Artículos
- Maity, Ritwik; Zhang, Xuepei; Liberati, Francesca Romana; Scribani Rossi, Chiara; Cutruzzolá, Francesca; Rinaldo, Serena; Gaetani, Massimiliano; Aínsa, José Antonio; Sancho, Javier. Merging multi-omics with proteome integral solubility alteration unveils antibiotic mode of action. ELIFE. 2024. DOI: 10.7554/eLife.96343
- Galano-Frutos, Juan José; Maity, Ritwik; Iguarbe, Verónica; Aínsa, José Antonio; Velázquez-Campoy, Adrián; Schaible, Ulrich E.; Mamat, Uwe; Sancho, Javier. L-Thyroxine and L-thyroxine-based antimicrobials against Streptococcus pneumoniae and other Gram-positive bacteria. HELIYON. 2024. DOI: 10.1016/j.heliyon.2024.e27982
- Galano-Frutos, Juan José; Sancho, Javier. Energy, water, and protein folding: A molecular dynamics-based quantitative inventory of molecular interactions and forces that make proteins stable. PROTEIN SCIENCE. 2024. DOI: 10.1002/pro.4905
- Beyria, Lilha; Gourbeyre, Ophelie; Salillas, Sandra; Mahía, Alejandro; Díaz de Villegas, María Dolores; Aínsa, José Antonio; Sancho, Javier; Bousquet-Mélou, Alain; Ferran, Aude A. Antimicrobial combinations against Helicobacter pylori including benzoxadiazol-based flavodoxin inhibitors: in vitro characterization. MICROBIOLOGY SPECTRUM. 2024. DOI: 10.1128/spectrum.02623-23
- Alonso, Natalia; Menao, Sebastián; Lastra, Rodrigo; Arruebo, María; Bueso, María P.; Pérez, Esther; Murillo, M. Laura; Álvarez, María; Alonso, Alba; Rebollar, Soraya; Cruellas, Mara; Arribas, Dolores; Ramos, Mónica; Isla, Dolores; Galano-Frutos, Juan José; García-Cebollada, Helena; Sancho, Javier; Andrés, Raquel. Association between missense variants of uncertain significance in the CHEK2 gene and hereditary breast cancer: a cosegregation and bioinformatics analysis. FRONTIERS IN GENETICS. 2024. DOI: 10.3389/fgene.2023.1274108
- Casado, Javier; Oliván-Muro, Irene; Algarate, Sonia; Chueca, Eduardo; Salillas, Sandra; Velázquez-Campoy, Adrián; Piazuelo, Elena; Fillat, María F.; Sancho, Javier; Lanas, Ángel; González, Andrés Novel drug-like HsrA inhibitors exhibit potent narrow-spectrum antimicrobial activities against Helicobacter pylori. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. DOI: 10.3390/ijms251810175
- Galano-Frutos, Juan J.; Nerín-Fonz, Francho; Sancho, Javier. Calculation of protein folding thermodynamics using molecular dynamics simulations. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2023. DOI: 10.1021/acs.jcim.3c01107
- López-Villellas, L.; Kjelgaard Mikkelsen C. Ch.; Galano-Frutos, J. J.; Marco-Sola, S.; Alastruey-Benedé, J.; Ibáñez, P.; Moretó, M.; Sancho, J.; García-Risueño, P. Accurate and efficient constrained molecular dynamics of polymers using Newton's method and special purpose code. COMPUTER PHYSICS COMMUNICATIONS. 2023. DOI: 10.1016/j.cpc.2023.108742
- Conde-Giménez, M.; Galano-Frutos, J. J.; Galiana-Cameo, M.; Mahía Moros, A.; Victor, B. L.; Salillas Berges, S.; Velázquez-Campoy, A.; Brito, R. M. M.; Gálvez Lafuente, J. A.; Díaz-De-Villegas, M. D.; Sancho Sanz, J. Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022. DOI: 10.3390/ijms23094502
- Sancho, Javier. Protein engineering: the present and the future. BIOPHYSICA. 2022. DOI: 10.3390/biophysica2020011
- Galano-Frutos, Juan José; Torreblanca, Renzo; García-Cebollada, Helena; Sancho, Javier. A look at the face of the molten globule: Structural model of the Helicobacter pylori apoflavodoxin ensemble at acidic pH. PROTEIN SCIENCE. 2022. DOI: 10.1002/pro.4445
- García-Cebollada, Helena; López, Alfonso; Sancho, Javier. Protposer: The web server that readily proposes protein stabilizing mutations with high PPV. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2022. DOI: 10.1016/j.csbj.2022.05.008
- Galano-Frutos, J.; García-Cebollada, H.; López, A.; Rosell, M.; de la Cruz, X.; Fernández-Recio, J.; Sancho, J. PirePred: an accurate online consensus tool to interpret newborn screening–related genetic variants in structural context. JOURNAL OF MOLECULAR DIAGNOSTICS. 2022. DOI: 10.1016/j.jmoldx.2022.01.005
- Conde-Giménez, María; Sancho, Javier. Unravelling the Complex Denaturant and Thermal-Induced Unfolding Equilibria of Human Phenylalanine Hydroxylase. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021. DOI: 10.3390/ijms22126539
- Galano-Frutos, Juan J.; García-Cebollada, Helena; Sancho Sanz, Javier. Molecular dynamics simulations for genetic interpretation in protein coding regions: where we are, where to go and when. BRIEFINGS IN BIOINFORMATICS. 2021. DOI: 10.1093/bib/bbz146
- Salillas S.; Galano-Frutos J.J.; Mahía A.; Maity R.; Conde-Giménez M.; Anoz-Carbonell E.; Berlamont H.; Velazquez-Campoy A.; Touati E.; Mamat U.; Schaible U.E.; Gálvez J.A.; Díaz-De-Villegas M.D.; Haesebrouck F.; Aínsa J.A.; Sancho J. Selective targeting of human and animal pathogens of the helicobacter genus by flavodoxin inhibitors: Efficacy, synergy, resistance and mechanistic studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021. DOI: 10.3390/ijms221810137
- Suay-Corredera C.; Pricolo M.R.; Herrero-Galán E.; Velázquez-Carreras D.; Sánchez-Ortiz D.; García-Giustiniani D.; Delgado J.; Galano-Frutos J.J.; García Cebollada H.; Vilches S.; Domínguez F.; Molina M.S.; Barriales-Villa R.; Frisso G.; Sancho Sanz J.; Serrano L.; García-Pavía P.; Monserrat L.; Alegre-Cebollada J. Protein haploinsufficiency drivers identify MYBPC3 variants that cause hypertrophic cardiomyopathy. JOURNAL OF BIOLOGICAL CHEMISTRY. 2021. DOI: 10.1016/j.jbc.2021.100854
- Mahía A.; Peña-Díaz S.; Navarro S.; Galano-Frutos J.J.; Pallarés I.; Pujols J.; Díaz-De-Villegas M.D.; Gálvez J.A.; Ventura S.; Sancho J. Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of a-synuclein aggregation with potentially improved BBB permeability. BIOORGANIC CHEMISTRY. 2021. DOI: 10.1016/j.bioorg.2021.105472
- González Rodríguez, Andrés; Casado, Javier; Chueca, Eduardo; Salillas, Sandra; Velázquez-Campoy, Adrián; Sancho, Javier; Lanas, Ángel. Small molecule inhibitors of the response regulator ArsR exhibit bactericidal activity against Helicobacter pylori. MICROORGANISMS. 2020. DOI: 10.3390/microorganisms8040503
- Caron, P.; Broussaud, S.; Galano-Frutos, Juan José; Sancho, Javier; Savagner, F. New variant (Val597Ile) in transmembrane region of the TSH receptor with human chorionic gonadotropin hypersensitivity in familial gestational hyperthyroidism. CLINICAL ENDOCRINOLOGY. 2020. DOI: 10.1111/cen.14215
- Salillas, Sandra; Sancho, Javier. Flavodoxins as novel therapeutic targets against helicobacter pylori and other gastric pathogens. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020. DOI: 10.3390/ijms21051881
- Peña-Díaz, S.; Pujols, J.; Pinheiro, F.; Santos, J.; Pallarés, I.; Navarro, S.; Conde-Gimenez, M.; García, J.; Salvatella, X.; Dalfó, E.; Sancho, J.; Ventura, S. Inhibition of a-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2020. DOI: 10.3389/fbioe.2020.588947
- Piñana, M.; Vila, J.; Maldonado, C.; Galano-Frutos, J.J.; Valls, M.; Sancho, J.; Nuvials, F.X.; Andrés, C.; Martín-Gómez, M.T.; Esperalba, J.; Codina, M.G.; Pumarola, T.; Antón, A. Insights into immune evasion of human metapneumovirus: novel 180- and 111-nucleotide duplications within viral G gene throughout 2014-2017 seasons in Barcelona, Spain. JOURNAL OF CLINICAL VIROLOGY. 2020. DOI: 10.1016/j.jcv.2020.104590
- Villanueva, Raquel; Romero-Tamayo, Silvia; Laplaza, Ruben; Martinez-Olivan, Juan; Velazquez-Campoy, Adrián; Sancho, Javier; Ferreira, Patricia; Medina, Milagros. Redox-and ligand binding-dependent conformational ensembles in the human apoptosis-inducing factor regulate its pro-life and cell death functions. ANTIOXIDANTS & REDOX SIGNALING. 2019. DOI: 10.1089/ars.2018.7658
- Salillas, Sandra; Alías, Miriam; Michel, Valérie; Mahía, Alejandro; Lucía, Ainhoa; Rodrigues, Liliana; Bueno, Jessica; Galano-Frutos, Juan José; de Reuse, Hilde; Velázquez-Campoy, Adrián; Carrodeguas, José Alberto; Sostres, Carlos; Castillo, Javier; Aínsa. José Antonio; Díaz-De-Villegas, María Dolores; Lanas, Ángel; Touati, Eliette; Sancho, Javier. Design, synthesis, and efficacy testing of nitroethylene- and 7-nitrobenzoxadiazol-based flavodoxin inhibitors against helicobacter pylori drug-resistant clinical strains and in helicobacter pylori-infected mice. JOURNAL OF MEDICINAL CHEMISTRY. 2019. DOI: 10.1021/acs.jmedchem.9b00355
- González, Andrés; Casado, Javier; Chueca, Eduardo; Salillas, Sandra; Velázquez-Campoy, Adrián; Espinosa Angarica, Vladimir; Bénejat, Lucie; Guignard, Jérome; Giese, Alban; Sancho, Javier; Lehours, Philippe; Lanas, Ángel. Repurposing dihydropyridines for treatment of helicobacter pylori infection. PHARMACEUTICS. 2019. DOI: 10.3390/pharmaceutics11120681
- Peña-Díaz, S.; Pujols, J.; Conde-Giménez, M.; Carija, A.; Dalfo, E.; García, J.; Navarro, S.; Pinheiro, F.; Santos, J.; Salvatella, X.; Sancho, J.; Ventura, S. ZPD-2, a Small Compound That Inhibits a-Synuclein Amyloid Aggregation and Its Seeded Polymerization. FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019. DOI: 10.3389/fnmol.2019.00306
- González, Andrés;Salillas, Sandra;Velázquez-Campoy, Adrián;Espinosa Angarica, Vladimir;Fillat, María F.;Sancho, Javier;Lanas, Ángel. Identifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2019. DOI: 10.1038/s41598-019-47746-9
- Gálvez, José A.; Clavería-Gimeno, Rafael; Galano-Frutos, Juan J.; Sancho, Javier; Velázquez-Campoy, Adrian; Abian, Olga; Díaz-De-Villegas, María D. Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2019. DOI: 10.1016/j.ejmech.2019.03.019
