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5 Sexenios reconocidos (último tramo finaliza 31/12/2021).
Tesis doctorales dirigidas: 13 (9 en los últimos diez años).
Artículos totales: 102 (ver abajo listado de los últimos diez años).
Artículos indexados: 102 (Web of Science); 93 (PubMed/MEDLINE).
Citas totales: 11136. Citas excluyendo autocitas: 10890
Citas totales/año en el periodo 2018-2021: 384 citas/año
Publicaciones en Q1: 72
Journal articles
- Luengo, Andres; Marzo, Isabel; Fernandez-Moreira, Vanesa; Gimeno, M. Concepcion. Synthesis and antiproliferative study of phosphorescent multimetallic Re(I)/Au(I) complexes containing fused imidazo[4, 5-f]-1, 10-phenanthroline core. APPLIED ORGANOMETALLIC CHEMISTRY. 2022. DOI: 10.1002/aoc.6661
- Allende-Vega, Nerea; Marco Brualla, Joaquin; Falvo, Paolo; Alexia, Catherine; Constantinides, Michael; Maudave, Alexis Fayd’herbe De; Coenon, Lois; Gitenay, Delphine; Mitola, Giulia; Massa, Paul; Orecchioni, Stefania; Bertolini, Francesco; Marzo, Isabel; Anel, Alberto; Villalba, Martin. Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1). SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2022. DOI: 10.1038/s41598-022-05470-x
- Reina-Ortiz, Chantal; Giraldos, David; Azaceta, Gemma; Palomera, Luis; Marzo, Isabel; Naval, Javier; Villalba, Martín; Anel, Alberto. Harnessing the potential of NK cell-based immunotherapies against multiple myeloma. CELLS. 2022. DOI: 10.3390/cells11030392
- Akesolo, Olaia; Buey, Berta; Beltrán-Visiedo, Manuel; Giraldos, David; Marzo, Isabel; Latorre, Eva. Toll-like receptors: New targets for multiple myeloma treatment?. BIOCHEMICAL PHARMACOLOGY. 2022. DOI: 10.1016/j.bcp.2022.114992
- Canudo-Barreras G.; Ortego L.; Izaga A.; Marzo Rubio I.; Herrera R.P.; Gimeno M.C. Synthesis of new thiourea-metal complexes with promising anticancer properties. MOLECULES. 2021. DOI: 10.3390/molecules26226891
- Serrano-del Valle A.; Reina-Ortiz C.; Benedi A.; Anel A.; Naval J.; Marzo I. Future prospects for mitosis-targeted antitumor therapies. BIOCHEMICAL PHARMACOLOGY. 2021. DOI: 10.1016/j.bcp.2021.114655
- Redrado M.; Benedi A.; Marzo I.; Gimeno M.C.; Fernández-Moreira V. Dual emissive ir(Iii) complexes for photodynamic therapy and bioimaging. PHARMACEUTICS. 2021. DOI: 10.3390/pharmaceutics13091382
- Redrado M.; Benedi A.; Marzo I.; García-Otín A.L.; Fernández-Moreira V.; Gimeno M. Concepción. Multifunctional heterometallic Iriii-Aui probes as promising anticancer and antiangiogenic agents. CHEMISTRY - A EUROPEAN JOURNAL. 2021. DOI: 10.1002/chem.202100707
- Reina-Ortiz, C.; Constantinides, M.; Fayd-Herbe-De-Maudave, A.; Présumey, J.; Hernandez, J.; Cartron, G.; Giraldos, D.; Díez, R.; Izquierdo, I.; Azaceta, G.; Palomera, L.; Marzo, I.; Naval, J.; Anel, A.; Villalba, M. Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients. ONCOIMMUNOLOGY. 2021. DOI: 10.1080/2162402X.2020.1853314
- Johnson, Alice; Marzo, Isabel; Gimeno, M. Concepción. Heterobimetallic propargyl gold complexes with p-bound copper or silver with enhanced anticancer activity. DALTON TRANSACTIONS. 2020. DOI: 10.1039/d0dt02113j
- Luengo, A.; Redrado, M.; Marzo, I.; Fernández-Moreira, V.; Gimeno, M.C. Luminescent Re(I)/Au(I) Species As Selective Anticancer Agents for HeLa Cells. INORGANIC CHEMISTRY. 2020. DOI: 10.1021/acs.inorgchem.0c00813
- Serrano-del Valle, A.; Naval, J.; Anel, A.; Marzo, I. Novel Forms of Immunomodulation for Cancer Therapy. TRENDS IN CANCER. 2020. DOI: 10.1016/j.trecan.2020.02.015
