Profile (CV) of the research teaching staff

Menao Guillén, Sebastián
Department: Departamento de Bioquímica y Biología Molecular y Celular
Field: Toxicología
Faculty: Facultad de Medicina

UNESCO codes
  • Genética clínica
  • Toxicología
Academic position: Prof. Asociado
Office phone: 976556400
Email: smenao@unizar.es
ORCID number: 0000-0002-1817-4549

University degrees
  • FACULTATIVO ESPECIALISTA DE AREA EN BIOQUIMICA CLINICA. Hospital Clínico Universitario Lozano Blesa. 2006
  • Licenciado en Ciencias Especialidad Ciencias Químicas. Universidad de Zaragoza. 1999
  • Bioquímica. Universidad de Zaragoza. 1999

PhDs
  • Doctor en Programa Oficial de Posgrado en Bioquímica y biología molecular. Universidad de Zaragoza. 2006

Download curriculum in PDF format Go to ORCID page

 
         

Journal articles

  • Zurera, María; Laguna, Juan Carlos; Mezquita, Laura; Higuera, Oliver; Menao, Sebastián; Arruebo, María; Jimenez, Javier Torres; de Castro, Javier; Isla, Dolores; Lastra, Rodrigo. Germline Mutation Analysis and Real-World Impact in a Selected Cohort of Patients with Non-Small Cell Lung Cancer: INHERITY LC Study. CLINICAL LUNG CANCER. 2025. DOI: 10.1016/j.cllc.2025.10.012

  • Perales-Afán, Juan José; Menao, Sebastián; García-Gutiérrez, Almudena; García-Zafra, Laura; del Castillo-Díez, Enrique; Torralba-Cabeza, Miguel Ángel. Alpha-1 Antitrypsin Deficiency Screening Using Serum Protein Electrophoresis. RESPIRATORY CARE. 2025. DOI: 10.1089/respcare.12524

  • Menao Guillén, S.; Pedrola, L.; Orellana, C.; Roselló, M.; Arruebo, M.; Lahuerta Pueyo, C.; Sobreviela Laserrada, M.; Marcos, B.; Pascual Mancho, J.; Cervera, J. V.; Tajada, M.; Quiroga, R. Clinical Utility of Opportunistic Genome-Wide cfDNA Prenatal Screening in Intermediate-Risk Pregnancies. GENES. 2025. DOI: 10.3390/genes16111344

  • Alonso, Natalia; Menao, Sebastián; Lastra, Rodrigo; Arruebo, María; Bueso, María P.; Pérez, Esther; Murillo, M. Laura; Álvarez, María; Alonso, Alba; Rebollar, Soraya; Cruellas, Mara; Arribas, Dolores; Ramos, Mónica; Isla, Dolores; Galano-Frutos, Juan José; García-Cebollada, Helena; Sancho, Javier; Andrés, Raquel. Association between missense variants of uncertain significance in the CHEK2 gene and hereditary breast cancer: a cosegregation and bioinformatics analysis. FRONTIERS IN GENETICS. 2024. DOI: 10.3389/fgene.2023.1274108

  • Pintanel-Raymundo, M.; Menao-Guillén, S.; Perales-Afán, J.J.; García-Gutiérrez, A.; Moreno-Gázquez, I.; Julián-Ansón, M.; Ramos-Álvarez, M.; Olivera-González, S.; Gutiérrez-Cía, I.; Torralba-Cabeza, M.A. Análisis de la expresión del gen SERPINA1 en la infección por SARS-CoV-2: estudio de un nuevo biomarcador. REVISTA CLÍNICA ESPAÑOLA. 2024. DOI: 10.1016/j.rce.2024.03.002

  • Moreno-Gázquez, Inmaculada; Pérez-Palacios, Raquel; Abengochea-Quílez, Lucia; Lahuerta Pueyo, Carmen; Roteta Unceta Barrenechea, Ana; Andrés Gracia, Alejandro; Aibar Arregui, Miguel Angel; Menao Guillén, Sebastián. Targeted sequencing of selected functional genes in patients with wild-type transthyretin amyloidosis. BBMC RESEARCH NOTES. 2023. DOI: 10.1186/s13104-023-06491-z