- Galano-Frutos, Juan José; Sancho, Javier. Accurate Calculation of Barnase and SNase Folding Energetics Using Short Molecular Dynamics Simulations and an Atomistic Model of the Unfolded Ensemble: Evaluation of Force Fields and Water Models. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2019. DOI: 10.1021/acs.jcim.9b00430
- Mahía, A.; Conde-Giménez, M.; Salillas, S.; Pallarés, I.; Galano-Frutos, J.J.; Lasa, Í.; Ventura, S.; Díaz de Villegas, M.D.; Gálvez, J.A.; Sancho, J. A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aß1-42, a-synuclein, and amylin amyloid fibrils as well as amyloid-containing Staphylococcus aureus biofilms. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2019. DOI: 10.1007/s00216-018-1433-8
- Martínez-Júlvez, M.; Goñi, G.; Pérez-Amigot, D.; Laplaza, R.; Ionescu, I.A.; Petrocelli, S.; Tondo, M.L.; Sancho, J.; Orellano, E.G.; Medina, M. Identification of inhibitors targeting ferredoxin-NADP+ reductase from the xanthomonas citri subsp. Citri phytopathogenic bacteria. MOLECULES. 2018. DOI: 10.3390/molecules23010029
- Pujols, J.; Pena-Diaz, S.; Lazaro, D.F.; Peccati, F.; Pinheiro, F.; Gonzalez, D.; Carija, A.; Navarro, S.; Conde-Gimenez, M.; Garcia, J.; Guardiola, S.; Giralt, E.; Salvatella, X.; Sancho, J.; Sodupe, M.; Outeiro, T.F.; Dalfo, E.; Ventura, S. Small molecule inhibits alpha-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018. DOI: 10.1073/pnas.1804198115
- Pujols, J.; Peña-Díaz, S.; Conde-Giménez, M.; Pinheiro, F.; Navarro, S.; Sancho, J.; Ventura, S. High-throughput screening methodology to identify alpha-synuclein aggregation inhibitors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017. DOI: 10.3390/ijms18030478
- Lamazares, E.; Vega, S.; Ferreira, P.; Medina, M.; Galano-Frutos, J.J.; Martínez-Júlvez, M.; Velázquez-Campoy, A.; Sancho, J. Direct examination of the relevance for folding, binding and electron transfer of a conserved protein folding intermediate. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2017. DOI: 10.1039/c7cp02606d
- Hidalgo, J.; Latorre, P.; Carrodeguas, J.A.; Velázquez-Campoy, A.; Sancho, J.; López-Buesa, P. Inhibition of pig phosphoenolpyruvate carboxykinase isoenzymes by 3-Mercaptopicolinic acid and novel inhibitors. PLOS ONE. 2016. DOI: 10.1371/journal.pone.0159002
- Velázquez-Campoy,A.;Sancho,J.;Abian,O;Vega,S.;. Biophysical screening for identifying pharmacological chaperones and inhibitors against conformational and infectious diseases. CURRENT DRUG TARGETS. 2016. DOI: 10.2174/1389450117666160201110449
- López, L.C.; Varea, O.; Navarro, S.; Carrodeguas, J.A.; de Groot, N.S.; Ventura, S.; Sancho, J. Benzbromarone, quercetin, and folic acid inhibit amylin aggregation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016. DOI: 10.3390/ijms17060964
- Rodríguez-Cardenas, Á.; Rojas, A.L.; Conde-Giménez, M.; Velazquez-Campoy, A.; Hurtado-Guerrero, R.; Sancho, J. Streptococcus pneumoniae TIGR4 flavodoxin: Structural and biophysical characterization of a novel drug target. PLOS ONE. 2016. DOI: 10.1371/journal.pone.0161020
- Espinosa Angarica, Vladimir; Orozco, Modesto; Sancho Sanz, Javier. Exploring the complete mutational space of the LDL receptor LA5 domain using molecular dynamics: Linking snps with disease phenotypes in familial hypercholesterolemia. HUMAN MOLECULAR GENETICS. 2016. DOI: 10.1093/hmg/ddw004
- Llamazares, Emilio; Clemente, Isabel; Bueno, Marta; Velázquez-Campoy, Adrián; Sancho, Javier. Rational stabilization of complex proteins: A divide and combine approach. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2015. DOI: 10.1038/srep09129
- Estrada, Jorge; Echenique, Pablo; Sancho Sanz, Javier. Predicting stabilizing mutations in proteins using Poisson-Boltzmann based models: Study of unfolded state ensemble models and development of a successful binary classifier based on residue interaction energies. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2015. DOI: 10.1039/c5cp04348d
- Laurents, D. V.; Pantoja-Uceda, D.; López, L. C.; Carrodeguas, J. A.; Mompeán, M.; Jiménez, M. Á.; Sancho, J. DMSO affects Aß1-40's conformation and interactions with aggregation inhibitors as revealed by NMR. RSC ADVANCES. 2015. DOI: 10.1039/c5ra12100k
- Galano-Frutos, J.; Morón, M.C.; Sancho, J. The mechanism of water/ion exchange at a protein surface: A weakly bound chloride in Helicobacter pylori apoflavodoxin. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2015. DOI: 10.1039/c5cp04504e
- Martínez-Oliván, J; Arias-Moreno, X; Hurtado-Guerrero, R; Carrodeguas, Ja; Miguel-Romero, L; Marina, A; Bruscolini, P; Sancho, J. The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome. FEBS LETTERS. 2015. DOI: 10.1016/j.febslet.2015.10.014
- Luján, M.A.; Martínez, J.I.; Alonso, P.J.; Torrado, A.; Roncel, M.; Ortega, J.M.; Sancho, J.; Picorel, R. In vivo reconstitution of a homodimeric cytochrome b559 like structure: The role of the N-terminus a-subunit from Synechocystis sp. PCC 6803. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY. 2015. DOI: 10.1016/j.jphotobiol.2015.07.006
- Romero, C. M.; Abella, J. S.; Velázquez, A.; Sancho, J. Thermal denaturation of a-chymotrypsinogen A in presence of polyols at pH 2.0 and pH 3.0. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY. 2015. DOI: 10.1007/s10973-014-4374-2
- Martínez-Oliván, J.; Fraga, H.; Arias-Moreno, X.; Ventura, S.; Sancho, J. Intradomain confinement of disulfides in the folding of two consecutive modules of the LDL receptor. PLOS ONE. 2015. DOI: 10.1371/journal.pone.0132141
- González, Andrés; Espinosa Angarica, Vladimir; Sancho, Javier; Fillat, María F. The FurA regulon in Anabaena sp. PCC 7120: In silico prediction and experimental validation of novel target genes. NUCLEIC ACIDS RESEARCH. 2014. DOI: 10.1093/nar/gku123
- Martínez-Oliván, J.; Rozado-Aguirre, Z.; Arias-Moreno, X.; Angarica, V. E.; Velázquez-Campoy, A.; Sancho, J. Low-density lipoprotein receptor is a calcium/magnesium sensor - Role of LR4 and LR5 ion interaction kinetics in low-density lipoprotein release in the endosome. FEBS JOURNAL. 2014. DOI: 10.1111/febs.12811
- Espinosa Angarica, V.; Angulo, A.; Giner, A.; Losilla, G.; Ventura, S.; Sancho, J. PrionScan: An online database of predicted prion domains in complete proteomes. BMC GENOMICS. 2014. DOI: 10.1186/1471-2164-15-102
- Martínez-Oliván, J.; Arias-Moreno, X.; Velazquez-Campoy, A.; Millet, O.; Sancho, J. LDL receptor/lipoprotein recognition: Endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat. FEBS JOURNAL. 2014. DOI: 10.1111/febs.12721
- Galano, J. J.;Alías, M.;Pérez, R.;Velázquez-Campoy, A.;Hoffman, P. S.;Sancho, J. Improved flavodoxin inhibitors with potential therapeutic effects against Helicobacter pylori infection. JOURNAL OF MEDICINAL CHEMISTRY. 2013. DOI: 10.1021/jm400786q
- Abian, O.; Vega, S.; Sancho, J.; Velazquez-Campoy, A. Allosteric Inhibitors of the NS3 Protease from the Hepatitis C Virus. PLOS ONE. 2013. DOI: 10.1371/journal.pone.0069773
- Sancho Sanz, Javier; Galano, Juan J. QSAR Models for Prediction of Binding and Inhibitory Properties of [(E)-2-R-vinyl]benzene Derivatives with Therapeutic Effects against Helicobacter pylori.. MEDICINAL CHEMISTRY. 2013. DOI: 10.4172/2161-0444.1000157
- Sancho, J. The stability of 2-state, 3-state and more-state proteins from simple spectroscopic techniques... plus the structure of the equilibrium intermediates at the same time. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2013. DOI: 10.1016/j.abb.2012.10.014
- Espinosa Angarica, V.; Ventura, S.; Sancho, J. Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains. BMC GENOMICS. 2013. DOI: 10.1186/1471-2164-14-316
- Secka,O.;Berg,D. E.;Antonio,M.;Corrah,T.;Tapgun,M.;Walton,R.;Thomas,V.;Galano,J. J.;Sancho,J.;Adegbola,R. A.;Thomas,J. E. Antimicrobial susceptibility and resistance patterns among helicobacter pylori strains from the gambia, west africa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2013. DOI: 10.1128/AAC.00517-12
- Graña-Montes,R.;de Groot,N. S.;Castillo,V.;Sancho,J.;Velazquez-Campoy,A.;Ventura,S. Contribution of disulfide bonds to stability, folding, and amyloid fibril formation: The PI3-SH3 domain case. ANTIOXIDANTS & REDOX SIGNALING. 2012. DOI: 10.1089/ars.2011.3936
- Torreblanca,R.;Lira-Navarrete,E.;Sancho,J.;Hurtado-Guerrero,R. Structural and Mechanistic Basis of the Interaction between a Pharmacological Chaperone and Human Phenylalanine Hydroxylase. CHEMBIOCHEM. 2012. DOI: 10.1002/cbic.201200188
- Espinosa Angarica, V. E.;Sancho, J. Protein Dynamics Governed by Interfaces of High Polarity and Low Packing Density. PLOS ONE. 2012. DOI: 10.1371/journal.pone.0048212
- López, L.C.; Dos-Reis, S.; Espargaró, A.; Carrodeguas, J.A.; Maddelein, M.-L; Ventura, S.; Sancho, J. Discovery of novel inhibitors of amyloid ß-Peptide 1-42 Aggregation. JOURNAL OF MEDICINAL CHEMISTRY. 2012. DOI: 10.1021/jm301186p
- Martínez-Júlvez, M.;Rojas, A. L.;Olekhnovich, I.;Espinosa Angarica, V. ;Hoffman, P. S.;Sancho, J. Structure of RdxA - An oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori. FEBS JOURNAL. 2012. DOI: 10.1111/febs.12020
- García-Fandiño, R.; Bernadó, P.; Ayuso-Tejedor, S.; Sancho, J.; Orozco, M. Defining the Nature of Thermal Intermediate in 3 State Folding Proteins: Apoflavodoxin, a Study Case. PLOS COMPUTATIONAL BIOLOGY. 2012. DOI: 10.1371/journal.pcbi.1002647
- Ayuso-Tejedor, S.; Abián, O.; Sancho, J. Underexposed polar residues and protein stabilization. PROTEIN ENGINEERING DESIGN & SELECTION. 2011. DOI: 10.1093/protein/gzq072
- Conesa, C.; Doss, M-X.; Antzelevitch,C.; Sachinidis, A.; Sancho, J.; Carrodeguas, J.A. Identification of Specific Pluripotent Stem Cell Death-inducing Small Molecules by Chemical Screening. STEM CELL REVIEWS. 2011. DOI: 10.1007/s12015-011-9248-4
