Perfil (CV) del personal docente investigador

Gracia Lostao, Ana Isabel
Departamento: Bioquímica y Biología Molecular y Celular
Área: Bioquímica; Biofísica; Ciencia de Materiales; Nanobiología
Centro: Instituto de Nanociencia y Materiales de Aragón (INMA; CSIC-UZ)

Research Institute: INSTITUTO DE NANOCIENCIA Y MATERIALES DE ARAGÓN (INMA)
Grupo: E09_23R QUANTUM MATERIALS AND DEVICES
Categoría profesional: Investigador permanente ARAID
Teléfono fijo: 876555357
Teléfono móvil: 636371517
Correo electrónico: aglostao@unizar.es
ORCID: 0000-0001-7460-5916

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Artículos

  • Gimeno, Ignacio; Luis, Fernando; Marcuello, Carlos; Pallarés, Maria Carmen; Lostao, Anabel; Calero de Ory, Marina; Gomez, Alicia; Granados, Daniel; Tejedor, Inés; Natividad, Eva; Urtizberea, Ainhoa; Roubeau, Olivier. Localized nanoscale formation of vanadyl porphyrin 2D MOF nanosheets and their optimal coupling to lumped element superconducting resonators. JOURNAL OF PHYSICAL CHEMISTRY. C. 2024. DOI: 10.1021/acs.jpcc.4c07265

  • Repollés, Ana; Pallarés, María Carmen; Aguilà, David; Roubeau, Olivier; Velasco, Verónica; Gella, Diego; Barrios, Leoní A.; Martínez-Pérez, María José; Sesé, Javier; Drung, Dietmar; Martínez, Jesús Ignacio; Schurig, Thomas; Le Guennic, Boris; Lostao, Anabel; Aromí, Guillem; Luis, Fernando. Asymmetric [Dy2] molecules deposited into microSQUID susceptometers: in situ characterization of their magnetic integrity. NANOSCALE. 2024. DOI: 10.1039/d4nr03484h

  • Pele, Karinna Georgiana; Amaveda, Hippolyte; Mora, Mario; Marcuello, Carlos; Lostao, Anabel; Alamán-Díez, Pilar; Pérez-Huertas, Salvador; Pérez, María Ángeles; García-Aznar, José Manuel; García-Gareta, Elena. Hydrocolloids of egg white and gelatin as a platform for hydrogel-based tissue engineering. GELS. 2023. DOI: 10.3390/gels9060505

  • Lostao, Anabel; Lim, Keesiang; Pallarés, María Carmen; Ptak, Arkadiusz; Marcuello, Carlos. Recent advances in sensing the inter-biomolecular interactions at the nanoscale – A comprehensive review of AFM-based force spectroscopy. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2023. DOI: 10.1016/j.ijbiomac.2023.124089

  • Novo, Nerea; Romero-Tamayo, Silvia; Marcuello, Carlos; Boneta, Sergio; Blasco-Machin, Irene; Velázquez-Campoy, Adrián; Villanueva, Raquel; Moreno-Loshuertos, Raquel; Lostao, Anabel; Medina, Milagros; Ferreira, Patricia. Beyond a platform protein for the degradosome assembly: the apoptosis-inducing factor as an efficient nuclease involved in chromatinolysis. PNAS NEXUS. 2022. DOI: 10.1093/pnasnexus/pgac312

  • Marcuello, C.; Miguel, R. De; Lostao, A. Molecular recognition of proteins through quantitative force maps at single molecule level. BIOMOLECULES. 2022. DOI: 10.3390/biom12040594

  • Pérez-Domínguez, S. ; Caballero-Mancebo, S. ; Marcuello, C. ; Martínez-Júlvez, M. ; Medina, M. ; Gracia Lostao, A. Nanomechanical Study of Enzyme: Coenzyme Complexes: Bipartite Sites in Plastidic Ferredoxin-NADP+ Reductase for the Interaction with NADP+. ANTIOXIDANTS. 2022. DOI: 10.3390/antiox11030537

  • Marcuello, Carlos; Lostao, Anabel. Recent Progress in Molecular Recognition Imaging of Protein Systems at the Nanoscale Level. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2022. DOI: 10.3390/IECBM2022-13722

