Profile (CV) of the research teaching staff

Sancho Sanz, Javier
Department: Departamento de Bioquímica y Biología Molecular y Celular
Field: Bioquímica y Biología Molecular
Faculty: Facultad de Ciencias

Research Institutes: INSTITUTO DE BIOCOMPUTACIÓN Y FÍSICA DE SISTEMAS COMPLEJOS (BIFI)
INSTITUTO INVESTIGACIÓN SANITARIA DE ARAGÓN (IIS)
Group: E45_17R: PROTEIN TARGETS AND BIOACTIVE COMPOUNDS (PROTBIOCOMS)
Academic position: Cated. Universidad

Education
  • Doctor en Ciencias. Universidad de Zaragoza. 1988
  • Licenciado en Ciencias (sección Químicas). Universidad de Zaragoza. 1984

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Journal articles

  • Mahía, A.; Conde-Giménez, M.; Salillas, S.; Pallarés, I.; Galano-Frutos, J.J.; Lasa, Í.; Ventura, S.; Díaz de Villegas, M.D.; Gálvez, J.A.; Sancho, J. A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aß1-42, a-synuclein, and amylin amyloid fibrils as well as amyloid-containing Staphylococcus aureus biofilms. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2019

  • Villanueva, Raquel; Romero-Tamayo, Silvia; Laplaza, Ruben; Martinez-Olivan, Juan; Velazquez-Campoy, Adrián; Sancho, Javier; Ferreira, Patricia; Medina, Milagros. Redox-and ligand binding-dependent conformational ensembles in the human apoptosis-inducing factor regulate its pro-life and cell death functions. ANTIOXIDANTS & REDOX SIGNALING. 2019

  • Salillas, S.; Alías, M.; Michel, V.; Mahía, A.; Lucía, A.; Rodrigues, L.; Bueno, J.; Galano-Frutos, Jj.; de Reuse, H.; Velázquez-Campoy, A.; Carrodeguas, J.A.; Sostres, C.; Castillo, J.; Aínsa. J.A.; Díaz-De-Villegas, M.D.; Lanas, Á.; Touati, E.; Sancho, J. Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice. JOURNAL OF MEDICINAL CHEMISTRY. 2019

  • González, Andrés;Salillas, Sandra;Velázquez-Campoy, Adrián;Espinosa Angarica, Vladimir;Fillat, María F.;Sancho, Javier;Lanas, Ángel. Identifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA. SCIENTIFIC REPORTS. 2019

  • Gálvez, José A.; Clavería-Gimeno, Rafael; Galano-Frutos, Juan J.; Sancho, Javier; Velázquez-Campoy, Adrian; Abian, Olga; Díaz-De-Villegas, María D. Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2019

  • Pujols, J.; Pena-Diaz, S.; Lazaro, D.F.; Peccati, F.; Pinheiro, F.; Gonzalez, D.; Carija, A.; Navarro, S.; Conde-Gimenez, M.; Garcia, J.; Guardiola, S.; Giralt, E.; Salvatella, X.; Sancho, J.; Sodupe, M.; Outeiro, T.F.; Dalfo, E.; Ventura, S. Small molecule inhibits alpha-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. 2018

  • Martínez-Júlvez, M.; Goñi, G.; Pérez-Amigot, D.; Laplaza, R.; Ionescu, I.A.; Petrocelli, S.; Tondo, M.L.; Sancho, J.; Orellano, E.G.; Medina, M. Identification of inhibitors targeting ferredoxin-NADP+ reductase from the xanthomonas citri subsp. Citri phytopathogenic bacteria. MOLECULES. 2018

  • Pujols, J.; Peña-Díaz, S.; Conde-Giménez, M.; Pinheiro, F.; Navarro, S.; Sancho, J.; Ventura, S. High-throughput screening methodology to identify alpha-synuclein aggregation inhibitors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017

  • Lamazares, E.; Vega, S.; Ferreira, P.; Medina, M.; Galano-Frutos, J.J.; Martínez-Júlvez, M.; Velázquez-Campoy, A.; Sancho, J. Direct examination of the relevance for folding, binding and electron transfer of a conserved protein folding intermediate. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2017

  • Hidalgo, J.; Latorre, P.; Carrodeguas, J.A.; Velázquez-Campoy, A.; Sancho, J.; López-Buesa, P. Inhibition of pig phosphoenolpyruvate carboxykinase isoenzymes by 3-Mercaptopicolinic acid and novel inhibitors. PLOS ONE. 2016