  • Iranzo, Patricia; Callejo, Ana; Arbej, Julio; Menao, Sebastian; Isla, Dolores; Andrés, Raquel. Factores de riesgo de deterioro cognitivo asociado a cáncer en pacientes con carcinoma de mama y colon que reciben tratamiento con quimioterapia. ANALES DEL SISTEMA SANITARIO DE NAVARRA. 2023. DOI: 10.23938/ASSN.1040

  • Fernández-Gomez, Beatriz; Menao-Guillén, Sebastian; Fernandez Gonzalez, Ayla; Arruebo Muñio, Maria; Ramos Alvarez, Monica; Inda Landaluce, Mercedes; Castillo Arce, Maria Angeles; Torralba-Cabeza, Miguel Ángel. Utility of the serum protein electrophoresis in the opportunistic screening for the deficiency of Alpha-1 Antitrypsin. DIAGNOSTICS. 2023. DOI: 10.3390/diagnostics13172778

  • Bularca E.; Merino-Casallo M.I.; Olivera-González S.; Menao-Guillén S.; Sierra-Monzón J.L.; Domingo-Morera J.M.; Torralba-Cabeza M.Á. Correction to: Study of cellular aging in a cohort of patients with heart failure (High Blood Pressure & Cardiovascular Prevention, (2021), 28, 1, (49-55), 10.1007/s40292-020-00421-x). HIGH BLOOD PRESSURE AND CARDIOVASCULAR PREVENTION. 2021. DOI: 10.1007/s40292-021-00459-5

  • Bueno Juana, E.; Gracia Gutiérrez, A.; Melero Polo, J.; Roteta Unceta-Barrenechea, A.; Andrés Gracia, A.; Lahuerta Pueyo, C.; Menao Guillén, S.; Revilla Martí, P.; Aibar Arregui, M.Á. Estudio descriptivo de la amiloidosis por transtiretina en un hospital de tercer nivel sin unidad de referencia. REVISTA CLÍNICA ESPAÑOLA. 2021. DOI: 10.1016/j.rce.2021.01.007

  • Roteta Unceta Barrenechea, A.; Lahuerta Pueyo, C.; Melero Polo, J.; Menao Guillén, S.; Andrés Gracia, A.; Revilla Marti, P.; Aibar Arregui, M.Á. DISCOVERY: prevalence of transthyretin (TTR) mutations in a US-centric patient population suspected of having cardiac amyloidosis: a comment. AMYLOID. 2021. DOI: 10.1080/13506129.2020.1830272

  • Bularca, Elena; Merino-Casallo, María Izarbe; Olivera-González, Susana; Menao-Guillén, Sebastián; Sierra-Monzón, José Luis; Domingo-Morera, José María; Torralba-Cabeza, Miguel Ángel. Study of cellular aging in a cohort of patients with heart failure. HIGH BLOOD PRESSURE AND CARDIOVASCULAR PREVENTION. 2021. DOI: 10.1007/s40292-020-00421-x

  • Roteta Unceta Barrenechea, Ana; Aibar Arregui, Miguel Ángel; Andrés Gracia, Alejandro; Melero Polo, Jorge; Lahuerta Pueyo, Carmen; Menao Guillén, Sebastián; Torralba Cabeza, Miguel Ángel. Clinical manifestations in hereditary amyloidosis with the variant Glu54Gln transthyretin: a comment. AMYLOID. 2020. DOI: 10.1080/13506129.2019.1710126

  • Lahuerta, Carmen; Menao, Sebastián; Gracia-Gutierrez, Anyuli; Bueno-Juana, Esperanza; Guillén, Natalia; Sorribas, Víctor; Andrés Gracia, Alejandro; Aibar, Miguel A. Diagnosis of genetic amyloidosis through the analysis of transthyretin gene mutation using high-resolution melting. INTERNATIONAL JOURNAL OF CARDIOLOGY. 2020. DOI: 10.1016/j.ijcard.2019.10.028

