Profile (CV) of the research teaching staff

Journal articles

• Campos Sáenz de Santamaría, A.; Alcaine Otín, A.; Crespo Aznarez, S.; Josa Laorden, C.; Esterellas Sánchez, L.; Sánchez Marteles, M.; Garcés Horna, V.; Albines Fiestas, Z.; Giménez López, I.; Rubio Gracia, J. Multimodal analysis of congestion and prognostic utility of the VExUS protocol in hospitalized heart failure patients at a tertiary care hospital. REVISTA CLÍNICA ESPAÑOLA (ENGLISH EDITION). 2025. DOI: 10.1016/j.rceng.2025.502332
  
  
• Campos Sáenz de Santamaría, A.; Alcaine Otín, A.; Crespo Aznarez, S.; Josa Laorden, C.; Esterellas Sánchez, L.; Sánchez Marteles, M.; Garcés Horna, V.; Albines Fiestas, Z.; Giménez López, I.; Rubio Gracia, J. Análisis multimodal de la congestión y utilidad pronóstica del protocolo VExUS en pacientes hospitalizados por insuficiencia cardiaca en un hospital terciario. REVISTA CLÍNICA ESPAÑOLA. 2025. DOI: 10.1016/j.rce.2025.502332
  
  
• Campos-Sáenz de Santamaría, Amelia; Albines Fiestas, Zoila Stany; Crespo-Aznarez, Silvia; Esterellas-Sánchez, Laura Karla; Sánchez-Marteles, Marta; Garcés-Horna, Vanesa; Josa-Laorden, Claudia; Alcaine-Otín, Alejandro; Giménez-López, Ignacio; Rubio-Gracia, Jorge. VExUS protocol along cardiorenal syndrome: An updated review. JOURNAL OF CLINICAL MEDICINE. 2025. DOI: 10.3390/jcm14041334
  
  
• Esterellas-Sánchez, Laura Karla; Campos-Sáenz de Santamaría, Amelia; Albines Fiestas, Zoila Stany; Crespo-Aznarez, Silvia; Sánchez-Marteles, Marta; Garcés-Horna, Vanesa; Alcaine-Otín, Alejandro; Gimenez-Lopez, Ignacio; Rubio-Gracia, Jorge. How Does Left Ventricular Ejection Fraction Affect the Multimodal Assessment of Congestion in Patients with Acute Heart Failure? Results from a Prospective Study. APPLIED SCIENCES (SWITZERLAND). 2025. DOI: 10.3390/app15158157
  
  
• Jimenez-Perez, Guillermo; Acosta, Juan; Alcaine, Alejandro; Camara, Oscar. Generalising electrocardiogram detection and delineation: training convolutional neural networks with synthetic data augmentation. FRONTIERS IN CARDIOVASCULAR MEDICINE. 2024. DOI: 10.3389/fcvm.2024.1341786
  
  
• Riccio, Jennifer; Alcaine, Alejandro; Rocher, Sara; Martinez-Mateu, Laura; Saiz, Javier; Invers-Rubio, Eric; Guillem, Maria S.; Martínez, Juan Pablo; Laguna, Pablo. Atrial fibrosis identification with unipolar electrogram eigenvalue distribution analysis in multi-electrode arrays. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING. 2022. DOI: 10.1007/s11517-022-02648-3
  
  
• Riccio, J; Alcaine, A; Rocher, S; Martinez-Mateu, L; Laranjo, S; Saiz, J; Laguna, P; Martinez, Jp. Characterization of Atrial Propagation Patterns and Fibrotic Substrate With a Modified Omnipolar Electrogram Strategy in Multi-Electrode Arrays. FRONTIERS IN PHYSIOLOGY. 2021. DOI: 10.3389/fphys.2021.674223
  
