Peleato, M. Luisa; Fillat, María F.; Sevilla, Emma. FurC (PerR) from Anabaena sp. PCC7120: a versatile transcriptional regulator engaged in the regulatory network of heterocyst development and nitrogen fixation. ENVIRONMENTAL MICROBIOLOGY. 2021. DOI: 10.1111/1462-2920.15552
- Guio, Jorge; Sarasa-Buisán, Cristina; Velázquez-Campoy, Adrián; Bes, María Teresa; Fillat, María F; Peleato, María Luisa; Sevilla, Emma. 2-oxoglutarate modulates the affinity of FurA for the ntcA promoter in Anabaena sp. PCC 7120. FEBS LETTERS. 2019. DOI: 10.1002/1873-3468.13610
Projects
- E35_23R: Grupo de referencia biología estructural. 01/01/23 - 31/12/25
- E35_20R: Biología Estructural. 01/01/20 - 31/12/22
Supervision of undergraduate dissertations
- Purificación y caracterización del regulador transcripcional AII 1651 de la cianobacteria Anabaena sp PCC7120. Universidad de Zaragoza. Sobresaliente. 27/06/23
- Purificación y caracterización del regulador transcripcional All7016 de la cianobacteria Anabaena sp. PCC7120. Universidad de Zaragoza. Sobresaliente. 22/06/23
- Desarrollo de una nueva herramienta de conjugación en la cianobacteria Anabaena sp. PCC 7120 y su aplicación al estudio del papel de FurA en la formación de biofilms. Universidad de Zaragoza. Sobresaliente. 14/07/22
- Avances en la caracterización de las redes de regulación mediadas por las proteínas FUR en Anabaena sp. PCC 7120: análisis de la corregulación por NtcA y estudio de la participación de factores sigma. Universidad de Zaragoza. Sobresaliente. 12/07/22
- Redes de regulación global mediadas por las proteínas FUR en Anabaena sp. PCC7120. Universidad de Zaragoza. Matrícula de honor. 09/07/21
- Identificación de genes implicados en la síntesis de biofilms en Anabaena sp. PCC7120 y análisis de su modulación por la familia de proteínas FUR (ferric uptake regulation). Universidad de Zaragoza. Matrícula de honor. 08/07/21
- Genes lin en Anabaena PCC7120: bases experimentales para el desarrollo de un biosensor de lindano. Universidad de Zaragoza. Matrícula de honor. 17/07/20
Supervision of master's theses
- Purificación y estudio de dos nuevos reguladores transcripcionales de la cianobacteria Anabaena sp. PCC7120. Universidad de Zaragoza. Matrícula de honor. 22/06/23
Participation in conferences
- 27th European Nitrogen cycle Meeting-NITROGEN 2024. Participativo - Ponencia invitada/ Keynote. Untangling the regulatory networks between FUR (ferric uptake regulator) proteins and nitrogen metabolism in Anabaena (Nostoc) sp. PCC7120. Granada. 01/10/24
- 45th Congress of the Spanish Society of Biochemistry and Molecular Biology. Participativo - Ponencia oral (comunicación oral). Beyond zinc homeostasis: the link between metalloregulator Zur / FurB of cyanobacteria Anabaena sp. PCC7120 and metal trafficking, biofilm formation and heterocyst development. Zaragoza. 05/09/23
- XI National Conference BIFI 2023. Participativo - Póster. NOVEL METABOLIC NETWORKS LINKED TO ZUR (FURB) REGULATION IN ANABAENA SP. PCC7120. Zaragoza. 26/01/23
- 44º Congreso Nacional de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Nuevas funciones del regulador transcripcional FurB (Zur) de Anabaena sp. PCC7120: impacto en el metabolismo del nitrógeno. Málaga. 06/09/22
- 44º Congreso Nacional de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Nuevas funciones del regulador transcripcional FurB (Zur) de Anabaena sp. PCC7120: impacto en el metabolismo del nitrógeno. Málaga. 06/09/22
- 44º Congreso Nacional de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Nuevas funciones del regulador transcripcional FurB (Zur) de Anabaena sp. PCC7120: impacto en el metabolismo del nitrógen. Málaga. 06/09/22
- XV Reunión Nacional del Metabolismo del Nitrógeno. Participativo - Póster. El regulador transcripcional FurB (Zur) de Anabaena sp. PCC7120: consecuencias de su desregulación en la formación de heterocistos. Córdoba. 02/02/22
