Profile (CV) of the research teaching staff

Fratila, Raluca María
Faculty: Instituto de Nanociencia de Aragon

Research Institute: INSTITUTO DE NANOCIENCIA Y MATERIALES DE ARAGÓN (INMA)
Academic position: Investigador ARAID
Email: rfratila@unizar.es
ORCID number: 0000-0001-5559-8757

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Journal articles

  • Fernández-Afonso, Yilian; Asín, Laura; Beola, Lilianne; Moros, María; Martínez de la Fuente, Jesús; Fratila, Raluca M.; Grazú, Valeria; Gutiérrez, Lucía. Iron Speciation in Animal Tissues Using AC Magnetic Susceptibility Measurements: Quantification of Magnetic Nanoparticles, Ferritin, and Other Iron-Containing Species; 35179873. ACS APPLIED BIO MATERIALS. 2022. DOI: 10.1021/acsabm.1c01200

  • Idiago-Lopez, Javier; Moreno-Antolin, Eduardo; Eceiza, Maite; Aizpurua, Jesus M.; Grazu, Valeria; Martínez de la Fuente, Jesús; Fratila, Raluca M. From Bench to Cell: A Roadmap for Assessing the Bioorthogonal "Click" Reactivity of Magnetic Nanoparticles for Cell Surface Engineering. BIOCONJUGATE CHEMISTRY. 2022. DOI: 10.1021/acs.bioconjchem.2c00230

  • Fernández-Afonso, Yilian; Asín, Laura; Beola, Lilianne; Fratila, Raluca M.; Gutiérrez, Lucía. Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments. ACS APPLIED NANO MATERIALS. 2022. DOI: 10.1021/acsanm.2c03220

  • Sol Fernández, S. Del; Martínez Vicente, P.; Gomollón Zueco, P.; Castro Hinojosa, C.; Gutiérrez, L.; Fratila, R. M.; Moros, M. Magnetogenetics: remote activation of cellular functions triggered by magnetic switches. NANOSCALE. 2022. DOI: 10.1039/d1nr06303k

  • Idiago López, J.; Moreno Antolín, E.; Fuente, J.M. de La; Fratila, R.M. Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications. NANOSCALE ADVANCES. 2021. DOI: 10.1039/d0na00873g

  • Beola, L.; Grazu, V.; Fernandez-Afonso, Y.; Fratila, R.M.; de las Heras, M.; de la Fuente, J.M.; Gutierrez, L.; Asin, L. Critical Parameters to Improve Pancreatic Cancer Treatment Using Magnetic Hyperthermia: Field Conditions, Immune Response, and Particle Biodistribution. ACS APPLIED MATERIALS & INTERFACES. 2021. DOI: 10.1021/acsami.1c02338

  • Pem, B; Curlin, M; Jurasin, Dd; Vrcek, V; Barbir, R; Micek, V; Fratila, Rm; de la Fuente, Jm; Vrcek, Iv. Fate and transformation of silver nanoparticles in different biological conditions. BEILSTEIN JOURNAL OF NANOTECHNOLOGY. 2021. DOI: 10.3762/bjnano.12.53

  • Hildebrand, S.; Löwa, N.; Paysen, H.; Fratila, R.M.; Reverte-Salisa, L.; Trakoolwilaiwan, T.; Niu, Z.; Kasparis, G.; Preuss, S.F.; Kosch, O.; de la Fuente, J.M.; Thanh, N.T.K.; Wiekhorst, F.; Pfeifer, A. Quantification of Lipoprotein Uptake in Vivo Using Magnetic Particle Imaging and Spectroscopy. ACS NANO. 2021. DOI: 10.1021/acsnano.0c03229

