Perfil (CV) del personal docente investigador

Herguedas Frances, Beatriz
Departamento: Departamento de Bioquímica y Biología Molecular y Celular
Área: Bioquímica y Biología Molecular
Centro: Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos

Research Institute: INSTITUTO DE BIOCOMPUTACIÓN Y FÍSICA DE SISTEMAS COMPLEJOS (BIFI)
Grupo: B49_23R: NeuroBioSys - Molecular Neurobiology and Systems Biology
Categoría profesional: Investigador Ramón y Cajal
ORCID: 0000-0003-2044-4795

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Artículos

  • Lee, Ji Young; Krieger, James; Herguedas, Beatriz; García-Nafría, Javier; Dutta, Anindita; Shaikh, Saher A.; Greger, Ingo H.; Bahar, Ivet. Druggability Simulations and X-Ray Crystallography Reveal a Ligand-Binding Site in the GluA3 AMPA Receptor N-Terminal Domain. STRUCTURE. 2019. DOI: 10.1016/j.str.2018.10.017

  • Herguedas, Beatriz; Watson, Jake F.; Ho, Hinze; Cais, Ondrej; García-Nafría, Javier; Greger, Ingo H. Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP y8. SCIENCE. 2019. DOI: 10.1126/science.aav9011

  • Serrano, A.; Sebastián, M.; Arilla-Luna, S.; Baquedano, S.; Herguedas, B.; Velázquez-Campoy, A.; Martínez-Júlvez, M.; Medina, M. The trimer interface in the quaternary structure of the bifunctional prokaryotic FAD synthetase from Corynebacterium ammoniagenes. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2017. DOI: 10.1038/s41598-017-00402-6

  • Herguedas, Beatriz; García-Nafría, Javier; Cais, Ondrej; Fernández-Leiro, Rafael; Krieger, James; Ho, Hinze; Greger, Ingo H. Structure and organization of heteromeric AMPA-type glutamate receptors. SCIENCE. 2016. DOI: 10.1126/science.aad3873

  • García-Nafría, J.; Herguedas, B.; Watson, J. F.; Greger, I. H. The dynamic AMPA receptor extracellular region: a platform for synaptic protein interactions. JOURNAL OF PHYSIOLOGY-LONDON. 2016. DOI: 10.1113/JP271844

  • Ferreira, P.; Hernández-Ortega, A.; Lucas, F.; Carro, J.; Herguedas, B.; Borrelli, K. W.; Guallar, V.; Martínez, A. T.; Medina, M. Aromatic stacking interactions govern catalysis in aryl-alcohol oxidase. FEBS JOURNAL. 2015. DOI: 10.1111/febs.13221

  • Herguedas, Beatriz; Lans, Isaías; Sebastián, María; Hermoso, Juan; Martínez-Júlvez, Marta; Medina, Milagros. Structural insights into the synthesis of FMN in prokaryotic organisms. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY. 2015. DOI: 10.1107/S1399004715019641

  • Serrano, A.;Sebastián, M.;Arilla-Luna, S.;Baquedano, S.;Pallarés, M. C.;Lostao, A.;Herguedas, B.;Velázquez-Campoy, A.;Martínez-Júlvez, M.;Medina, M. Quaternary organization in a bifunctional prokaryotic FAD synthetase: Involvement of an arginine at its adenylyltransferase module on the riboflavin kinase activity. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2015. DOI: 10.1016/j.bbapap.2015.03.005

  • Sánchez-Azqueta,A.; Herguedas,B.; Hurtado-Guerrero,R.; Hervás,M.; Navarro,J. A.; Martínez-Júlvez,M.; Medina,M. A hydrogen bond network in the active site of Anabaena ferredoxin-NADP + reductase modulates its catalytic efficiency. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2014. DOI: 10.1016/j.bbabio.2013.10.010

  • Cais, Ondrej; Herguedas, Beatriz; Krol, Karolina; G.Cull-Candy, Stuard; Farrant, Marck; H.Greger, Ingo. Mapping the Interaction Sites between AMPA Receptors and TARPs Reveals a Role for the Receptor N-Terminal Domain in Channel Gating. CELL REPORTS. 2014. DOI: 10.1016/j.celrep.2014.09.029

  • Ferreira, P; Villanueva, R; Martínez-Júlvez, M; Herguedas, B; Marcuello, C; Fernandez-Silva, P; Cabon, L; Hermoso, J.A.; Lostao, A; Susin, S.A.; Medina, M. Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic Apoptosis Inducing Factor. BIOCHEMISTRY. 2014. DOI: 10.1021/bi500343r

  • Herguedas, Beatriz; Krieger, James; Greger, Ingo H. Receptor Heteromeric Assembly\u2014How It Works and Why It Matters. PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE. 2013. DOI: 10.1016/B978-0-12-386931-9.00013-1