- Calvo, T.; Reina-Ortiz, C.; Giraldos, D.; Gascón, M.; Woods, D.; Asenjo, J.; Marco-Brualla, J.; Azaceta, G.; Izquierdo, I.; Palomera, L.; Sánchez-Martínez, D.; Marzo, I.; Naval, J.; Vilches, C.; Villalba, M.; Anel, A. Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2020. DOI: 10.1038/s41598-020-76051-z
- Luengo, A.; Marzo, I.; Reback, M.; Daubit, I.M.; Fernández-Moreira, V.; Metzler-Nolte, N.; Gimeno, M.C. Luminescent Bimetallic IrIII /AuI Peptide Bioconjugates as Potential Theranostic Agents. CHEMISTRY - A EUROPEAN JOURNAL. 2020. DOI: 10.1002/chem.202002067
- Auria-Luna, F.; Marqués-López, E.; Romanos, E.; Fernández-Moreira, V.; Gimeno, M.C.; Marzo, I.; Herrera, R.P. Novel ureido-dihydropyridine scaffolds as theranostic agents. BIOORGANIC CHEMISTRY. 2020. DOI: 10.1016/j.bioorg.2020.104364
- de la Cueva-Alique, I.; Sierra, S.; Pérez-Redondo, A.; Marzo, I.; Gude, L.; Cuenca, T.; Royo, E. Study of the anticancer properties of optically active titanocene oximato compounds. JOURNAL OF ORGANOMETALLIC CHEMISTRY. 2019. DOI: 10.1016/j.jorganchem.2018.12.011
- Fernández-Moreira, V.; Val-Campillo, C.; Ospino, I.; Herrera, R.P.; Marzo, I.; Laguna, A.; Gimeno, M.C. Bioactive and luminescent indole and isatin based gold(i) derivatives. DALTON TRANSACTIONS. 2019. DOI: 10.1039/c8dt00298c
- Serrano del Valle, Alfonso; Anel, Alberto; Naval, Javier; Marzo, Isabel. Immunogenic cell death and immunotherapy of multiple myeloma. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2019. DOI: 10.3389/fcell.2019.00050
- de la Cueva-Alique, I.; Sierra, S.; Muñoz-Moreno, L.; Pérez-Redondo, A.; Bajo, A.M.; Marzo, I.; Gude, L.; Cuenca, T.; Royo, E. Biological evaluation of water soluble arene Ru(II) enantiomers with amino-oxime ligands. JOURNAL OF INORGANIC BIOCHEMISTRY. 2018. DOI: 10.1016/j.jinorgbio.2018.02.018
- Johnson, A.; Marzo, I.; Gimeno, M.C. Ylide Ligands as Building Blocks for Bioactive Group 11 Metal Complexes. CHEMISTRY - A EUROPEAN JOURNAL. 2018. DOI: 10.1002/chem.201801600
- Luengo, A.; Fernández-Moreira, V.; Marzo, I.; Gimeno, M.C. Bioactive Heterobimetallic Re(I)/Au(I) Complexes Containing Bidentate N-Heterocyclic Carbenes. ORGANOMETALLICS. 2018. DOI: 10.1021/acs.organomet.8b00601
- Opydo-Chanek, M.; Gonzalo, O.; Marzo, I. Multifaceted anticancer activity of BH3 mimetics: Current evidence and future prospects. BIOCHEMICAL PHARMACOLOGY. 2017. DOI: 10.1016/j.bcp.2017.03.006
- Salvador-Gil, D.; Ortego, L.; Herrera, R.P.; Marzo, I.; Gimeno, M.C. Highly active group 11 metal complexes with a-hydrazidophosphonate ligands. DALTON TRANSACTIONS. 2017. DOI: 10.1039/c7dt02743e
- Luengo, A.; Fernández-Moreira, V.; Marzo, I.; Gimeno, M.C. Trackable Metallodrugs Combining Luminescent Re(I) and Bioactive Au(I) Fragments. INORGANIC CHEMISTRY. 2017. DOI: 10.1021/acs.inorgchem.7b02470
- Fernández-Moreira, V.; Alegre-Requena, J.; Herrera, R. P.; Marzo, I.; Gimeno, M. C. Synthesis of luminescent squaramide monoesters: Cytotoxicity and cell imaging studies in HeLa cells. RSC ADVANCES. 2016. DOI: 10.1039/c5ra24521d
- Jarauta, V.;Jaime, P.;Gonzalo, O.;de Miguel, D.;Ramírez-Labrada, A.;Martínez-Lostao, L.;Anel, A.;Pardo, J.;Marzo, I.;Naval, J. Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo. CANCER LETTERS. 2016. DOI: 10.1016/j.canlet.2016.08.019
- Visbal, R.; Fernandez-Moreira, V.; Marzo, I.; Laguna, A.; Gimeno, M.C. Cytotoxicity and biodistribution studies of luminescent Au(I) and Ag(I) N-heterocyclic carbenes. Searching for new biological targets. DALTON TRANSACTIONS. 2016. DOI: 10.1039/c6dt02878k