  • Beola, L.; Asín, L.; Roma-Rodrigues, C.; Fernández-Afonso, Y.; Fratila, R.M.; Serantes, D.; Ruta, S.; Chantrell, R.W.; Fernandes, A.R.; Baptista, P.V.; de la Fuente, J.M.; Grazú, V.; Gutiérrez, L. The Intracellular Number of Magnetic Nanoparticles Modulates the Apoptotic Death Pathway after Magnetic Hyperthermia Treatment. ACS APPLIED MATERIALS & INTERFACES. 2020. DOI: 10.1021/acsami.0c12900

  • Ruiz-Rincón, S.; González-Orive, A.; Grazú, V.; Fratila, R.M.; Fuente, J.M.D.L.; Cea, P. Altering model cell membranes by means of localized magnetic heating. COLLOIDS AND SURFACES B-BIOINTERFACES. 2020. DOI: 10.1016/j.colsurfb.2020.111315

  • Beola, L.; Asín, L.; Fratila, R.M.; Herrero, V.; de la Fuente, J.M.; Grazú, V.; Gutiérrez, L. Dual Role of Magnetic Nanoparticles as Intracellular Hotspots and Extracellular Matrix Disruptors Triggered by Magnetic Hyperthermia in 3D Cell Culture Models. ACS APPLIED MATERIALS & INTERFACES. 2018. DOI: 10.1021/acsami.8b18270

  • Sanguiñedo, P.; Fratila, R.M.; Estevez, M.B.; de la Fuente, J.M.; Grazú, V.; Alborés, S. Extracellular biosynthesis of silver nanoparticles using fungi and their antibacterial activity. NANO BIOMEDICINE AND ENGINEERING. 2018. DOI: 10.5101/nbe.v10i2.p156-164

  • Moros, M.; Idiago-López, J.; Asín, L.; Moreno-Antolín, E.; Beola, L.; Grazú, V.; Fratila, R.M.; Gutiérrez, L.; de la Fuente, J.M. Triggering antitumoural drug release and gene expression by magnetic hyperthermia. ADVANCED DRUG DELIVERY REVIEWS. 2018. DOI: 10.1016/j.addr.2018.10.004

  • Arriortua, O.K.; Insausti, M.; Lezama, L.; Gil de Muro, I.; Garaio, E.; de la Fuente, J.M.; Fratila, R.M.; Morales, M.P.; Costa, R.; Eceiza, M.; Sagartzazu-Aizpurua, M.; Aizpurua, J.M. RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia. COLLOIDS AND SURFACES B-BIOINTERFACES. 2018. DOI: 10.1016/j.colsurfb.2018.02.031

  • Stepien, G.; Moros, M.; Pérez-Hernández, M.; Monge, M.; Gutiérrez, L.; Fratila, R.M.; Las Heras, M.D.; Menao Guillén, S.; Puente Lanzarote, J.J.; Solans, C.; Pardo, J.; Martínez de la Fuente, J. Effect of surface chemistry and associated protein corona on the long-term biodegradation of iron oxide nanoparticles in Vivo. ACS APPLIED MATERIALS & INTERFACES. 2018. DOI: 10.1021/acsami.7b18648

  • Fratila, Raluca M.; Navascuez, Marcos; Idiago-López, Javier; Ezeiza, Maite; Miranda, José I.; Aizpurua, Jesús M.; Martínez de la Fuente, Jesús. Covalent immobilisation of magnetic nanoparticles on surfaces via strain-­promoted azide-­alkyne click chemistry. NEW JOURNAL OF CHEMISTRY. 2017. DOI: 10.1039/c7nj01822c

  • Hernández, Y.; Coello, Y.; Fratila, R. M.; de la Fuente, J.M.; Lionberger, T. A. Highly sensitive ratiometric quantification of cyanide in water with gold nanoparticles via Resonance Rayleigh Scattering. TALANTA. 2017. DOI: 10.1016/j.talanta.2017.02.006

