Artículos
- Beyria, Lilha; Gourbeyre, Ophelie; Salillas, Sandra; Mahía, Alejandro; Díaz de Villegas, María Dolores; Aínsa, José Antonio; Sancho, Javier; Bousquet-Mélou, Alain; Ferran, Aude A. Antimicrobial combinations against Helicobacter pylori including benzoxadiazol-based flavodoxin inhibitors: in vitro characterization. MICROBIOLOGY SPECTRUM. 2024. DOI: 10.1128/spectrum.02623-23
- Conde-Giménez, M.; Galano-Frutos, J. J.; Galiana-Cameo, M.; Mahía Moros, A.; Victor, B. L.; Salillas Berges, S.; Velázquez-Campoy, A.; Brito, R. M. M.; Gálvez Lafuente, J. A.; Díaz-De-Villegas, M. D.; Sancho Sanz, J. Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022. DOI: 10.3390/ijms23094502
- Lopez-Ram-De-Viu, Pilar; Galvez, Jose A.; Diaz-De-Villegas, Maria D. Synthesis, resolution, and absolute configuration determination of a vicinal amino alcohol with axial chirality. Application to the synthesis of new box and pybox ligands. CHIRALITY. 2022. DOI: 10.1002/chir.23475
- Mahía A.; Peña-Díaz S.; Navarro S.; Galano-Frutos J.J.; Pallarés I.; Pujols J.; Díaz-De-Villegas M.D.; Gálvez J.A.; Ventura S.; Sancho J. Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of a-synuclein aggregation with potentially improved BBB permeability. BIOORGANIC CHEMISTRY. 2021. DOI: 10.1016/j.bioorg.2021.105472
- Salillas S.; Galano-Frutos J.J.; Mahía A.; Maity R.; Conde-Giménez M.; Anoz-Carbonell E.; Berlamont H.; Velazquez-Campoy A.; Touati E.; Mamat U.; Schaible U.E.; Gálvez J.A.; Díaz-De-Villegas M.D.; Haesebrouck F.; Aínsa J.A.; Sancho J. Selective targeting of human and animal pathogens of the helicobacter genus by flavodoxin inhibitors: Efficacy, synergy, resistance and mechanistic studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021. DOI: 10.3390/ijms221810137
- Gálvez J.A.; Badorrey R.; Mahía A.; Díaz-De-Villegas M.D. Asymmetric synthesis of (1R, 5S)-2-methyl-6, 7-benzomorphan via Aza-Prins reaction. CHIRALITY. 2021. DOI: 10.1002/chir.23338
- Castan, A.; Badorrey, R.; Diez, J.A.; Christoffersen, C.T.; Rasmussen, L.K.; Kehler, J.; Kohler, R.; Galvez, J.A.; Diaz-De-Villegas, M.D. Debenzylative Cycloetherification as a Synthetic Tool in the Diastereoselective Synthesis of 3, 6-Disubstituted Hexahydro-2H-furo[3, 2-b]pyrroles, PDE1 Enzyme Inhibitors with an Antiproliferative Effect on Melanoma Cells. JOURNAL OF ORGANIC CHEMISTRY. 2020. DOI: 10.1021/acs.joc.0c00276
- Gálvez, José A.; Clavería-Gimeno, Rafael; Galano-Frutos, Juan J.; Sancho, Javier; Velázquez-Campoy, Adrian; Abian, Olga; Díaz-De-Villegas, María D. Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2019. DOI: 10.1016/j.ejmech.2019.03.019
- Mahía, A.; Conde-Giménez, M.; Salillas, S.; Pallarés, I.; Galano-Frutos, J.J.; Lasa, Í.; Ventura, S.; Díaz de Villegas, M.D.; Gálvez, J.A.; Sancho, J. A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aß1-42, a-synuclein, and amylin amyloid fibrils as well as amyloid-containing Staphylococcus aureus biofilms. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2019. DOI: 10.1007/s00216-018-1433-8
- Salillas, Sandra; Alías, Miriam; Michel, Valérie; Mahía, Alejandro; Lucía, Ainhoa; Rodrigues, Liliana; Bueno, Jessica; Galano-Frutos, Juan José; de Reuse, Hilde; Velázquez-Campoy, Adrián; Carrodeguas, José Alberto; Sostres, Carlos; Castillo, Javier; Aínsa. José Antonio; Díaz-De-Villegas, María Dolores; Lanas, Ángel; Touati, Eliette; Sancho, Javier. Design, synthesis, and efficacy testing of nitroethylene- and 7-nitrobenzoxadiazol-based flavodoxin inhibitors against helicobacter pylori drug-resistant clinical strains and in helicobacter pylori-infected mice. JOURNAL OF MEDICINAL CHEMISTRY. 2019. DOI: 10.1021/acs.jmedchem.9b00355
- Castán, A.; Badorrey, R.; Gálvez, J.A.; López-Ram-De-Víu, P.; Díaz-De-Villegas, M.D. Michael addition of carbonyl compounds to nitroolefins under the catalysis of new pyrrolidine-based bifunctional organocatalysts. ORGANIC & BIOMOLECULAR CHEMISTRY. 2018. DOI: 10.1039/c7ob02798b
- Mahía, Alejandro; Badorrey, Ramón; Gálvez, José A.; Díaz-De-Villegas, María D. Diastereoselective construction of the 6-Oxa-2-azabicyclo[3.2.1]octane Scaffold from Chiral a-Hydroxyaldehyde derivatives by the Aza-Prins reaction. JOURNAL OF ORGANIC CHEMISTRY. 2017. DOI: 10.1021/acs.joc.7b01291
- Castán, A.; Badorrey, R.; Gálvez, J.A.; Díaz de Villegas, M.D. Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY. 2017. DOI: 10.3762/bjoc.13.59
- Valero, M.S.; Oliván-Viguera, A.; Amor, S.; García Villalón, A.L.; Coleman, N.; Laría, C.; Calvín-Tienza, V.; García-Otín, A.L.; Fernández-Fernández, J.M.; Murillo, M.D.; Gálvez, J.A.; Díaz-De-Villegas, M.D.; Badorrey, R.; Rivera, L; Wulff, H.; Köhler, R. Vascular reactivity profile of novel KCa3.1-selective positive-gating modulators in the coronary vascular bed. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2016. DOI: 10.1111/bcpt.12560
- López-Ram-De-Víu, P.; Gálvez, J.A.; Díaz-De-Villegas, M.D. High-performance liquid chromatographic enantioseparation of unusual amino acid derivatives with axial chirality on polysaccharide-based chiral stationary phases. JOURNAL OF CHROMATOGRAPHY A. 2015. DOI: 10.1016/j.chroma.2015.02.055
- Oliván-Viguera, Aida; Valero, Marta Sofía; Coleman, Nicole; Brown, Brandon M.; Laría, Celia; Murillo, María Divina; Gálvez, José A.; Díaz-De-Villegas, María D.; Wulff, Heike; Badorrey, Ramón; Köhler, Ralf. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits Endothelium-derived hyperpolarization–type relaxation in coronary artery and produces bradycardia in vivo. MOLECULAR PHARMACOLOGY. 2015. DOI: 10.1124/mol.114.095745
- Díaz-De-Villegas, M. D.; Gálvez, J. A.; Badorrey, R.; López-Ram-De-Víu, P. Organocatalysis in enantioselective -Functionalization of 2-Cyanoacetates. ADVANCED SYNTHESIS AND CATALYSIS. 2014. DOI: 10.1002/adsc.201400404
- Gálvez, J.A.; Díaz-De-Villegas, M.D.; Alías, M.; Badorrey, R. Chiral Iminoesters Derived from D-Glyceraldehyde in [3 + 2] Cycloaddition Reactions. Asymmetric Synthesis of a Key Intermediate in the Synthesis of Neuramidinase Inhibitors. JOURNAL OF ORGANIC CHEMISTRY. 2013. DOI: 10.1021/jo401967a
- Díez, J.A.; Gálvez, J.A.; Díaz-De-Villegas, M.D.; Badorrey, R.; Bartholomew, B.; Nash, R.J. Stereoselective synthesis and biological evaluation of D-fagomine, D-3-epi-fagomine and D-3,4-epi-fagomine analogs from D-glyceraldehyde acetonide as a common building block. ORGANIC & BIOMOLECULAR CHEMISTRY. 2012. DOI: 10.1039/c2ob26732b
- Díaz-De-Villegas, M. D.; Gálvez, J. A.; Badorrey, R.; López-Ram-De-Víu, M. P. Organocatalyzed enantioselective desymmetrization of diols in the preparation of chiral building blocks. CHEMISTRY - A EUROPEAN JOURNAL. 2012. DOI: 10.1002/chem.201202264
- Gálvez,J. A.;Díaz de Villegas;Badorrey,R.;López-Ram-De-Víu,P. Switch in regioselectivity of epoxide ring-opening by changing the organometallic reagent. ORGANIC & BIOMOLECULAR CHEMISTRY. 2011. DOI: 10.1039/c1ob06216f