- Miguel, D. De; Gallego-Lleyda, A.; Ayuso, J. M.; Pejenaute-Ochoa, D.; Jarauta, V.; Marzo, I.; Fernández, L. J.; Ochoa, I.; Conde, B.; Anel, A.; Martinez-Lostao, L. High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancer. CANCER LETTERS. 2016. DOI: 10.1016/j.canlet.2016.10.005
- Benito, Juliana M.; Godfrey, Laura; Kojima, Kensuke; Hogdal, Leah; Wunderlich, Mark; Geng, Huimin; Marzo, Isabel; Harutyunyan, Karine G.; Golfman, Leonard; North, Phillip; Kerry, Jon; Ballabio, Erica; Chonghaile, Triona Ní; Gonzalo, Oscar; Qiu, Yihua; Jeremias, Irmela; Debose, Lakiesha; O\u2019brien, Eric; Ma, Helen; Zhou, Ping; Jacamo, Rodrigo; Park, Eugene; Coombes, Kevin R.; Zhang, Nianxiang; Thomas, Deborah A.; O\u2019brien, Susan; Kantarjian, Hagop M.; Leverson, Joel D.; Kornblau, Steven M.; Andreeff, Michael; Müschen, Markus; Zweidler-Mckay, Patrick A.; Mulloy, James C.; Letai, Anthony; Milne, Thomas A.; Konopleva, Marina. MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199. CELL REPORTS. 2015. DOI: 10.1016/j.celrep.2015.12.003
- Ramirez-Labrada, A; Lopez-Royuela, N; Jarauta, V; Galan-Malo, P; Azaceta, G; Palomera, L; Pardo, J; Anel, A; Marzo, I; Naval, J. Two death pathways induced by sorafenib in myeloma cells: Puma-mediated apoptosis and necroptosis. CLINICAL AND TRANSLATIONAL ONCOLOGY. 2015. DOI: 10.1007/s12094-014-1201-y
- Frik, Malgorzata ; Fernández-Gallardo, Jacob; Gonzalo, Óscar; Mangas-Sanjuan, Víctor; González-Alvarez, Marta; Serrano del Valle, Alfonso; Hu, Chunhua; González-Alvarez, Isabel; Bermejo, Marival; Marzo, Isabel; Contel, María. Cyclometalated Iminophosphorane Gold(III) and Platinum(II) Complexes. A Highly Permeable Cationic Platinum(II) Compound with Promising Anticancer Properties. JOURNAL OF MEDICINAL CHEMISTRY. 2015. DOI: 10.1021/acs.jmedchem.5b00427
- Vela, L.;Marzo, I. Bcl-2 family of proteins as drug targets for cancer chemotherapy: the long way of BH3 mimetics from bench to bedside. CURRENT OPINION IN PHARMACOLOGY. 2015. DOI: 10.1016/j.coph.2015.05.014
- de Miguel, D.; Gallego-Lleyda, A.; Galan-Malo, P.; Rodriguez-Vigil, C.; Marzo, I.; Anel, A.; Martinez-Lostao, L. Immunotherapy with liposome-bound TRAIL overcomes partial protection to soluble TRAIL-induced apoptosis offered by down-regulation of Bim in leukemic cells. CLINICAL AND TRANSLATIONAL ONCOLOGY. 2015. DOI: 10.1007/s12094-015-1295-x
- Sanchez-Martínez, D; Azaceta, G; Muntasell, A; Aguiló, N; Núñez, D; Gálvez, Em; Naval, J; Anel, A; Palomera, L; Vilches, C;Marzo, I; Villalba, M; Pardo, J. Human NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in hematological cancer cells. ONCOIMMUNOLOGY. 2015. DOI: 10.4161/2162402X.2014.991613
- Gutiérrez, A.; Marzo, I.; Cativiela, C.; Laguna, A.; Gimeno, M. C. Highly Cytotoxic Bioconjugated Gold(I) Complexes with Cysteine-Containing Dipeptides. CHEMISTRY - A EUROPEAN JOURNAL. 2015. DOI: 10.1002/chem.201501458
- Aporta, A; Catalán, E; Galán-Malo, P; Ramírez-Labrada, A; Pérez, M; Azaceta, G; Palomera, L; Naval, J; Marzo, I; Pardo, J; Anel, A . Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors. BIOCHEMICAL PHARMACOLOGY. 2014. DOI: 10.1016/j.bcp.2013.11.004
- Gutiérrez, A.; Gimeno, M. C.; Marzo, I.; Metzler-Nolte, N. Synthesis, characterization, and cytotoxic activity of auI n, s-heterocyclic carbenes derived from peptides containing l -thiazolylalanine. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. 2014. DOI: 10.1002/ejic.201402103