  • López, L.C.; Varea, O.; Navarro, S.; Carrodeguas, J.A.; de Groot, N.S.; Ventura, S.; Sancho, J. Benzbromarone, quercetin, and folic acid inhibit amylin aggregation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016

  • Velázquez-Campoy,A.;Sancho,J.;Abian,O;Vega,S.;. Biophysical screening for identifying pharmacological chaperones and inhibitors against conformational and infectious diseases. CURRENT DRUG TARGETS. 2016

  • Espinosa Angarica, Vladimir; Orozco, Modesto; Sancho Sanz, Javier. Exploring the complete mutational space of the LDL receptor LA5 domain using molecular dynamics: Linking snps with disease phenotypes in familial hypercholesterolemia. HUMAN MOLECULAR GENETICS. 2016

  • Rodríguez-Cardenas, Á.; Rojas, A.L.; Conde-Giménez, M.; Velazquez-Campoy, A.; Hurtado-Guerrero, R.; Sancho, J. Streptococcus pneumoniae TIGR4 flavodoxin: Structural and biophysical characterization of a novel drug target. PLOS ONE. 2016

  • Galano-Frutos, J.; Morón, M.C.; Sancho, J. The mechanism of water/ion exchange at a protein surface: A weakly bound chloride in Helicobacter pylori apoflavodoxin. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2015

  • Martínez-Oliván, J; Arias-Moreno, X; Hurtado-Guerrero, R; Carrodeguas, Ja; Miguel-Romero, L; Marina, A; Bruscolini, P; Sancho, J. The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome. FEBS LETTERS. 2015

  • Luján, M.A.; Martínez, J.I.; Alonso, P.J.; Torrado, A.; Roncel, M.; Ortega, J.M.; Sancho, J.; Picorel, R. In vivo reconstitution of a homodimeric cytochrome b559 like structure: The role of the N-terminus a-subunit from Synechocystis sp. PCC 6803. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY. 2015

  • Laurents, D. V.; Pantoja-Uceda, D.; López, L. C.; Carrodeguas, J. A.; Mompeán, M.; Jiménez, M. Á.; Sancho, J. DMSO affects Aß1-40''s conformation and interactions with aggregation inhibitors as revealed by NMR. RSC ADVANCES. 2015

  • Martínez-Oliván, J.; Fraga, H.; Arias-Moreno, X.; Ventura, S.; Sancho, J. Intradomain confinement of disulfides in the folding of two consecutive modules of the LDL receptor. PLOS ONE. 2015

  • Llamazares, Emilio; Clemente, Isabel; Bueno, Marta; Velázquez-Campoy, Adrián; Sancho, Javier. Rational stabilization of complex proteins: A divide and combine approach. SCIENTIFIC REPORTS. 2015

  • Estrada, Jorge; Echenique, Pablo; Sancho Sanz, Javier. Predicting stabilizing mutations in proteins using Poisson-Boltzmann based models: Study of unfolded state ensemble models and development of a successful binary classifier based on residue interaction energies. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2015

  • Romero, C. M.; Abella, J. S.; Velázquez, A.; Sancho, J. Thermal denaturation of a-chymotrypsinogen A in presence of polyols at pH 2.0 and pH 3.0. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY. 2015

  • Espinosa Angarica, V.; Angulo, A.; Giner, A.; Losilla, G.; Ventura, S.; Sancho, J. PrionScan: An online database of predicted prion domains in complete proteomes. BMC GENOMICS. 2014

  • Martínez-Oliván, J.; Rozado-Aguirre, Z.; Arias-Moreno, X.; Angarica, V. E.; Velázquez-Campoy, A.; Sancho, J. Low-density lipoprotein receptor is a calcium/magnesium sensor - Role of LR4 and LR5 ion interaction kinetics in low-density lipoprotein release in the endosome. FEBS JOURNAL. 2014

  • Martínez-Oliván, J.; Arias-Moreno, X.; Velazquez-Campoy, A.; Millet, O.; Sancho, J. LDL receptor/lipoprotein recognition: Endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat. FEBS JOURNAL. 2014

  • González, Andrés; Espinosa Angarica, Vladimir; Sancho, Javier; Fillat, María F. The FurA regulon in Anabaena sp. PCC 7120: In silico prediction and experimental validation of novel target genes. NUCLEIC ACIDS RESEARCH. 2014

  • Abian, O.; Vega, S.; Sancho, J.; Velazquez-Campoy, A. Allosteric Inhibitors of the NS3 Protease from the Hepatitis C Virus. PLOS ONE. 2013

  • Espinosa Angarica, V.; Ventura, S.; Sancho, J. Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains. BMC GENOMICS. 2013