- 43rd Annual Meeting of the Spanish Society of Biochemistry & Molecular Biology. Participativo - Póster. Factors affecting biofilm formation in the filamentous cyanobacterium Anabaena sp. PCC7120. Barcelona. 19/07/21
- 43r¿ Congress of the SEBBM – Barcelona 2021. Participativo - Ponencia oral (comunicación oral). Modulation of the redox status of the Ferric Uptake regulator FurA in Anabaena sp. PCC 7120. Barcelona. 19/07/21
- XIV Congreso Anual de Biotecnología (BAC 2021 Zaragoza). Participativo - Póster. Thioredoxin dependent changes in the redox states of FurA from Anabaena sp. PCC 7120. Zaragoza. 07/07/21
- XXVIII Congreso Sociedad Española de Microbiología. Participativo - Póster. Formación de biofilms en la cianobacteria Anabaena sp. PCC7120: factores implicados en su desarrollo y regulación por proteínas FUR. Virtual. 28/06/21
- XXVIII Congreso Sociedad Española de Microbiología. Participativo - Ponencia oral (comunicación oral). Control del estado redox del regulador transcripcional FurA de Anabaena sp. PCC7120 mediado por Tiorredoxina A. Virtual. 28/06/21
- 7th European Chemical Biology Symposium 2021. Participativo - Póster. Unveiling new roles for FUR (Ferric Uptake Regulator) proteins in Anabaena sp. PCC7120: FurA as a putative carbon/nitrogen balance sensor via 2-oxoglutarate. Berlín. 26/05/21
- XIII Jornadas de Genética y Biotecnología / III Jornadas Ibéricas de Genética y Biotecnología. Participativo - Póster. New roles for FUR (Ferric Uptake Regulator) proteins in Anabaena sp. PCC7120 beyond transcriptional regulation: exploring FurA interaction with photosynthetic electron carrier proteins. León (Spain) and Vila Real (Portugal). 15/04/21
- X National Conference BIFI 2021. Participativo - Póster. Unraveling biofilm formation in the filamentous cyanobacterium Anabaenasp. PCC7120. Zaragoza. 03/02/21
- X National Conference BIFI 2021. Participativo - Póster. Exploring FurA interaction with photosynthetic electron carrier proteins in Anabaena sp. PCC7120. Zaragoza. 03/02/21
- Biometals 2020. 12th International Biometals web-symposium. Participativo - Ponencia oral (comunicación oral). Interaction of Ferric Uptake Regulator FurA from Anabaena sp. PCC7120 with 2-oxoglutarate: a possible link between iron homeostasis and nitrogen metabolism. Online por Covid19 (Anteriormente, Villard-de-Lans). 06/07/20
- Applied bioinformatics in Life Sciences (3rd edition). Participativo - Póster. Exploring the interaction of FurA from Anabaena sp. PCC7120 with 2-oxoglutarate: a bioinformatic approach. Leuven. 13/02/20
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Póster. FurA from Anabaena PCC7120: a putative sensor of carbon-nitrogen balance via 2-oxoglutarate. Zaragoza. 03/02/20
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Póster. Molecular interaction between the ferric uptake regulator Fur from the cyanobacterium Anabaena sp. PCC 7120 and the electron transport proteins ferredoxin and flavodoxin. Zaragoza. 03/02/20
- 42nd Congress of the Spanish Society of Biochemistry and Molecular Biology. SEBBM19madrid. Participativo - Póster. 2-Oxoglutarate Enhances FurA Binding Activity to the ntcA Promoter in Anabaena PCC 7120. Madrid. 16/07/19
- 13th Annual Biotechnology Congress (BAC Madrid 2019). Participativo - Póster. Fur proteins as putative sensors of carbon/nitrogen balance in cyanobacteria: 2-oxoglutarate modulates the affinity of FurA for the ntcA promoter in Anabaena sp. PCC 7120. Madrid. 10/07/19
- IX Conferencia Nacional BIFI 2019. Participativo - Ponencia oral (comunicación oral). 2-Oxoglutarate Enhances FurA Binding Activity to NtcA Promoter Region in Anabaena PCC 7120. Zaragoza. 30/01/19
Research stays
- Washington University in St. Louis. St. Louis, Missouri. Estados Unidos de América. 01/09/21 - 30/11/21
UNIZAR teaching of the last six courses
Teaching not UNIZAR
- Taller 'perfiles del investigador'. I Congreso Estatal de Estudiantes de Biociencias (CEEBI). Universidad de Granada. 21/07/2022 - 21/07/2022
|