- Abian,O.; Alfonso,P.; Velazquez-Campoy,A.; Giraldo,P.; Pocovi,M.; Sancho,J. Therapeutic strategies for Gaucher disease: Miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. MOLECULAR PHARMACEUTICS. 2011. DOI: 10.1021/mp200313e
- Ayuso-Tejedor,S.;Abián,O.;Velázquez-Campoy,A.;Sancho,J. Mechanism of FMN binding to the apoflavodoxin from Helicobacter pylori. BIOCHEMISTRY. 2011. DOI: 10.1021/bi201025y
- Pérez-Llarena, F. J.; Kerff, F.; Abián, O.; Mallo, S.; Fernández, M. C.; Galleni, M.; Sancho, J.; Bou, G. Distant and new mutations in CTX-M-1 ß-lactamase affect cefotaxime hydrolysis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2011. DOI: 10.1128/AAC.00298-11
- Albis, A.;Lozano, J. M.;Sancho, J. ;Romero, C. M. Influence of calcium on the thermal stabilization of bovine -lactalbumin by selected polyols. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY. 2011. DOI: 10.1007/s10973-010-1156-3
- Arias-Moreno, Xabier; Cuesta-Lopez, Santiago; Millet, Oscar; Sancho, Javier; Velazquez-Campoy, Adrian. Thermodynamics of protein-cation interaction: Ca+2 and Mg+2 binding to the fifth binding module of the LDL receptor. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2010. DOI: 10.1002/prot.22619
- Alias, M.; Ayuso-Tejedor, S.; Fernandez-Recio, J.; Cativiela, C. ; Sancho, J. Helix propensities of conformationally restricted amino acids. Non-natural substitutes for helix breaking proline and helix forming alanine. ORGANIC & BIOMOLECULAR CHEMISTRY. 2010. DOI: 10.1039/b919671d
- Sancho Sanz, Javier; Contreras-Moreira, B; Angarica, Ve. Comparison of DNA-binding across protein superfamilies. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2010. DOI: 10.1002/prot.22525
- Ayuso-Tejedor, S.;Angarica, V. E.;Bueno, M.;Campos, L. A.;Abian, O.;Bernado, P.;Sancho, J. ;Jimenez, M. A. Design and structure of an equilibrium protein folding intermediate: A hint into dynamical regions of proteins. JOURNAL OF MOLECULAR BIOLOGY. 2010
- Sancho Sanz, Javier; Stevens, Raymond C; Martinez, Aurora. Rescue of misfolded proteins and stabilization by small molecules. METHODS IN MOLECULAR BIOLOGY. 2010. DOI: 10.1007/978-1-60761-756-3_22
- Ayuso-Tejedor, S.;Nishikori, S.;Okuno, T.;Ogura, T. ;Sancho, J. FtsH cleavage of non-native conformations of proteins. JOURNAL OF STRUCTURAL BIOLOGY. 2010
- Arias-Moreno, X.;Cuesta-Lopez, S.;Millet, O.;Sancho, J. ;Velazquez-Campoy, A. Thermodynamics of protein-cation interaction: Ca+2 and Mg +2 binding to the fifth binding module of the LDL receptor. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2010
- Estrada, Jorge; Bernado, Pau; Blackledge, Martin; Sancho, Javier. ProtSA: a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble. BMC BIOINFORMATICS. 2009. DOI: 10.1186/1471-2105-10-104
- Romero, Carmen M.; Albis, Alberto; Lozano, José Manuel; Sancho, Javier. Thermodynamic study of the influence of polyols and glucose on the thermal stability of holo-bovine \u03b1-lactalbumin. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY. 2009. DOI: 10.1007/s10973-009-0138-9
- Estrada, J.;Bernado,P.;Blackledge,M.;Sancho,J. ProtSA: A Web Application for Calculating Sequence Specific Protein Solvent Accessibilities in the Unfolded Ensemble. BMC BIOINFORMATICS. 2009
- Gil-Redondo, R.;Estrada,J.;Morreale,A.;Herranz,F.;Sancho,J.;Ortiz,A. R. VSDMIP: Virtual Screening Data Management on an Integrated Platform. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. 2009
- Cremades, N.;Velazquez-Campoy, A.;Martinez-Julvez, M.;Neira, J. L.;Perez-Dorado, I.;Hermoso, J.;Jimenez, P.;Lanas, A.;Hoffman, P. S.;Sancho, J. Discovery of Specific Flavodoxin Inhibitors as Potential Therapeutic Agents Against Helicobacter Pylori Infection. ACS CHEMICAL BIOLOGY. 2009
- Cremades, N.;Bueno,M.;Neira,J. L.;Velazquez-Campoy,A.;Sancho,J. Conformational Stability of Helicobacter Pylori Flavodoxin Fit to Function at pH 5. JOURNAL OF BIOLOGICAL CHEMISTRY. 2008
- Cremades, Nunilo; Bueno, Marta; Neira, José Luis; Velázquez-Campoy, Adrián; Sancho, Javier. Conformational Stability ofHelicobacter pyloriFlavodoxin. JOURNAL OF BIOLOGICAL CHEMISTRY. 2008. DOI: 10.1074/jbc.M705677200
- N. Cremades; J. Sancho. Molten Globule and Native State Ensemble of Helicobacter pylori Flavodoxin. Can crowding, osmolytes or cofactors stabilize the native conformation relative to the molten globule?. BIOPHYSICAL JOURNAL. 2008
- X. Arias-Moreno; J. L. Arolas; F. X. Aviles; J. Sancho; S. Ventura. Scrambled Isomers as Key Intermediates in the Oxidative Folding of Ligand Binding Module 5 of the Low Density. JOURNAL OF BIOLOGICAL CHEMISTRY. 2008
- Arias-Moreno, X.;Velazquez-Campoy,A.;Rodriguez,J. C.;Pocovi,M.;Sancho,J. Mechanism of Low Density Lipoprotein (LDL) Release in the Endosome: Implications of the Stability and Ca2+ Affinity of the Fifth Binding Module of the LDL Receptor. JOURNAL OF BIOLOGICAL CHEMISTRY. 2008
- Cremades, N.;Velazquez-Campoy,A.;Freire,E.;Sancho,J. The Flavodoxin from Helicobacter Pylori: Structural Determinants of Thermostability and FMN Cofactor Binding. BIOCHEMISTRY. 2008
- Gonzalo-Asensio, J.;Soto, C. Y.;Arbues, A.;Sancho, J.;Menendez, M. D. C.;Garcia, M. J.;Gicquel, B.;Martin, C. The Mycobacterium Tuberculosis phoPR Operon is Positively Autoregulated in the Virulent Strain H37Rv. JOURNAL OF BACTERIOLOGY. 2008
- Pey, A. L.;Ying, M.;Cremades, N.;Velazquez-Campoy, A.;Scherer, T.;Thoeny, B.;Sancho, J.;Martinez, A. Identification of Pharmacological Chaperones as Potential Therapeutic Agents to Treat Phenylketonuria. JOURNAL OF CLINICAL INVESTIGATION. 2008
- Romero, C. M.;Lozano,J. M.;Sancho,J.;Giraldo,G. I. Thermal Stability of Beta-Lactoglobulin in the Presence of Aqueous Solution of Alcohols and Polyols. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2007
- Bueno, M; Camacho, C.J.; Sancho, J. Simple estimate of the free energy change due to aliphatic mutations: superior predictions based on first principles. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2007
- M. St. Maurice; N. Cremades; M. A. Croxen; G. Sisson; J. Sancho; P. S. Hoffman. Flavodoxin: Quinone Reductase (FqrB): A Redox Partner of Pyruvate: Ferredoxin Oxidoreductase that Reversibly Couples Pyruvate Oxidation to NADPH Production in Helicobacter pylori and Campylobacter jejuni. JOURNAL OF BACTERIOLOGY. 2007
- Cuesta-Lopez, S.; Falo,F.; Sancho,J. Computational Diagnosis of Protein Conformational Diseases: Short Molecular Dynamics Simulations Reveal a Fast Unfolding of r-LDL Mutants that Cause Familial Hypercholesterolemia. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2007. DOI: 10.1002/prot.21181
- Cremades,N.;Sancho,J.;Freire,E. The native-state ensemble of proteins provides clues for folding, misfolding and function. TRENDS IN BIOCHEMICAL SCIENCES. 2006. DOI: 10.1016/j.tibs.2006.07.001
- Bueno, Marta; Cremades ,Nunilo; Neira, Jose Luis; Sancho, Javier. Filling small, empty protein cavities: Structural and energetic consequences. JOURNAL OF MOLECULAR BIOLOGY. 2006. DOI: 10.1016/j.jmb.2006.02.060
- Bueno,Marta;Ayuso Tejedor,Sara;Sancho,Javier. Do proteins with similar folds have similar transition state structures? A diffuse transition state of the 169 residue apoflavodoxin. JOURNAL OF MOLECULAR BIOLOGY. 2006
- Sancho,J. Flavodoxins: Sequence, folding, binding, function and beyond. CELLULAR AND MOLECULAR LIFE SCIENCES. 2006
- Lopez-Llano,J.;Campos,L. A.;Bueno,M.;Sancho,J. Equilibrium Phi-analysis of a molten globule: The 1-149 apoflavodoxin fragment. JOURNAL OF MOLECULAR BIOLOGY. 2006
- Bueno,M.;Campos,L. A.;Estrada,J.;Sancho,J. Energetics of aliphatic deletions in protein cores. PROTEIN SCIENCE. 2006
- Bernado,P.;Blackledge,M.;Sancho,J. Sequence-specific solvent accessibilities of protein residues in unfolded protein ensembles. BIOPHYSICAL JOURNAL. 2006
- Campos,A.;Sancho,J. Native-specific stabilization of flavodoxin by the FAIN cofactor: Structural and thermodynamical explanation. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2006
- Lidon Moya, M.C;Barrera, F.N;Bueno, M;Perez Jimenez, R;Sancho, J;Mateu, M.G;Neira, J.L. An Extensive Thermodynamic Characterization of the Dimerization Domain of the Hiv-1 Capsid Protein. PROTEIN SCIENCE. 2005
- Alfonso, P.;Pampin, S.;Estrada, J.;Rodriguez Rey, J. C.;Giraldo, P.;Sancho, J.;Pocovi, M. Miglustat (Nb-Dnj) Works as a Chaperone for Mutated Acid Beta-Glucosidase in Cells Transfected With Several Gaucher Disease Mutations. BLOOD CELLS, MOLECULES, AND DISEASES. 2005
- Machicado, C.;Lopez Llano, J.;Cuesta Lopez, S.;Bueno, M.;Sancho, J. Design of Ligand Binding to an Engineered Protein Cavity Using Virtual Screening and Thermal up-Shift Evaluation. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. 2005
- Cremades, N.;Bueno, M.;Toja, M.;Sancho, J. Towards a New Therapeutic Target: Helicobacter Pylori Flavodoxin. BIOPHYSICAL CHEMISTRY. 2005. DOI: 10.1016/j.bpc.2004.12.045
- Campos, Luis A.; Cuesta López, Santiago; López Llano, Jon; Falo, Fernando; Sancho, Javier. A double-deletion method to quantifying incremental binding energies in proteins from experiment: example of a destabilizing hydrogen bonding pair. BIOPHYSICAL JOURNAL. 2005. DOI: 10.1529/biophysj.104.050203
- Lopez Llano, J.;Campos, L. A.;Bueno, M.;Sancho, J. Equilibrium phi-analysis of a molten globule: the 1-149 apoflavodoxin fragment. JOURNAL OF MOLECULAR BIOLOGY. 2005
- Campos, L. A.;Bueno, M.;Lopez Llano, J.;Jimenez, M. A.;Sancho, J. Structure of Stable Protein Folding Intermediates by Equilibrium Phi-Analysis: the Apoflavodoxin Thermal Intermediate. JOURNAL OF MOLECULAR BIOLOGY. 2004
- J. López-Llano; S. Maldonado; S. Jain; A. Lostao; R. Godoy-Ruiz; J.M. Sanchez-Ruiz; M. Cortijo; J. Fernández-Recio; J. Sancho. The long and short flavodoxins. II: role of the differentiating loop in apoflavodoxin stability and folding mechanism. JOURNAL OF BIOLOGICAL CHEMISTRY. 2004