- Díaz,de Villegas;Gálvez,J. A.;Etayo,P.;Badorrey,R.;López-Ram-De-Víu,P. Recent advances in enantioselective organocatalyzed anhydride desymmetrization and its application to the synthesis of valuable enantiopure compounds. CHEMICAL SOCIETY REVIEWS. 2011. DOI: 10.1039/c1cs15120g
- Etayo, P.;Badorrey, R.;Diaz-De-Villegas, M. D.;Galvez, J. A. ;Lopez-Ram-De-Viu, P. An expeditious method for the first asymmetric synthesis of dexoxadrol from the chiral pool. SYNLETT. 2010
- Etayo, Pablo; Badorrey, Ramón; Díaz-De-Villegas, María Dolores; Gálvez, José Antonio. Chiral amino diol derivatives as new modular organocatalysts for the enantioselective a-chlorination of cyclic b-keto esters. ADVANCED SYNTHESIS AND CATALYSIS. 2010
- Allepuz, Ana; Badorrey, Ramon, Díaz-De-Villegas, Maria Dolores, Galvez, Jose Antonio. Diastereoselective reduction of ketimines derived from (R)-3,4-dihydroxybutan-2-one. An alternative route to key intermediates for the synthesis of anticancer agent ES-285. TETRAHEDRON: ASYMMETRY. 2010
- Etayo, P.;Badorrey,R.;Diaz-De-Villegas,M. D.;Galvez,J. A. First Stereoselective Synthesis of (1R,2R,4R)- and (1S,2R,4S)-2-Substituted-1-Azabicyclo[2.2.1]Heptanes. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2009
- Allepuz, A. C.;Badorrey,R.;Diaz-De-Villegas,M. D.;Galvez,J. A. Asymmetric Synthesis of ES-285, an Anticancer Agent Isolated from Marine Sources. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2009
- Badorrey, R.;Diaz Villegas,M. D.;Galvez,J. A. Expedient Asymmetric Synthesis of (2S,3S)-Boc-Phenylalanine Epoxide, a Key Intermediate for the Synthesis of Biologically Active Compounds. TETRAHEDRON: ASYMMETRY. 2009
- Badorrey, R.;Portaña,E.;Diaz-De-Villegas,M. D.;Galvez,J. A. Stereocontrolled Synthesis of Orthogonally Protected 2-Substituted 4-Aminopiperidines. ORGANIC & BIOMOLECULAR CHEMISTRY. 2009
- Etayo,E.;Badorrey,R.;Díaz-De-Villegas,M.D.;Gálvez,J.A. Asymmetric synthesis of novel conformationally constrained D-lysine analogue with a piperidine skeleton. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2008
- Etayo,P.; Badorrey,R.; Diazdevillegas,M.D.; Galvez,J.A. Synthesis of (R)-quinuclidine-2-carboxylic acid in enantiomerically pure form. TETRAHEDRON LETTERS. 2008
- Etayo, P.; Badorrey, R.; Díaz de Villegas, M. D.; Gálvez, J. A. Asymmetric homologation of ketones. A new entry to orthogonally protected (2R,4R)-piperidine-2,4-dicarboxylic acid. JOURNAL OF ORGANIC CHEMISTRY. 2008
- Etayo, P.;Badorrey,R.;Diaz-De-Villegas,M. D.;Galvez,J. A. Stereoselective Synthesis of Chiral 2,3-Disubstituted 2,3-Dihydro-4(1H)-Pyridones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2008
- Etayo, P.; Badorrey, R.; Diazdevillegas, M.D.; Galvez, J.A. Efficient stereoselective synthesis of enantiopure cis- and trans-1,2,4-trisubstituted piperidines. TETRAHEDRON: ASYMMETRY. 2007
- Cativiela, C.;Diaz Villegas,M. D. Recent Progress on the Stereoselective Synthesis of Acyclic Quaternary Alpha-Amino Acids. TETRAHEDRON: ASYMMETRY. 2007
- Diez, R.; Badorrey, R; Diaz de Villegas, M.D.; Galvez, J.A. Highly stereoselective synthesis of stereochemically defined polyhydroxylated propargylamines by alkynynation of N-benzyl imines derived from (R)-glyceraldehyde. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2007
- Etayo, P.; Badorrey, R.; Diazdevillegas, M.D.; Galvez, J.A. Base-controlled diastereodivergent synthesis of (R)- and (S)-2-substituted-4-alkylidenepiperidines by the Wadswoth-Emmons reaction. JOURNAL OF ORGANIC CHEMISTRY. 2007
- Aguirre,D.;Cativiela,C.;Diaz-De-Villegas,M. D.;Galvez,J. A. First asymmetric synthesis of an acyclic beta,beta-dialkylated-gamma-aminobutyric acid. TETRAHEDRON. 2006
- Etayo,P.;Badorrey,R.;Diaz-De-Villegas,M. D.;Galvez,J. A. Efficient stereodivergent synthesis of cis-(2R,4S)- and trans-(2R,4R)-4-phosphonomethyl-2-piperidinecarboxylic acids from the same chiral imine derived from (R)-glyceraldehyde. SYNLETT. 2006
- Etayo,P.;Badorrey,R.;Diaz-De-Villegas,M. D.;Galvez,J. A. Unexpected epimerization at C-2 in the Horner-Wadsworth-Emmons reaction of chiral 2-substituted-4-oxopiperidines. CHEMICAL COMMUNICATIONS. 2006
- Badorrey, R.;Cativiela, C.;Diaz de Villegas, M. D.;Diez, R.;Galbiati, F.;Galvez, J. A. Highly Diastereoselective Cyanation of Methyl Ketimines Obtained From (R)-Glyceraldehyde. JOURNAL OF ORGANIC CHEMISTRY. 2005
- Badorrey, R.;Cativiela, C.;Diaz de Villegas, M. D.;Diez, R.;Galvez, J. A. The First Asymmetric Synthesis of 1,4-Dideoxy-1,4-Imino-D-Talitol. SYNLETT. 2005
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A.;Su, G. Horner-Wadsworth-Emmons Reaction for the Synthesis of Unusual Alpha,Beta-Didehydroamino Acids With a Chiral Axis. ARKIVOC. 2004
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A.;Ronco, E. Allylation and Propargylation of Chiral Cyanopropanoates: an Efficient Route to Long Chain Alpha-Substituted Alpha-Methyl Alpha-Amino Acids. CHIRALITY. 2004
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A.;Su, G. F. Synthesis and Conformational Properties of Model Dipeptides Containing Novel Axially Chiral Alpha,Beta-Didehydroamino Acids at the (I+1) Position of a Beta-Turn Conformation. TETRAHEDRON. 2004
- Badorrey, R.;Cativiela, C.;Diaz de Villegas, M. D.;Diez, R.;Galvez, J. A. Efficient Stereodivergent Synthesis of 1,4-Dideoxy-1,4-Iminohexitols From an (S)-Glyceraldimine. TETRAHEDRON LETTERS. 2004
- Badorrey, R.;Cativiela, C.;Diaz-De-Villegas, M. D.;Galvez, J. A. Efficient Resolution of Rac-2-Cyano-2-Methyl-3-Phenylpropanoic Acid. An Appropriate Starting Material for the Enantioconvergent Synthesis of (S)-Alpha-Methylphenylalanine on a Large Laboratory Scale. TETRAHEDRON: ASYMMETRY. 2003
- Badorrey, R.;Cativiela, C.;Diaz-De-Villegas, M. D.;Galvez, J. A. Study of the Lewis acid-promoted addition of silylenol ethers to imines derived from glyderaldehyde. TETRAHEDRON LETTERS. 2003
- Badorrey, R.;Cativiela, C.;Diaz de Villegas, M. D.;Diez, R.;Galvez, J. A. Study of the Reactions Between Vinylmagnesium Bromide and Imines Derived From (R)-Glyceraldehyde - the Key Step in the Stereodivergent Synthesis of Conveniently Protected, Enantiopure Syn- and Anti-2-Amino-1,3,4-Butanetriol Derivatives. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2003
- Badorrey, R.;Cativiela, C.;Diaz-De-Villegas, M. D.;Galvez, J. A.;Gil, A. Efficient Enantioconvergent Synthesis of (S)-Alpha-Benzyl-Alpha-Methyl-Beta-Alanine From (R)- and (S)-2-Cyano-2-Methyl-3-Phenylpropanoic Acid. TETRAHEDRON: ASYMMETRY. 2003
- Gil, A. M.;Buñuel, E.;Diaz de Villegas, M. D.;Cativiela, C. Olefination of Methyl (1s,2r,4r)-N-Benzoyl-2-Formyl-7-Azabicyclo[2.2.1]Heptane-1-Carboxylate, a Synthetic Approach to New Conformationally Constrained Prolines. TETRAHEDRON: ASYMMETRY. 2003
