Perfil (CV) del personal docente investigador

Aínsa Claver, José Antonio
Departamento: Departamento de Microbiología, Pediatría, Radiología y Salud Pública
Área: Microbiología
Centro: Facultad de Medicina

Research Institutes: INSTITUTO DE BIOCOMPUTACIÓN Y FÍSICA DE SISTEMAS COMPLEJOS (BIFI)
INSTITUTO INVESTIGACIÓN SANITARIA DE ARAGÓN (IIS)
Grupo: GENÉTICA DE MICROBACTERIAS
Categoría profesional: Prof. Titular Univ.

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Artículos

  • Andreu, Vanesa; Larrea, Ane; Rodriguez-Fernandez, Pablo; Alfaro, Salvador; Gracia, Begoña; Lucía, Ainhoa; Usón, Laura; Gómez, Andromeda-Celeste; Mendoza, Gracia; Lacoma, Alicia; Domínguez, José; Prat, Cristina; Sebastián, Victor; Ainsa, José Antonio; Arruebo, Manuel. Matryoshka-type gastro-resistant microparticles for the oral treatment of Mycobacterium tuberculosis. NANOMEDICINE. 2019

  • Soria-Carrera, H.; Lucía, A.; de Matteis, L.; Aínsa, J.A.; de la Fuente, J.M.; Martín-Rapún, R. Polypeptidic Micelles Stabilized with Sodium Alginate Enhance the Activity of Encapsulated Bedaquiline. MACROMOLECULAR BIOSCIENCE. 2019

  • Sanz-García, F.; Anoz-Carbonell, E.; Pérez-Herrán, E.; Martín, C.; Lucía, A.; Rodrigues, L.; Aínsa, J.A. Mycobacterial aminoglycoside acetyltransferases: a little of drug resistance, and a lot of other roles. FRONTIERS IN MICROBIOLOGY. 2019

  • Jiménez-Andreu, M.M.; Lucía Quintana, A.; Aínsa, J.A.; Sayago, F.J.; Cativiela, C. Synthesis and biological activity of dehydrophos derivatives. ORGANIC & BIOMOLECULAR CHEMISTRY. 2019

  • Glaus, F.; Dedic, D.; Tare, P.; Nagaraja, V.; Rodrigues, L.; Aínsa, J.A.; Kunze, J.; Schneider, G.; Hartkoorn, R.C.; Cole, S.T.; Altmann, K.H. Total Synthesis of Ripostatin B and Structure-Activity Relationship Studies on Ripostatin Analogs. JOURNAL OF ORGANIC CHEMISTRY. 2018

  • García, M.T.; Carreño, D.; Tirado-Vélez, J.M.; Ferrándiz, M.J.; Rodrigues, L.; Gracia, B.; Amblar, M.; Ainsa, J.A.; de la Campa, A.G. Boldine-derived Alkaloids inhibit the activity of DNA topoisomerase I and growth of Mycobacterium tuberculosis. FRONTIERS IN MICROBIOLOGY. 2018

  • Aguilar-Pérez, C.; Gracia, B.; Rodrigues, L.; Vitoria, A.; Cebrián, R.; Deboosère, N.; Song, O.R.; Brodin, P.; Maqueda, M.; Aínsa, J.A. Synergy between circular bacteriocin AS-48 and ethambutol against mycobacterium tuberculosis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2018

  • Mori, G.; Orena, B.S.; Franch, C.; Mitchenall, L.A.; Godbole, A.A.; Rodrigues, L.; Aguilar-Pérez, C.; Zemanová, J.; Huszár, S.; Forbak, M.; Lane, T.R.; Sabbah, M.; Deboosere, N.; Frita, R.; Vandeputte, A.; Hoffmann, E.; Russo, R.; Connell, N.; Veilleux, C.; Kumar, R.; Kumar, P.; Freundlich, J.S.; Brodin, P.; Aínsa, J.A.; Nagaraja, V.; Maxwell, A.; Mikušová, K.; Pasca, M.R.; Ekins, S. The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase. TUBERCULOSIS. 2018

  • Song, Lijun; Merceron, Romain; Gracia, Begoña; Lucía Quintana, Ainhoa; Risseeuw, Martijn D. P.; Hulpia, Fabian; Cos, Paul; Aínsa, José A.; Munier-Lehmann, Hélène; Savvides, Savvas N.; Van Calenbergh, Serge. Structure Guided Lead Generation towards non-chiral M. tuberculosis Thymidylate Kinase Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY. 2018