- Campos, L. A.;Garcia Mira, M. M.;Godoy Ruiz, R.;Sanchez Ruiz, J. M.;Sancho, J. Do Proteins Always Benefit From a Stability Increase? Relevant and Residual Stabilisation in a Three-State Protein by Charge Optimisation. JOURNAL OF MOLECULAR BIOLOGY. 2004
- Nogues, Isabel;Campos, Luis Alberto;Sancho, Javier;Gomez Moreno, Carlos;Mayhew, Stephen G.;Medina, Milagros. Role of neighboring FMN side chains in the modulation of flavin reduction potentials and in the energetics of the FMN:apoprotein interaction in Anabaena flavodoxin. BIOCHEMISTRY. 2004
- Machicado, C;Castillo, S;Bueno, M;Pocoví, M;Sancho, J. Mutaciones del receptor de LDL que permiten considerar la hipercolesterolemia familiar dentro de las enfermedades del plegamiento de las proteínas. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 2003
- Acin Perez, R.;Bayona Bafaluy, M. P.;Bueno, M.;Machicado, C.;Fernandez Silva, P.;Perez Martos, A.;Montoya, J.;Lopez Perez, M. J.;Sancho, J.;Enriquez, J. A. An Intragenic Suppressor in the Cytochrome C Oxidase I Gene of Mouse Mitochondrial Dna. HUMAN MOLECULAR GENETICS. 2003
- Lostao, A.; Daoudi, F.; Irun, M. P.; Ramon, A.; Fernandez Cabrera, C.; Romero, A.; Sancho, J. How Fmn Binds to Anabaena Apoflavodoxin - a Hydrophobic Encounter at an Open Binding Site. JOURNAL OF BIOLOGICAL CHEMISTRY. 2003
- Campos, L. A.;Sancho, J. The Active Site of Pepsin Is Formed in the Intermediate Conformation Dominant at Mildly Acidic Ph. FEBS LETTERS. 2003
- Bes, M. T.;Sancho, J.;Peleato, M. L.;Medina, M.;Gomez-Moreno, C.;Fillat, M. F. Purification of Colored Photosynthetic Proteins for Understanding Protein Isolation Principles. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION. 2003
- Iddar, A.;Campos, L. A.;Sancho, J.;Serrano, A.;Soukri, A. Different Thermostability of Skeletal Muscle Glyceraldehyde-3-Phosphate Dehydrogenase From Hibernating and Euthermic Jerboa (Jaculus Orientalis). SHENGWU HUAXUE YU SHENGWU WULI XUEBAO. 2003
- Garcia, Jose I.;Medina, Milagros;Sancho, Javier;Alonso, Pablo J.;Gomez-Moreno, Carlos;Mayoral, Jose A.;Martinez, Jesus I. Theoretical Analysis of the Electron Spin Density Distribution of the Flavin Semiquinone Isoalloxazine Ring within Model Protein Environments. JOURNAL OF PHYSICAL CHEMISTRY A. 2002
- Sancho Sanz, Javier; Bueno, Marta; Campos, Luis A.; Fernández Recio, Juan; Irún, María Pilar; López, Jon; Machicado, Claudia; Pedroso, Idolka; Toja, Miguel. The ‘relevant’ stability of proteins with equilibrium intermediates. THE SCIENTIFIC WORLD JOURNAL. 2002. DOI: 10.1100/tsw.2002.196
- Maldonado, Susana;Irun, Maria, = Pilar;Campos, Luis, = Alberto;Rubio, Jose, = Antonio;Luquita, Alejandra;Lostao, Anabel;Wang, Renjie;Garcia Moreno, E. Bertrand;Sancho, Javier. Salt-induced stabilization of apoflavodoxin at neutral pH is mediated through cation-specific effects. PROTEIN SCIENCE. 2002
- Pedroso, Idolka;Irun, Maria, P. ;Machicado, Claudia;Sancho, Javier. Four-state equilibrium unfolding of an scFv antibody fragment. BIOCHEMISTRY. 2002
- Casaus, Jose, L.;Navarro, Jose, A.;Hervas, Manuel;Lostao, Anabel;de la Rosa, Miguel, A.;Gomez Moreno, Carlos;Sancho, Javier;Medina, Milagros. Anabaena sp. PCC 7119 flavodoxin as electron carrier from photosystem I to ferredoxin-NADP+ reductase. Role of Trp(57) and Tyr(94). JOURNAL OF BIOLOGICAL CHEMISTRY. 2002
- Machicado, C. ;Bueno, M. ;Sancho, J. Predicting the structure of protein cavities created by mutation. PROTEIN ENGINEERING. 2002
- Fernandez Recio, J. ;Genzor, C. G. ;Sancho, J. Apoflavodoxin folding mechanism: An < alpha >/< beta > protein with an essentially off-pathway intermediate. BIOCHEMISTRY. 2001
- Irun, M. P;Garcia Mira, M. M;Sanchez Ruiz, J. M;Sancho, J. Native hydrogen bonds in a molten globule: the apoflavodoxin thermal intermediate. JOURNAL OF MOLECULAR BIOLOGY. 2001
- Alexis Balme; Manuel Hervás; Luis A. Campos; Javier Sancho; Miguel A. de la Rosa; José A. Navarro. A comparative study of the thermal stability of plastocyanin, cytochrome c6 and photosystem I in thermophylic and mesophylic cyanobacteria. PHOTOSYNTHESIS RESEARCH. 2001
- G.M. Langdon; M.A. Jiménez; C.G. Genzor; S. Maldonado; J. Sancho; M. Rico. Anabaena apoflavodoxin hydrogen exchange: on the stable exchange core of the alpha/beta(21345) flavodoxin-like family. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2001
- Irun, M. P;Maldonado, S. ;Sancho, J. Stabilization of apoflavodoxin by replacing hydrogen-bonded charged Asp or Glu residues by the neutral isosteric Asn or Gln. PROTEIN ENGINEERING. 2001
- Lostao, A. ;El Harrous, M. ;Daoudi, F. ;Romero, A. ;Parody Morreale, A. ;Sancho, J. Dissecting the energetics of the apoflavodoxin-FMN complex. JOURNAL OF BIOLOGICAL CHEMISTRY. 2000
- Sancho Sanz, J. The conformational stability of proteins: Rational stabilization by protein engineering. BIOTECNOLOGÍA APLICADA. 2000
- Fernandez-Recio, J.;Romero, A.;Sancho, J. Energetics of a hydrogen bond (charged and neutral) and of a cation-pi interaction in apoflavodoxin. JOURNAL OF MOLECULAR BIOLOGY. 1999
- Medina, M.; Lostao, A.; Sancho, J.; Gomez-Moreno, C.; Cammack, R.; Alonso, P. J.; Martinez, J. I. Electron-nuclear double resonance and hyperfine sublevel correlation spectroscopic studies of flavodoxin mutants from Anabaena sp PCC 7119. BIOPHYSICAL JOURNAL. 1999
- Maldonado, S.; Lostao, A.; Irún, M.P.; Férnandez-Recio, J.; Genzor, C.G.; González, E.B.; Rubio, J.A.; Luquita, A.; Daoudi, F.; Sancho, J. Apoflavodoxin: Structure, stability, and FMN binding. BIOCHIMIE. 1998. DOI: 10.1016/S0300-9084(00)88876-8
- Maldonado, S.;Jimenez, M. A.;Langdon, G. M.;Sancho, J. Cooperative stabilization of a molten globule apoflavodoxin fragment. BIOCHEMISTRY. 1998
- Fernandez-Recio, J.;Sancho, J. Intrahelical side chain interactions in alpha-helices: poor correlation between energetics and frequency. FEBS LETTERS. 1998
- Fernandez-Recio, J.;Vazquez, A.;Civera, C.;Sevilla, P.;Sancho, J. The tryptophan/histidine interaction in alpha-helices. JOURNAL OF MOLECULAR BIOLOGY. 1997
- Lostao, A.; Gómez-Moreno, C.; Mayhew, S.G.; Sancho, J. Differential stabilization of the three FMN redox forms by tyrosine 94 and tryptophan 57 in flavodoxin from Anabaena and its influence on the redox potentials. BIOCHEMISTRY. 1997. DOI: 10.1021/bi971384h
- Genzor, C. G.;Perales Alcon, A.;Sancho, J.;Romero, A. Closure of a tyrosine. NATURE STRUCTURAL BIOLOGY. 1996
- Genzor, C. G.;Beldarrain, A.;Gomez-Moreno, C.;Lopezlacomba, J. L.;Cortijo, M.;Sancho, J. Conformational stability of apoflavodoxin. PROTEIN SCIENCE. 1996
- Kippen, Ad; Sancho, J; Fersht, Ar. Folding of barnase in parts. BIOCHEMISTRY. 1994
- Vuilleumier, S; Sancho, J; Loewenthal , R; Fersht, Ar. Circular dichroism studies of barnase and its mutants. Contribution of aromatic side chains. BIOCHEMISTRY. 1993
- Loewenthal, R; Sancho, J; Reinikainen, T; Fersht, Ar. Longe range surface charge-charge interactions in proteins. Comparison of experimental results with calculations from a theoretical method. JOURNAL OF MOLECULAR BIOLOGY. 1993
- Serrano, L; Neira, Jl; Sancho, J; Fersht, Ar. Effect of alanine versus glycine in alpha-helices on protein stability. NATURE. 1992
- Sancho, J; Fersht, Ar. Disection of an Enzyme by Protein Engineering: the N-and C-Terminal fragments of Barnase form a Native-Like Complex with Restored Enzymic Activity. JOURNAL OF MOLECULAR BIOLOGY. 1992
- Sancho, J; Neira, Jl; Fersht, Ar. An N-Terminal Fragment of Barnase has Residual Helical Structure Similar to that in a Refolding Intermediate. JOURNAL OF MOLECULAR BIOLOGY. 1992
- Loewenthal, R; Sancho, J; Fersht., Ar. Histidine-aromatic Interactions in Barnase: Elevation of Histidine pKa and Contribution to Protein Stability. JOURNAL OF MOLECULAR BIOLOGY. 1992
- Sancho, J; Serrano, L; Fersht, Ar. Histidine residues at the N- and C-termini of á helices: perturbed pKas and protein stability. BIOCHEMISTRY. 1992
- Fersht, Ar; Matouschek, A; Sancho, J; Serrano, L; Vuilleumier, S. Pathway of protein folding. FARADAY DISCUSSIONS. 1992. DOI: 10.1039/FD9929300183
- Serrano, L; Sancho, J; Hirshberg, M; Fersht, Ar. Alpha-helix stability in proteins. I. Empirical correlations concerning substitution of side-chains at the N and C-caps and the replacement of alanine by glycine or serine at solvent-exposed surfaces. JOURNAL OF MOLECULAR BIOLOGY. 1992
- K. Willaert, R. Loewenthal, J. Sancho, M. Froeyen, A. Fersht & Y. Engelborghs. Determination of the excited-state lifetimes of the tryptophan residues in barnase, via multifrequency phase fluorometry of tryptophan mutants. BIOCHEMISTRY. 1992
- Sancho, J; Meiering, Em; Fersht, Ar. Mapping transition states of protein unfolding by protein engineering of ligand binding sites. JOURNAL OF MOLECULAR BIOLOGY. 1991
- Loewenthal, R; Sancho, J; Fersht, Ar. Fluorescence spectrum of barnase: contributions of three tryptophan residues and a histidine-related pH-dependence. BIOCHEMISTRY. 1991
- Sancho, J.;Gomez Moreno, C. Interaction of Ferredoxin-Nadp+ Reductase from Anabaena with its Substrates. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1991
- Sancho, J.;Medina, M.;Gomez-Moreno, C. Arginyl Groups Involved in the Binding of Anabaena Ferredoxin-Nadp+ Reductase to Nadp+ and to Ferredoxin. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1990
- Pueyo, J. J.;Sancho, J.;Edmondson, D. E.;Gomez Moreno, C. Preparation and Properties of a Cross-Linked Complex between Ferrdoxin-Nadp+ Reductase and Flavodoxin. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1989