  • Galano, J. J.;Alías, M.;Pérez, R.;Velázquez-Campoy, A.;Hoffman, P. S.;Sancho, J. Improved flavodoxin inhibitors with potential therapeutic effects against Helicobacter pylori infection. JOURNAL OF MEDICINAL CHEMISTRY. 2013

  • Secka,O.;Berg,D. E.;Antonio,M.;Corrah,T.;Tapgun,M.;Walton,R.;Thomas,V.;Galano,J. J.;Sancho,J.;Adegbola,R. A.;Thomas,J. E. Antimicrobial susceptibility and resistance patterns among helicobacter pylori strains from the gambia, west africa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2013

  • Sancho Sanz, Javier; Galano, Juan J. QSAR Models for Prediction of Binding and Inhibitory Properties of [(E)-2-R-vinyl]benzene Derivatives with Therapeutic Effects against Helicobacter pylori. MEDICINAL CHEMISTRY. 2013

  • Sancho, J. The stability of 2-state, 3-state and more-state proteins from simple spectroscopic techniques... plus the structure of the equilibrium intermediates at the same time. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2013

  • Graña-Montes,R.;de Groot,N. S.;Castillo,V.;Sancho,J.;Velazquez-Campoy,A.;Ventura,S. Contribution of disulfide bonds to stability, folding, and amyloid fibril formation: The PI3-SH3 domain case. ANTIOXIDANTS & REDOX SIGNALING. 2012

  • Torreblanca,R.;Lira-Navarrete,E.;Sancho,J.;Hurtado-Guerrero,R. Structural and Mechanistic Basis of the Interaction between a Pharmacological Chaperone and Human Phenylalanine Hydroxylase. CHEMBIOCHEM. 2012

  • García-Fandiño, R.; Bernadó, P.; Ayuso-Tejedor, S.; Sancho, J.; Orozco, M. Defining the Nature of Thermal Intermediate in 3 State Folding Proteins: Apoflavodoxin, a Study Case. PLOS COMPUTATIONAL BIOLOGY. 2012

  • López, L.C.; Dos-Reis, S.; Espargaró, A.; Carrodeguas, J.A.; Maddelein, M.-L; Ventura, S.; Sancho, J. Discovery of novel inhibitors of amyloid ß-Peptide 1-42 Aggregation. JOURNAL OF MEDICINAL CHEMISTRY. 2012

  • Martínez-Júlvez, M.;Rojas, A. L.;Olekhnovich, I.;Espinosa Angarica, V. ;Hoffman, P. S.;Sancho, J. Structure of RdxA - An oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori. FEBS JOURNAL. 2012

  • Espinosa Angarica, V. E.;Sancho, J. Protein Dynamics Governed by Interfaces of High Polarity and Low Packing Density. PLOS ONE. 2012

  • Albis, A.;Lozano, J. M.;Sancho, J. ;Romero, C. M. Influence of calcium on the thermal stabilization of bovine -lactalbumin by selected polyols. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY. 2011

  • Pérez-Llarena, F. J.; Kerff, F.; Abián, O.; Mallo, S.; Fernández, M. C.; Galleni, M.; Sancho, J.; Bou, G. Distant and new mutations in CTX-M-1 ß-lactamase affect cefotaxime hydrolysis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2011

  • Conesa, C.; Doss, M-X.; Antzelevitch,C.; Sachinidis, A.; Sancho, J.; Carrodeguas, J.A. Identification of Specific Pluripotent Stem Cell Death-inducing Small Molecules by Chemical Screening. STEM CELL REVIEWS. 2011

  • Ayuso-Tejedor, S.; Abián, O.; Sancho, J. Underexposed polar residues and protein stabilization. PROTEIN ENGINEERING DESIGN & SELECTION. 2011

  • Abian,O.; Alfonso,P.; Velazquez-Campoy,A.; Giraldo,P.; Pocovi,M.; Sancho,J. Therapeutic strategies for Gaucher disease: Miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. MOLECULAR PHARMACEUTICS. 2011

  • Ayuso-Tejedor,S.;Abián,O.;Velázquez-Campoy,A.;Sancho,J. Mechanism of FMN binding to the apoflavodoxin from Helicobacter pylori. BIOCHEMISTRY. 2011

  • Arias-Moreno, X.;Cuesta-Lopez, S.;Millet, O.;Sancho, J. ;Velazquez-Campoy, A. Thermodynamics of protein-cation interaction: Ca+2 and Mg +2 binding to the fifth binding module of the LDL receptor. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2010