  
• Riccio, J.; Alcaine, A.; Rocher, S.; Laguna, P.; Saiz, J.; Martínez, J.P. Omnipolar EGM voltage mapping for atrial fibrosis identification evaluated with an electrophysiological model. EUROPEAN SIGNAL PROCESSING CONFERENCE. 2021. DOI: 10.23919/Eusipco47968.2020.9287670
  
  
• Jimenez-Perez, Guillermo; Alcaine, Alejandro; Camara, Oscar. Delineation of the electrocardiogram with a mixed-quality-annotations dataset using convolutional neural networks. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2021. DOI: 10.1038/s41598-020-79512-7
  
  
• Doste, Ruben; Sebastian, Rafael; Gomez, Juan Francisco; Soto-Iglesias, David; Alcaine, Alejandro; Mont, Lluis; Berruezo, Antonio; Penela, Diego; Camara, Oscar. In silico pace-mapping: prediction of left vs. right outflow tract origin in idiopathic ventricular arrhythmias with patient-specific electrophysiological simulations. EUROPACE. 2020. DOI: 10.1093/europace/euaa102
  
  
• Riccio, Jennifer; Rocher Ventura, Sara; Martínez Mateu, Laura; Alcaine Otín, Alejandro; Sáiz Rodríguez, Javier; Martínez Cortés, Juan Pablo; Laguna Lasaosa, Pablo. Unipolar Electrogram Eigenvalue Distribution Analysis for the Identification of Atrial Fibrosis. COMPUTING IN CARDIOLOGY. 2020. DOI: 10.22489/CinC.2020.434
  
  
• Alcaine, Alejandro; Jáuregui, Beatriz; Soto-Iglesias, David; Acosta, Juan; Penela, Diego; Fernández-Armenta, Juan; Linhart, Markus; Andreu, David; Mont, Lluis; Laguna, Pablo; Cámara, Óscar; Martínez, Juan Pablo; Berruezo, Antonio. Automatic detection of slow conducting channels during substrate ablation of scar-related ventricular arrhythmias. JOURNAL OF INTERVENTIONAL CARDIOLOGY. 2020. DOI: 10.1155/2020/4386841
  
  
• Riccio, J.; Alcaine, A.; de Groot, N.M.S.; Houben, R.; Laguna, P.; Martínez, J.P. Characterization of Propagation Patterns with Omnipolar EGM in Epicardial Multi-Electrode Arrays. COMPUTING IN CARDIOLOGY. 2019. DOI: 10.23919/CinC49843.2019.9005931
  
  
• Alcaine, A.; Soto-Iglesias, D.; Acosta, J.; Korshunov, V.; Penela, D.; Martínez, M.; Linhart, M.; Andreu, D.; Fernández-Armenta, J.; Laguna, P.; Martínez, J.P.; Camara, O.; Berruezo, A. Automatic activation mapping and origin identification of idiopathic outflow tract ventricular arrhythmias. JOURNAL OF ELECTROCARDIOLOGY. 2018. DOI: 10.1016/j.jelectrocard.2017.10.015
  
  
• Alcaine, Alejandro; Masè, Michela; Cristoforetti, Alessandro; Ravelli, Flavia; Nollo, Giandomenico; Laguna, Pablo; Martinez, Juan Pablo; Faes, Luca. A multi-variate predictability framework to assess invasive cardiac activity and interactions during atrial fibrillation. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 2017. DOI: 10.1109/TBME.2016.2592953
  
  
• Alcaine, Alejandro; de Groot, N.M.; Laguna, Pablo; Martínez, J.P.; Houben, R.P. Spatiotemporal Model-Based Estimation of High-Density Atrial Fibrillation Activation Map. DIGITAL SIGNAL PROCESSING. 2016. DOI: 10.1016/j.dsp.2016.04.002
  
  
• Alcaine, A.; de Groot, N.M.S.; Laguna, P.; Martínez, J.P.; Houben, R.P.M. Estimation of high-density activation maps during atrial fibrillation. COMPUTING IN CARDIOLOGY. 2015. DOI: 10.1109/CIC.2015.7411038
  