  • Gomez, M. V.; Rodriguez, A. M.; Hoz, de La; Jimenez-Marquez, F.; Fratila, R. M.; Barneveld, P. A.; Velders, A. H. Determination of Kinetic Parameters within a Single Nonisothermal On-Flow Experiment by Nanoliter NMR Spectroscopy. ANALYTICAL CHEMISTRY. 2015. DOI: 10.1021/acs.analchem.5b02811

  • Fratila, R.M.; Rivera-Fernández, S.; de la Fuente, J.M. Shape matters: Synthesis and biomedical applications of high aspect ratio magnetic nanomaterials. NANOSCALE. 2015. DOI: 10.1039/c5nr01100k

  • Fratila, R. M.; Moros, M.; de la Fuente, J.M. Recent advances in biosensing using magnetic glyconanoparticles. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2015. DOI: 10.1007/s00216-015-8953-2

  • Wimbush, Kim S.; Fratila, Raluca M.; Wang, Dandan; Qi, Dongchen; Liang, Cao; Yuan, Li; Yakovlev, Nikolai; Loh, Kian Ping; Reinhoudt, David N.; Velders, Aldrik H.; Nijhuis, Christian A. Bias Induced Transition from an Ohmic to a Non-Ohmic Interface in Supramolecular Tunneling Junctions with Ga2O3/EGaIn Top Electrodes. NANOSCALE. 2014. DOI: 10.1039/C4NR02933J

  • Fratila, Raluca M.; Mitchell, Scott M.; Grazu, Valeria; del Pino, Pablo; Martínez de la Fuente, Jesús. Strategies for the biofunctionalization of gold and iron oxide nanoparticles. LANGMUIR. 2014. DOI: 10.1021/la5015658

  • Aizpurua, Jesus M; Fratila, Raluca M.; Monasterio, Zaira; Pérez-Esnaola, Nerea; Andreieff, Elena; Irastorza, Aitziber; Sagartzazu-Aizpurua, Maialen. Triazolium cations: from the ‘‘click’’ pool to multipurpose applications. NEW JOURNAL OF CHEMISTRY. 2014. DOI: 10.1039/C3NJ00667K

  • Fratila, Raluca M.; Gomez, M. Victoria; Sykora, Stanislav; Velders, Aldrik H. Multinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil. NATURE COMMUNICATIONS. 2014. DOI: 10.1038/ncomms4025

  • Azcune, Itxaso; Balentova, Eva; Sagartzazu-Aizpurua, Maialen ; Santos, J. Ignacio; Miranda, Jose I.; Fratila, Raluca M.; Aizpurua, Jesus M. Modulating Lectin Inhibition with N-Glycosyl-1,2,3-triazole Scaffolds. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2013. DOI: 10.1002/ejoc.201201674

  • Anninga, Bauke; Ahmed, Muneer; Pouw, Joost J.; Fratila, Raluca M.; Ten Haken, Bennie; Westbroek, David; Pinder, Sarah; Douek, Michael. Lymphatic mapping and sentinel lymph node biopsy in an in-vivo porcine model using a novel magnetic technique. EUROPEAN JOURNAL OF CANCER. 2013. DOI: 10.1016/S0959-8049(13)70061-3

  • Grootendorst, Diederik J.; Fratila, Raluca M.; Visscher, Martijn; Ten Haken, Bennie; Van Wezel, Richard J. A.; Rottenberg, Sven; Steenbergen, Wiendelt; Manohar, Srirang; Ruers, Theo J. M. Intra-operative ex vivo photoacoustic nodal staging in a rat model using a clinical superparamagnetic iron oxide nanoparticle dispersion. JOURNAL OF BIOPHOTONICS. 2013. DOI: 10.1002/jbio.201200204

  • Grootendorst, Diederik J.; Jose, Jithin; Fratila, Raluca M.; Visscher, Martijn; Velders, Aldrik H.; Ten Haken, Bennie; Van Leeuwen, Ton G.; Steenbergen, Wiendelt; Manohar, Srirang; Ruers, Theo J. M. Evaluation of superparamagnetic iron oxide nanoparticles (EndoremW) as a photoacoustic contrast agent for intra-operative nodal staging. CONTRAST MEDIA & MOLECULAR IMAGING. 2013. DOI: 10.1002/cmmi.1498