  • Ayuso-Tejedor, S.;Nishikori, S.;Okuno, T.;Ogura, T. ;Sancho, J. FtsH cleavage of non-native conformations of proteins. JOURNAL OF STRUCTURAL BIOLOGY. 2010

  • Ayuso-Tejedor, S.;Angarica, V. E.;Bueno, M.;Campos, L. A.;Abian, O.;Bernado, P.;Sancho, J. ;Jimenez, M. A. Design and structure of an equilibrium protein folding intermediate: A hint into dynamical regions of proteins. JOURNAL OF MOLECULAR BIOLOGY. 2010

  • Sancho Sanz, Javier; Stevens, Raymond C; Martinez, Aurora. Rescue of misfolded proteins and stabilization by small molecules. METHODS IN MOLECULAR BIOLOGY. 2010

  • Sancho Sanz, Javier; Contreras-Moreira, B; Angarica, Ve. Comparison of DNA-binding across protein superfamilies. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2010

  • Alias, M.; Ayuso-Tejedor, S.; Fernandez-Recio, J.; Cativiela, C. ; Sancho, J. Helix propensities of conformationally restricted amino acids. Non-natural substitutes for helix breaking proline and helix forming alanine. ORGANIC & BIOMOLECULAR CHEMISTRY. 2010

  • Estrada, J.;Bernado,P.;Blackledge,M.;Sancho,J. ProtSA: A Web Application for Calculating Sequence Specific Protein Solvent Accessibilities in the Unfolded Ensemble. BMC BIOINFORMATICS. 2009

  • Cremades, N.;Velazquez-Campoy, A.;Martinez-Julvez, M.;Neira, J. L.;Perez-Dorado, I.;Hermoso, J.;Jimenez, P.;Lanas, A.;Hoffman, P. S.;Sancho, J. Discovery of Specific Flavodoxin Inhibitors as Potential Therapeutic Agents Against Helicobacter Pylori Infection. ACS CHEMICAL BIOLOGY. 2009

  • Gil-Redondo, R.;Estrada,J.;Morreale,A.;Herranz,F.;Sancho,J.;Ortiz,A. R. VSDMIP: Virtual Screening Data Management on an Integrated Platform. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. 2009

  • N. Cremades; J. Sancho. Molten Globule and Native State Ensemble of Helicobacter pylori Flavodoxin. Can crowding, osmolytes or cofactors stabilize the native conformation relative to the molten globule?. BIOPHYSICAL JOURNAL. 2008

  • X. Arias-Moreno; J. L. Arolas; F. X. Aviles; J. Sancho; S. Ventura. Scrambled Isomers as Key Intermediates in the Oxidative Folding of Ligand Binding Module 5 of the Low Density. JOURNAL OF BIOLOGICAL CHEMISTRY. 2008

  • Arias-Moreno, X.;Velazquez-Campoy,A.;Rodriguez,J. C.;Pocovi,M.;Sancho,J. Mechanism of Low Density Lipoprotein (LDL) Release in the Endosome: Implications of the Stability and Ca2+ Affinity of the Fifth Binding Module of the LDL Receptor. JOURNAL OF BIOLOGICAL CHEMISTRY. 2008

  • Pey, A. L.;Ying, M.;Cremades, N.;Velazquez-Campoy, A.;Scherer, T.;Thoeny, B.;Sancho, J.;Martinez, A. Identification of Pharmacological Chaperones as Potential Therapeutic Agents to Treat Phenylketonuria. JOURNAL OF CLINICAL INVESTIGATION. 2008

  • Cremades, N.;Velazquez-Campoy,A.;Freire,E.;Sancho,J. The Flavodoxin from Helicobacter Pylori: Structural Determinants of Thermostability and FMN Cofactor Binding. BIOCHEMISTRY. 2008

  • Gonzalo-Asensio, J.;Soto, C. Y.;Arbues, A.;Sancho, J.;Menendez, M. D. C.;Garcia, M. J.;Gicquel, B.;Martin, C. The Mycobacterium Tuberculosis phoPR Operon is Positively Autoregulated in the Virulent Strain H37Rv. JOURNAL OF BACTERIOLOGY. 2008

  • Cremades, N.;Bueno,M.;Neira,J. L.;Velazquez-Campoy,A.;Sancho,J. Conformational Stability of Helicobacter Pylori Flavodoxin Fit to Function at pH 5. JOURNAL OF BIOLOGICAL CHEMISTRY. 2008

  • M. St. Maurice; N. Cremades; M. A. Croxen; G. Sisson; J. Sancho; P. S. Hoffman. Flavodoxin: Quinone Reductase (FqrB): A Redox Partner of Pyruvate: Ferredoxin Oxidoreductase that Reversibly Couples Pyruvate Oxidation to NADPH Production in Helicobacter pylori and Campylobacter jejuni. JOURNAL OF BACTERIOLOGY. 2007