  
• Lazaro Plaza, Jesus; Alcaine Otin, Alejandro; Romero Perez, Daniel; Gil Herrando, Eduardo; Laguna Lasaosa, Pablo; Pueyo Paules, Esther; Bailon Luesma, Raquel. Electrocardiogram derived respiratory rate from QRS slopes and R-wave angle. ANNALS OF BIOMEDICAL ENGINEERING. 2014. DOI: 10.1007/s10439-014-1073-x
  
  
• Alcaine, Alejandro; Soto-Iglesias, David; Calvo, Mireia; Guiu, Esther; Andreu, David; Fernández-Armenta, Juan; Berruezo, Antonio; Laguna, Pablo; Camara, Oscar; Martínez, Juan Pablo. A Wavelet-Based Electrogram Onset Delineator for Automatic Ventricular Activation Mapping. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 2014. DOI: 10.1109/TBME.2014.2330847
  
  
• Lázaro Plaza, Jesús; Alcaine Otín, Alejandro; Gil Herrando, Eduardo; Laguna Lasaosa, Pablo; Bailón Luesma, Raquel. Electrocardiogram derived respiration from QRS slopes. CONFERENCE PROCEEDINGS (IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. CONF.). 2013. DOI: 10.1109/EMBC.2013.6610400
  
  
• Hernando,D.; Alcaine,A.; Laguna,P.; Pueyo,E.; Bailon,R. Very low frequency modulation in QRS slopes and its relation with respiration and heart rate variability during hemodialysis. CONFERENCE PROCEEDINGS (IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. CONF.). 2013. DOI: 10.1109/EMBC.2013.6610761
  
  
• Alcaine, A.;Simón, F.;Árenal, A.;Laguna, P.;Martínez, J. P. A wavelet-based activation detector for bipolar electrogram analysis during atrial fibrillation. COMPUTING IN CARDIOLOGY. 2012
  
  
• Alcaine, A.; Bailón, R.; Romero, D.; Pueyo, E.; Laguna, P. Very-low-frequency modulation of QRS slopes in patients with angina pectoris. COMPUTING IN CARDIOLOGY. 2011
  
  

Conference presentations

• Alcaine, Alejandro; Soto-Iglesias, David; Acosta, Juan; Penela, Diego; Andreu, David; Fernández-Armenta, Juan; Laguna, Pablo; Camara, Oscar; Martínez, Juan Pablo; Berruezo, Antonio. Automatic delineation of slow conducting channels from electroanatomical maps in patients with scar-related ventricular arrhythmias. EUROPEAN HEART JOURNAL SUPPLEMENTS. 2017. DOI: 10.1093/eurheartj/ehx501.P795
  
  
• Alcaine Otín, Alejandro; Soto-Iglesias, David; Calvo, Mireia; Guiu, Esther; Andreu,David; Fernández-Armenta, Juan; Laguna, Pablo; Camara, Oscar; Martínez, Juan Pablo; Berruezo, Antonio. Evaluation of an Automatic Delineation Algorithm for Activation Mapping of Focal Ventricular Tachycardias. EUROPEAN HEART JOURNAL SUPPLEMENTS. 2014
  
  
• Lázaro Plaza, Jesús; Alcaine Otín, Alejandro; Romero Pérez, Daniel; Gil Herrando, Eduardo; Laguna Lasaosa, Pablo; Sörnmo, Leif; Bailón Luesma, Raquel. Electrocardiogram derived respiration from QRS slopes: Evaluation with stress testing recordings. COMPUTING IN CARDIOLOGY. 2013
  
  

Projects

• PID2022-139143OA-I00 DESARROLLO DE HERRAMIENTAS COMPUTACIONALES PARA LA MEJORA DEL DIAGNOSTICO, PRONOSTICO Y MANEJO DE LA INSUFICIENCIA CARDIACA CONGESTIVA. 01/09/23 - 31/08/26
  