- Rainaldi, M.;Moretto, A.;Peggion, C.;Formaggio, F.;Mammi, S.;Peggion, E.;Galvez, J. A.;Diaz-De-Villegas, M. D.;Cativiela, C.;Toniolo, C. Lipopeptaibol Metabolites of Tolypocladium Geodes: Total Synthesis, Preferred Conformation, and Membrane Activity. CHEMISTRY - A EUROPEAN JOURNAL. 2003
- Badorrey, Ramon;Cativiela, Carlos;Diaz-De-Villegas, Maria D.;Galvez, Jose A. tert-Butyl (7R)-7-[(4S)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE. 2002
- Badorrey, Ramon; Cativiela, Carlos; Díaz-De-Villegas, Maria D.; Gálvez, Jose A. tert-Butyl (7R)-7-[(4S)-2, 2-dimethyl-[1, 3]dioxolan-4-yl]-1, 4-dioxa-8-azaspiro[4.5]decane-8-carboxylate. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE. 2002. DOI: 10.1107/S160053680200898X
- Badorrey,R.; Cativiela,C.; Diaz de Villegas,M.D.; Diez,R.;Galvez,J.A. Stereodivergent addition of allylmetal reagents to imines derived from (R)-2,3-di-O-benzylglyceraldehyde via appropriate metal selection and double stereodifferentiation. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2002
- Rainaldi,M.;Moretto,A.;Peggion,C.;Formaggio,F.;Mammi,S.;Peggion, E.;Gálvez,J.A.;Díaz de Villegas,M.D.;Cativiela,C.;Toniolo,C. Preferred conformation and membrane activity of the LP237-F lipopeptaibols. JOURNAL OF PEPTIDE SCIENCE. 2002
- Badorrey, Ramon;Cativiela, Carlos;Diaz, de Villegas Maria D;Galvez, Jose A. Highly convergent stereoselective synthesis of chiral key intermediates in the synthesis of Palinavir from imines derived from L-glyceraldehyde. TETRAHEDRON. 2002
- Bunuel, E. ;Gil, A. M. ;Diaz de Villegas, M. D. ;Cativiela, C. Synthesis of constrained prolines by Diels-Alder reaction using a chiral unsaturated oxazolone derived from (R)-glyceraldehyde as starting material. TETRAHEDRON. 2001
- Badorrey, R. ;Cativiela, C. ;Diaz de Villegas, M. D. ;Galvez, J. A. Asymmetric synthesis of (2R,3S)-4-halo-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)butyronitriles as precursors for the synthesis of < beta >-hydroxy-< alpha >-amino acids. TETRAHEDRON: ASYMMETRY. 2000
- Cativiela, C.;Diazdevillegas, M.D. Stereoselective Synthesis of Quaternary Alpha-Amino-Acids - Part 2 - Cyclic-Compounds. TETRAHEDRON: ASYMMETRY. 2000
- Moretto, A.;Peggion, C.;Formaggio, F.;Crisma, M.;Toniolo, C.;Piazza, C.;Kaptein, B.;Broxterman, Q.B.;Ruiz, I.;Diazdevillegas, M.D.;Galvez, J.A.;Cativiela, C. (Alpha-Me)Nva - Stereoselective Syntheses and Preferred Conformations of Selected Model Peptides. JOURNAL OF PEPTIDE RESEARCH. 2000
- Bunuel, E. ;Cativiela, C. ;Diaz de Villegas, M. D;Galvez, J. A. Two new conformationally restricted 4,5-dihydroxynorvaline analogues with a norbornane skeleton. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 2000
- Alias, M.;Bunuel, E.;Cativiela, C.;Diaz-De-Villegas, M. D.;Galvez, J. A. (1R,2R,3S,4S,5S,6S)-exo-2-cyano-exo-3-[(S)-1,2-dibenzyloxyethyl]-exo-5-i odo-bicyclo[2,2.1]heptane-endo-2,6-carbolactone. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1999
- Badorrey, R.;Cativiela, C.;Diaz-De-Villegas, M. D.;Galvez, J. A.;Lapena, Y. 2-Tert-Butoxycarbonylamino-2-Isopropyl-4-Pentenamide, a New Conformationally Restricted Alpha,alpha-Dialkylglycine Derivative. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1999
- Dias-De-Villegas, M. D.;Urriolabeitia, E. P. A simple method for determining the absolute configuration of alpha-amino acids. JOURNAL OF CHEMICAL EDUCATION. 1999
- Cativiela, C.;Diaz-De-Villegas, M. D.;Jimenez, A. I.;Lopez, P.;Marraud, M.;Oliveros, L. Efficient access to all four stereoisomers of phenylalanine cyclopropane analogues by chiral HPLC. CHIRALITY. 1999
- Badorrey, R.;Cativiela, C.;Diaz-De-Villegas, M. D.;Galvez, J. A. Stereocontrolled synthesis of all four stereoisomers of fully protected 2-amino-3-hydroxypentanoic acid from imines derived from D-glyceraldehyde. TETRAHEDRON. 1999
- Badorrey, R.;Cativiela, C.;Diaz-De-Villegas, M. D.;Galvez, J. A. Study of the reaction of imines derived from (R)-glyceraldehyde with Danishefsky's diene. TETRAHEDRON. 1999
- Cativiela, C.;Diaz-De-Villegas, M. D.;Galvez, J. A. Synthesis and chemical resolution of unique alpha,beta-didehydroamino acids with a chiral axis. TETRAHEDRON LETTERS. 1999
- Bunuel, E.;Cativiela, C.;Diaz-De-Villegas, M. D.;Galvez, J. A. Crystal structure of (1S,2S,3R,4R)-3-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-bicyclo[2.2.1]-hept -5-en-2-spiro-{4 '[2 '-phenyl-5 '(4 ' H)-oxazolone]}, C20H21NO4. ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES. 1998
- Cativiela, C.;Diaz-De-Villegas, M. D. Stereoselective synthesis of quaternary alpha-amino acids. Part 1: Acyclic compounds. TETRAHEDRON: ASYMMETRY. 1998
- Alias, M.;Cativiela, C.;Diaz-De-Villegas, M. D.;Galvez, J. A.;Lapeña, Y. Synthesis of (S)-N-tert-butoxycarbonyl-N,O-isopropylidene-alpha-methylserinal: A potential building block for the asymmetric synthesis of non-natural amino acids. TETRAHEDRON. 1998
- Cativiela, C.;Diaz de Villegas, M.;Garcia, J. I.;Jimenez, A. I. 1,3-dipolar cycloaddition of diazomethane to chiral azlactones. Experimental and theoretical studies. TETRAHEDRON. 1997
- Badorrey, R.;Cativiela, C.;Diazdevillegas, M. D.;Galvez, J. A. Asymmetric hetero Diels-Alder reaction of N-benzylimines derived from R-glyceraldehyde: A new approach to homochiral piperidine building blocks and its application to the synthesis of (2R)-4-oxopipecolic acid. TETRAHEDRON LETTERS. 1997
- Bunuel, E.;Cativiela, C.;Diazdevillegas, D.;Galvez, J. A. A conformationally restricted aspartic acid analogue with a norbornane skeleton .2. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1997
- Cativiela, C.;Diazdevillegas, M. D.;Galvez, J. A.;Lapena, Y. On the synthesis of (S)-alpha-methylaspartic acid by diastereoselective alkylation of a chiral 2-cyanopropanoate. TETRAHEDRON. 1997
- Cativiela, C.;Diazdevillegas, M. D.;Galvez, J. A. A chiral hydrazone derived from D-glyceraldehyde: A convenient starting material for the stereoselective synthesis of alpha-hydrazino acids. TETRAHEDRON: ASYMMETRY. 1997
- Badorrey, R.;Cativiela, C.;Diazdevillegas, M. D.;Galvez, J. A.;Lapena, Y. A new approach to the stereoselective synthesis of conveniently protected alpha-allyl substituted amino acids; Chiral key compounds in the synthesis of constrained peptide isostere constituents. TETRAHEDRON: ASYMMETRY. 1997
- Badorrey, R.;Cativiela, C.;Diazdevillegas, M. D.;Galvez, J. A. Reversal of the stereochemical course of the addition of phenylmagnesium bromide to N-benzylimines derived from R-glyceraldehyde depending on the O-protecting group and its application to the synthesis of both enantiomers of phenylglycine. TETRAHEDRON. 1997
- Badorrey, R.;Cativiela, C.;Diazdevillegas, M. D.;Galvez, J. A. A convenient synthesis of L-alpha-vinylglycine from D-mannitol. SYNTHESIS-STUTTGART. 1997
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. A conformationally restricted aspartic acid analogue. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1996