- Fernández-Moreira, V.; Marzo, I.; Gimeno, M. C. Luminescent Re(i) and Re(i)/Au(i) complexes as cooperative partners in cell imaging and cancer therapy. CHEMICAL SCIENCE. 2014. DOI: 10.1039/c4sc01684j
- Gutiérrez,A.; Gracia-Fleta,L.; Marzo,I.; Cativiela,C.; Laguna,A.; Gimeno,M. C. Gold(i) thiolates containing amino acid moieties. Cytotoxicity and structure-activity relationship studies. DALTON TRANSACTIONS. 2014. DOI: 10.1039/c4dt02299h
- Frik,M.; Martínez,A.; Elie,B. T.; Gonzalo,O.; Ramírez de Mingo,D.; Sanaú,M.; Sánchez-Delgado,R.; Sadhukha,T.; Prabha,S.; Ramos,J. W.; Marzo,I.; Contel,M. In vitro and in vivo evaluation of water-soluble iminophosphorane ruthenium(II) compounds. A potential chemotherapeutic agent for triple negative breast cancer. JOURNAL OF MEDICINAL CHEMISTRY. 2014. DOI: 10.1021/jm5012337
- Vela,L.;Gonzalo,O.;Naval,J.;Marzo,I. Direct interaction of bax and bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation. JOURNAL OF BIOLOGICAL CHEMISTRY. 2013. DOI: 10.1074/jbc.M112.422204
- de Miguel, D.; Basáñez, G.; Sánchez, D.; Galán-Malo, P.; Marzo, I.; Larrad, L.; Naval, J.; Pardo, J.; Anel, A.; Martinez Lostao, L. Liposomes decorated with Apo2L/TRAIL overcome chemoresistance of human hematologic tumor cells. MOLECULAR PHARMACEUTICS. 2013. DOI: 10.1021/mp300258c
- Sanchez, D; Azaceta, G; Muntasell, A; Moraru, M; Cisneros, E; Núñez, D; Gálvez, Em; Marzo, I; Palomera, L; Lopez-Botet, M; Vilches, C; Pardo, J. Human NK cells activated in the absence of exogenous cytokines kill B chronic lymphocytic leukemia (B-CLL) cells and overcome apoptosis resistance in hematological neoplasias. INMUNOLOGIA. 2013
- Marzo,I.;Naval,J. Antimitotic drugs in cancer chemotherapy: Promises and pitfalls. BIOCHEMICAL PHARMACOLOGY. 2013. DOI: 10.1016/j.bcp.2013.07.010
- Carreira,M.;Calvo-Sanjuán,R.;Sanaú,M.;Zhao,X.;Magliozzo,R. S.;Marzo,I.;Contel,M. Cytotoxic hydrophilic iminophosphorane coordination compounds of d 8 metals. Studies of their interactions with DNA and HSA. JOURNAL OF INORGANIC BIOCHEMISTRY. 2012. DOI: 10.1016/j.jinorgbio.2012.06.017
- Carreira,M.;Calvo-Sanjuán,R.;Sanaú,M.;Marzo,I.;Contel,M. Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents. ORGANOMETALLICS. 2012. DOI: 10.1021/om3006239
- Martinez-Lostao,L.;Marzo,I.;Anel,A.;Naval,J. Targeting the Apo2L/TRAIL system for the therapy of autoimmune diseases and cancer. BIOCHEMICAL PHARMACOLOGY. 2012. DOI: 10.1016/j.bcp.2011.12.036
- Balsas,P.;Galán-Malo,P.;Marzo,I.;Naval,J. Bortezomib resistance in a myeloma cell line is associated to PSM 5 overexpression and polyploidy. LEUKEMIA RESEARCH. 2012. DOI: 10.1016/j.leukres.2011.09.011
- Galâ·n-Malo, P.;Vela, L.;Gonzalo, O.;Calvo-Sanjuâ·n, R.;Gracia-Fleta, L.;Naval, J.;Marzo, I. Cell fate after mitotic arrest in different tumor cells is determined by the balance between slippage and apoptotic threshold. TOXICOLOGY AND APPLIED PHARMACOLOGY. 2012. DOI: 10.1016/j.taap.2011.11.021
- Vela, Laura; Contel, María; Palomera, Luis; Azaceta, Gemma; Marzo, Isabel. Iminophosphorane-organogold(III) complexes induce cell death through mitochondrial ROS production. JOURNAL OF INORGANIC BIOCHEMISTRY. 2011. DOI: 10.1016/j.jinorgbio.2011.06.004
- Lavilla, M.; Marzo, I.; de Luis, R.; Perez, M.D.; Calvo, M.; Sánchez, L. Detection of Clostridium tyrobutyricumspores using polyclonal antibodies and flow cytometry. JOURNAL OF APPLIED MICROBIOLOGY. 2010. DOI: 10.1111/j.1365-2672.2009.04435.x
- López-Royuela, Nuria; Balsas, Patricia; Galán-Malo, Patricia; Anel, Alberto; Marzo, Isabel; Naval, Javier. Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells. BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - MOLECULAR CELL RESEARCH. 2010. DOI: 10.1016/j.bbamcr.2009.11.004