  
• PID2019-104881RB-I00: Análisis de señal basado en la fisiología para el guiado del manejo y terapia de arritmias cardiacas. 01/06/20 - 31/05/23
  
  
• T39_20R: BSICoS. 01/01/20 - 31/12/22
  
  
• GRUPO DE REFERENCIA BSICoS. 01/01/17 - 31/12/19
  
  
• GRUPO CONSOLIDADO T96 BIOMEDICAL SIGNAL INTERPRETATION AND COMPUTATIONAL SIMULATION (BSICoS). 01/01/16 - 31/12/16
  
  
• GRUPO CONSOLIDADO T96 BIOMEDICAL SIGNAL INTERPRETATION AND COMPUTATIONAL SIMULATION (BSICoS). 01/01/15 - 31/12/15
  
  
• GRUPO CONSOLIDADO T96 BIOMEDICAL SIGNAL INTERPRETATION AND COMPUTATIONAL SIMULATION (BSICoS). 01/01/14 - 31/12/14
  
  
• GRUPO CONSOLIDADO T30 GRUPO DE TECNOLOGÍAS DE LAS COMUNICACIONES (GTC). 01/01/13 - 31/12/13
  
  
• GRUPO CONSOLIDADO T30 GRUPO DE TECNOLOGIAS DE LAS COMUNICACIONES. 01/01/11 - 31/12/12
  
  
• TEC2010-21703-C03-02.PROCESADO MULTIMODAL DE SEÑALES BIOMEDICAS PARA EL ANALISIS Y LA CARACTERIZACION FISIOLOGICA DE AFECCIONES CARDIOVASCULARES, RESPIRATORIAS Y AUTONÓMICAS. 01/01/11 - 31/12/14
  
  

Supervision of undergraduate dissertations

• Análisis de la regularidad morfológica de activaciones en señales EGM intracardíacas de pacientes con fibrilación auricular. Universidad de Zaragoza. Matrícula Honor. 29/09/14
  
  

Patents

• EP16002222.4. A computer implemented method to identify the ventricular arrhythmogenic substrate in myocardial scar or fibrotic tissue and computer programs thereof. MARTÍNEZ CORTÉS, JUAN PABLO - ALCAINE OTÍN, ALEJANDRO - LAGUNA LASAOSA, PABLO - BERRUEZO SANCHEZ, ANTONIO - CAMARA REY, OSCAR - SOTO IGLESIAS, DAVID. 2016
  
  

Participation in conferences

• ATRIAL SIGNALS 2021. Participativo - Ponencia oral (comunicación oral). Analysis of Unipolar Electrogram Eigenvalue Dispersion for the Detection of Atrial Fibrosis. Karlsruhe. 23/09/21
  
  
• 28th European Signal Processing Conference (EUSIPCO 2020). Participativo - Ponencia oral (comunicación oral). Omnipolar EGM Voltage Mapping for Atrial Fibrosis Identi¿cation Evaluated with an Electrophysiological Model. Amsterdam (virtual). 18/01/21
  
  
• Computing in Cardiology 2020. Participativo - Ponencia oral (comunicación oral). Unipolar Electrogram Eigenvalue Distribution Analysis for the Identification of Atrial Fibrosis. Rimini. 13/09/20
  
  
• Computing in Cardiology 2019. Participativo - Ponencia oral (comunicación oral). Characterization of Propagation Patterns with Omnipolar EGM in Epicardial Multi-electrode Arrays Singapur. 08/09/19
  
  
• ESC Congress 2017. Participativo - Póster. Automatic Delineation of Slow Conducting Channels from Electroanatomical Maps in Patients with Scar-Related Ventricular Arrhythmias. Barcelona. 26/08/17
  
  
• Computing in Cardiology 2015. Participativo - Ponencia oral (comunicación oral). Estimation of High-Density Activation Maps During Atrial Fibrillation. Niza. 06/09/15
  