  • Romero, C. M.;Lozano,J. M.;Sancho,J.;Giraldo,G. I. Thermal Stability of Beta-Lactoglobulin in the Presence of Aqueous Solution of Alcohols and Polyols. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2007

  • Cuesta-Lopez, S.; Falo,F.; Sancho,J. Computational Diagnosis of Protein Conformational Diseases: Short Molecular Dynamics Simulations Reveal a Fast Unfolding of r-LDL Mutants that Cause Familial Hypercholesterolemia. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2007

  • Bueno, M; Camacho, C.J.; Sancho, J. Simple estimate of the free energy change due to aliphatic mutations: superior predictions based on first principles. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2007

  • Bueno,M.;Campos,L. A.;Estrada,J.;Sancho,J. Energetics of aliphatic deletions in protein cores. PROTEIN SCIENCE. 2006

  • Bueno,Marta;Ayuso Tejedor,Sara;Sancho,Javier. Do proteins with similar folds have similar transition state structures? A diffuse transition state of the 169 residue apoflavodoxin. JOURNAL OF MOLECULAR BIOLOGY. 2006

  • Bueno,Marta;Cremades,Nunilo;Neira,Jose Luis;Sancho,Javier. Filling small, empty protein cavities: Structural and energetic consequences. JOURNAL OF MOLECULAR BIOLOGY. 2006

  • Sancho,J. Flavodoxins: Sequence, folding, binding, function and beyond. CELLULAR AND MOLECULAR LIFE SCIENCES. 2006

  • Bernado,P.;Blackledge,M.;Sancho,J. Sequence-specific solvent accessibilities of protein residues in unfolded protein ensembles. BIOPHYSICAL JOURNAL. 2006

  • Campos,A.;Sancho,J. Native-specific stabilization of flavodoxin by the FAIN cofactor: Structural and thermodynamical explanation. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2006

  • Cremades,N.;Sancho,J.;Freire,E. The native-state ensemble of proteins provides clues for folding, misfolding and function. TRENDS IN BIOCHEMICAL SCIENCES. 2006

  • Lopez-Llano,J.;Campos,L. A.;Bueno,M.;Sancho,J. Equilibrium Phi-analysis of a molten globule: The 1-149 apoflavodoxin fragment. JOURNAL OF MOLECULAR BIOLOGY. 2006

  • Machicado, C.;Lopez Llano, J.;Cuesta Lopez, S.;Bueno, M.;Sancho, J. Design of Ligand Binding to an Engineered Protein Cavity Using Virtual Screening and Thermal up-Shift Evaluation. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. 2005

  • Alfonso, P.;Pampin, S.;Estrada, J.;Rodriguez Rey, J. C.;Giraldo, P.;Sancho, J.;Pocovi, M. Miglustat (Nb-Dnj) Works as a Chaperone for Mutated Acid Beta-Glucosidase in Cells Transfected With Several Gaucher Disease Mutations. BLOOD CELLS MOLECULES AND DISEASES. 2005

  • Lidon Moya, M.C;Barrera, F.N;Bueno, M;Perez Jimenez, R;Sancho, J;Mateu, M.G;Neira, J.L. An Extensive Thermodynamic Characterization of the Dimerization Domain of the Hiv-1 Capsid Protein. PROTEIN SCIENCE. 2005

  • Cremades, N.;Bueno, M.;Toja, M.;Sancho, J. Towards a New Therapeutic Target: Helicobacter Pylori Flavodoxin. BIOPHYSICAL CHEMISTRY. 2005

  • Lopez Llano, J.;Campos, L. A.;Bueno, M.;Sancho, J. Equilibrium phi-analysis of a molten globule: the 1-149 apoflavodoxin fragment. JOURNAL OF MOLECULAR BIOLOGY. 2005

  • Campos, L. A.;Cuesta Lopez, S.;Lopez Llano, J.;Falo, F.;Sancho, J. A double-deletion method to quantifying incremental binding energies in proteins from experiment: example of a destabilizing hydrogen bonding pair. BIOPHYSICAL JOURNAL. 2005

  • Campos, L. A.;Garcia Mira, M. M.;Godoy Ruiz, R.;Sanchez Ruiz, J. M.;Sancho, J. Do Proteins Always Benefit From a Stability Increase? Relevant and Residual Stabilisation in a Three-State Protein by Charge Optimisation. JOURNAL OF MOLECULAR BIOLOGY. 2004