- López-Royuela, Nuria; Pérez-Galán, Patricia; Galán-Malo, Patricia; Yuste, Victor J.; Anel, Alberto; Susín, Santos A.; Naval, Javier; Marzo, Isabel. Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells. BIOCHEMICAL PHARMACOLOGY. 2010. DOI: 10.1016/j.bcp.2010.02.010
- Balsas, Patricia; López-Royuela, Nuria; Galán-Malo, Patricia; Anel, Alberto; Marzo, Isabel; Naval, Javier. Cooperation between Apo2LTRAIL and bortezomib in multiple myeloma apoptosis. BIOCHEMICAL PHARMACOLOGY. 2009. DOI: 10.1016/j.bcp.2008.11.024
- Marzo, Isabel; Naval, Javier. Bcl-2 family members as molecular targets in cancer therapy. BIOCHEMICAL PHARMACOLOGY. 2008. DOI: 10.1016/j.bcp.2008.06.009
- Lamarca, V; Marzo, I; Sanzclemente, A; Carrodeguas, J. Exposure of any of two proapoptotic domains of presenilin 1-associated proteinmitochondrial carrier homolog 1 on the surface of mitochondria is sufficient for induction of apoptosis in a BaxBak-independent manner. EUROPEAN JOURNAL OF CELL BIOLOGY. 2008. DOI: 10.1016/j.ejcb.2008.02.004
- Martín-Fuentes, Paula; Civeira, Fernando; Recalde, Delia; García-Otín, Angel Luis; Jarauta, Estíbaliz; Marzo, Isabel; Cenarro, Ana. Individual Variation of Scavenger Receptor Expression in Human Macrophages with Oxidized Low-Density Lipoprotein Is Associated with a Differential Inflammatory Response. THE JOURNAL OF IMMUNOLOGY. 2007. DOI: 10.4049/jimmunol.179.5.3242
- Orzáez, Mar; Mondragón, Laura; Marzo, Isabel; Sanclimens, Gloria; Messeguer, Angel; Pérez-Payá, Enrique; Vicent, María J. Conjugation of a novel Apaf-1 inhibitor to peptide-based cell-membrane transporters:. PEPTIDES. 2007. DOI: 10.1016/j.peptides.2007.02.014
- Gómez-Benito, Maria; Martinez-Lorenzo, Maria José; Anel, Alberto; Marzo, Isabel; Naval, Javier. Membrane expression of DR4, DR5 and caspase-8 levels, but not Mcl-1, determine sensitivity of human myeloma cells to Apo2LTRAIL. EXPERIMENTAL CELL RESEARCH. 2007. DOI: 10.1016/j.yexcr.2007.03.018
- Bosque, Alberto; Marzo, Isabel; Naval, Javier; Anel, Alberto. Apoptosis by IL-2 deprivation in human CD8+ T cell blasts predominates over death receptor ligation, requires Bim expression and is associated with Mcl-1 loss. MOLECULAR IMMUNOLOGY. 2007. DOI: 10.1016/j.molimm.2006.04.029
- Gómez-Benito, Maria; Balsas, Patricia; Carvajal-Vergara, Xonia; Pandiella, Atanasio; Anel, Alberto; Marzo, Isabel; Naval, Javier. Mechanism of apoptosis induced by IFN-a in human myeloma cells: Role of Jak1 and Bim and potentiation by rapamycin. CELLULAR SIGNALLING. 2007. DOI: 10.1016/j.cellsig.2006.10.009
- Gómez-Benito, María; Marzo, Isabel; Anel, Alberto; Naval, Javier. Farnesyltransferase Inhibitor BMS-214662 Induces Apoptosis in Myeloma Cells through PUMA Up-Regulation, Bax and Bak Activation, and Mcl-1 Elimination. MOLECULAR PHARMACOLOGY. 2005. DOI: 10.1124/mol.104.007021
- Bosque, Alberto; Pardo, Julián; Martínez-Lorenzo, María José; Lasierra, Pilar; Larrad, Luis; Marzo, Isabel; Naval, Javier; Anel, Alberto. Human CD8+ T cell blasts are more sensitive than CD4+ T cell blasts to regulation by APO2L/TRAIL. EUROPEAN JOURNAL OF IMMUNOLOGY. 2005. DOI: 10.1002/eji.200526046
- Gómez-Benito, Maria; Balsas, Patricia; Bosque, Alberto; Anel, Alberto; Marzo, Isabel; Naval, Javier. Apo2LTRAIL is an indirect mediator of apoptosis induced by interferon-a in human myeloma cells. FEBS LETTERS. 2005. DOI: 10.1016/j.febslet.2005.10.007