- Sancho, J.;Peleato, M. L.;Gomez-Moreno, C.;Edmondson, D. E. Purification and properties of ferredoxin-NADP+ oxidoreductase from the nitrogen-fixing cyanobacteria Anabaena variabilis. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1988
Libros
- Carlos Gómez-Moreno Calera y Javier Sancho Sanz (coords.). Estructura de proteínas. 2003
- Javier Sancho. Cuentos de colores. 2003
Capítulos
- Marta Bueno, Claudia Machicado, Nunilo Cremades y Javier Sancho. Estructuras tridimensionales: bases de datos y visualización. ESTRUCTURA DE PROTEÍNAS. 2003
- C. Gómez-Moreno ... [et al.]. Ingeniería y diseño de proteínas para su utilización en procesos para su utilización en procesos industriales. CIENCIA Y TECNOLOGÍA DEL SIGLO XXI. 2001
Proyectos
- OENOPROT / Nuevas Tecnologías digitales y de proteinas en procesos de vinificación para abordar los retos del sector enlógico en el Territorio POCTEFA (Poctefa 2021-2027). 01/03/24 - 28/02/27
- PID2022-141068NB-I00: The stability of Proteins: in deph analysis, new predictive tools and applications in biomedicine and biotechnology. 01/09/23 - 31/08/26
- E45_23R: Protein Targets and Bioactive Compounds (ProtBioCom). 01/01/23 - 31/12/25
- LMP40_21: Nuevas herramientas de diagnóstico y terapia para Medicina Personalizada. 18/09/21 - 30/09/23
- MOSBRI / Molecular Scale Biophysics Research Infrastructure (H2020-INFRAIA-2020-1). 01/07/21 - 31/10/25
- PID2019-107293GB-I00: Comprensión cuantitativa de estabilidad de proteínas por modelado y simulación, y aplicación a la interpretación cinética y termodinámica de variantes en un solo aminoácido. 01/06/20 - 31/05/23
- E45_20R: Protein Targets And Bioactive Compounds (ProtBioCom). 01/01/20 - 31/12/22
- Iberus Talent (H2020-G.A.number 801586)-Dotación Ritwik Maity
Línea Health1 17/10/19 - 16/03/23
- FLAV4AMR / Flavodoxin inhibitors to kill resistant bacteria. 15/05/19 - 31/05/23
- DISEÑO Y DESARROLLO DE NUEVOS FÁRMACOS PARA MEDICINA PERSONALIZADA Y SU APLICACIÓN A TEST DIAGNÓSTICOS (LMP30_18). 01/09/18 - 30/11/20
- NINGUN PACIENTE DE FENILCETONURIA SIN UN TRATAMIENTO EFICAZ. 18/12/17 - 28/02/19
- GRUPO DE REFERENCIA PROTEIN TARGETS AND BIOACTIVE COMPOUNDS (PROTBIOCOMS). 01/01/17 - 31/12/19
- REPARACIÓN DE UNA CENTRÍFUGA BECKMAN AVANTI J-E. 01/01/17 - 31/12/17
- BFU2016-78232-P: ESTRUCTURA, ENERGÉTICA Y SIMULACIÓN DE CONFORMACIONES (PARCIALMENTE) DESPLEGADAS DE LAS PROTEINAS. HACIA MODELOS ATÓMICOS CUANTITATIVOS DE LA ESTABILIDAD DE LAS PROTEÍNAS. 30/12/16 - 29/12/19
- PIREPRED / Red Transfronteriza de interpretación del cribado neonatal: de la mutación al paciente (EFA086/15). 01/09/16 - 30/06/21
- GRUPO CONSOLIDADO B89 PROTEIN TARGET. 01/01/16 - 31/12/16
- REPARACIÓN DE UNA PLATAFORMA SEMIAUTOMÁTICA DE DISPENSACIÓN AUTOMATIZADA NANODROP II. 01/01/16 - 30/11/16
- INTERNATIONAL CONFERENCE BIFI2016: MOLECULAR RECOGNITION BY PROTEINS. 20/10/15 - 19/10/16
- GRUPO CONSOLIDADO B89 PROTEIN TARGETS. 01/01/15 - 31/12/15
- REPARACIÓN DE UN CALORÍMETRO DE TITULACIÓN ISOTÉRMICA AUTO-ITC2000. 01/01/15 - 31/12/15
- BIO2014-57314- REDT: COMPRENSIÓN, PREDICCIÓN Y VALIDACIÓN DEL FENOTIPO DE LAS MUTACIONES PATOLÓGICAS: TRANSFORMANDO LOS RESULTADOS BÁSICOS EN HERRAMIENTAS DE DIAGNÓSTICO. 01/12/14 - 30/11/16
- Neuromed / Diagnóstico y combate molecular de tres enfermedades neurodegenerativas (Parkinson, fenilcetonuria y amiloidosis TTR. 01/05/14 - 30/06/15
- BFU2013-47064-P: ESTABILIDAD DE PROTEÍNAS: PRINCIPIOS BÁSICOS DE LOS ESTADOS (PARCIALMENTE) DESPLEGADOS Y ESTUDIOS MOLECULARES EN ENFERMEDADES CONFORMACIONALES. 01/01/14 - 31/10/17
- GRUPO CONSOLIDADO B89 PROTEIN TARGETS. 01/01/14 - 31/12/14
- REPARACIÓN DE UN INCUBADOR TERMOSTATIZADO CON AGITACIÓN ORBITAL (MAXQ-5000 BARNSTEAD DE LabLine. 01/01/14 - 31/12/14
- GRUPO CONSOLIDADO B89 PROTEIN TARGETS. 01/01/13 - 31/12/13
- REPARACIÓN CALORÍMETRO ISOTÉRMICO DE TITULACIÓN DE ALTA SENSIBILIDAD AUTO ITC200 (MicroCal, GE Healthcare LifeSciences). 01/01/13 - 31/12/13
- CONTRATACIÓN DE UN TÉCNICO SUPERIOR PARA EL LABORATORIO DE CRIBADO DEL BIFI. 16/10/12 - 31/12/13
- FUNDACION CAJA NAVARRA 2011- . NUEVOS FARMACOS CONTRA ENFERMEDAD DE ALZHEIMER Y DIABETES TIPO II: ESTUDIOS IN VIVO. 01/01/12 - 31/12/12
- REPARACIÓN DE UN EQUIPO DE CROMATROGRAFÍA LÍQUIDA (FAST PERFORMANCE LIQUID CHROMATOGRAPHY, FPLC) AKTABASIS UPC 100 FRAN-920 (GE HEALTHCARE). 01/01/12 - 31/12/12
- SAF2011-15732-E. BIFI2012-PROTEIN TARGETS: DISCOVERY OF BIOACTIVE COMPOUNDS. 26/10/11 - 25/10/13
- BFU2010-16297.ESTABILIDAD CONFORMACIONAL DE PROTEINAS: PRINCIPIOS GENERALES,ANALISIS ESTABILIDAD/FUNCION DEL R-LDL Y BUSQUEDA DE NUEVAS CHAPERONAS FARMACOLÓGICAS (ESTABILIPROT). 01/01/11 - 30/09/14
- GRUPO CONSOLIDADO B89 PROTEIN TARGETS. 01/01/11 - 31/12/12
- BFU2009-07508-E: IV SPANISH PORTUGUESE BIOPHYSICAL CONGRESS. 01/01/10 - 01/12/10
- CTPR02/09 AGREGACIÓN DE PROTEÍNAS EN ENFERMEDADES NEURODEGENERATIVAS: DE LACIENCIA BÁSICA A LA TERAPIA. 01/01/10 - 31/12/11
- GRUPO CONSOLIDADO B89 PROTEIN TARGETS. 01/01/10 - 31/12/10
- IV SPANISH-PORTUGUESE BIOPHYSICAL CONGRESS. 01/01/10 - 31/12/10
- SUBV.NO SUJETA A CONV.2010 - IV SPANISH PORTUGUESE BIOPHYSICAL CONGRESS. 01/01/10 - 14/11/10
- VI CONGRESOS 2009 (1).IV SPANISH-PORTUGUESE BIOPHYSICALCONGRESS. 01/09/09 - 31/08/10
- PI078/08. DESARROLLO RACIONAL DE COMPUESTOS BIOACTIVOS FRENTE A CINCO ENFERMEDADES HUMANAS. 01/10/08 - 30/09/10
- BIO2007-29813-E 16TH INTERNATIONAL SYMPOSIUM ON FLAVINS AND FLAVOPROTEINS. 01/02/08 - 15/12/08
- GRUPO EXCELENTE B18 BIOLOGIA ESTRUCTURAL. 01/01/08 - 31/12/10
- BFU2007-61476/BMC PRINCIPIOS DE ESTABILIDAD CONFORMACIÓNAL DE PROTEÍNAS, ANÁLISIS ESTRUCTURAL Y ENERGÉTICO DE CONFORMACIONES NO NATIVAS E IDENTIFICACIÓN DE LIGANDOS BIOACTIVOS. 01/10/07 - 31/12/10
- PIPAMER07/02 IDENTIFICACIÓN DE COMPUESTOS QUÍMICOS CAPACES DE INDUCIR DIFERENCIACIÓN CELULAR ESPECÍFICA A PARTIR DE CÉLULAS MADRE EMBRIONARIAS DE RATÓN. 27/07/07 - 30/09/08
- BIO2007-28712-E. INTERNATIONAL NETWORK OF PROTEIN ENGINEERING CENTERS. 01/03/07 - 15/12/07
- PM076/2006. DESARROLLO Y OPTIMIZACIÓN DE NUEVOS INHIBIDORES PRECLÍNICOS CONTRA HELICOBACTER PYLORI: UNA APROXIMACIÓN MULTIDISCIPLINAR. 01/10/06 - 30/09/08
- VII JORNADAS DE BIOINFORMATICA. 01/09/06 - 31/12/06
- INF2006-BIO-14/MONOCROMADOR DE EMISION PARA FLUORIMETRO CHIRASCAN-INTERCAMBIADOR DE CUBETAS PARA FLUORIMETRO. 29/06/06 - 31/12/06
- INF2005-BIO-006. ACCESORIO INTEGRADOR PARA LA ADQUISICION DE SEÑAL EN MODO PULSDO DEL ESPECTROMETRO DE EPR BRUKER ESP 380. 13/07/05 - 31/12/05
- GRUPO EXCELENTE DGA B18 BIOLOGIA ESTRUCTURAL. 01/01/05 - 31/12/07
- VI INFRAESTRUCTURA 2004. INF2004-BIO-15. 01/01/05 - 31/12/05
- BFU2004-01411. PRINCIPIOS DE ESTABILIDAD CONFORMACIONAL Y ESTABILIZACIÓN DE PROTEINAS SENCILLAS Y MODERADAMENTE COMPLEJAS. 13/12/04 - 12/12/07
- DOTACION ADICIONAL 2004. BFU2004-01411. 13/12/04 - 12/12/07
- BFM2003-08532-C03-01.SIMULACIONES DE MONTE CARLO DE SISTEMAS COMPLEJOS: SISTEMAS FERMIONICOS, PLEGAMIENTO DE PROTEINAS Y ORDENADORES DEDICADOS. 01/12/03 - 30/11/06
- BMC2002-10758-E. SPANISH-PORTUGUESE MEETING ON PROTEIN SCIENCE. 18/11/03 - 18/12/04
- BMC2002-11089-E. VIAJE A COPENHAGUE PREPARATORIO DE PETICION PROYECTO VI PROGRAMA MARCO. 18/11/03 - 18/11/04
- P120/2001 ACOPLAMIENTO AUTOMATICO DE LIGANDOS EN HUECOS DE PROTEINAS: HACIA UNA NUEVA ESTRATEGIA DE VEHICULIZACION DE FARMACOS. 01/01/02 - 31/12/04
- BMC2001-2522. LA ESTABILIDAD CONFORMACIONAL RELEVANTE DE LAS PROTEINAS ¿QUE ESTABILIZA A LOS ESTADOS NATIVOS Y A LOS INTEMEDIARIOS EN EQUILIBRIO?. 28/12/01 - 27/12/04
- DOTACION ADICIONAL 2001. BMC2001-2522. 28/12/01 - 27/12/04
- 2FD97-0758. "ESTABILIDAD CONFORMACIONAL Y PLEGAMIENTO DE ANTICUERPOS Y SUSCADENAS Y DOMINIOS CONSTITUYENTES. APLICACION A LA INMOVILIZACION DE. 10/06/99 - 31/12/01
- ESTABILIDAD, ESTRUCTURA Y PLEGAMIENTO DE LA FLAVODOXINA Y SUS CONFORMACIONES NO NATIVAS. 01/10/98 - 01/10/01
- P15/97.DISEÑO DE PROTEINAS MAS ESTABLES Y CON NUEVAS FUNCIONES DE INTERES TERAPEUTICO E INDUSTRIAL. 26/02/98 - 26/02/01
Contratos
- USING THE SERVER PROTPOSER FOR COMMERCIAL PURPOSES. 15/09/24 - 15/09/25
- USING THE PROTPOSER TOOL FOR COMMERCIAL PURPOSES. 22/07/24 - 29/07/24
- CONGRESO INTERNACIONALl: 2ND MOSBRI CONFERENCE. 01/01/23 - 31/12/23
- RYM2023-CIE-16: Reparación de Calorímetro Auto-iTC200 (MicroCal). 01/01/23 - 30/11/23
- DISEÑO DE MUTANTES PARA EL DESARROLLO DE MOLÉCULAS DE BIORECONOCIMIENTO. 15/03/21 - 15/09/21
- CERTIFICACIÓN DE PROYECTOS DE I+D+I. 01/01/17 - 31/12/17
- ANÁLISIS DE LA ACTIVIDAD Y DE LA IDENTIDAD QUÍMICA DE DISTINTAS MUESTRAS DE BUSERELINA. 10/12/15 - 15/02/16
- BIFI. 01/11/15 - 31/10/25
- PROTEIN TARGETS. 01/11/15 - 31/10/25
- Protein Targets And Bioactive Compounds (ProtBioCom) (Retorno UZ). 14/10/10 - 31/12/25
- CRIBADO MASIVO DE COMPUESTOS QUÍMICOS PARA COMBATIR LA HIPERCOLESTEROLEMIA FAMILIAR: ENSAYOS CON EL MÓDULO CINCO DEL RECEPTOR DE LAS LDL. 15/12/08 - 14/12/10
Dirección de tesis
- Prediction of protein stability with molecular dynamics and machine learning: From protein stabilization to clinical diagnosis. Universidad de Zaragoza. Sobresaliente cum laude. 11/11/22
- Combate de las resistencias asociadas a Helicobacter pylori: síntesis y evaluación in vivo de nuevos antimicrobianos contra dianas específicas de la bacteria. Universidad de Zaragoza. Sobresaliente cum laude. 16/04/21
- CHAPERONAS FARMACOLÓGICAS EN FENILCETONURIA: ESTUDIO DEL DESPLEGAMIENTO DE LA ENZIMA PAH E IDENTIFICACIÓN DE COMPUESTOS CON PROPIEDADES FARMACOLÓGICAS. Universidad de Zaragoza. Sobresaliente cum laude. 09/04/21
- Nuevas herramientas terapéuticas y analíticas basadas en moléculas orgánicas con capacidad para interaccionar con proteínas implicadas en las enfermedades de Alzheimer, Parkinson, fenilcetonuria y a infección causada por Helicobacter pylori. Universidad de Zaragoza. Sobresaliente cum laude. 19/12/19