  • Serrano,A.; Frago,S.; Herguedas,B.; Martinez-Julvez,M.; Velazquez-Campoy,A.; Medina,M. Key Residues at the Riboflavin Kinase Catalytic Site of the Bifunctional Riboflavin Kinase/FMN Adenylyltransferase From Corynebacterium ammoniagenes. CELL BIOCHEMISTRY AND BIOPHYSICS. 2013. DOI: 10.1007/s12013-012-9403-9

  • Herguedas Beatriz; Martínez-Júlvez Marta; Frago Susana; Medina Milagros; Hermoso Juan A. Oligomeric state in the crystal structure of modular FAD synthetase provides insights into its sequential catalysis in prokaryotes. JOURNAL OF MOLECULAR BIOLOGY. 2010. DOI: 10.1016/j.jmb.2010.05.018

  • Ferreira, P.; Hernandez-Ortega, A.; Herguedas, B.; Rencoret, J.; Gutierrez, A.; Martinez, M. J.; Jimenez-Barbero, J.; Medina, M.; Martinez, A. T. Kinetic and chemical characterization of aldehyde oxidation by fungal aryl-alcohol oxidase. BIOCHEMICAL JOURNAL. 2010. DOI: 10.1042/BJ20091499

  • Peregrina, J. R.;Sanchez-Azqueta, A.;Herguedas, B.;Martinez-Julvez, M. ;Medina, M. Role of specific residues in coenzyme binding, charge-transfer complex formation, and catalysis in Anabaena ferredoxin NADP+-reductase. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2010

  • Goñí, Guillermina; Herguedas, Beatriz; Hervás, Manuel; Peregrina, José R.; de la Rosa, Miguel A.; Gómez-Moreno, Carlos; Navarro, José A.; Hermoso, Juan A.; Martínez-Júlvez, Marta; Medina, Milagros . Flavodoxin: A compromise between efficiency and versatility in the electron transfer from Photosystem I to Ferredoxin-NADP(+) reductase. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2009. DOI: 10.1016/j.bbabio.2008.12.006

  • Herguedas, B.;Martinez-Julvez,M.;Frago,S.;Medina,M.;Hermoso,J. A. Crystallization and Preliminary X-Ray Diffraction Studies of FAD Synthetase from Corynebacterium Ammoniagenes. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009

  • Peregrina, José R.; Herguedas, Beatriz; Hermoso, Juan A.; Martínez-Júlvez, Marta; Medina, Milagros. Protein Motifs Involved in Coenzyme Interaction and Enzymatic Efficiency in Anabaena Ferredoxin-NADP+ Reductase. BIOCHEMISTRY. 2009. DOI: 10.1021/bi802077c

  • Ferreira, Patricia; Hernández-Ortega, Aitor; Herguedas, Beatriz; Martínez, Ángel T.; Medina, Milagros. Aryl-alcohol oxidase involved in lignin degradation. A mechanistic study based on steady and pre-steady state kinetics and primary and solvent isotope effects with two alcohol substrates. JOURNAL OF BIOLOGICAL CHEMISTRY. 2009. DOI: 10.1074/jbc.M109.011593

  • Frago, Susana; Goñi, Guillermina; Herguedas, Beatriz; Peregrina, Jose Ramon; Serrano , Ana; Perez-Dorado, Inmaculada; Molina, Rafael; Gomez-Moreno, Carlos; Hermoso, Juan A.; Martinez-Julvez, Marta; Mayhew, Stephen G.; Medina, Milagros. Tuning of the FMN Binding and Oxido-Reduction Properties by Neighboring Side Chains in Anabaena Flavodoxin. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2007. DOI: 10.1016/j.abb.2007.08.024

  • Carpena, Xavier; Wiseman, Ben; Deemagarn, Taweewat; Herguedas, Beatriz; Ivancich, Anabella; Singh, Rahul; Loewen, Peter C.; Fita, Ignacio. Roles for Arg426 and Trp111 in the Modulation of NADH Oxidase Activity of the Catalase-peroxidase KatG from Burkholderia pseudomallei Inferred from pH-Induced Structural Changes. BIOCHEMISTRY. 2006. DOI: 10.1021/bi060017f

Capítulos

  • FMN and FAD biosynthesis in prokaryotes: The FAD synthetase family. Serrano,A.//Herguedas,B.//Frago,S.//Arilla-Luna,A.//Ferreira,P.//Yruela,I.//Hermoso,J. A.//Velazquez. FLAVINS AND FLAVOPROTEINS 2011 - PROCEEDINGS OF THE 17TH INTERNATIONAL SYMPOSIUM ON FLAVINS AND FLAVOPROTEINS. 2013

  • Mapping hot spots on the Anabaena flavodoxin binding site for the interaction with its counterpart ferredoxin-NADP+ reductase. Guillermina Goñi, Beatriz Herguedas, José R. Peregrina, Carlos Gómez-Moreno, Juan A. Hermoso, Marta. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2008. 2008



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