- Bosque, Alberto; Pardo, Julián; Martínez-Lorenzo, M\u00aa José; Iturralde, María; Marzo, Isabel; Piñeiro, Andrés; Alava, M\u00aa Angeles; Naval, Javier; Anel, Alberto. Down-regulation of normal human T cell blast activation: roles of APO2LTRAIL, FasL, and c- FLIP, Bim, or Bcl-x isoform expression. JOURNAL OF LEUKOCYTE BIOLOGY. 2005. DOI: 10.1189/jlb.0904514
- Marzo, I; Pérez-Galán, P; Giraldo, P; López-Royuela, N; Gómez-Benito, M; Larrad, L; Lasierra, P; Rubio-Félix, D; Anel, A; Naval, J. Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells. LEUKEMIA. 2004. DOI: 10.1038/sj.leu.2403469
- Pérez-Galán, P; Marzo, I; Giraldo, P; Rubio-Félix, D; Lasierra, P; Larrad, L; Anel, A; Naval, J. Role of caspases and apoptosis-inducing factor (AIF) in cladribine-induced apoptosis of B cell chronic lymphocytic leukemia. LEUKEMIA. 2002. DOI: 10.1038/sj.leu.2402650
- Pardo, Julián; Pérez-Galán, Patricia; Gamen, Susana; Marzo, Isabel; Monleón, Inmaculada; Kaspar, Allan A.; Susín, Santos A.; Kroemer, Guido; Krensky, Alan M.; Naval, Javier; Anel, Alberto. A Role of the Mitochondrial Apoptosis-Inducing Factor in Granulysin-Induced Apoptosis. THE JOURNAL OF IMMUNOLOGY. 2001. DOI: 10.4049/jimmunol.167.3.1222
- Marzo, Isabel; Pérez-Galán, Patricia; Giraldo, Pilar; Rubio-Félix, Daniel; Anel, Alberto; Naval, Javier. Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria. BIOCHEMICAL JOURNAL. 2001. DOI: 10.1042/0264-6021:3590537
- Brenner, Catherine; Cadiou, Hervé; Vieira, Helena La; Zamzami, Naoufal; Marzo, Isabel; Xie, Zhihua; Leber, Brian; Andrews, David; Duclohier, Hervé; Reed, John C; Kroemer, Guido. Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. ONCOGENE. 2000. DOI: 10.1038/sj.onc.1203298
- Brenner, Catherine; Marzo, Isabel; de Araujo Vieira, Helena L.; Kroemer, Guido. Purification and Liposomal Reconstitution of Permeability Transition Pore Complex. METHODS IN ENZYMOLOGY. 2000. DOI: 10.1016/s0076-6879(00)22025-9
- Larochette, Nathanael; Decaudin, Didier; Jacotot, Etienne; Brenner, Catherine; Marzo, Isabel; Susin, Santos A.; Zamzami, Naoufal; Xie, Zhihua; Reed, John; Kroemer, Guido. Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore. EXPERIMENTAL CELL RESEARCH. 1999. DOI: 10.1006/excr.1999.4519
- Susin, Santos A.; Lorenzo, Hans K.; Zamzami, Naoufal; Marzo, Isabel; Snow, Bryan E.; Brothers, Greg M.; Mangion, Joan; Jacotot, Etienne; Costantini, Paola; Loeffler, Markus; Larochette, Nathanael; Goodlett, David R.; Aebersold, Ruedi; Siderovski, David P.; Penninger, Josef M.; Kroemer, Guido. Molecular characterization of mitochondrial apoptosis-inducing factor. NATURE. 1999. DOI: 10.1038/17135
- Susin, Santos A.; Lorenzo, Hans K.; Zamzami, Naoufal; Marzo, Isabel; Brenner, Catherine; Larochette, Nathanael; Prévost, Marie-Christine; Alzari, Pedro M.; Kroemer, Guido. Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process. JOURNAL OF EXPERIMENTAL MEDICINE. 1999. DOI: 10.1084/jem.189.2.381
- Ravagnan, Luigi; Marzo, Isabel; Costantini, Paola; Susin, Santos A; Zamzami, Naoufal; Petit, Patrice X; Hirsch, François; Goulbern, Marc; Poupon, Marie-France; Miccoli, Laurent; Xie, Zhihua; Reed, John C; Kroemer, Guido. Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore. ONCOGENE. 1999. DOI: 10.1038/sj.onc.1202625
- Marzo, I.; Piñeiro, A.; Naval, J. Loss of delta-6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. PROSTAGLANDINS, LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 1998. DOI: 10.1016/S0952-3278(98)90076-X