- Caracterización bioquímica y estructural de la flavodoxina de streptococcus pneumoniae cepa TIGR4. Universidad de Zaragoza. Sobresaliente cum laude. 26/06/17
- Estabilización racional de la apoflavodoxina de Anabaena PCC 7119 y estudio de la relevancia de su intermediario de equilibrio. Universidad de Zaragoza. Sobresaliente cum laude. 23/06/17
- Helicobacter pylori: Eventos biomoleculares asociados a la aparición de resistencia y al mecanismo de intercambio anión/ agua en la superficie de Fld. Diseño y optimización de nuevos compuestos con actividades farmacológicas. Universidad de Zaragoza. Sobresaliente cum laude. 18/12/15
- Herramientas computacionales para el estudio de la estabilidad de proteínas y de la interacción entre proteínas y pequeñas moléculas. Universidad de Zaragoza. Sobresaliente "Cum Laude". 23/10/15
- Mecanismo de incorporación clular de LDL y beta-VLDL: análisis estructural y funcional de la región extracelular del receptor de LDL. Universidad de Zaragoza. Sobresaliente cum laude. 20/06/14
- A bioinformatics study of protein conformational flexibility and misfolding: a sequence, structure and dynamics approach. Universidad de Zaragoza. Sobresaliente "Cum Laude". 01/04/14
- Análisis estructural y termodinámico de las conformaciones que pueblan la desnaturalización térmica de la apoflavodoxina de anabaena PCC7119. Universidad de Zaragoza. Apto cum laude. 13/04/12
- El módulo 5 del receptor de lipoproteínas de baja densidad: implicaciones mecanísticas de su estabilidad, plegamiento e interacciones moleculares. Universidad de Zaragoza. Sobresaliente "Cum Laude". 15/07/10
- La flavodoxina de Helicobacter Pylori: Paisaje conformacional e identificación de inhibidores específicos. Universidad de Zaragoza. Sobresaliente "Cum Laude". 04/12/07
- Estudio de la estabilidad conformacional de un anticuerpo monoclonal y su fragmento de cadena pequeña. Universidad de Zaragoza. Sobresaliente "Cum Laude". 06/10/06
- Estabilidad y estabilización de proteínas con el modelo de la apoflavodoxina de anabaena PCC7119. Universidad de Zaragoza. Sobresaliente "Cum Laude". 19/01/06
- Hélices, bucles y glóbulos fundidos. Estudio estructural y energético en la apoflavodoxina de anabaena pcc 7119. Universidad de Zaragoza. Sobresaliente "Cum Laude". 09/11/04
- Análisis energético y estructural de una proteína modelo con un equilibrio de tres estados: la flavodoxina de anabaena pcc 7119. Universidad de Zaragoza. Sobresaliente "Cum Laude". 15/07/04
- Hacia la generación de proteínas portadoras de ligandos: Modelización molecular de complejos proteína-ligando y cribado automático de librerías de ligandos. Universidad de Zaragoza. Sobresaliente "Cum Laude". 03/12/03
- Estructura del intermediario térmico y del estado de transición del desplegamiento de la apoflavodoxina energética de puentes de hidrógeno cargados y neutros. Universidad de Zaragoza. Sobresaliente "Cum Laude". 17/11/00
- ESTRUCTURA Y ESTABILIDAD DE FRAGMENTOS DE APOFLAVODOXINA COMO MODELOS DE ESTUDIO DE LAS ETAPAS INICIALES DEL PLEGAMIENTO DE LAS PROTEINAS. Universidad de Zaragoza. Sobresaliente "Cum Laude". 19/11/99
- EL COMPLEJO APOFLAVODOXINA-FMN: FORMACION, ESTABILIDAD Y MODULACION DEL POTENCIAL REDOX DEL COFACTOR POR AMINOACIDOS DEL SITIO DE UNION. Universidad de Zaragoza. Sobresaliente "Cum Laude". 30/04/99
- PLEGAMIENTO DE LA APOFLALODOXINA E INTERACCIONES MOLECULARES EN PROTEINAS: ANALISIS ENERGETICO Y MUTACIONAL. Universidad de Zaragoza. Sobresaliente "Cum Laude". 19/04/99
- Ingeniería de proteínas aplicada al estudio de reacciones de transferencia de electrones en proteínas rédox. Universidad de Zaragoza. APTO Cum Laude. 01/01/96
Dirección de proyectos fin de grado
- Evaluación computacional de la energética de proteínas: la flavodoxina de Anabaena sp. PCC 7119. Universidad de Zaragoza. Matrícula de honor. 28/07/20
- Evaluación del mutoma asociado al síndrome de Rett. Universidad de Zaragoza. Sobresaliente. 27/09/19
Dirección de proyectos fin de master
- Fine Tuning Protein Stability and Unfolding Kinetics Analyses from Molecular Dynamics Simulations. Universidad de Zaragoza. Sobresaliente. 12/07/21
- Towards the calculation of protein stability in wild type and mutant proteins associated to Rett syndrome. Universidad de Zaragoza. Aprobado. 24/09/20
- Desarrollo de estrategias para la inhibición de la agregación amiloide de alfa-sinucleína y la estabilización de nuevos agregados intermedios como posibles biomarcadores para el diagnóstico de la enfermedad de Parkinson. Universidad de Zaragoza. Notable. 21/02/20
- Identificación de compuestos inhibidores dirigidos contra la flavodoxina de Streptococcus pneumoniae. Universidad de Zaragoza. Notable. 14/12/17
- Prototipo de aplicación bioinformática para estabilizar proteínas de manera racional. Universidad de Zaragoza. Matrícula de honor. 02/10/17
- Síntesis y ensayo de nuevas chaperonas farmacológicas para tratamiento de fenilcetonuria. Universidad de Zaragoza. Sobresaliente. 25/09/14
- Estudio computacional del mecanismo de unión-disociación de la flavodoxina de Helicobacter pylori y su ligando. Universidad de Zaragoza. Notable. 26/09/13
- Identificación de posibles chaperonas farmacológicas útiles en terapia de enfermedades conformacionales. Universidad de Zaragoza. Matrícula de honor. 12/07/12
- Estabilidad e interacciones del dominio de unión del receptor de LDL. Universidad de Zaragoza. Sobresaliente. 12/07/12
- Aumento racional de la estabilidad de una proteína modelo. Universidad de Zaragoza. Sobresaliente. 12/07/12
- Procedimiento "in sílico" para la obtención de modelos QSAR en derivados de [(E)-2-R-vinil] benceno. Aplicación al diseño de nuevas moléculas contra enfermedades producidas por Helicobacter pylori. Universidad de Zaragoza. Sobresaliente. 16/02/12
Patentes de invención
- P202230102. Compuestos para el tratamiento y/o prevención de una infección o
enfermedad causada por Helicobacter o Campylobacter. SANCHO SANZ, JAVIER - SALILLAS BERGES, SANDRA - LANAS ARBELOA, ANGEL - GONZÁLEZ RODRÍGUEZ, ANDRÉS - LANAS ARBELOA, ANGEL - CHUECA LAPUENTE, EDUARDO - PIAZUELO ORTEGA, ELENA - CASADO APASTEGUI, JAVIER. 2022
- P201930445. Compounds for the treatment of diseases caused by Helicobacter. SALILLAS BERGES, SANDRA - CARRODEGUAS VILLAR, JOSÉ ALBERTO - MAHÍA MOROS, ALEJANDRO JOSÉ - GALANO FRUTOS, JUAN JOSÉ - LANAS ARBELOA, ANGEL - AÍNSA CLAVER, JOSÉ ANTONIO - DÍAZ DE VILLEGAS SOLANS, MARÍA DOLORES - VELÁZQUEZ CAMPOY, ADRIÁN - TOUATI, ELIETTE - MICHEL, VALERIE - SANCHO SANZ, JAVIER - LANAS ARBELOA, ANGEL - VELÁZQUEZ CAMPOY, ADRIÁN - MICHEL, VALERIE. 2019
- P201831019. Derivados de 4-fenildihidropiridina para el tratamiento y/o prevención de una infección o enfermedad causada por Helicobacter. SANCHO SANZ, JAVIER - VELÁZQUEZ CAMPOY, ADRIÁN - SALILLAS BERGES, SANDRA - LANAS ARBELOA, ANGEL - GONZÁLEZ RODRÍGUEZ, ANDRÉS - VELÁZQUEZ CAMPOY, ADRIÁN - LANAS ARBELOA, ANGEL. 2018
- EP17158468.3 (Compuesto D). COMPOUNDS FOR TREATING SYNUCLEINOPATHIES (Compuesto D). VENTURA, SALVADOR - PEÑA DIAZ, SAMUEL - PUJOLS PUJOL, JORDI - DALFO CAPELLA, ESTHER - SANCHO SANZ, JAVIER - CONDE GIMÉNEZ, MARÍA. 2017
- EP17158503.7 (Compuesto A). COMPOUNDS FOR TREATING SYNUCLEINOPATHIES (Compuesto A). SANCHO SANZ, JAVIER - VENTURA, SALVADOR - CONDE GIMÉNEZ, MARÍA - PEÑA DIAZ, SAMUEL - PUJOLS PUJOL, JORDI - DALFO CAPELLA, ESTHER. 2017
- EP17158509.4 (Compuesto G). COMPOUNDS FOR TREATING SYNUCLEINOPATHIES (Compuesto G). DALFO CAPELLA, ESTHER - SANCHO SANZ, JAVIER - CONDE GIMÉNEZ, MARÍA - VENTURA, SALVADOR - PEÑA DIAZ, SAMUEL - PUJOLS PUJOL, JORDI. 2017
- EP17382552.2. COMPOUNDS FOR TREATING SYNUCLEINOPATHIES (Compuesto H). SANCHO SANZ, JAVIER - PEÑA DIAZ, SAMUEL - VENTURA, SALVADOR - DALFO CAPELLA, ESTHER - PUJOLS PUJOL, JORDI - CONDE GIMÉNEZ, MARÍA. 2017
- EP17382553.0. COMPOUNDS FOR TREATING SYNUCLEINOPATHIES (Compuesto I). SANCHO SANZ, JAVIER - PEÑA DIAZ, SAMUEL - VENTURA, SALVADOR - DALFO CAPELLA, ESTHER - PUJOLS PUJOL, JORDI - CONDE GIMÉNEZ, MARÍA. 2017
- EP17382554.8. COMPOUNDS FOR TREATING SYNUCLEINOPATHIES (Compuesto J). SANCHO SANZ, JAVIER - PEÑA DIAZ, SAMUEL - VENTURA, SALVADOR - DALFO CAPELLA, ESTHER - PUJOLS PUJOL, JORDI - CONDE GIMÉNEZ, MARÍA. 2017
- ES20120031189 20120725. Method and system for molecular dynamics simulation with stability control. Martinez Aban Roldan; Echenique Robba Pablo; Sancho Sanz Javier; Martinez Benito Roberto; Campo Camacho Alfonso; Lopez Medrano Alvaro. 2016
- PCT/ES2014/070011. DERIVADOS DE BENZO[C][1,2,5]OXADIAZOL PARA EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR HELICOBAcTER. SANCHO SANZ, JAVIER 48 % (U.Z.) - VELÁZQUEZ CAMPOY, ADRIÁN 10% (5% U.Z. 5% ARAID) - CREMADES CASASÍN, NUNILO 10% (U.Z.) - ALIAS NIÑO, MIRIAN 10% (U.Z.) - GALANO FRUTOS, JUAN JOSÉ 10% (U.Z.) - TOUATI. 2014
- PCT/ES2014/070011. DERIVADOS DE BENZO[C][1,2,5]OXADIAZOL PARA EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR HELICOBAcTER. SANCHO SANZ, JAVIER 48 % (U.Z.) - VELÁZQUEZ CAMPOY, ADRIÁN 10% (5% U.Z. 5% ARAID) - CREMADES CASASÍN, NUNILO 10% (U.Z.) - ALIAS NIÑO, MIRIAN 10% (U.Z.) - GALANO FRUTOS, JUAN JOSÉ 10% - TOUATI, ELIETTE 10% (INSTITUTO PASTEUR) - MICHEL, VALÉRIE 2% (INSTITUTO PASTEUR). 2014
- PCT/ES2014/070011. DERIVADOS DE BENZO[C][1,2,5]OXADIAZOL PARA EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR HELICOBACTER. SANCHO SANZ, JAVIER - VELÁZQUEZ CAMPOY, ADRIÁN - CREMADES CASASIN, NUNILO - ALÍAS NIÑO, MIRIAM - GALANO FRUTOS, JUAN JOSÉ - TOUATI, ELIETTE - MICHEL, VALERIE - VELÁZQUEZ CAMPOY, ADRIÁN. 2014
- EP12382218.1. ALLOSTERIC INHIBITORS OF NS3 PROTEASE FROM HEPATITIS C VIRUS. ABIÁN FRANCO, OLGA - VELÁZQUEZ CAMPOY, ADRIÁN - SANCHO SANZ, JAVIER - VEGA SÁNCHEZ, SONIA. 2012