  • Sebastián, M.; Anoz-Carbonell, E.; Gracia, B.; Cossio, P.; Aínsa, J.A.; Lans, I.; Medina, M. Discovery of antimicrobial compounds targeting bacterial type FAD synthetases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 2018

  • de Matteis, Laura; Jary, Dorothée; Lucia Quintana, Ainhoa; García-Embid, Sonia; Serrano-Sevilla, Inés; Pérez, Daniel; Aínsa Claver, Jose Antonio; Navarro, Fabrice; Martínez de la Fuente, Jesús. New active formulations against M. tuberculosis: Bedaquiline encapsulation in lipid nanoparticles and chitosan nanocapsules. CHEMICAL ENGINEERING JOURNAL. 2018

  • Costa-Gouveia, J.; Aínsa, J. A.; Brodin, P.; Lucía, A. How can nanoparticles contribute to antituberculosis therapy?. DRUG DISCOVERY TODAY. 2017

  • Huang, W.; Briffotaux, J.; Wang, X.; Liu, L.; Hao, P.; Cimino, M.; Buchieri, M.V.; Namouchi, A.; Ainsa, J.-A.; Gicquel, B. Ionophore A23187 shows anti-tuberculosis activity and synergy with tebipenem. TUBERCULOSIS. 2017

  • Rodrigues, L.; Parish, T.; Balganesh, M.; Ainsa, J.A. Antituberculosis drugs: reducing efflux = increasing activity. DRUG DISCOVERY TODAY. 2017

  • Liu, J.; Bruhn, D.F.; Lee, R.B.; Zheng, Z.; Janusic, T.; Scherbakov, D.; Scherman, M.S.; Boshoff, H.I.; Das, S.; Ramesh; Waidyarachchi, S.L.; Brewer, T.A.; Gracia, B.; Yang, L.; Bollinger, J.; Robertson, G.T.; Meibohm, B.; Lenaerts, A.J.; Ainsa, J.; Böttger, E.C.; Lee, R.E. Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions. ACS INFECTIOUS DISEASES. 2017

  • Singh, Vinayak; Dhar, Neeraj; Pató, János; Kolly, Gaëlle S.; Korduláková, Jana; Forbak, Martin; Evans, Joanna C.; Székely, Rita; Rybniker, Jan; Palceková, Zuzana; Zemanová, Júlia; Santi, Isabella; Signorino-Gelo, François; Rodrigues, Liliana; Vocat, Anthony; Covarrubias, Adrian S.; Rengifo, Monica G.; Johnsson, Kai; Mowbray, Sherry; Buechler, Joseph; Delorme, Vincent; Brodin, Priscille; Knott, Graham W.; Aínsa, José A.; Warner, Digby F.; Kéri, G.; Mikušová, Katarina; Mckinney, John D.; Cole, Stewark T.; Mizrahi, Valerie; Hartkoorn, Ruben C. Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. MOLECULAR MICROBIOLOGY. 2017

  • Bailo, R.; Bhatt, A.; Aínsa, J. A. Lipid transport in Mycobacterium tuberculosis and its implications in virulence and drug development. BIOCHEMICAL PHARMACOLOGY. 2015

  • Rodrigues, Liliana; Viveiros, Miguel; Aínsa, José A. Measuring efflux and permeability in mycobacteria. METHODS IN MOLECULAR BIOLOGY. 2015

  • Lee, R. E.; Hurdle, J. G.; Liu, J.; Bruhn, D. F.; Matt, T.; Scherman, M. S.; Vaddady, P. K.; Zheng, Z.; Qi, J.; Akbergenov, R.; Das, S.; Madhura, D. B.; Rathi, C.; Trivedi, A.; Villellas, C.; Lee, R. B.; Rakesh; Waidyarachchi, S. L.; Sun, D.; Mcneil, M. R.; Ainsa, J. A.; Boshoff, H. I.; Gonzalez-Juarrero, M.; Meibohm, B.; Böttger, E. C.; Lenaerts, A. J. Spectinamides: A new class of semisynthetic antituberculosis agents that overcome native drug efflux. NATURE MEDICINE. 2014

  • Rodrigues, L; Villellas, Cristina; Bailo, Rebeca; Viveiros, Miguel; Aínsa, José A. Role of the Mmr efflux pump in drug resistance in M. tuberculosis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2013