  • Gracia Lostao, Anabel; Medina, Milagros. Atomic Force Microscopy: Single-Molecule Imaging and Force Spectroscopy in the Study of Flavoproteins Ligand Binding and Reaction Mechanisms. METHODS IN MOLECULAR BIOLOGY. 2021. DOI: 10.1007/978-1-0716-1286-6_10

  • Marcuello C.; Frempong G.A.; Balsera M.; Medina M.; Lostao A. Atomic force microscopy to elicit conformational transitions of ferredoxin-dependent flavin thioredoxin reductases. ANTIOXIDANTS. 2021. DOI: 10.3390/antiox10091437

  • Lira-Navarrete E.; Pallarés M.C.; Castello F.; Ruedas-Rama M.J.; Orte A.; Gracia Lostao A.; Hurtado-Guerrero R. Protein o-fucosyltransferase 1 undergoes interdomain flexibility in solution. MOLECULES. 2021. DOI: 10.3390/molecules26082105

  • Gimeno, Ignacio; Kersten, Wenzel; Pallarés, María C.; Hermosilla, Pablo; Martínez-Pérez, María José; Jenkins, Mark D.; Angerer, Andreas; Sánchez-Azqueta, Carlos; Zueco, David; Majer, Johannes; Lostao, Anabel; Luis, Fernando. Enhanced Molecular Spin-Photon Coupling at Superconducting Nanoconstrictions. ACS NANO. 2020. DOI: 10.1021/acsnano.0c03167

  • de las Rivas, Matilde; Paul Daniel, Earnest James; Narimatsu, Yoshiki; Compañón, Ismael; Kato, Kentaro; Hermosilla, Pablo; Thureau, Aurélien; Ceballos-Laita, Laura; Coelho, Helena; Bernadó, Pau; Marcelo, Filipa; Hansen, Lars; Maeda, Ryota; Lostao, Anabel; Corzana, Francisco; Clausen, Henrik; Gerken, Thomas A.; Hurtado-Guerrero, Ramon. Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3. NATURE CHEMICAL BIOLOGY. 2020. DOI: 10.1038/s41589-019-0444-x

  • Sein-Echaluce, Violeta C.; Pallarés, María Carmen; Lostao, Anabel; Yruela, Inmaculada; Velázquez-Campoy, Adrián; Peleato, M. Luisa; Fillat, Maria F. Molecular basis for the integration of environmental signals by FurB from Anabaena sp. PCC 7120 . BIOCHEMICAL JOURNAL. 2018. DOI: 10.1042/BCJ20170692

  • Tapia-Rojo, Rafael; Marcuello, Carlos; Lostao, Anabel; Gómez-Moreno, Carlos; Mazo, Juan J.; Falo, Fernando. A physical picture for mechanical dissociation of biological complexes: From forces to free energies. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2017. DOI: 10.1039/c6cp07508h

  • Ceballos-Laita, L.; Marcuello, C.; Lostao, A.; Calvo-Begueria, L.; Velazquez-Campoy, A.; Bes, M.T.; Fillat, M.F.; Peleato, M.-L. Microcystin-LR Binds Iron, and Iron Promotes Self-Assembly. ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2017. DOI: 10.1021/acs.est.6b05939

  • Sebastián, María; Lira-Navarrete, Erandi; Serrano, Ana; Marcuello, Carlos; Velázquez-Campoy, Adrián; Lostao, Anabel; Hurtado-Guerrero, Ramón; Medina, Milagros; Martínez-Júlvez, Marta. The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2017. DOI: 10.1038/s41598-017-07716-5

  • Valero-González, J.; Leonhard-Melief, C.; Lira-Navarrete, E.; Jiménez-Osés, G.; Hernández-Ruiz, C.; Pallarés, M.C.; Yruela, I.; Vasudevan, D.; Lostao, A.; Corzana, F.; Takeuchi, H.; Haltiwanger, R.S.; Hurtado-Guerrero, R. A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2. NATURE CHEMICAL BIOLOGY. 2016. DOI: 10.1038/nchembio.2019