  • Merino-Casallo, Izarbe; Friaza, Vicente; Menao, Sebastián; Domingo, José María; Olivera S.; Calderón E.J.; Torralba M.Á. Pneumocystis jirovecii in Spanish Patients With Heart Failure. FRONTIERS IN PUBLIC HEALTH. 2019. DOI: 10.3389/fpubh.2019.00289

  • Andres, Raquel; Menao, Sebastián; Arruebo, María; Quilez, Elisa; Cardiel, María José. Double heterozygous mutation in the BRCA1 and ATM genes involved in development of primary metachronous tumours: a case report. BREAST CANCER RESEARCH AND TREATMENT. 2019. DOI: 10.1007/s10549-019-05343-4

  • Lahuerta Pueyo, C.; Aibar Arregui, M.Á.; Gracia Gutierrez, A.; Bueno Juana, E.; Menao Guillén, S. Estimating the prevalence of allelic variants in the transthyretin gene by analysing large-scale sequencing data. EUROPEAN JOURNAL OF HUMAN GENETICS. 2019. DOI: 10.1038/s41431-019-0337-1

  • Stepien, G.; Moros, M.; Pérez-Hernández, M.; Monge, M.; Gutiérrez, L.; Fratila, R.M.; Las Heras, M.D.; Menao Guillén, S.; Puente Lanzarote, J.J.; Solans, C.; Pardo, J.; Martínez de la Fuente, J. Effect of surface chemistry and associated protein corona on the long-term biodegradation of iron oxide nanoparticles in Vivo. ACS APPLIED MATERIALS & INTERFACES. 2018. DOI: 10.1021/acsami.7b18648

  • Pérez-Hernández, Marta; Moros, María; Stepien, Grazyna; del Pino, Pablo; Menao, Sebastián; Heras, Marcelo de Las; Arias, Maykel; Mitchell, Scott G.; Pelaz, Beatriz ; Gálvez, Eva M.; Fuente, Jesús M. de La; Pardo, Julián. Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo. PARTICLE AND FIBRE TOXICOLOGY. 2017. DOI: 10.1186/s12989-017-0222-4

  • Miranda Arto, P.; Ferrer Dufol, A.; Ruiz Ruiz, F. J.; Menao Guillén, S.; Civeira Murillo, E. Intoxicaciones agudas en pacientes mayores de 65 años ANALES DEL SISTEMA SANITARIO DE NAVARRA. 2014

  • Arias, Ma; Jiménez de Bagües, Mp; Aguilo, N; Menao, S; Hervás-Stubbs, S; de Martino, A; Alcaraz, A; Simon, Mm; Froelich, Cj; Pardo, J. Elucidating sources and roles of Granzymes A and B during bacterial infection and sepsis. CELL REPORTS. 2014. DOI: 10.1016/j.celrep.2014.06.012

  • Ramos, M.;Menao, S.;Arnedo, M.;Puisac, B.;Gil-Rodríguez, M. C.;Teresa-Rodrigo, M.;Hernández-Marcos, M.;Pierre, G.;Ramaswami, U.;Baquero-Montoya, C.;Bueno, G.;Casale, C.;Hegardt, F. G.;Gómez-Puertas, P.;Pié, J. New case of mitochondrial HMG-CoA synthase deficiency: Functional analysis of eight mutations. EUROPEAN JOURNAL OF MEDICAL GENETICS. 2013. DOI: 10.1016/j.ejmg.2013.05.008

  • Arnedo,M.;Menao,S.;Puisac,B.;Teresa-Rodrigo,M.;Gil-Rodríguez,M. C.;López-Viñas,E.;Gómez-Puertas,P.;Casals,N.;Casale,C. H.;Hegardt,F. G.;Pié,J. Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol. JOURNAL OF LIPID RESEARCH. 2012. DOI: 10.1194/jlr.M025700