- Buñuel, E.; Cativiela, C.; Díaz-De-Villegas, M. D.; Gálvez, J. A. A New Conformationally Restricted Aspartic Acid Analogue with a Cyclohexanone Skeleton. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1996. DOI: 10.1107/S0108270196008712
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. A new conformationally restricted aspartic acid analogue with a bicyclo[2.2.2]octane skeleton. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1996
- Cantin, O.;Cativiela, C.;Diaz de Villegas, M. D.;Navarro, R.;Urriolabeitia, E. P. A practical method for the absolute configuration assignment of alpha-amino acids using their Pd(dmba) amino acidato complexes. TETRAHEDRON: ASYMMETRY. 1996
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Crystal structure of 3,5-dimethyl-5-diphenylmethylhydantoin, C18H18N2O2. ZEITSCHRIFT FUR KRISTALLOGRAPHIE. 1996
- Navarro, R.;Urriolabeitia, E. P.;Cativiela, C.;Diazdevillegas, M. D.;Lopez, M. P.;Alonso, E. Chiral Pd organometallic complexes as catalysts in cyclopropanation reactions. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL. 1996
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A.;Garcia, J. I. Diastereoselective Strecker reaction of D-glyceraldehyde derivatives. A novel route to (2S,3S)- and (2R,3S)-2-amino-3,4-dihydroxybutyric acid. TETRAHEDRON. 1996
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D. Diastereoselective synthesis of (1S,2S,3R,4R) and (1R,2S,3R,4S)-bicyclo[2.2.1]hept-2-amino-2,3-dicarboxylic acids: New conformationally-constrained (S)-aspartic acid analogues. TETRAHEDRON: ASYMMETRY. 1996
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A.;Jimenez, A. I.;Lopez, M. P. Methyl (1R,2R)- and (1S,2S)-1-cyano-2[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclopropane-1-carb oxylate. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1996
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Methyl 2-methoxycarbonylamino-3,3-diphenylpropionate, an interesting diphenylalanine (DIP) derivative. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1996
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Stereoselective synthesis of alpha-hydroxy-beta-amino acids using D-glyceraldehyde as the homochiral source. TETRAHEDRON: ASYMMETRY. 1996
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. The synthesis of enantiomerically pure (2R)-alpha-methylisoserine. TETRAHEDRON. 1996
- Cativiela, C.;Diaz de Villegas, M. D.;Jimenez, A. I. Wittig olefination of methyl (1S,2R)-1-benzamido-2-formylcyclopropanecarboxylate. A powerful tool for the synthesis of new conformationally constrained cyclopropyl amino acids. TETRAHEDRON. 1996
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A.;Jimenez, A. I. (Z)-4-[(S)-2,2-Dimethyl-1,3-dioxolan-4-yl-methylidene]-2-phenyl-1,3-oxaz ol-5(4H)-one. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1996
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D. Z-2-phenyl-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-ylmethylen]-5(4H)-oxazolon e as the dienophile in asymmetric Diels-Alder reactions .2. TETRAHEDRON: ASYMMETRY. 1996
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. A lactone derived from an amino acid with a cyclohexyl skeleton: (1S,6R,9S)-6-benzamido-9-hydroxymethyl-8-oxabicyclo-[4.3.0]non-3-en-7-on e. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1996
- Cativiela, C.;Diaz de Villegas, M. D.;Jimenez, A. I. A Simple Synthesis of (-)-(1s,2r)-Allocoronamic Acid in its Enantiomerically Pure Form. TETRAHEDRON: ASYMMETRY. 1995
- Cativiela, C.;Diaz de Villegas, M. D.;Jimenez, A. I. A Straightforward Synthesis of (-)-(1s,2r)-Allonorcoronamic Acid using D-Mannitol as the Chiral Source. TETRAHEDRON: ASYMMETRY. 1995
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Diastereoselective Strecker Reaction of Imines Derived from D-Glyceraldehyde - a New Route to Beta-Hydroxy-Alpha-Amino Acids. TETRAHEDRON LETTERS. 1995
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A.;Lopez, M. P. Trans-1-cyano-2-phenylcyclopropane-carboxamide. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS. 1995
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A.;Lapeña, Y. Chiral 2-Cyano Esters as Synthetic Intermediates in the Synthesis of R-Alpha-Methylvaline and S-Alpha-Methylvaline. TETRAHEDRON. 1995
- Navarro, R.;Garcia, J.;Urriolabeitia, E. P.;Cativiela, C.;Diaz de Villegas, M. D. Metal-Complexes of Biologically Important Ligands - Synthesis of Amino Acidato Complexes of Pd-Ii Containing a C,n-Cyclometalated Group as an Ancillary Ligand. JOURNAL OF ORGANOMETALLIC CHEMISTRY. 1995
- Badorrey, R.;Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Stereoselective Amination of Chiral Enolates - Synthesis of Enantiomerically Pure Alpha,beta-Diamino Acids, Chiral Key Compounds in the Synthesis of Conformationally Constrained Peptidomimetrics and Non-Peptidomimetics. TETRAHEDRON: ASYMMETRY. 1995
- Cativiela, C.;Diaz de Villegas, M. D.;Jimenez, A. I. Study of the Reaction of a Chiral Oxazolone with Oxosulfonium Methylides as Cyclopropanating Agents. TETRAHEDRON. 1995
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D. Z-2-Phenyl-4-[(S)-2,2-Dimethyl-1,3-Dioxolan-4-Ylmethylen]-5(4h)-Oxazone as the Dienophile in Asymmetric Diels-Alder Reactions. TETRAHEDRON. 1995
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Stereoselective Amination of Chiral Enolates - Synthesis of Chiral Key Intermediates for Beta-Lactam Antibiotics. TETRAHEDRON: ASYMMETRY. 1994
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D.;Garcia, J. I. Study of the Asymmetric Diels-Alder Reaction of a Chiral Azlactone. TETRAHEDRON: ASYMMETRY. 1994
- Cativiela, C.;Diaz de Villegas, M. D.;Jimenez, A. I.;Lahoz, F. 1,3-Dipolar Cycloaddition of Diazomethane with a Chiral Azlactone. TETRAHEDRON LETTERS. 1994
- Cativiela, C.;de Villegas, M. D. D.;Galvez, J. A. A New Approach to the Asymmetric-Synthesis of Alpha-Methyltryptophan. SYNLETT. 1994
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. New Approaches to the Asymmetric-Synthesis of Alpha-Methylphenylalanine. TETRAHEDRON: ASYMMETRY. 1994
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Asymmetric-Synthesis of 3,3-Diphenyl-2-Methylalanine, a New Unusual Alpha-Amino-Acid for Peptides of Biological Interest. TETRAHEDRON. 1994
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Asymmetric-Synthesis of Beta-Lactams - Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters. JOURNAL OF ORGANIC CHEMISTRY. 1994
- Cativiela, C.;Diaz de Villegas, M. D.;Jimenez, A. I. New Alpha,beta-Didehydroamino Acid-Derivatives as Precursors in the Synthesis of 1-Aminocyclopropanecarboxylic Acids. TETRAHEDRON. 1994
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D. Asymmetric Diels-Alder Reaction of a Chiral Azlactone. TETRAHEDRON: ASYMMETRY. 1994