  • Villellas, C.; Aristimuño, L.; Vitoria, M.A.; Prat, C.; Blanco, S.; de Viedma, D.G.; Domínguez, J.; Samper, S.; Aínsa, J.A. Analysis of mutations in streptomycin-resistant strains reveals a simple and reliable genetic marker for identification of the Mycobacterium tuberculosis Beijing genotype. JOURNAL OF CLINICAL MICROBIOLOGY. 2013

  • Luo,X.;Pires,D.;Ainsa,J. A.;Gracia,B.;Duarte,N.;Mulhovo,S.;Anes,E.;Ferreira,M. -J U. Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages. JOURNAL OF ETHNOPHARMACOLOGY. 2013

  • Eitson, J. L.;Medeiros, J. J.;Hoover, A. R.;Srivastava, S.;Roybal, K. T.;Aínsa, J. A.;Hansen, E. J.;Gumbo, T.;Van Oersa, N. S. C. . Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2012

  • Ramón-García,S.;Mick,V.;Dainese,E.;Martín,C.;Thompson,C. J.;de Rossi,E.;Manganelli,R.;Aínsa,J. A. Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2012

  • Viveiros, M; Martins, M; Rodrigues, L; Machado, D; Couto, I; Ainsa, J; Amaral, L. Inhibitors of Mycobacterial Efflux Pumps as Potential Boosters for Antitubercular Drugs. EXPERT REVIEW OF ANTI-INFECTIVE THERAPY. 2012

  • Rodrigues, L.; Aínsa, J.A.; Amaral, L.; Viveiros, M. Inhibition of Drug Efflux in Mycobacteria with Phenothiazines and Other Putative Efflux Inhibitors. RECENT PATENTS ON ANTI-INFECTIVE DRUG DISCOVERY. 2011

  • Tizón, L.;Otero, J. M.;Prazeres, V. F. V.;Llamas-Saiz, A.;Fox, G. C.;Van Raaij, M. J.;Lamb, H.;Hawkins, A. R.;Ainsa, J. A.;Castedo, L.;González-Bello,C. . A prodrug approach for improving antituberculosis activity of potent mycobacterium tuberculosis type II dehydroquinase inhibitors. JOURNAL OF MEDICINAL CHEMISTRY. 2011

  • Luo,X.;Pires,D.;Aínsa,J. A.;Gracia,B.;Mulhovo,S.;Duarte,A.;Anes,E.;Ferreira,M. -J U. Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique. JOURNAL OF ETHNOPHARMACOLOGY. 2011

  • Luo, X.; Pires, D.; Ainsa, J.; Gracia, B.; Mulhovo, S.; Anes, E. ; Ferreira, M. Antimycobacterial activity of traditional medicinal plants used in Mozambique. PLANTA MEDICA. 2010

  • Aínsa, Ja; Bird, N; Ryding, Nj; Findlay, Kc; Chater, Kf. The complex whiJ locus mediates environmentally sensitive repression of development of Streptomyces coelicolor A3(2). ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY. 2010

  • Familiar, O.;Munier-Lehmann, H.;Ainsa, J. A.;Camarasa, M. -. ;Perez-Perez, M. -. Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2010

  • Ramon-Garcia, S.;Martin,C.;Thompson,C. J.;Ainsa,J. A. Role of the Mycobacterium Tuberculosis P55 Efflux Pump in Intrinsic Drug Resistance, Oxidative Stress Responses, and Growth. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2009

  • Mick, Virginie; Rebollo, María José; Lucía, Ainhoa; García, María Jesús; Martín, Carlos; Aínsa, José Antonio. Transcriptional analysis of and resistance level conferred by the aminoglycoside acetyltransferase gene aac(2’)-Id from Mycobacterium smegmatis. THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2008

  • Ramon-Garcia, Santiago; Martín, Carlos; de Rossi, Edda; Aínsa, José Antonio. Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG. THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2007

  • Ramon-Garcia,S.;Otal,I.;Martin,C.;Gomez-Lus,R.;Ainsa,J. A. Novel streptomycin resistance gene from Mycobacterium fortuitum. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2006

  • Ramon Garcia,Santiago;Martin,Carlos;Ainsa,Jose A.;de Rossi,Edda. Characterization of tetracycline resistance mediated by the efflux pump Tap from Mycobacterium fortuitum. THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2006