- EP12382218.1. ALLOSTERIC INHIBITORS OF NS3 PROTEASE FROM HEPATITIS C VIRUS. VELÁZQUEZ CAMPOY, ADRIÁN - ABIÁN FRANCO, OLGA MARÍA - SANCHO SANZ, JAVIER - VEGA SÁNCHEZ, SONIA - VELÁZQUEZ CAMPOY, ADRIÁN - ABIÁN FRANCO, OLGA MARÍA. 2012
- P201231452. COMPUESTOS PARA SU USO EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER (COMPUESTO 3). SANCHO SANZ, JAVIER (UZ) - LOPEZ RODRIGUEZ, LAURA CATALINA (UZ) - CARRODEGUAS VILLAR, JOSE ALBERTO (UZ) - VENTURA ZAMORA,SALVADOR (UAB). 2012
- P201231452. COMPUESTOS PARA SU USO EN EL TRATAMIENTO DE LAENFERMEDAD DE ALZHEIMER (COMPUESTO 3). SANCHO SANZ, JAVIER - CARRODEGUAS VILLAR, JOSÉ ALBERTO - LOPEZ RODRIGUEZ, LAURA CATALINA - VENTURA, SALVADOR. 2012
- P201130803. USO DE DERIVADOS DE BENCETONIO PARA LA ELIMINACIÓN DE CÉLULAS MADRE. CARRODEGUAS VILLAR, JOSÉ ALBERTO - SANCHO SANZ, JAVIER - CONESA MONTANEL, CELIA - SACHINIDIS, AGAPIOS. 2011
- P201130803. USO DE DERIVADOS DE BENCETONIO PARA LA ELIMINACIÓN DE CÉLULAS MADRE. CARRODEGUAS VILLAR. JOSÉ ALBERTO - CONESA MONTANEL. CELIA - SACHINIDIS. AGAPIOS - SANCHO SANZ. JAVIER. 2011
- P201131955. COMPUESTOS INHIBIDORES DE LA AGREGACIÓN DEL PÉPTIDO BETA AMILOIDE. carrodeguas villar. jose alberto (uz) - lopez rodriguez. laura catalina (UZ) - sancho SANZ. javier (uz) - VENTURA ZAMORA.SALVADOR(uab). 2011
- P201131955. COMPUESTOS INHIBIDORES DE LA AGREGACIÓN DEL PÉPTIDOBETA AMILOIDE (COMPUESTO 1). SANCHO SANZ, JAVIER - CARRODEGUAS VILLAR, JOSÉ ALBERTO - LOPEZ RODRIGUEZ, LAURA CATALINA - VENTURA, SALVADOR. 2011
- P201132020. AGENTE INHIBIDOR DE LA AGREGACION DEL PÉPTIDO BETA AMILOIDE. carrodeguas villar. jose alberto (uz) - lopez rodriguez. laura catalina (UZ) - sancho SANZ. javier (uz) - VENTURA ZAMORA.SALVADOR(uab). 2011
- P201132020. COMPUESTOS INHIBIDORES DE LA AGREGACIÓN DEL PÉPTIDO BETAAMILOIDE (COMPUESTO 2). SANCHO SANZ, JAVIER - CARRODEGUAS VILLAR, JOSÉ ALBERTO - LOPEZ RODRIGUEZ, LAURA CATALINA - VENTURA, SALVADOR. 2011
- PCT/EP08/005294 - WO2009/000552. COMPOSITIONS FOR TREATMENT OF HYPERPHENYLALANINEMIA. CREMADES CASAÍN. NUNILO. 2008
- P200700566 - PCT/ES08/000093. USO DE COMPUESTOS COMO INHIBIDORES DE LA FLAVODOXINA DE HELICOBACTER. CREMADES CASASÍN. NUNILO. 2007
- P200700566. USO DE COMPUESTOS COMO INHIBIDORES DE LA FLAVODOXINA DE HELICOBACTER. SANCHO SANZ, JAVIER - VELÁZQUEZ CAMPOY, ADRIÁN - CREMADES CASASIN, NUNILO. 2007
- P200700645 - PCT/ES08/000098. COMPOSICIÓN PARA EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS. CREMADES CASASÍN. NUNILO. 2007
- P200700645. COMPOSICIÓN PARA EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS. SANCHO SANZ, JAVIER - VELÁZQUEZ CAMPOY, ADRIÁN - CREMADES CASASIN, NUNILO. 2007
- P200700646 - PCT/ES08/000097. COMPOSICIÓN PARA EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS CAUSADAS POR HELICOBACTER. CREMADES CASASÍN. NUNILO. 2007
- P200700646. COMPOSICIÓN PARA EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS CAUSADAS POR HELICOBACTER. SANCHO SANZ, JAVIER - VELÁZQUEZ CAMPOY, ADRIÁN - CREMADES CASASIN, NUNILO. 2007
- P200700647 - PCT/ES08/000099. USO DE COMPUESTOS PARA EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS CAUSADAS POR HELICOBACTER PYLORI. CREMADES CASASÍN. NUNILO. 2007
- P200700647. USO DE COMPUESTOS PARA EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS CAUSADAS POR HELICOBACTER PYLORI. SANCHO SANZ, JAVIER - VELÁZQUEZ CAMPOY, ADRIÁN - CREMADES CASASIN, NUNILO. 2007
- PCT/EP08/005294. COMPOSITIONS FOR TREATMENT OF HYPERPHENYLALANINEMIA. SANCHO SANZ, JAVIER - VELÁZQUEZ CAMPOY, ADRIÁN - CREMADES CASASIN, NUNILO - MARTÍNEZ RUIZ, AURORA - PEY RODRÍGUEZ, ÁNGEL - YING, MING. 2007
Protección de software
- Protposer, una aplicación web que propone mutaciones que estabilizan las proteínas. GARCÍA CEBOLLADA, HELENA - SANCHO SANZ, JAVIER
Participaciones en congresos
- 45th Congress of the Spanish Society of Biochemistry and Molecular Biology (SEBBM). Participativo - Póster. How Molecular Interactions and Forces Make Proteins to Fold? Insights from MD Simulations. Zaragoza. 05/09/23
- XVII International Congress of the Spanish Biophysics Society (SBE). Participativo - Ponencia oral (comunicación oral). Integrating Experiments and MD simulations to Model the Structural Ensemble of the Helicobacter pylori apoflavodoxin’s Molten Globule. Castelldefels. 27/06/23
- 2nd MOSBRI Scientific Conference. Participativo - Póster. Molecular Interactions and Forces that make Proteins to Fold: A Quantitative Balance from MD simulations. Zaragoza. 05/06/23
- XIth National Conference BIFI 2023 Participativo - Ponencia oral (comunicación oral). Integrating Experiments and MD Simulations for Modeling the Structural Ensemble of a Protein Molten Globule: the Helicobacter pylori apoflavodoxin at acidic pH. Zaragoza. 25/01/23
- III Conferencia PRISMA: STEM y STEAM, ¿a qué llamamos ciencia?. Participativo - Ponencia oral (comunicación oral). PirePred: Un servidor para interpretar patogenicidad hacia la medicina personalizada. Barcelona. 12/11/22
- 44th Congress of the Spanish Society of Biochemistry and Molecular Biology (SEBBM). Participativo - Póster. The Power of Molecular Dynamics: Protein Folding and Stability Applications. Málaga. 06/09/22
- TSRC Protein Dynamics Workshop. Participativo - Póster. MD-Based Approach for Accurate Calculation of Protein Thermodynamics. Aussois (French Alps). 27/05/22
- Les Houches-TSRC Online Workshop on Protein Dynamics. Participativo - Póster. Calculation of Protein Folding Thermodynamics using Molecular Dynamics Simulations. Online. 18/03/21
- Xth National (online) Conference BIFI 2021 Participativo - Ponencia oral (comunicación oral). PirePred: Linking Bioinformatics to Clinical Diagnosis. Zaragoza. 03/02/21
- X National Conference BIFI 2021. Participativo - Ponencia oral (comunicación oral). Computational pathogenicity prediction in Rett Syndrome using 2D-RMSD clustering Zaragoza. 03/02/21
- I Conferencia PRISMA. Participativo - Ponencia oral (comunicación oral). Prediction of Pathogenicity in Rett Syndrome Using Relaxation Molecular Dynamics Simulations Madrid. 17/11/20
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Póster. Design and synthesis of FMN derivatives for covalent union to flavoproteins. Zaragoza. 03/02/20
- IXth International Conference BIFI 2020 Participativo - Ponencia oral (comunicación oral). Novel Duplications in Human Metapneumovirus G Gene: Are we Witnessing the Evolution of an Immune Evasion Mechanism?. Zaragoza. 03/02/20
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Póster. In vitro validation of new PAH binding compounds for non-Kuvan responsive PKU patients. Zaragoza. 03/02/20
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Póster. Design and testing of a colorimetric immunoassay for the measurement of phenylalanine blood levels in patients with phenylketonuria. Zaragoza. 03/02/20
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Póster. Resisting antimicrobial resistante: Flavodoxin inhibitors to combat Helicobacter pylori infection. Zaragoza. 03/02/20
- IX International Conference BIFI 2020. New Challenges in Molecular Biotechnology. Participativo - Ponencia oral (comunicación oral). Protposer: Rational Proposal of Potentially Stabilizing Mutations Zaragoza. 03/02/20
- 24th International Network of Protein Engineering Centres (INPEC) and 3rd Australasian Protein Engineering Meeting (APEM). Participativo - Ponencia oral (comunicación oral). Protposer: a server that proposes protein stabilizing mutations Sídney. 05/12/19
- XXXIInd Workshop of the European Helicobacter & Microbiota Study Group. Participativo - Póster. Efficacy of flavodoxin inhibitors against Helicobacter pylori drug-resistant clinical strains and in Hp-infected mice. Innsbruck. 05/09/19
- XIII Congreso Anual de Biotecnología. Participativo - Ponencia oral (comunicación oral). Assessment of Genetic Variants Performing Structural Relaxation Molecular Dynamics. Madrid. 10/07/19
- Workshop "Computer Simulation and Theory of Macromolecules 2019". Participativo - Póster. Genetic Interpretation with Molecular Dynamics: How About Assessing the Complete Variome of the Human Proteome?. Hünfeld. 22/03/19
- Workshop "Computer Simulation and Theory of Macromolecules 2019". Participativo - Póster. Machine Learning for Rational Stabilization of Proteins Hünfeld. 22/03/19
- IX Conferencia Nacional BIFI 2019. Participativo - Póster. Familial Gestational Hyperthyroidism Caused by Val597Ile Mutant of TSH Receptor: A Complementary In Vitro / In Silico Functional Analysis. Zaragoza. 30/01/19
- IX Conferencia Nacional BIFI 2019. Participativo - Póster. Relaxation Molecular Dynamics for the Assessment of Pathogenicity in Genetic Variants: A Structural Dynamic Approach. Zaragoza. 30/01/19
- IX Conferencia Nacional BIFI 2019. Participativo - Póster. Bioactive Compounds as an Alternative Treatment for H. pylori Infection. Zaragoza. 30/01/19
- IX Conferencia Nacional BIFI 2019. Participativo - Póster. Evaluation of Novel PAH Stabilizing Compounds as Potential PKU Treatment. Zaragoza. 30/01/19
- IX National Conference BIFI 2019. Participativo - Ponencia oral (comunicación oral). Relaxation Molecular Dynamics for the Assessment of Pathogenicity in Genetic Variants: A Structural Dynamic Approach Zaragoza. 30/01/19
- IX Conferencia Nacional BIFI 2019. Participativo - Ponencia oral (comunicación oral). Synthesis and Testing of a Novel, Large Stokes Shift Fluorescent Probe for the Staining of Aß1-42, a-synuclein, and Amylin Amyloid Fibrils, and for the Detection of Amyloid-Containing Staphylococcus aureus Biofilms. Zaragoza. 30/01/19