  
• XXXII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Participativo - Ponencia oral (comunicación oral). Algoritmo de consistencia espacial basado en la morfología del electrograma para mejorar la delineación durante mapeo electroanatómico ventricular. Barcelona. 26/11/14
  
  
• Jornadas CIBER-BBN. Participativo - Póster. Evaluation of an Automatic Delineation Algorithm for Activation Mapping of Focal Ventricular Tachycardias. Gerona. 10/11/14
  
  
• Computing in Cardiology 2014. Participativo - Ponencia oral (comunicación oral). A Morphology-Based Spatial Consistency Algorithm to Improve EGM Delineation in Ventricular Electroanatomical Mapping. Boston. 07/09/14
  
  
• ESC Congress. Participativo - Póster. Evaluation of an Automatic Delineation Algorithm for Activation Mapping of Focal Ventricular Tachycardias. Barcelona. 30/08/14
  
  
• 8th Conference of the European Study Group on Cardiovascular Oscillations. Participativo - Ponencia oral (comunicación oral). Study of Electrogram Organization and Synchronization in Paroxysmal and Persistent/Permanent Atrial Fibrillation. Trento-Milan. 25/05/14
  
  
• Computing in Cardiology 2013. Participativo - Ponencia oral (comunicación oral). Influence of Respiration in the Very Low Frequency Modulation of QRS Slopes and Heart Rate Variability in Cardiomyopathy Patients. Zaragoza. 22/09/13
  
  
• Computing in Cardiology 2013. Participativo - Ponencia oral (comunicación oral). Electrocardiogram Derived Respiration from QRS Slopes: Evaluation over Stress Testing Recordings. Zaragoza. 22/09/13
  
  
• Computing in Cardiology 2013. Participativo - Ponencia oral (comunicación oral). Wavelet-Based Electrogram Onset Identification for Ventricular Electroanatomical Mapping. Zaragoza. 22/09/13
  
  
• 35th Annual International Conference of IEEE Engineering in Medicine and Biology Society (EMBC13). Participativo - Ponencia oral (comunicación oral). Very low frequency modulation in QRS slopes and its relation with respiration and heart rate variability during hemodialysis. Osaka. 03/07/13
  
  
• 35th Annual International Conference of IEEE Engineering in Medicine and Biology Society (EMBC13). Participativo - Ponencia oral (comunicación oral). Electrocardiogram Derived Respiration from QRS Slopes. Osaka. 03/07/13
  
  
• XXX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Participativo - Ponencia oral (comunicación oral). Detector de Activaciones Basado en Wavelet para el Análisis de Electrogramas Bipolares Durante Fibrilación Auricular. San Sebastián. 19/11/12
  
  
• Computing in Cardiology, 2012. Participativo - Ponencia oral (comunicación oral). A Wavelet-Based Activation Detector for Bipolar Electrogram Analysis During Atrial Fibrillation. Cracovia. 09/09/12
  
  
• Computing in Cardiology, 2011. Participativo - Póster. Very-Low-Frequency Modulation of QRS slopes in Patients with Angina Pectoris. Hangzhou. 18/09/11
  
  

Research stays

• Universidad Pompeu Fabra. Barcelona. España. 19/04/15 - 19/06/15
  
  
• Università degli Studi di Trento, BioTech Centre. Trento. Italia. 22/07/14 - 28/10/14
  
  
• Applied Biomedical Systems B.V. Maastricht. Holanda. 02/06/13 - 28/11/13
  
  

UNIZAR teaching of the last six courses

• Basic principles of computer studies. Bachelor's Degree in Electrical Engineering. During academic year 2026-27
  
  
• Programming 2. Bachelor's Degree in Informatics Engineering. During academic year 2026-27
  
  
• Programming 2. During academic year 2026-27
  
  
• Information and telemedicine systems. Degree in Biomedical Engineering. During academic year 2026-27
  
  
• Fundamentals of computing. Bachelor Degree in Mechanical Engineering. From the 2025-26 course to the 2026-27 course