  • Puisac, B; Ramos, M; Arnedo, M; Menao, S; Gil-Rodríguez, Mc; Teresa-Rodrigo, Me; Pié, A; de Karam, Jc; Wesselink, Jj; Giménez, I; Ramos, Fj; Casals, N; Gómez-Puertas, P; Hegardt, Fg; Pié, J . Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway. MOLECULAR BIOLOGY REPORTS. 2011. DOI: 10.1007/s11033-011-1270-8

  • Ferrer-Dufol, A.;Munarriz, J.;Martin, L.;Civeira, E.;Marin, A.;Menao, S. ;Arruebo, M. Toxicokinetics of ethanol and methanol in a severe case of methanol poisoning. CLINICAL TOXICOLOGY. 2010

  • Menao, S; López-Viñas, E; Mir, C; Puisac, B; Gratacós, E; Arnedo, M; Carrasco, P; Moreno, S; Ramos, M; Gil, Mc; Pié, A; Ribes, A; Pérez-Cerda, C; Ugarte, M; Clayton, Pt; Korman, Sh; Serra D; Asins, G; Ramos, Fj; Gómez-Puertas, P; Hegardt, Fg; Casals, N; Pié, J. . Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria. HUMAN MUTATION. 2009. DOI: 10.1002/humu.20966

  • Ferrer-Dufol, A.;Nogue Xarau, S.;Menao Guillen, S.;Ramos, M.;Royo, R.;Civeira Murillo, E.;Martinez Arrieta, R.;Ballesteros, S.;Ramon, F. Evaluation of Poisoning by Chemical Agents in Spain. Comparison of Two Sources of Data for Toxicosurveillance. CLINICAL TOXICOLOGY. 2009

  • Ferrer-Dufol, A.;Menao Guillen,S.;Latorre Garces,V.;Ramos,M.;Civeira Murillo,E. Trends in the Management of Pure Benzodiazepine Overdoses. the Role of the Clinical Toxicology Unit in Improving Treatment Procedures. CLINICAL TOXICOLOGY. 2009

  • Ferrer-Dufol, A.;Menao-Guillen,S. Toxicogenomics and Clinical Toxicology: An Example of the Connection between Basic and Applied Sciences. TOXICOLOGY LETTERS. 2009

  • Ferrer-Dufol, A.;Nogue Xarau,S.;Menao Guillen,S.;Martinez Arieta,R.;Ballesteros,S.;Ramon,F. The Role of Clinical Toxicology Units in Public Hospitals an Important Source of Data for Toxicosurveillance. TOXICOLOGY LETTERS. 2009

  • Ferrer-Dufol, A.;Menao,S.;Ramos,M. Time Evolution of the Ratio between Blood-Alcohol and Breath-Alcohol Concentrations in Traffic Controls. TOXICOLOGY LETTERS. 2008

  • Ferrer, A.;Menao,S.;Lara,E.;Royo,R.;Azua,M. De;Civeira,E. Benzodiazepines Overdoses. is there Anything to do about it?. CLINICAL TOXICOLOGY. 2008

  • Menao, S.;Jimenez,D.;Monica,R.;Ferrerdufol,A. Uncertainty Analytical Zone in CEDIA Techniques used for the Diagnosis of Drug Abuse. TOXICOLOGY LETTERS. 2008

  • Ferrer, A.;Nogue,S.;Royo,R.;Civeira,E.;Menao,S.;Ramos,M.;Carreras,F.;Alonso,M. A Toxic Event Surveillance System in the Emergency Department of Spanish Hospitals. CLINICAL TOXICOLOGY. 2008

  • Pie, J;Lopez-Vinas, E;Puisac, B;Menao, S;Pie, A;Casale, C;Ramos, F.J;Hegardt, F.G;Gomez-Puertas, P;Casals, N. Molecular Genetics of HMG-CoA Lyase Deficiency. MOLECULAR GENETICS AND METABOLISM. 2007