  • de Rossi,E.;Ainsa,J. A.;Riccardi,G. Role of mycobacterial efflux transporters in drug resistance: an unresolved question. FEMS MICROBIOLOGY REVIEWS. 2006

  • de Rossi, Edda; Arrigo, P.; Bellinzoni, Marco; Silva, Pedro E. A.; Martín, Carlos; Aínsa, José Antonio; Guglierame, Paola; Riccardi, Giovanna. The multidrug transporters belonging to Major Facilitator Superfamily (MFS) in Mycobacterium tuberculosis. MOLECULAR MEDICINE. 2002

  • Silva, P. E;Bigi, F. ;de la Paz Santangelo, M. ;Romano, M. I;Martin, C. ;Cataldi, A. ;Ainsa,. Characterization of P55, a multidrug efflux pump in Mycobacterium bovis and Mycobacterium tuberculosis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2001

  • Ainsa, J. A. ;Martin, C. ;Gicquel, B. Molecular approaches to tuberculosis. MOLECULAR MICROBIOLOGY. 2001

  • Aínsa, José Antonio; Ryding, Nicholas Jamie; Hartley, Nigel; Findlay, Kim C.; Bruton, Celia J.; Chater, Keith F. WhiA, a protein of unknown function conserved among Gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2). JOURNAL OF BACTERIOLOGY. 2000

  • Aínsa, José Antonio; Parry, Huw D.; Chater, Keith F. A response regulator-like protein that functions at an intermediate stage of sporulation in Streptomyces coelicolor A3(2). MOLECULAR MICROBIOLOGY. 1999

  • Ainsa, J. A.;Blokpoel, M. C. J.;Otal, I.;Young, D. B.;de Smet, K. A. L.;Martin, C. Molecular cloning and characterization of tap, a putative multidrug efflux pump present in Mycobacterium fortuitum and Mycobacterium tuberculosis. JOURNAL OF BACTERIOLOGY. 1998

  • Ainsa, J. A.;Perez, E.;Pelicic, V.;Berthet, F. X.;Gicquel, B.;Martin, C. Aminoglycoside 2'-N-acetyltransferase genes are universally present in mycobacteria: Characterization of the aac(2')-lc gene from Mycobacterium tuberculosis and the aac(2')-ld gene from Mycobacterium smegmatis. MOLECULAR MICROBIOLOGY. 1997

  • Menendez, M. C.;Ainsa, J. A.;Martin, C.;Garcia, M. J. katGI and katGII encode two different catalases-peroxidases in Mycobacterium fortuitum. JOURNAL OF BACTERIOLOGY. 1997

  • Gavigan, J. A.;Ainsa, J. A.;Perez, E.;Otal, I.;Martin, C. Isolation by genetic labeling of a new mycobacterial plasmid, pJAZ38, from Mycobacterium fortuitum. JOURNAL OF BACTERIOLOGY. 1997

  • Ainsa, J. A.;Martin, C.;Gicquel, B.;Gomez Lus, R. Characterization of the chromosomal aminoglycoside 2'-N-acetyltransferase gene from Mycobacterium fortuitum. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 1996

  • Ainsa, J. A.;Martin, C.;Cabeza, M.;de la Cruz, F.;Mendiola, M. V. Construction of a family of Mycobacterium/Escherichia coli shuttle vectors derived from pAL5000 and pACYC184: their use for cloning an antibiotic-resistance gene from Mycobacterium fortuitum. GENE. 1996

Capítulos

  • Los Retos de la Erradicacion de la Tuberculosis en el Siglo XXI. Gonzalo Asensio, Jesús Ángel ; Samper Blasco, Sofía ; Aínsa, José Antonio, Otal Gil, Isabel y Martín Montañés, Carlos. APLICACIÓN DE LA BIOTECNOLOGÍA EN LA CIENCIA VETERINARIA. 2012

  • Drugs and drug interactions. P.E.A. Silva; J.A. Aínsa. TUBERCULOSIS 2007: FROM BASIC SCIENCE TO PATIENT CARE. 2007

  • Transport processes. J. Content; M. Braibant; N.D. Connel; J.A. Aínsa. TUBERCULOSIS AND THE TUBERCLE BACILLUS. 2004

Colaboraciones en ediciones de revista

  • The Journal of antimicrobial chemotherapy. 1460-2091. 01/01/10 - 31/12/12



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