  • Serrano, A.;Sebastián, M.;Arilla-Luna, S.;Baquedano, S.;Pallarés, M. C.;Lostao, A.;Herguedas, B.;Velázquez-Campoy, A.;Martínez-Júlvez, M.;Medina, M. Quaternary organization in a bifunctional prokaryotic FAD synthetase: Involvement of an arginine at its adenylyltransferase module on the riboflavin kinase activity. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2015. DOI: 10.1016/j.bbapap.2015.03.005

  • Lira-Navarrete, E.; Rivas, M.de Las; Compañón, I.; Pallarés, M.C.; Kong, Y.; Iglesias-Fernández, J.; Bernardes, G.J.L.; Peregrina, J.M.; Rovira, C.; Bernadó, P.; Bruscolini, P.; Clausen, H.; Lostao, A.; Corzana, F.; Hurtado-Guerrero, R. Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation. NATURE COMMUNICATIONS. 2015. DOI: 10.1038/ncomms7937

  • Marcuello, C.; de Miguel, R.; Martínez-Júlvez, M.; Gómez-Moreno, C.; Lostao, A. Mechanostability of the Single-Electron-Transfer Complexes of Anabaena Ferredoxin-NADP+ Reductase. CHEMPHYSCHEM. 2015. DOI: 10.1002/cphc.201500534

  • Villanueva, R.; Ferreira, P.; Marcuello, C.; Usón, A.; Miramar, M. D.; Peleato, M. L.; Lostao, A.; Susin, S. A.; Medina, M. Key Residues Regulating the Reductase Activity of the Human Mitochondrial Apoptosis Inducing Factor. BIOCHEMISTRY. 2015. DOI: 10.1021/acs.biochem.5b00696

  • Marcuello, Carlos; de Miguel, Rocío; Martínez-Júlvez, Marta; Gómez-Moreno, Carlos; Lostao, Anabel. Inside Cover: Mechanostability of the Single-Electron-Transfer Complexes ofAnabaenaFerredoxin-NADP+Reductase (ChemPhysChem 152015). CHEMPHYSCHEM. 2015. DOI: 10.1002/cphc.201500840

  • Pallarés, M. C.; Marcuello, C.; Botello-Morte, L.; González, A.; Fillat, M. F.; Lostao, A. Sequential binding of FurA from Anabaena sp. PCC 7120 to iron boxes: Exploring regulation at the nanoscale. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2014. DOI: 10.1016/j.bbapap.2014.01.005

  • Ferreira, P; Villanueva, R; Martínez-Júlvez, M; Herguedas, B; Marcuello, C; Fernandez-Silva, P; Cabon, L; Hermoso, J.A.; Lostao, A; Susin, S.A.; Medina, M. Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic Apoptosis Inducing Factor. BIOCHEMISTRY. 2014. DOI: 10.1021/bi500343r

  • Moro, F.; de Miguel, R.; Jenkins, M.; Gómez-Moreno, C.; Sells, D.; Tuna, F.; Mcinnes, E. J. L.; Lostao, A.; Luis, F.; Van Slageren, J. Magnetic anisotropy of polycrystalline magnetoferritin investigated by SQUID and electron magnetic resonance. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS. 2014. DOI: 10.1016/j.jmmm.2014.02.053

  • Marcuello,C.;Arilla-Luna,S.;Medina,M.;Lostao,A. Detection of a quaternary organization into dimer of trimers of Corynebacterium ammoniagenes FAD synthetase at the single-molecule level and at the in cell level. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2013. DOI: 10.1016/j.bbapap.2012.12.013

  • Vega,S.; Neira,J. L.; Marcuello,C.; Lostao,A.; Abian,O.; Velazquez-Campoy,A. NS3 protease from hepatitis C virus: Biophysical studies on an intrinsically disordered protein domain. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2013. DOI: 10.3390/ijms140713282

  • Marcuello, C.; de Miguel, R.; Gomez-Moreno, C.; Lostao, A. Discrimination of protein receptors through quantitative adhesion force maps. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2013

  • Lux, T.; Ballester, O.; Illa, J.; Jover Manas, G.; Lostao, A.; Martin-Mari, C.; Sanchez, F.; Rico, J.; Santorelli, R. A readout for electroluminescence TPCs based on avalanche photodiodes. IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD (1997). 2012. DOI: 10.1109/NSSMIC.2012.6551475