  • Carrasco, P; Menao, S; López-Viñas, E; Santpere, G; Clotet, J; Sierra, Ay; Gratacós, E; Puisac, B; Gómez-Puertas, P; Hegardt, Fg; Pie, J; Casals, N. . C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity. MOLECULAR GENETICS AND METABOLISM. 2007. DOI: 10.1016/j.ymgme.2007.03.007

  • Leon-Cinto, C.;Escos-Orta, J.;Lander-Azcona, A.;Labartal-Monzon, L.;Avellanas-Chavala, M.;Seron-Arbeloa, C.;Canamero-Calvo, C.;Cuso-Torello, E.;Menao-Guillen, S.;Ferrer-Dufol, A. Suicidal Arsenic Poisoning. A Classic that Needs to be Remembered. TOXICOLOGY LETTERS. 2007

  • Puisac, B.; López-Viñas, E.; Moreno, S.; Mir, C.; Pérez-Cerdá, C.; Menao, S.; Lluch, D.; Pié, A.; Gómez-Puertas, P.; Casals, N.; Ugarte, M.; Hegardt, F.; Pié, J. Skipping of exon 2 and exon 2 plus 3 of HMG-CoA lyase (HL) gene produce the loss of beta sheet 1 and 2 at the recently proposed (beta-alfa)8 TIM Barrel model of HL. BIOPHYSICAL CHEMISTRY. 2005

  • Casals, N.; Gómez-Puertas, P.; Pié, J.; Mir, C.; Roca, R.; Puisac, B.; Aledo, R.; Clotet, J.; Menao, S.; Serrat, D.; Asins, G.; Till, J.; Elias-Jones, Ac.; Cresto, Jc.; Chamoles, Na.; Abdenur, Je.; Mayatepek, E.; Besley, G.; Valencia, A.; Hegardt, Fg. . Structural (Beta Alpha)(8) Tim Barrel Model of 3-Hydroxy-3-Methylglutaryl-Coenzyme a Lyase. JOURNAL OF BIOLOGICAL CHEMISTRY. 2003. DOI: 10.1074/jbc.M304276200

Conference presentations

  • Ferrer Dufol, A; Menao, S; Ruiz, F; Founaud, B; Castrillo, Ma; Ramos, P; Serrano, C. Evaluation of the quality of current procedures in the management of ethanol overdose in the emergency department. CLINICAL TOXICOLOGY. 2020

  • Torralba-Cabeza, M.A.; Sierra Monzon, J.L.; Olivera Gonzalez, S.; Camon Pueyo, A.M.; Menao Guillen, S. Study of telomeres in monocytes from a cohort of Spanish patients with Gaucher disease. MOLECULAR GENETICS AND METABOLISM. 2019. DOI: 10.1016/j.ymgme.2018.12.376

  • Alonso Llorente, A.; Arruebo Muñio, M.; Menao Guillen, S.; Rebollar Gonzalez, S.; Lahuerta Pueyo, C.; Barra Pardos, M.V.; Andres Conejero, R.; Alonso Marin, N.; Iranzo Gomez, P. Identification of pathogenic variants related to colorectal cancer in non-colorectal cancer. CLINICA CHIMICA ACTA. 2019. DOI: 10.1016/j.cca.2019.03.1208

  • Ferrer-Dufol,A.;Menao-Guillen,S. Analytical and demographic profile of the toxic incidents related to alcohol in a University Hospital in Zaragoza (Spain) - Prospective study of 10 years. TOXICOLOGY LETTERS. 2006

Scientific chapters

  • Consideraciones específicas propias de intoxicaciones agudas: Diagnóstico Analítico. Menao Guillén S. MANUAL DE TOXICOLOGÍA CLÍNICA. 2006

  • Perfil epidemiológico actual de las intoxicaciones agudas en urgencias. A. Ferrer; S. Nogué; A. Dueñas; E. Civeira; A. Bajo; R. Royo; S. Menao; M. Rivas; F. Vargas; O. Cas. INTOXICACIONES AGUDAS GRAVES. 2006



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