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D. N-[Bis(methylthio)methylene]-Didehydroalanine Methyl-Ester a New and Excellent Dienophile for the Synthesis of 2-Aminonorbornene-2-Carboxylic Acid. TETRAHEDRON. 1993
- Cativiela, C.;Devillegas, M. D. D. Stereospecific Synthesis of N-[Bis(methylthio)methylene]-Alpha,beta-Didehydroamino Acid Methyl-Esters, New Synthons in the Synthesis of Alpha-Amino-Acids. TETRAHEDRON. 1993
- Busetti, V.;Mayoral, J. A.;Cativiela, C.;de Villegas, M. D. D.;Ajo, D. Crystal-Structure of Cyclic Dehydroamino-Acid Derivatives .2. an (E)-5(4h)-Oxazolone. ZEITSCHRIFT FUR KRISTALLOGRAPHIE. 1993
- Cativiela, C.;de Villegas, M. D. D.;Mayoral, J. A.;Avenoza, A.;Peregrina, J. M. Synthesis of the 4 D,l-Pairs of 2-Amino-3-Phenylnorbornane-2-Carboxylic Acids .2. the use of 5(4h)-Oxazolones as Dienophiles. TETRAHEDRON. 1993
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Synthesis of (R)-2-Amino-2-Methylbutanoic Acid and (S)-2-Amino-2-Methylbutanoic Acid (Iva) in Enantiomerically Pure Form. TETRAHEDRON: ASYMMETRY. 1993
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Synthesis of (R)-3-Alkyl-3-Benzyl-2-Azetidinones in Enantiomerically Pure Form. TETRAHEDRON: ASYMMETRY. 1993
- Cativiela, C.;Diaz de Villegas, M. D.;Avenoza, A.;Peregrina, J. M. Synthesis of New Conformationally Rigid Phenylalanine Analogs. TETRAHEDRON. 1993
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Chiral 2-Acetamidoacrylates in Conjugate Addition Asymmetric Enolate Trapping Reactions - Asymmetric-Synthesis of Phenylalanine. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE. 1992
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Chiral 2-Cyanocinnamates in Conjugate Addition Asymmetric Enolate Trapping Reactions. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN. 1992
- Cativiela, C.;de Villegas, M. D. D.;Fayet, J. P.;Garcia, J. I.;Mayoral, J. A.;Vertut, M. C. A Theoretical (Am1) and Experimental Dipole-Moment Study of 5(4h)-Oxazolones. BULLETIN DES SOCIETES CHIMIQUES BELGES. 1992
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Efficient Asymmetric-Synthesis of Amino-Acids through Hydrogenation of the Didehydroamino Acid Residue in Cyclic Imino-Ester Derivatives. TETRAHEDRON: ASYMMETRY. 1992
- Abboud, J.L.M;Caada, T;Homan, H;Notario, R;Cativiela, C;Diaz de Villegas, M.D;Bordeje, M.C;Mo, O;Yaez, M. Gas-Phase Basicities of Beta-Lactams and Azetidines - Cyclization Effects - an Experimental and Theoretical-Study. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1992
- Aguilar Parrilla, F;Cativiela, C;de Villegas, M.D.D;Elguero, J;Foces Foces, C;Laureiro, J.I.G;Cano, F.H;Limbach, H.H;Smith, J.A.S;Toiron, C. The Tautomerism of 3(5)-Phenylpyrazoles - an Experimental (H-1, C-13, N-15 Nmr and X-Ray Crystallography) Study. JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. II. 1992
- Cativiela, C.;Diaz de Villegas, M. D.;Jimenez, A. I. New Efficient Synthesis of 1-Aminocyclopropanecarboxylic Acid (Acc). SYNTHETIC COMMUNICATIONS. 1992
- Cativiela, C.;Diaz de Villegas, M.D.;Galvez, J. A. Síntesis de e-2-cianocinamatos quirales por transesterificación con ésteres de dimetilaluminio. ANALES DE QUÍMICA. 1992
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Synthesis of Chiral 2-Chloroacrylic Esters. SYNTHETIC COMMUNICATIONS. 1992
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Synthesis of (R)-3-Benzyl-3-Methyl-2-Azetidinone and (S)-3-Benzyl-3-Methyl-2-Azetidinone in Enantiomerically Pure Form. TETRAHEDRON: ASYMMETRY. 1992
- Buñuel, E.;Cativiela, C.;Diaz de Villegas, M. D.;Jimenez, A. I. New Efficient Synthesis of 1-Aminocyclopropanecarboxylic Acid. SYNLETT. 1992
- Cativiela, C.;Diaz de Villegas, M. D.;Galvez, J. A. Synthesis of Cyanocinnamic Esters by the Knoevenagel Reaction. SYNTHETIC COMMUNICATIONS. 1990
- Busetti, V.; Mayoral J.A.; Cativiela, C.; Diaz-De-Villegas, M. D.; Ajò, D. Dehydroaminoacid derivatives. Crystal structure of 5(4H)-oxazolones. ACTA CRYSTALLOGRAPHICA SECTION A. 1990
- Curcuruto, O.;Traldi, P.;Cativiela, C.;Devillegas, M. D. D.;Garcia, J. I.;Mayoral, J. A.;Ajo, D. Electron-Impact Mass-Spectrometry and Collisional Spectroscopy in the Structural Characterization of 4-Benzylidene and 4-Phenylethylidene-2-Phenyl-5(4h)-Oxazolones. JOURNAL OF HETEROCYCLIC CHEMISTRY. 1990
- Cativiela, C.;de Villegas, M. D. D.;Galvez, J. A. Synthesis of Optically-Active N-Acetyldehydroalanine Esters. SYNTHESIS-STUTTGART. 1990
- Busetti, V.;Mayoral, J. A.;Cativiela, C.;Diaz Villegas, M. D.;Ajo, D. Crystal-Structure of Cyclic Dehydroaminoacid Derivatives .1. Tetrasubstituted (Z)-5(4h)-Oxazolones. ZEITSCHRIFT FUR KRISTALLOGRAPHIE. 1989
- Blasco, J.;Cativiela, C.;Devillegas, M. D. D.;Garcia, J. I.;Jaime, C.;Mayoral, J. A. On the Reactivity of 5(4h)-Oxazolones with Amines. HETEROCYCLES. 1988
- Busetti, V.; Mayoral, J. A.; Cativiela, C.; Díaz-De-Villegas, M. D.; Ajò, D.; de Zuane, F. Crystal structure of dehydroamino acid derivatives. ZEITSCHRIFT FUR KRISTALLOGRAPHIE. 1988
- Cabeza, J. A.;Cativiela, C.;Devillegas, M. D. D.;Oro, L. A. Homogeneous Hydrogenation of Tetrasubstituted Alkene Moieties in Prochiral Didehydro Amino-Acid Derivatives Catalyzed by Iridium Complexes. JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. 1988
- Cativiela, C.;Devillegas, M. D. D.;Mayoral, J. A.;Avenoza, A.;Roy, M. A. On the Synthesis of 3(5)-Carbomethoxy-4-Hetarylpyrazoles. JOURNAL OF HETEROCYCLIC CHEMISTRY. 1988
- Blasco, J.;Cativiela, C.;Devillegas, M. D. D. New Efficient Synthesis of Methyl Trans-2-Aryl (Or Hetaryl)-1-Benzamidocyclopropancarboxylates. SYNTHETIC COMMUNICATIONS. 1987
- Cativiela, C.;Devillegas, M. D. D.;Gainza, M. P. New Efficient Synthesis of 3(5)-Carbomethoxy-4-Aryl Pyrazoles from 3-Aryl-2,3-Dehydroamino Acid-Derivatives. SYNTHETIC COMMUNICATIONS. 1987
- Cativiela, C.; Díaz-De-Villegas, M. D.; Meléndez, E. On the synthesis of methyl (Z/E)-2-acetamido(or benzamido)-3-aryl-2-butenoates. TETRAHEDRON. 1986
- Cativiela, C.; Díaz-De-Villegas, M.D.; Meléndez, E. Synthesis of methyl (Z)-2-acetamido-3-aryl-2-butenoates in two highly selective steps. SYNTHESIS-STUTTGART. 1986
- Cativiela, C.;Diaz de Villegas, M.D.;Garcia, J. I.;Mayoral, J. A.;Melendez, E. Síntesis de Z-2-acetamido(benzamido)-3-hetaril-2-propenóicos. ANALES DE QUÍMICA. SERIE C, QUÍMICA ORGÁNICA Y BIOQUÍMICA. 1985
- Cativiela, C.; Díaz-De-Villegas, M. D.; Meléndez, E. On the synthesis of geometric isomers of 2-methyl(or phenyl)-4-(alfa-arylethylidene)-5(4H)-ozaxolones. JOURNAL OF HETEROCYCLIC CHEMISTRY. 1985
- Cativiela, C.; Díaz-De-Villegas, M. D.; Mayoral, J. A.; Meléndez, E. Action of diazomethane on methyl (Z(or E))-2-(acylamino)cinnamates. A new route to methyl (Z)-2-(acylamino)-3-methylcinnamates. JOURNAL OF ORGANIC CHEMISTRY. 1985