- Marzo, Isabel; Brenner, Catherine; Zamzami, Naoufal; Susin, Santos A.; Beutner, Gisela; Brdiczka, Dieter; Rémy, René; Xie, Zhi-Hua; Reed, John C.; Kroemer, Guido. The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2-related Proteins. JOURNAL OF EXPERIMENTAL MEDICINE. 1998. DOI: 10.1084/jem.187.8.1261
- Hirsch, T; Dallaporta, B; Zamzami, N; Susin, Sa; Ravagnan, L; Marzo Rubio, Isabel; Brenner, C; Kroemer, G. Proteasome activation occurs at an early, premitochondrial step of thymocyte apoptosis. THE JOURNAL OF IMMUNOLOGY. 1998
- Dallaporta, B; Hirsch, T; Susin, Sa; Zamzami, N; Larochette, N; Brenner, C; Marzo Rubio, Isabel; Kroemer, G. Potassium leakage during the apoptotic degradation phase. THE JOURNAL OF IMMUNOLOGY. 1998
- Decaudin, D; Marzo Rubio, Isabel; Brenner, C; Kroemer, G. Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy. INTERNATIONAL JOURNAL OF ONCOLOGY. 1998
- Jacotot, E.; Kroemer, G.; Marzo Rubio, Isabel. Mitochondria, a director of cellular death. BIOFUTUR. 1998
- Marzo, Isabel; Susin, Santos A; Petit, Patrice X; Ravagnan, Luigi; Brenner, Catherine; Larochette, Nathanael; Zamzami, Naoufal; Kroemer, Guido. Caspases disrupt mitochondrial membrane barrier function. FEBS LETTERS. 1998. DOI: 10.1016/s0014-5793(98)00424-4
- Zamzami, Naoufal; Brenner, Catherine; Marzo, Isabel; Susin, Santos A; Kroemer, Guido. Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins. ONCOGENE. 1998. DOI: 10.1038/sj.onc.1201989
- Zamzami, Naoufal; Marzo, Isabel; Susin, Santos A; Brenner, Catherine; Larochette, Nathanael; Marchetti, Philippe; Reed, John; Kofler, Reinhard; Kroemer, Guido. The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition. ONCOGENE. 1998. DOI: 10.1038/sj.onc.1201864
- Brenner, C.; Marzo, I.; Zamzami, N.; Susin, Sa.; Vieira, Hla.; Kroemer, G. Cooperation between the proapoptotic protein Bax and the adenine nucleotide translocator for the mitochondrial control of apoptosis. M S-MEDECINE SCIENCES. 1998. DOI: 10.4267/10608/981
- Brenner, C.; Marzo Rubio, Isabel; Kroemer, G. A revolution in apoptosis: from a nucleocentric to a mitochondriocentric perspective. EXPERIMENTAL GERONTOLOGY. 1998. DOI: 10.1016/s0531-5565(98)00025-4
- Marzo, I; Brenner, C; Kroemer, G. The central role of the mitochondrial megachannel in apoptosis: evidence obtained with intact cells, isolated mitochondria, and purified protein complexes. BIOMEDICINE & PHARMACOTHERAPY. 1998. DOI: 10.1016/S0753-3322(98)80009-7
- Marzo, I. Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis. SCIENCE. 1998. DOI: 10.1126/science.281.5385.2027
- Métivier, Didier; Dallaporta, Bruno; Zamzami, Naoufal; Larochette, Nathanael; Susin, Santos A; Marzo, Isabel; Kroemer, Guido. Cytofluorometric detection of mitochondrial alterations in early CD95FasAPO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes. IMMUNOLOGY LETTERS. 1998. DOI: 10.1016/S0165-2478(98)00013-3
- Hirsch, T.; Susin, S.A.; Marzo, I.; Marchetti, P.; Zamzami, N.; Kroemer, G. Mitochondrial permeability transition in apoptosis and necrosis. CELL BIOLOGY AND TOXICOLOGY. 1998. DOI: 10.1023/A:1007486022411
- Susin, Santos A.; Zamzami, Naoufal; Larochette, Nathanael; Dallaporta, Bruno; Marzo, Isabel; Brenner, Catherine; Hirsch, Tamara; Petit, Patrice X.; Geuskens, Maurice; Kroemer, Guido. A Cytofluorometric Assay of Nuclear Apoptosis Induced in a Cell-Free System: Application to Ceramide-Induced Apoptosis. EXPERIMENTAL CELL RESEARCH. 1997. DOI: 10.1006/excr.1997.3733
- Hirsch, Tamara; Marchetti, Philippe; Susin, Santos A; Dallaporta, Bruno; Zamzami, Naoufal; Marzo, Isabel; Geuskens, Maurice; Kroemer, Guido. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. ONCOGENE. 1997. DOI: 10.1038/sj.onc.1201324