  • Campos, L. A.;Bueno, M.;Lopez Llano, J.;Jimenez, M. A.;Sancho, J. Structure of Stable Protein Folding Intermediates by Equilibrium Phi-Analysis: the Apoflavodoxin Thermal Intermediate. JOURNAL OF MOLECULAR BIOLOGY. 2004

  • Nogues, Isabel;Campos, Luis Alberto;Sancho, Javier;Gomez Moreno, Carlos;Mayhew, Stephen G.;Medina, Milagros. Role of neighboring FMN side chains in the modulation of flavin reduction potentials and in the energetics of the FMN:apoprotein interaction in Anabaena flavodoxin. BIOCHEMISTRY. 2004

  • J. López-Llano; S. Maldonado; S. Jain; A. Lostao; R. Godoy-Ruiz; J.M. Sanchez-Ruiz; M. Cortijo; J. Fernández-Recio; J. Sancho. The long and short flavodoxins. II: role of the differentiating loop in apoflavodoxin stability and folding mechanism. JOURNAL OF BIOLOGICAL CHEMISTRY. 2004

  • Campos, L. A.;Sancho, J. The Active Site of Pepsin Is Formed in the Intermediate Conformation Dominant at Mildly Acidic Ph. FEBS LETTERS. 2003

  • Machicado, C;Castillo, S;Bueno, M;Pocoví, M;Sancho, J. Mutaciones del receptor de LDL que permiten considerar la hipercolesterolemia familiar dentro de las enfermedades del plegamiento de las proteínas. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 2003

  • Bes, M. T.;Sancho, J.;Peleato, M. L.;Medina, M.;Gomez-Moreno, C.;Fillat, M. F. Purification of Colored Photosynthetic Proteins for Understanding Protein Isolation Principles. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION. 2003

  • Acin Perez, R.;Bayona Bafaluy, M. P.;Bueno, M.;Machicado, C.;Fernandez Silva, P.;Perez Martos, A.;Montoya, J.;Lopez Perez, M. J.;Sancho, J.;Enriquez, J. A. An Intragenic Suppressor in the Cytochrome C Oxidase I Gene of Mouse Mitochondrial Dna. HUMAN MOLECULAR GENETICS. 2003

  • Iddar, A.;Campos, L. A.;Sancho, J.;Serrano, A.;Soukri, A. Different Thermostability of Skeletal Muscle Glyceraldehyde-3-Phosphate Dehydrogenase From Hibernating and Euthermic Jerboa (Jaculus Orientalis). SHENGWU HUAXUE YU SHENGWU WULI XUEBAO. 2003

  • Lostao, A.; Daoudi, F.; Irun, M. P.; Ramon, A.; Fernandez Cabrera, C.; Romero, A.; Sancho, J. How Fmn Binds to Anabaena Apoflavodoxin - a Hydrophobic Encounter at an Open Binding Site. JOURNAL OF BIOLOGICAL CHEMISTRY. 2003

  • Pedroso, Idolka;Irun, Maria, P. ;Machicado, Claudia;Sancho, Javier. Four-state equilibrium unfolding of an scFv antibody fragment. BIOCHEMISTRY. 2002

  • Sancho Sanz, Javier; Bueno, Marta; Campos, Luis A.; Fernández Recio, Juan; Irún, María Pilar; López, Jon; Machicado, Claudia; Pedroso, Idolka; Toja, Miguel. The ‘relevant’ stability of proteins with equilibrium intermediates. THE SCIENTIFIC WORLD JOURNAL. 2002

  • Machicado, C. ;Bueno, M. ;Sancho, J. Predicting the structure of protein cavities created by mutation. PROTEIN ENGINEERING. 2002

  • Maldonado, Susana;Irun, Maria, = Pilar;Campos, Luis, = Alberto;Rubio, Jose, = Antonio;Luquita, Alejandra;Lostao, Anabel;Wang, Renjie;Garcia Moreno, E. Bertrand;Sancho, Javier. Salt-induced stabilization of apoflavodoxin at neutral pH is mediated through cation-specific effects. PROTEIN SCIENCE. 2002

  • Casaus, Jose, L.;Navarro, Jose, A.;Hervas, Manuel;Lostao, Anabel;de la Rosa, Miguel, A.;Gomez Moreno, Carlos;Sancho, Javier;Medina, Milagros. Anabaena sp. PCC 7119 flavodoxin as electron carrier from photosystem I to ferredoxin-NADP+ reductase. Role of Trp(57) and Tyr(94). JOURNAL OF BIOLOGICAL CHEMISTRY. 2002