- Cativiela, C.; Díaz-De-Villegas, Mayoral, J. A.; Meléndez, E. Action of diazomethane on (Z/E)--2-methyl(or phenyl)-4-benzylidene-5(4H)-oxazolones. JOURNAL OF ORGANIC CHEMISTRY. 1984
- Cativiela, C.; Díaz-De-Villegas, M. D.; García, J. I.; Mayoral, J. A.; Meléndez, E. Determination of the enantiomeric purity by 1H-NMR with Eu(tfc)3 of beta-hetarylalanine derivatives. Correlation of the enantiomeric shift difference with absolute configuration. BULLETIN DES SOCIETES CHIMIQUES BELGES. 1984
- C. Cativiela, M. D. Díaz de Villegas, J. A. Mayoral, E. Meléndez. Synthesis and stereospecific ring opening of (Z/E)-isomers of 2-methyl(phenyl)-4-thenylmethylene-5(4H)-oxazolones. SYNTHESIS-STUTTGART. 1983
- Oro, L. A.; Cabeza, J. A.; Cativiela, C.; Díaz-De-Villegas, M. D.; Meléndez, E. Iridium-catalysed homogeneous hydrogenation of prochiral enamides containing tetrasubstututed alkene moieties. JOURNAL OF THE CHEMICAL SOCIETY. CHEMICAL COMMUNICATIONS. 1983
Capítulos
- 5(2H)-Oxazolones and 5(4H)-Oxazolones. C. Cativiela. THE CHEMISTRY OF HETEROCYCLIC COMPOUNDS. VOLUME 60: OXAZOLES. SYNTHESIS, REACTIONS, AND SPECTROSCOPY, PART B. 2004
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- DISEÑO Y DESARROLLO DE NUEVOS FÁRMACOS PARA MEDICINA PERSONALIZADA Y SU APLICACIÓN A TEST DIAGNÓSTICOS (LMP30_18). 01/09/18 - 30/11/20
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- GRUPO DE REFERENCIA PROTEIN TARGETS AND BIOACTIVE COMPOUNDS (PROTBIOCOMS). 01/01/17 - 31/12/19
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- Neuromed / Diagnóstico y combate molecular de tres enfermedades neurodegenerativas (Parkinson, fenilcetonuria y amiloidosis TTR. 01/05/14 - 30/06/15
- CEPS - COMPUESTOS ENANTIOPUROS Y PROCESOS SOSTENIBLES. 01/01/14 - 31/12/14
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- CEPS - COMPUESTOS ENANTIOPUROS Y PROCESOS SOSTENIBLES. 01/01/12 - 31/12/12
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- ADQUISICIÓN DE SONDAS PARA EL REGISTRO DE ESPECTROS DE RMN DE M5STRAS SÓLIDAS. 01/01/10 - 31/12/12
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- PROCESOS ESTEREOSELECTIVOS: COMPUESTOS BIOLÓGICAMENTE ACTIVOS Y CATÁLISIS ASIMÉTRICA. 01/01/08 - 31/12/08
- SÍNTESIS ESTEREOSELECTIVA DE AMINAS DERIVADAS DE D-GLICERALDEHÍDO Y ESTUDIO DE SU COMPORTAMIENTO COMO ORGANOCATALIZADORES EN PROCESOS ENANTIOSELECTIVOS. 01/01/08 - 31/12/08
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- BQU2002-12517-E. XX REUNION BIENAL DE QUIMICA ORGANICA. 14/04/04 - 14/04/05
- PPQ2001-1834. NUEVOS AMINOACIDOS EN FORMA ENANTIOMERICAMENTE PURA. DISEÑO, SINTESIS E INCORPORACION EN PEPTIDOS CON INTERES ESTRUCTURAL, INDUSTRIAL Y/O BIOLÓGICO. 28/12/01 - 27/12/04
- P22/98 SINTESIS ASIMETRICA DE AMINOACIDOS NOPROTINOGENICOS Y SU INCORPORACION EN PEQUEÑOS PEPTIDOS. 11/02/99 - 11/02/02
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- PETRI:DESARROLLO DE NUEVOS EDULCORANTES DIPEPTIDOS. 18/02/00 - 17/02/03
Dirección de tesis
- Síntesis de nuevos heterociclos nitrogenados y estudio de su comportamiento como organocatalizadores. Ministerio de Educación y Cultura. Sobresaliente cum laude. 23/11/18
- Síntesis estereoselectiva y aplicaciones de piperidinas polisustituidas enantioméricamente puras. Universidad de Zaragoza. Sobresaliente "Cum Laude". 18/07/08
- Estudio de la adición de compuestos organometálicos a iminas derivadas de D-gliceraldehído. Síntesis de productos de interés biológico. Universidad de Zaragoza. Sobresaliente "Cum Laude". 14/12/07
- ESTUDIO DE LA REACTIVIDAD DE IMINAS DERIVADAS DE GLICERALDEHIDO. OBTENCION DE INTERMEDIOS VERSATILES PARA LA SINTESIS ESTEREOSELECTIVA DE PRODUCTOS DE INTERES... Universidad de Zaragoza. Sobresaliente "Cum Laude". 15/12/00
- Alquilación diastereoselectiva de cianoesteres quirales. Una nueva metodología para la síntesis asimétrica de x-metilaminoácidos. Universidad de Zaragoza. Apto cum laude. 28/01/98
- Síntesis aimétrica de aminoácidos cicloalifáticos por reacción de Diels-Alder utilizando como filodieno una oxazolana homoquiral. Universidad de Zaragoza. Apto cum laude. 25/10/96
- Síntesis asimétrica de ciclopropilaminoácidos de interés biológico. Universidad de Zaragoza. Apto cum laude. 25/11/95
- ESTUDIO DE LAS REACCIONES DE ADICION CONJUGADA COMO UNA NUEVA RUTA SIMBOTICA PARA LA OBTENCION ASIMETRICA DE AMINOACIDOS. Universidad de Zaragoza. Apto cum laude. 21/09/90
Patentes de invención
- P201930445. Compounds for the treatment of diseases caused by Helicobacter. SALILLAS BERGES, SANDRA - CARRODEGUAS VILLAR, JOSÉ ALBERTO - MAHÍA MOROS, ALEJANDRO JOSÉ - GALANO FRUTOS, JUAN JOSÉ - LANAS ARBELOA, ANGEL - AÍNSA CLAVER, JOSÉ ANTONIO - DÍAZ DE VILLEGAS SOLANS, MARÍA DOLORES - VELÁZQUEZ CAMPOY, ADRIÁN - TOUATI, ELIETTE - MICHEL, VALERIE - SANCHO SANZ, JAVIER - LANAS ARBELOA, ANGEL - VELÁZQUEZ CAMPOY, ADRIÁN - MICHEL, VALERIE. 2019
- P201431319. ESTERES DE DI-BENZOATO Y SU USO TERAPÉUTICO COMO MODULADORES NEGATIVOS DE CANALES DE POTASIO KCa2/3. BADORREY MIGUEL, RAMÓN - KÖHLER, RALF - DÍAZ DE VILLEGAS SOLANS, MARÍA DOLORES - OLIVÁN VIGUERA, AÍDA - GÁLVEZ LAFUENTE, JOSÉ ANTONIO - KÖHLER, RALF. 2014
- P201431319. ESTERES DE DI-BENZOATO Y SU USO TERAPÉUTICO COMO MODULADORES NEGATIVOS DE CANALES DE POTASIO KCA2/3. KOLLER, RALF (IACS/ARAID - 40%) - BADORREY MIGUEL, RAMÓN (UZ) - GÁLVEZ LAFUENTE, JOSÉ ANTONIO - OLIVÁN VIGUERA, AIDA (IACS-20%) - DÍAZ DE VILLEGAS SOLANS, MARÍA DOLORES (CSIC - 13,3%). 2014
Participaciones en congresos
- XXXVIII Reunión Bienal de la Real Sociedad Española de Química. Participativo - Póster. Granada. 27/06/22
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Póster. In vitro validation of new PAH binding compounds for non-Kuvan responsive PKU patients. Zaragoza. 03/02/20
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Póster. Design and synthesis of FMN derivatives for covalent union to flavoproteins. Zaragoza. 03/02/20
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Póster. Design and testing of a colorimetric immunoassay for the measurement of phenylalanine blood levels in patients with phenylketonuria. Zaragoza. 03/02/20
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Póster. Resisting antimicrobial resistante: Flavodoxin inhibitors to combat Helicobacter pylori infection. Zaragoza. 03/02/20
- XXXIInd Workshop of the European Helicobacter & Microbiota Study Group. Participativo - Póster. Efficacy of flavodoxin inhibitors against Helicobacter pylori drug-resistant clinical strains and in Hp-infected mice. Innsbruck. 05/09/19
- IX Conferencia Nacional BIFI 2019. Participativo - Póster. Evaluation of Novel PAH Stabilizing Compounds as Potential PKU Treatment. Zaragoza. 30/01/19
- IX Conferencia Nacional BIFI 2019. Participativo - Póster. Bioactive Compounds as an Alternative Treatment for H. pylori Infection. Zaragoza. 30/01/19