- Macho, A; Hirsh, T; Marzo Rubio, Isabel; Marchetti, P; Dallaporta, B; Susin, S; Zamzami, N; Kroemer, G. Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis. THE JOURNAL OF IMMUNOLOGY. 1997
- Hortelano, Sonsoles; Dallaporta, Bruno; Zamzami, Naoufal; Hirsch, Tamara; Susin, Santos A; Marzo, Isabel; Boscá, Lisardo; Kroemer, Guido. Nitric oxide induces apoptosis via triggering mitochondrial permeability transition. FEBS LETTERS. 1997. DOI: 10.1016/S0014-5793(97)00623-6
- Hirsch, Tamara; Marzo, Isabel; Kroemer, Guido. Role of the Mitochondrial Permeability Transition Pore in Apoptosis. BIOSCIENCE REPORTS. 1997. DOI: 10.1023/A:1027339418683
- Gamen, Susana; Marzo, Isabel; Anel, Alberto; Piñeiro, Andrés; Naval, Javier. CPP32 inhibition prevents Fas-induced ceramide generation and apoptosis in human cells. FEBS LETTERS. 1996. DOI: 10.1016/0014-5793(96)00666-7
- Marzo, Isabel; Alava, María A.; Piñeiro, Andrés; Naval, Javier. Biosynthesis of docosahexaenoic acid in human cells: evidence that two different \u03946-desaturase activities may exist. BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - LIPIDS AND LIPID METABOLISM. 1996. DOI: 10.1016/0005-2760(96)00051-3
- Gamen, Susana; Anel, Alberto; Montoya, Julio; Marzo, Isabel; Piñeiro, Andrés; Naval, Javier. mtDNA-depleted U937 cells are sensitive to TNF and Fas-mediated cytototxicity. FEBS LETTERS. 1995. DOI: 10.1016/0014-5793(95)01236-1
- Marzo, Isabel; Martínez-Lorenzo, María J.; Anel, Alberto; Desportes, Paula; Alava, María A.; Naval, Javier; Piñeiro, Andrés. Biosynthesis of unsaturated fatty acids in the main cell lineages of human leukemia and lymphoma. BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - LIPIDS AND LIPID METABOLISM. 1995. DOI: 10.1016/0005-2760(95)00064-J
- Martinezlorenzo, M.J.; Marzo, I.; Naval, J.; Pineiro, A. Self-Staining of Polyunsaturated Fatty Acids in Argentation Thin-Layer Chromatography. ANALYTICAL BIOCHEMISTRY. 1994. DOI: 10.1006/abio.1994.1321
- Naval, J; Martínez-Lorenzo, M J; Marzo, I; Desportes, P; Piñeiro, A. Alternative route for the biosynthesis of polyunsaturated fatty acids in K562 cells. BIOCHEMICAL JOURNAL. 1993. DOI: 10.1042/bj2910841
Conference presentations
- Reina-Ortiz, C.; Ewing, T.; Serrano del Valle, A.; Marco-Brualla, J.; Izquierdo, I.; Azaceta, G.; Palomera, L.; Marzo, I.; Naval, J.; Anel, A. Expansion of human NK cells for the treatment of multiple myeloma. CELL DEATH DISCOVERY. 2019. DOI: 10.1038/s41420-018-0128-4
- Poves, Lv.; Naval, J.; Marzo Rubio, Isabel. Visualizing interactions between Bcl-2 proteins in living cells by fluorescence complementation. FEBS JOURNAL. 2012
Projects
- PID2019-105128RB-I00: Buscando combinaciones antitumorales eficientes: inhibidores metabólicos y de tirosín quinasas, quimioterapia inmunogénica y células NK alogénicas. 01/06/20 - 30/11/23
- B31_20R: Inmunidad, Cáncer Y Células Madre. 01/01/20 - 31/12/22
- LMP98_18: EVALUACIÓN PRECLÍNICA DE LA COMBINACIÓN DE INHIBIDORES DE PROTÉINAS ANTIAPOPTÓTICAS CON FÁRMACOS ANTIMOTÓTICOS COMO TERAPIA ANTITUMORAL. 01/09/18 - 30/11/20
PhD supervision
- Estudio de la apoptosis inducida por el inhibidor de farnesiltransferasas BMS-214662, APO2L/TRAIL e interferón-alfa en el mieloma múltiple humano. Aplicaciones terapeúticas. Universidad de Zaragoza. Sobresaliente "Cum Laude". 10/11/06
UNIZAR teaching of the last six courses
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