  • Braceras, Iñigo; Oyarbide, Joseba; Azpiroz, Patxi; Briz, Nerea; Ipiñazar, Enrique; Alvarez, Noelia; Atorrasagasti, Garbiñe; Fratila, Raluca M.; Aizpurua, Jesus M. "Plasma-Click" Based Strategy for Obtaining Antibacterial Surfaces on Implants. PLASMA PROCESSES AND POLYMERS. 2013. DOI: 10.1002/ppap.201200058

  • Aizpurua, Jesus M.;Sagartzazu-Aizpurua, Maialen; Monasterio, Zaira; Azcune, Itxaso; Mendicute, Claudio;Miranda, Jose I.; Garcia-Lecina, Eva; Altube, Ainhoa; Fratila, Raluca M. Introducing Axial Chirality into Mesoionic 4,4 '-Bis(1,2,3-triazole) Dicarbenes. ORGANIC LETTERS. 2012. DOI: 10.1021/ol3004657

  • Braceras, Iñigo; Azpiroz, Patxi; Briz, Nerea; Fratila, Raluca M.; Oyarbide, Joseba; Ipiñazar, Enrique; Alvarez, Noelia; Atorrasagasti, Garbiñe; Aizpurua, Jesus M. Plasma Polymerized Silylated Ciprofloxacin as an Antibiotic Coating. PLASMA PROCESSES AND POLYMERS. 2011. DOI: 10.1002/ppap.201000160

  • Aizpurua, Jesus M.; Ganboa, Jose I.; Palomo, Claudio; Loinaz, Iraida; Oyarbide, Joseba; Fernandez, Xabier; Balentova, Eva; Fratila, Raluca M.; Jimenez, Azucena; Miranda, Jose I.; Laso, Antonio; Avila, Silvia; Castrillo, Jose L. Cyclic RGD beta-Lactam Peptidomimetics Induce Differential Gene Expression in Human Endothelial Cells. CHEMBIOCHEM. 2011. DOI: 10.1002/cbic.201000572

  • Fratila, Raluca M.; Velders, Aldrik H. Small-Volume Nuclear Magnetic Resonance Spectroscopy. ANNUAL REVIEW OF ANALYTICAL CHEMISTRY. 2011. DOI: 10.1146/annurev-anchem-061010-114024

  • de la Rica, Roberto; Fratila, Raluca M.; Szarpak, Anna; Huskens, Jurriaan; Velders, Aldrik H. Multivalent Nanoparticle Networks as Ultrasensitive Enzyme Sensors. ANGEWANDTE CHEMIE (INTERNATIONAL ED.). 2011. DOI: 10.1002/anie.201008189

  • Aizpurua, Jesus M. ; Sagartzazu-Aizpurua, Maialen; Azcune, Itxaso; Miranda, Jose I.; Monasterio, Zaira;Garcia-Lecina, Eva; Fratila, Raluca M. 'Click' Synthesis of Nonsymmetrical 4,4 '-Bis(1,2,3-triazolium) Salts. SYNTHESIS-STUTTGART. 2011. DOI: 10.1055/s-0030-1260061

  • Adamczyk-Wozniak, Agnieszka; Fratila, Raluca M.;Madura, Izabela D.; Pawelko, Alicja; Sporzynski, Andrzej; Tumanowicz, Marta; Velders, Aldrik H.; Zyla, Jacek. Reactivity of 2-formylphenylboronic acid toward secondary aromatic amines in amination-reduction reactions. TETRAHEDRON LETTERS. 2011. DOI: 10.1016/j.tetlet.2011.10.008