- IX Conferencia Nacional BIFI 2019. Participativo - Ponencia oral (comunicación oral). Synthesis and Testing of a Novel, Large Stokes Shift Fluorescent Probe for the Staining of Aß1-42, a-synuclein, and Amylin Amyloid Fibrils, and for the Detection of Amyloid-Containing Staphylococcus aureus Biofilms. Zaragoza. 30/01/19
- XII Reunión del Grupo Microbiología Molecular. Participativo - Póster. Fighting superbugs: new promising compounds against Helicobacter pylori. Zaragoza. 05/09/18
- V Simposio de Jóvenes Investigadores del IQFR-CSIC. Participativo - Ponencia oral (comunicación oral). Diseño y síntesis de derivados más solubles de potenciales fármacos para el tratamiento de la infección causada por Helicobacter pylori Madrid. 29/05/18
- VIII International Conference BIFI 2018. Participativo - Póster. Development of novel stabilizing compounds of human phenylalanine hydroxylase for PKU patients. Zaragoza. 06/02/18
- VIII International Conference BIFI 2018. Participativo - Póster. Design, synthesis and testing of a novel fluorescent probe for the staining of amyloid fibrils of Aß1-42 peptide, a-synuclein and amylin and for the detection of amyloid-nature Staphylococcus aureus biofilms. Zaragoza. 06/02/18
- VIII International Conference BIFI 2018. Participativo - Póster. Combating bacterial multidrug resistance: new drugs against Helicobacter pylori. Zaragoza. 06/02/18
- VIII BIFI National Conference. Participativo - Póster. Studying the mechanism of action of novel stabilizing compounds of phenylalanine hydroxylase Zaragoza. 31/01/17
- VIII BIFI National Conference. Participativo - Póster. Design, synthesis and testing of a novel and efficient fluorescent compound for the staining of amyloid beta fibrillar aggregates Zaragoza. 31/01/17
- VIII BIFI National Conference. Participativo - Ponencia oral (comunicación oral). A new approach for Helicobacter pylori eradication: In vivo assessment of novel flavodoxin inhibitors efficacy. Zaragoza. 31/01/17
- 7ª Jornada de Jóvenes Investigadores de Aragón. Participativo - Póster. Estudios de la reacción de aza-Prins con aldehídos quiurales alfa-oxigenados. Zaragoza. 24/11/16
- 52nd International Conference on Medicinal Chemistry. Participativo - Póster. Design of diagnostic tools for Alzehimer´s disease: Synthesis and testing of fluorescent organic compounds as inhibitors of the amyloid beta peptide aggregation. Caen. 06/07/16
- 23rd Young Research Fellow Meeting (organized by the French Medicinal Chemistry Society, SCT). Participativo - Póster. Therapeutic index determination of new developed compounds toward Helicobacter pylori flavodoxin. Lille. 15/02/16
- VII International Conference of the Institute for Biocomputation and Physics of Complex Systems (BIFI). Participativo - Póster. Synthesis and testing of fluorescent chemical compounds as diagnostic tools for Alzheimer's disease. Zaragoza. 01/02/16
- VII International Conference of the Institute for Biocomputation and Physics of Complex Systems (BIFI). Participativo - Póster. Toxicity and efficacy evaluation of novel compounds targeting an essential protein of Helicobacter pylori. Zaragoza. 01/02/16
- VII Congreso Nacional BIFI. Participativo - Póster. Identification and development of new pharmacological chaperones for phenylketonuria. Zaragoza. 04/02/15
- VII Congreso Nacional BIFI. Participativo - Póster. Helicobacter pylori flavodoxin: a promising target in the develop of selective antimicrobials against this bacteria. Zaragoza. 04/02/15
- VI Jornada de Jóvenes Investigadores (Química y Física) de Aragón. Participativo - Póster. Síntesis de nuevas pirrolidinas enantioméricamente puras y estudio de su comportamiento como organocatalizadores. Zaragoza. 20/11/14
- E.S. PKU Meeting. Participativo - Ponencia oral (comunicación oral). Discovery and development of novel chaperones for PKU. Zagreb. 23/10/14
- XXV Reunión Bienal del Grupe Especializado de Química Orgánica. Organizativo - Comité científico y organizador. Alicante. 04/06/14
- Nano-Host School of Asymetric Catalysis. Participativo - Plenaria. Determination of enantioselectivity and absolute configuration. Zaragoza. 10/11/11
- XXXII Reunión Bienal de la Real Sociedad Española de Química 2009. Participativo - Póster. Síntesis estereoselectiva de aminas derivadas de D-gliceraldehído y estudio de su comportamiento como organocatalizadores quirales en procesos de a-cloración enantioselectiva. Oviedo. 13/09/09
- XXXII Reunión Bienal de la Real Sociedad Española de Química 2009. Participativo - Ponencia oral (comunicación oral). Síntesis asimétrica de dexoxadrol a partir de D-manitol Oviedo. 13/09/09
- XV Congreso de la Sociedad Española de Química Terapéutica. Participativo - Póster. Enantiomerically pure polysubstitutedsubstituted piperidines as analoues of biologically active compounds. San Lorenzo del Escorial. 11/09/07
- XV Congreso de la Sociedad Española de Química Terapéutica. Participativo - Póster. Enantiomerically pure 4-substituted D-pipecolic acids with interesting pharmacological properties San Lorenzo del Escorial. 11/09/07
- XXXI Reunión Bienal de la Real Sociedad Española de Química 2007. Participativo - Póster. Síntesis asimétrica de un análogo restringido de ácido glutámico y síntesis diastereodivergente de dos 1-azabicilo[2.2.1]heptanos via homologación de un intermedio común de tipo 4-piperidona Toledo. 09/09/07
- 2ª Jornada de Jóvenes Investigadores (Química y Física) de Aragón. Participativo - Póster. Síntesis diastereodivergente de dos potentes antagoniatas del receptor NMDA: Acidos cis- y trans-(2R,4R)-4-fosfonometilpipecólicos. Zaragoza. 21/11/06
- 19th Internacional Symposium: Synthesis in Organic Chemistry. Participativo - Póster. Stereocontrolled synthesis of orthogonally protected 2-substituted 4-aminopiperidines. Oxford. 18/07/05
- 19th Internacional Symposium: Synthesis in Organic Chemistry. Participativo - Póster. Imines derived form gryceraldehyde as intermediates in diversity-oriented synthesis. Oxford. 18/07/05
- 19th Internacional Symposium: Synthesis in Organic Chemistry. Participativo - Póster. Synthetic strategies to the stereodivergent synthesis of 2,4-disubstituted piperidines. Oxford. 18/07/05
- 7th International Symposium on Carbanion Chemistry. Participativo - Póster. Synthetic strategies to obtain 2,4-disubstitutes piperidines in enantiomerically pure form. Alicante. 07/11/04
- 7th International Symposium on Carbanion Chemistry. Participativo - Póster. Addition of organometallic compounds to imines derived from glyceraldehyde. How to control the sense of asymmetric induction. Alicante. 07/11/04
- 1ª Jornada de jóvenes investigadores en Química de Aragón. Participativo - Póster. Iminas derivadas de gliceraldehído como intermedios en el desarrollo de procesos sintéticos orientados a la generación de diversidad. Zaragoza. 20/09/04