  • Garcia, Jose I.;Medina, Milagros;Sancho, Javier;Alonso, Pablo J.;Gomez-Moreno, Carlos;Mayoral, Jose A.;Martinez, Jesus I. Theoretical Analysis of the Electron Spin Density Distribution of the Flavin Semiquinone Isoalloxazine Ring within Model Protein Environments. JOURNAL OF PHYSICAL CHEMISTRY A. 2002

  • Irun, M. P;Maldonado, S. ;Sancho, J. Stabilization of apoflavodoxin by replacing hydrogen-bonded charged Asp or Glu residues by the neutral isosteric Asn or Gln. PROTEIN ENGINEERING. 2001

  • Fernandez Recio, J. ;Genzor, C. G. ;Sancho, J. Apoflavodoxin folding mechanism: An < alpha >/< beta > protein with an essentially off-pathway intermediate. BIOCHEMISTRY. 2001

  • Irun, M. P;Garcia Mira, M. M;Sanchez Ruiz, J. M;Sancho, J. Native hydrogen bonds in a molten globule: the apoflavodoxin thermal intermediate. JOURNAL OF MOLECULAR BIOLOGY. 2001

  • Alexis Balme; Manuel Hervás; Luis A. Campos; Javier Sancho; Miguel A. de la Rosa; José A. Navarro. A comparative study of the thermal stability of plastocyanin, cytochrome c6 and photosystem I in thermophylic and mesophylic cyanobacteria. PHOTOSYNTHESIS RESEARCH. 2001

  • G.M. Langdon; M.A. Jiménez; C.G. Genzor; S. Maldonado; J. Sancho; M. Rico. Anabaena apoflavodoxin hydrogen exchange: on the stable exchange core of the alpha/beta(21345) flavodoxin-like family. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2001

  • Sancho Sanz, J. The conformational stability of proteins: Rational stabilization by protein engineering. BIOTECNOLOGÍA APLICADA. 2000

  • Lostao, A. ;El Harrous, M. ;Daoudi, F. ;Romero, A. ;Parody Morreale, A. ;Sancho, J. Dissecting the energetics of the apoflavodoxin-FMN complex. JOURNAL OF BIOLOGICAL CHEMISTRY. 2000

  • Fernandez-Recio, J.;Romero, A.;Sancho, J. Energetics of a hydrogen bond (charged and neutral) and of a cation-pi interaction in apoflavodoxin. JOURNAL OF MOLECULAR BIOLOGY. 1999

  • Medina, M.; Lostao, A.; Sancho, J.; Gomez-Moreno, C.; Cammack, R.; Alonso, P. J.; Martinez, J. I. Electron-nuclear double resonance and hyperfine sublevel correlation spectroscopic studies of flavodoxin mutants from Anabaena sp PCC 7119. BIOPHYSICAL JOURNAL. 1999

  • Maldonado, S.;Jimenez, M. A.;Langdon, G. M.;Sancho, J. Cooperative stabilization of a molten globule apoflavodoxin fragment. BIOCHEMISTRY. 1998

  • Maldonado, S.;Lostao, A.;Irun, M. P.;Fernandez-Recio, J.;Genzor, C. G.;Gonzalez, E. B.;Rubio, J. A.;Luquita, A.;Daoudi, F.;Sancho, J. Apoflavodoxin: Structure, stability, and FMN binding. BIOCHIMIE. 1998

  • Fernandez-Recio, J.;Sancho, J. Intrahelical side chain interactions in alpha-helices: poor correlation between energetics and frequency. FEBS LETTERS. 1998

  • Fernandez-Recio, J.;Vazquez, A.;Civera, C.;Sevilla, P.;Sancho, J. The tryptophan/histidine interaction in alpha-helices. JOURNAL OF MOLECULAR BIOLOGY. 1997

  • Lostao, A.; Gómez-Moreno, C.; Mayhew, S.G.; Sancho, J. Differential stabilization of the three FMN redox forms by tyrosine 94 and tryptophan 57 in flavodoxin from Anabaena and its influence on the redox potentials. BIOCHEMISTRY. 1997

  • Genzor, C. G.;Beldarrain, A.;Gomez-Moreno, C.;Lopezlacomba, J. L.;Cortijo, M.;Sancho, J. Conformational stability of apoflavodoxin. PROTEIN SCIENCE. 1996

  • Genzor, C. G.;Perales Alcon, A.;Sancho, J.;Romero, A. Closure of a tyrosine. NATURE STRUCTURAL BIOLOGY. 1996

  • Kippen, Ad; Sancho, J; Fersht, Ar. Folding of barnase in parts. BIOCHEMISTRY. 1994