  • Marcuello, C.; Arilla-Luna, S.; Medina, M.; Lostao, A. Atomic force microscopy reveals a dimer of trimers organization in Corynebacterium ammoniagenes FAD synthetase FEBS JOURNAL. 2012

  • Marcuello, C.;de Miguel, R.;Gómez-Moreno, C.;Martínez-Júlvez, M.;Lostao, A. An efficient method for enzyme immobilization evidenced by atomic force microscopy. PROTEIN ENGINEERING DESIGN & SELECTION. 2012. DOI: 10.1093/protein/gzs086

  • Marcuello, C.; de Miguel, R.; Medina, M.; Martínez-Júlvez, M.; Gómez-Moreno, G.; Lostao, A. Nanomechanics of ferredoxin-NADP+ reductase complexes analyzed by AFM single-molecule force spectroscopy. FEBS JOURNAL. 2012

  • de Miguel, R; Martínez-Pérez, M.J.; Martínez-Júlvez, M; Fiddyment, S.; García-Otín, A.L.; Gómez-Moreno, C.; Luis, F.; Lostao A. Ferritin: nanotechnology at the service of the new biomedicine. FEBS JOURNAL. 2011

  • Martínez-Pérez, M.-J.; Sesé, J; Luis, F.; Córdoba, R.; Drung, D.; Schurig, Th.; Bellido, E.; de Miguel, R.; Gomez-Moreno, C.; Lostao, A; Ruiz-Molina, D. Ultrasensitive broad band SQUID microsusceptometer for magnetic measurements at very low temperatures. IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY. 2011. DOI: 10.1109/TASC.2010.2082479

  • Martínez-Pérez, M. J.; Bellido,E.; de Miguel,R.; Sesé,J.; Lostao,A.; Gómez-Moreno,C.; Drung,D.; Schurig,T.; Ruiz-Molina,D.; Luis,F. Alternating current magnetic susceptibility of a molecular magnet submonolayer directly patterned onto a micro superconducting quantum interference device. APPLIED PHYSICS LETTERS. 2011. DOI: 10.1063/1.3609859

  • Bellido, Elena;de Miguel, Rocío;Sese, Javier;Ruiz-Molina, Daniel;Lostao, Anabel;Maspoch, Daniel. Nanoscale Positioning of Inorganic Nanoparticles using Biological Ferritin Arrays Fabricated by Dip-Pen Nanolithography. SCANNING. 2010. DOI: 10.1002/sca.20162

  • Bellido, E.; de Miguel, R.; Ruiz-Molina, D.; Lostao, A.; Maspoch, D. Controlling the number of proteins with dip-pen nanolithography. ADVANCED MATERIALS. 2010. DOI: 10.1002/adma.200902372

  • Lostao, A.; Peleato, M.L.; Gómez-Moreno, C.; Fillat, M.F. Oligomerization properties of FurA from the cyanobacterium Anabaena sp. PCC 7120: Direct visualization by in situ atomic force microscopy under different redox conditions. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2010. DOI: 10.1016/j.bbapap.2010.04.002

  • Martínez-Pérez, M.J.; de Miguel, R.; Carbonera, C.; Martínez-Júlvez, M.; Lostao, A.; Piquer, C.; Gómez-Moreno, C.; Bartolomé, J.; Luis, F. Size-dependent properties of magnetoferritin. NANOTECHNOLOGY. 2010. DOI: 10.1088/0957-4484/21/46/465707

  • Sotres, J.;Lostao, A.;Wildling, L.;Ebner, A.;Gomez-Moreno, C.;Gruber, H. J.;Hinterdorfer, P.;Baro, A. M. Unbinding Molecular Recognition Force Maps of Localized Single Receptor Molecules by Atomic Force Microscopy. CHEMPHYSCHEM. 2008

  • Sotres, J.; Lostao, A.; Gómez-Moreno, C.; Baró, A.M. Jumping mode AFM imaging of biomolecules in the repulsive electrical double layer. ULTRAMICROSCOPY. 2007. DOI: 10.1016/j.ultramic.2007.01.020