- 1ª Jornada de jóvenes investigadores en Química de Aragón. Participativo - Póster. La olefinación de compuestos carbonílicos como estrategia sintética en la obtención de piperidinas 2,4-disustituidas. Zaragoza. 20/09/04
- XX Reunión Bienal de Química Orgánica. Participativo - Ponencia oral (comunicación oral). Desarrollo de procesos sintéticos eficientes orientados a la generación de diversidad estructural y estereoquímica. Alcaloides hidroxilados. Zaragoza. 13/06/04
- XX Reunión Bienal de Química Orgánica. Organizativo - Comité científico y organizador. Zaragoza. 13/06/04
- 27th European Peptide Symposium. Participativo - Póster. Preferred conformation and membrane activity of the LP237-F lipopeptaibols. Sorrento. 31/08/02
- 9th Meeting on stereochemistry. Participativo - Póster. Total stereochemical control in the preparation of chiral key intermediates for the synthesis of Palinavir starting from (S)-glyceraldehyde imines. Praga. 15/06/01
- 9th Meeting on stereochemistry. Participativo - Ponencia oral (comunicación oral). Synthesis and conformational preferences of triamide model systems incorporating an axially chiral a,ß-didehydroamino acid residue. Praga. 15/06/01
- Peptidomimetics Symposium. Participativo - Póster. Asymmetric synthesis and preferred conformation in peptides of (S)-a-methylnorvaline Tipo de participación: Poster. Houffalize. 26/04/99
- XVII Reunión Bienal de Química Orgánica de la Real Sociedad Española de Química. Participativo - Ponencia oral (comunicación oral). Síntesis asimetrica de aminoacidos utilizando D-gliceraldehído como producto de partida. Logroño. 24/06/98
- 7ª Journée Chimie Grand Sud-Ouest. Participativo - Póster. N-(tert-butoxycarbonyl)-4-formyl-2,2,4-trimethyl-1,3-oxazolidine, un nouveau precurseur d'a-methyl-a-amino acides. Toulouse. 28/11/97
- X Congreso de la Sociedad Española de Química Terapeútica. Participativo - Póster. Síntesis estereoselectiva de amioacidos cicloalifaticos utilizando una oxazolona quiral derivada del D-gliceraldehído como producto de partida. Oviedo. 23/09/97
- IX Jornadas Hispano-Francesas de Química Orgánica. Participativo - Ponencia oral (comunicación oral). Síntesis asimetrica de aminoácidos ciclopropánicos de interés biológico. Aspet 02/06/96
- Electronic Conference on Trends in Organic Chemistry (ECTOC-1). Participativo - Otros. 1,3-dipolar cycloaddition of diazomethane with a chiral azlactone: A semiempirical study. Conferencia electrónica. 01/06/95
- VIII Jornadas Hispano-Francesas de Química Orgánica. Participativo - Ponencia oral (comunicación oral). Az-lactona derivada del D-gliceraldehido: excelente precursor quiral en la síntesis asimétrica de aminoácidos cíclicos. Elizondo. 16/05/94
- VIII European Symposium on Organic Chemistry. Participativo - Póster. New synthetic approaches to enantiomerically pure a-alkylamino acids. Sitges. 29/08/93
- VIII European Symposium on Organic Chemistry. Participativo - Póster. New a,ß-didehydroamino acid derivatives as precursors in the synthesis of cyclopropylamino acids. Sitges. 29/08/93
- VII Congreso de la Sociedad Española de Química Terapéutica. Participativo - Póster. Síntesis asimétrica de a-alquilaminoácidos por reacciones de adición conjugada. Jaca. 18/09/91
- VII European Symposium on Organic Chemistry. Participativo - Póster. New route in the asymmetric synthesis of a,ß-substituted pharmacologically promising unnatural aminoacids Tipo de participación: Poster Namur. 15/07/91
- V Jornadas de Química Orgánica. Organizativo - Comité científico y organizador. La Espluga de Francolí 16/06/91
- XXIII Reunión Bienal R.S.E.Q. Participativo - Ponencia oral (comunicación oral). Síntesis asimétrica estequiométrica de fenilalanina y a-metilfenilalanina por reacciones de adición conjugada tipo Michael sobre 2-ciano-E-cinamatos. Salamanca. 23/09/90
- XV Congress of the Internacional Union of Crystallography. Participativo - Póster. Dehydroaminoacid derivatives: crystal structure of 5(4H)-oxazolones. Burdeos 19/07/90
- EUCHEM Conference. New trends in asymmetric synthesis and related processes. Participativo - Póster. Chiral 2-acetamidoacrylates as Michael acceptors in the asymmetric synthesis of a-amino acids by ß-functionalization. Lyon. 01/10/89
- XI European Crystallographic Meeting. Participativo - Póster. Crystal structure of dehydroamino and derivatives. Viena 28/08/88
- XIII International Conference on Photochemistry. Participativo - Póster. New photosynthetic synthesis of "cis" and "trans" methyl-2-phenyl-1-benzamidocyclopropanecarboxylate. Budapest 09/08/87
- International Symposium on Organic Chemistry. Participativo - Póster. Reactivity of 5(4H)-oxazolones with nucleophiles. París. 06/07/87
- IV Jornadas Hispano-Francesas de Química Orgánica. Participativo - Ponencia oral (comunicación oral). A la búsqueda de descriptores de heterociclos: modelos de Free-Wilson. Jaca. 15/05/86
- IV European Symposium on Organic Chemistry. Participativo - Póster. Action of diazomethane on methyl (Z/E)-2-acylaminocinnamates. A new route to methyl Z-2-acylamino-3-methylcinnamates. Aix-en-Provence 02/09/85
- XI Reunión Bienal Grupo especializado de Química Orgánica. Participativo - Ponencia oral (comunicación oral). N-acil-ß-metil-a,ß-deshidrofenilalaninas. Valladolid. 01/09/85
- XX Reunión Bienal de la Real Sociedad Española de Química. Participativo - Póster. Reacción de diazometano con 2-acetamidocinamato de metilo. Castellón de la Plana. 24/09/84
- III Journées Franco-Espagnoles de Chimie Organique. Participativo - Ponencia oral (comunicación oral). Determinación del exceso enantiomérico por 1H-RMN con Eu(tfc)3 de ß-aril(hetaril)-alaninas obtenidas por hidrogenación asimétrica homogénea. Correlación con la configuración absoluta. Aix-en-Provence. 02/05/84
- III Congreso Internacional de Química Terapeútica. Participativo - Ponencia oral (comunicación oral). Síntesis de (Z/E)-1-aril-5-fenil-6-oxa-4-azaspiro[2.4]hept-4-en-7-ona. Pamplona. 07/09/83
- X Reunión Bienal Grupo especializado de Química Orgánica. Participativo - Póster. Síntesis de (Z/E)-2-metil(fenil)-4-(a-ariletiliden)-5(4H)-oxazolonas. Cáceres. 01/09/83
- X Reunión Bienal Grupo especializado de Química Orgánica. Participativo - Póster. Síntesis de N-formil-2,3-dehidroaminoácidos. Cáceres. 01/09/83
- X Reunión Bienal Grupo especializado de Química Orgánica. Participativo - Plenaria. Hidrogenación asimétrica. Cáceres. 01/09/83
- XIX Reunión Bienal de la Real Sociedad Española de Física y Química. Participativo - Póster. Síntesis estereosespecífica de ácidos Z(E)-2-benzamido(acetamido)-3-[(2 ó 3)-tienil]-2-propenoicos y sus ésteres metílicos. SANTANDER. 26/09/82
- II Reunión Hispano-Francesa de Química Orgánica Participativo - Plenaria. Obtención enantioselectiva de a-aminoácidos por hidrogenación asimétrica homogénea. Jaca. 01/04/82
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