  • Vuilleumier, S; Sancho, J; Loewenthal , R; Fersht, Ar. Circular dichroism studies of barnase and its mutants. Contribution of aromatic side chains. BIOCHEMISTRY. 1993

  • Loewenthal, R; Sancho, J; Reinikainen, T; Fersht, Ar. Longe range surface charge-charge interactions in proteins. Comparison of experimental results with calculations from a theoretical method. JOURNAL OF MOLECULAR BIOLOGY. 1993

  • Fersht, Ar; Matouschek, A; Sancho, J; Serrano, L; Vuilleumier, S. Pathway of protein folding. FARADAY DISCUSSIONS. 1992

  • Serrano, L; Sancho, J; Hirshberg, M; Fersht, Ar. Alpha-helix stability in proteins. I. Empirical correlations concerning substitution of side-chains at the N and C-caps and the replacement of alanine by glycine or serine at solvent-exposed surfaces. JOURNAL OF MOLECULAR BIOLOGY. 1992

  • Serrano, L; Neira, Jl; Sancho, J; Fersht, Ar. Effect of alanine versus glycine in alpha-helices on protein stability. NATURE. 1992

  • Loewenthal, R; Sancho, J; Fersht., Ar. Histidine-aromatic Interactions in Barnase: Elevation of Histidine pKa and Contribution to Protein Stability. JOURNAL OF MOLECULAR BIOLOGY. 1992

  • Sancho, J; Neira, Jl; Fersht, Ar. An N-Terminal Fragment of Barnase has Residual Helical Structure Similar to that in a Refolding Intermediate. JOURNAL OF MOLECULAR BIOLOGY. 1992

  • Sancho, J; Fersht, Ar. Disection of an Enzyme by Protein Engineering: the N-and C-Terminal fragments of Barnase form a Native-Like Complex with Restored Enzymic Activity. JOURNAL OF MOLECULAR BIOLOGY. 1992

  • K. Willaert, R. Loewenthal, J. Sancho, M. Froeyen, A. Fersht & Y. Engelborghs. Determination of the excited-state lifetimes of the tryptophan residues in barnase, via multifrequency phase fluorometry of tryptophan mutants. BIOCHEMISTRY. 1992

  • Sancho, J; Serrano, L; Fersht, Ar. Histidine residues at the N- and C-termini of á helices: perturbed pKas and protein stability. BIOCHEMISTRY. 1992

  • Loewenthal, R; Sancho, J; Fersht, Ar. Fluorescence spectrum of barnase: contributions of three tryptophan residues and a histidine-related pH-dependence. BIOCHEMISTRY. 1991

  • Sancho, J.;Gomez Moreno, C. Interaction of Ferredoxin-Nadp+ Reductase from Anabaena with its Substrates. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1991

  • Sancho, J; Meiering, Em; Fersht, Ar. Mapping transition states of protein unfolding by protein engineering of ligand binding sites. JOURNAL OF MOLECULAR BIOLOGY. 1991

  • Sancho, J.;Medina, M.;Gomez-Moreno, C. Arginyl Groups Involved in the Binding of Anabaena Ferredoxin-Nadp+ Reductase to Nadp+ and to Ferredoxin. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1990

  • Pueyo, J. J.;Sancho, J.;Edmondson, D. E.;Gomez Moreno, C. Preparation and Properties of a Cross-Linked Complex between Ferrdoxin-Nadp+ Reductase and Flavodoxin. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1989

  • Sancho, J.;Peleato, M. L.;Gomez-Moreno, C.;Edmondson, D. E. Purification and properties of ferredoxin-NADP+ oxidoreductase from the nitrogen-fixing cyanobacteria Anabaena variabilis. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1988

Books

  • Carlos Gómez-Moreno Calera y Javier Sancho Sanz (coords.). Estructura de proteínas. 2003

  • Javier Sancho. Cuentos de colores. 2003

Scientific chapters

  • Marta Bueno, Claudia Machicado, Nunilo Cremades y Javier Sancho. Estructuras tridimensionales: bases de datos y visualización. ESTRUCTURAS TRIDIMENSIONALES: BASES DE DATOS Y VISUALIZACIÓN. 2003

  • C. Gómez-Moreno ... [et al.]. Ingeniería y diseño de proteínas para su utilización en procesos para su utilización en procesos industriales. INGENIERÍA Y DISEÑO DE PROTEÍNAS PARA SU UTILIZACIÓN EN PROCESOS PARA SU UTILIZACIÓN EN PROCESOS INDUSTRIALES /C. GÓMEZ-MORENO ... [ET AL.]. 2001



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