- 41 Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Modeling observed features in protein MECP2, the main target associated to Rett Syndrome. Santander. 10/09/18
- XII Reunión del Grupo Microbiología Molecular. Participativo - Póster. Fighting superbugs: new promising compounds against Helicobacter pylori. Zaragoza. 05/09/18
- CONGRESO ANUAL DE BIOTECNOLOGIA BAC. Participativo - Ponencia oral (comunicación oral). Prediction of stabilizing point mutations in protein structures using rational features in a machine learning workflow. Gerona. 17/07/18
- 6th International Iberian Biophysics Congress anb X Iberoamerican Congress of Biophysics Participativo - Póster. From Molecular Dynamics simulations to Genetic Interpretation: How About Trying to Describe the Complete Proteome Mutational Space?. Castellón de la Plana. 20/06/18
- V Simposio de Jóvenes Investigadores del IQFR-CSIC. Participativo - Ponencia oral (comunicación oral). Diseño y síntesis de derivados más solubles de potenciales fármacos para el tratamiento de la infección causada por Helicobacter pylori Madrid. 29/05/18
- VIII International Conference BIFI 2018. Participativo - Póster. Design, synthesis and testing of a novel fluorescent probe for the staining of amyloid fibrils of Aß1-42 peptide, a-synuclein and amylin and for the detection of amyloid-nature Staphylococcus aureus biofilms. Zaragoza. 06/02/18
- VIII International Conference BIFI 2018. Participativo - Póster. Combating bacterial multidrug resistance: new drugs against Helicobacter pylori. Zaragoza. 06/02/18
- VIII International Conference BIFI 2018. Participativo - Póster. Development of novel stabilizing compounds of human phenylalanine hydroxylase for PKU patients. Zaragoza. 06/02/18
- VIII Conference Internacional BIFI 2018. Participativo - Ponencia oral (comunicación oral). An energetically validated structural model for the unfolded state of proteins. Zaragoza. 06/02/18
- Juan José Galano-Frutos. Participativo - Ponencia oral (comunicación oral). An energetically validated structural model for the unfolded state of proteins. Zaragoza. 06/02/18
- 7th Congress of European Microbiologists (FEMS). Participativo - Ponencia oral (comunicación oral). SCOUTING NEW ANTIMICROBIALS: THE FAD SYNTHETASE AS A NOVEL PROMISING TARGET. Valencia. 09/07/17
- XVIth International Congress of the Spanish Biophysical Society (SBE). Participativo - Ponencia oral (comunicación oral). Reliable structural and energetic model of the "unfolded state" of proteins. Sevilla. 06/06/17
- VIII BIFI National Conference. Participativo - Ponencia oral (comunicación oral). Development of a structural and energetic model of the "unfolded state" of proteins. Zaragoza. 31/01/17
- VIII BIFI National Conference. Participativo - Póster. Design, synthesis and testing of a novel and efficient fluorescent compound for the staining of amyloid beta fibrillar aggregates Zaragoza. 31/01/17
- VIII BIFI National Conference. Participativo - Póster. Studying the mechanism of action of novel stabilizing compounds of phenylalanine hydroxylase Zaragoza. 31/01/17
- VIII BIFI National Conference. Participativo - Ponencia oral (comunicación oral). A new approach for Helicobacter pylori eradication: In vivo assessment of novel flavodoxin inhibitors efficacy. Zaragoza. 31/01/17
- XXIII Congreso Latinoamericano de Microbiología. Participativo - Póster. Identificación y evaluación de potenciales inhibidores de flavoproteínas de Xanthomonas citri subsp.citri. Rosario. 26/09/16
- 52nd International Conference on Medicinal Chemistry. Participativo - Póster. Design of diagnostic tools for Alzehimer´s disease: Synthesis and testing of fluorescent organic compounds as inhibitors of the amyloid beta peptide aggregation. Caen. 06/07/16
- 23rd Young Research Fellow Meeting (organized by the French Medicinal Chemistry Society, SCT). Participativo - Póster. Therapeutic index determination of new developed compounds toward Helicobacter pylori flavodoxin. Lille. 15/02/16
- VIIth International Conference BIFI 2016. Participativo - Póster. Mechanism of water/ion exchange at the surface of Helicobacter pylori apoflavodoxin. Zaragoza. 01/02/16
- VII International Conference of the Institute for Biocomputation and Physics of Complex Systems (BIFI). Participativo - Póster. Synthesis and testing of fluorescent chemical compounds as diagnostic tools for Alzheimer's disease. Zaragoza. 01/02/16
- VII International Conference of the Institute for Biocomputation and Physics of Complex Systems (BIFI). Participativo - Póster. Toxicity and efficacy evaluation of novel compounds targeting an essential protein of Helicobacter pylori. Zaragoza. 01/02/16
- XVth International Congress of the Spanish Biophysical Society (SBE). Participativo - Póster. Optimization of phenylalanine hydroxilase stabilizers by a tested ‘alchemical’ free-energy approach. Granada. 10/06/15
- 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Participativo - Ponencia oral (comunicación oral). In vitro testing of new flavodoxin inhibitors against Helicobacter pylori infection. Copenhagen. 25/04/15
- VII Congreso Nacional BIFI. Participativo - Póster. Identification and development of new pharmacological chaperones for phenylketonuria. Zaragoza. 04/02/15
- VII Congreso Nacional BIFI. Participativo - Póster. Helicobacter pylori flavodoxin: a promising target in the develop of selective antimicrobials against this bacteria. Zaragoza. 04/02/15
- E.S. PKU Meeting. Participativo - Ponencia oral (comunicación oral). Discovery and development of novel chaperones for PKU. Zagreb. 23/10/14
- VIth International Conference BIFI 2014. Participativo - Ponencia oral (comunicación oral). Molecular Dynamic Simulations of Anion/Protein Unbinding Interactions in two Similar Apoflavodoxin Structures. Insights About the Complex FMN/Apoflavodoxin Binding Scenario Zaragoza. 24/01/14
- BioMed Conference "Frontiers in dynamic simulations of biological molecules". Participativo - Póster. Molecular Dynamic Simulations of an Anion/Protein Unbinding Interaction in the Helicobacter pylori Flavodoxin. Insights about the Complex FMN/Protein Binding Scenario. Barcelona. 06/11/13
- XXXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Fur proteins as antimicrobial targets: Purification and biochemical characterization and thermostability. Madrid. 03/09/13
- XV Reunión Anual de la Asociación Española de Gastroenterología. Participativo - Ponencia oral (comunicación oral). Capacidad inhibitoria "in vitro" de los inhibidores de la flavodoxina sobre Helicobacter pylori. Madrid. 20/03/13
- XIIth International Congress of the Spanish Biophysical Society (SBE). Participativo - Póster. Site-directed Mutagenesis and Binding Modes Modelling of [(E)-2-R-vinyl]benzene Derivatives on Helicobacter pylori Flavodoxin. Barcelona. 03/07/12
- Vth International Conference BIFI 2012. Participativo - Ponencia oral (comunicación oral). Development of QSAR Models for Fld-binding and Inhibitory Features of [(E)-2-R-vinyl]benzene Derivatives. Zaragoza. 01/02/12
- American Crystallographic Association Annual Meeting 2006. Participativo - Ponencia oral (comunicación oral). Structural studies on Helicobacter pylori apoflavodoxin contributes to investigate conformational changes in flavodoxins induced by FMN binding. Honolulu. 22/07/06
- II Congreso Nacional BIFI 2005. Participativo - Ponencia oral (comunicación oral). Cristalografía y difracción de rayos X; técnica aplicada a la resolución de estructuras tridimensionales de proteínas dependientes de flavina. Zaragoza. 10/02/05
Estancias
- Cambridge Centre for Protein Engineering (Medical Research Council). Cambridge. Reino Unido. 01/03/89 - 30/09/91
- Biochemistry Department (Emory University Medical School). Atlanta. Estados Unidos de América. 01/06/86 - 30/09/86
Organizaciones de actividades de I+D+i
- Congreso de la Sociedad de Biofísica de España. 01/03/12 - 04/03/12
- Congreso de la Sociedad de Biofísica de España. 01/03/11 - 04/03/11
- IV Spanish-Portuguese Biophysical Meeting 01/07/10 - 04/07/10
- Flavin and Flavoprotein Biannual Meeting 01/07/08 - 04/07/08
- VI Ibero-American Congress of Biophysics. 01/06/06 - 04/06/06
- VI Jornadas Nacionales de Bioinformática 01/03/06 - 04/03/06
- XXVI Congreso de la SEBBM. 01/09/05 - 04/09/05
Gestiones de actividades de I+D+i
- Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos. Director. 01/02/15
- Universidad de Zaragoza. Comisión de Investigación. 01/01/11 - 31/12/15
- ANEP. Comisión de base BMCG. 01/01/08 - 31/12/10
- Programa Nacional de Proyectos de Investigación Fundamental. Comisión BMC. 01/01/08 - 31/12/08
- Sociedad de Biofísica de España. Vocal de la Junta Directiva. 01/01/08 - 31/12/12
- Red Española de Supercomputación. Comité de Acceso. 01/01/08 - 31/12/10
- Sociedad Española de Bioquímica y Biología Molecular. Vocal de la Junta Directiva. 01/01/06 - 31/12/10
- Universidad de Zaragoza. Promotor y Corresponsable de la Unidad Asociada IQFR(CSIC)-BIFI. 01/01/05
- Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos. Subdirector. 31/12/02 - 01/02/15
- Universidad de Zaragoza. Instituto de Biocomputación y física de Sistemas Complejos de la Universidad de Zaragoza. 01/01/02 - 31/12/02
- Sociedad Española de Bioquímica y Biología Molecular. Coordinador del grupo de Estructura y Función de Proteínas de la SEBBM. 01/01/01 - 01/01/04
Otros méritos
- Premio Bruker de la Sociedad Española de Biofísica. 01/01/04
- Premio extraordinario de Doctorado de la Universidad de Zaragoza. 01/01/90
- Premio extraordinario de Licenciatura de la Universidad de Zaragoza. 01/01/85
- Premio extraordinario de Licenciatura de la Caja de Ahorros de la Inmaculada. 01/01/85
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