  • Aizpurua, Jesus M.; Palomo, Claudio; Fratila, Raluca M.; Ferron, Pablo; Miranda, Jose I. Stereomodulating effect of remote groups on the NADH-mimetic reduction of alkyl aroylformates with 1,4-dihydronicotinamide-beta-lactam amides. TETRAHEDRON. 2010. DOI: 10.1016/j.tet.2010.02.085

  • Aizpurua, Jesus M.; Azcune, Itxaso; Fratila, Raluca M.; Balentova, Eva; Sagartzazu-Aizpurua, Maialen; Miranda, Jose I. "Click" Synthesis of Nonsymmetrical Bis(1,2,3-triazoles). ORGANIC LETTERS. 2010. DOI: 10.1021/ol1003127

  • Aizpurua, Jesus M.; Palomo, Claudio; Fratila, Raluca M.; Ferron, Pablo; Benito, Ana; Gomez-Bengoa, Enrique; Miranda, Jose I.; Santos, Jose I. Mechanistic Insights on the Magnesium(II) Ion-Activated Reduction of Methyl Benzoylformate with Chelated NADH Peptide beta-Lactam Models. JOURNAL OF ORGANIC CHEMISTRY. 2009. DOI: 10.1021/jo901236d

  • Palomo, Claudio; Aizpurua, Jesus M.; Balentova, Eva; Jimenez, Azucena; Oyarbide, Joseba; Fratila, Raluca M.; Miranda, Jose I. Synthesis of beta-lactam scaffolds for ditopic peptidomimetics. ORGANIC LETTERS. 2007. DOI: 10.1021/ol0626241

  • Palomo, Claudio; Aizpurua, Jesus M.; Benito, Ana; Cuerdo, Lourdes; Fratila, Raluca M.; Miranda, Jose I.; Linden, Anthony. Functionalization of N-[(silyl)methyl]-beta-lactam carbanions with carbon electrophiles. JOURNAL OF ORGANIC CHEMISTRY. 2006. DOI: 10.1021/jo060537g

  • Palomo, Claudio; Aizpurua, Jesus M.; Ganboa, Jose I.; Benito, Ana; Cuerdo, Lourdes; Fratila, Raluca M.; Jimenez, Azucena; Loinaz, Iraida; Miranda, Jose I.; Pytlewska, Kinga R.; Micle, Andreea; Linden, Anthony. Synthesis of type II beta-turn surrogate dipeptides based on syn-alpha-amino-alpha,beta-dialkyl-beta-lactams. ORGANIC LETTERS. 2004. DOI: 10.1021/ol048348c

  • Palomo, Claudio; Aizpurua, Jesus M.; Benito, Ana; Miranda, Jose I.; Fratila, Raluca M.;Matute, Carlos; Domercq, Maria; Gago, Federico; Martin-Santamaria, Sonsoles; Linden, Anthony. Development of a new family of conformationally restricted peptides as potent nucleators beta-turns. Design, synthesis, structure, and biological evaluation of beta-lactam peptide analogue of melanostatin. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2003. DOI: 10.1021/ja038180a

Books

  • Nanomaterials for Magnetic and Optical Hyperthermia Applications. 2019

Scientific chapters

  • Conclusions: Magnetic and Optical Hyperthermia Using Nanomaterials—Limitations, Challenges and Future Perspectives. Fratila, Raluca; Martínez de la Fuente, Jesús. NANOMATERIALS FOR MAGNETIC AND OPTICAL HYPERTHERMIA APPLICATIONS. 2019

  • Introduction to hyperthermia. Fratila, Raluca Maria; Martínez de la Fuente, Jesús. NANOMATERIALS FOR MAGNETIC AND OPTICAL HYPERTHERMIA APPLICATIONS. 2019

  • Nanomaterials for Combined Thermo-Chemotherapy of Cancer. Idiago Lopez, Javier; Moreno Antolín, Eduardo; Fratila, Raluca María. NANOMATERIALS FOR MAGNETIC AND OPTICAL HYPERTHERMIA APPLICATIONS. 2019



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