  • López-Llano, J.; Maldonado, S.; Jain, S.; Lostao, A.; Godoy-Ruiz, R.; Sanchez-Ruiz, J.M.; Cortijo, M.; Fernández-Recio, J.; Sancho, J. The long and short flavodoxins: II. The role of the differentiating loop in apoflavodoxin stability and folding mechanism. JOURNAL OF BIOLOGICAL CHEMISTRY. 2004. DOI: 10.1074/jbc.M405791200

  • López-Llano, J.; Maldonado, S.; Bueno, M.; Lostao, A.; Ángeles-Jiménez, M.; Lillo, M.P.; Sancho, J. The long and short flavodoxins: I. The role of the differentiating loop in apoflavodoxin structure and FMN binding. JOURNAL OF BIOLOGICAL CHEMISTRY. 2004. DOI: 10.1074/jbc.M405792200

  • Lostao, A.; Daoudi, F.; Irún, M.P.; Ramón, Á.; Fernández-Cabrera, C.; Romero, A.; Sancho, J. How FMN binds to Anabaena apoflavodoxin: A hydrophobic encounter at an open binding site. JOURNAL OF BIOLOGICAL CHEMISTRY. 2003. DOI: 10.1074/jbc.M301049200

  • Casaus, J.L.; Navarro, J.A.; Hervás, M.; Lostao, A.; de la Rosa, M.A.; Gómez-Moreno, C.; Sancho, J.; Medina, M. Anabaena sp. PCC 7119 flavodoxin as electron carrier from photosystem I to ferredoxin-NADP + reductase. Role of Trp 57 and Tyr 94. JOURNAL OF BIOLOGICAL CHEMISTRY. 2002. DOI: 10.1074/jbc.M112258200

  • Maldonado, S.; Irún, M.P.; Campos, L.A.; Rubio, J.A.; Luquita, A.; Lostao, A.; Wang, R.; Bertrand García-Moreno, E.; Sancho, J. Salt-induced stabilization of apoflavodoxin at neutral pH is mediated through cation-specific effects. PROTEIN SCIENCE. 2002. DOI: 10.1110/ps.2980102

  • Lostao, A.; El Harrous, M.; Daoudi, F.; Romero, A.; Parody-Morreale, A.; Sancho, J. Dissecting the energetics of the apoflavodoxin-FMN complex. JOURNAL OF BIOLOGICAL CHEMISTRY. 2000. DOI: 10.1074/jbc.275.13.9518

  • Medina, M.; Lostao, A.; Sancho, J.; Gómez-Moreno, C.; Cammack, R.; Alonso, P.J.; Martínez, J.I. Electron-nuclear double resonance and hyperfine sublevel correlation spectroscopic studies of flavodoxin mutants from Anabaena sp. PCC 7119. BIOPHYSICAL JOURNAL. 1999. DOI: 10.1016/S0006-3495(99)77017-7

  • Maldonado, S.; Lostao, A.; Irún, M.P.; Férnandez-Recio, J.; Genzor, C.G.; González, E.B.; Rubio, J.A.; Luquita, A.; Daoudi, F.; Sancho, J. Apoflavodoxin: Structure, stability, and FMN binding. BIOCHIMIE. 1998. DOI: 10.1016/S0300-9084(00)88876-8

  • Lostao, A.; Gómez-Moreno, C.; Mayhew, S.G.; Sancho, J. Differential stabilization of the three FMN redox forms by tyrosine 94 and tryptophan 57 in flavodoxin from Anabaena and its influence on the redox potentials. BIOCHEMISTRY. 1997. DOI: 10.1021/bi971384h

Comunicaciones

  • Postigo, Alejandro; Marcuello, Carlos; Verstraeten, William; Sarasa, Santiago; Walther, Tobias; Lostao, Anabel; Göpfrich, Kerstin; Barrio, Jesús Del; Hernández-Ainsa, Silvia. Folding and Functionalizing DNA Origami: A Versatile Approach Using a Reactive Polyamine. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2025. DOI: 10.1021/jacs.4c12637

  • Tapia-Rojo, R.; Marcuello, C.; Gómez-Moreno, C.; Lostao, A.; Mazo, J.J.; Falo, F. Characterizing the mechanical dissociation of biological complexes: from forces to free energies. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2015

Capítulos

  • Atomic Force Microscopy as a tool to understand the mechanostability of Ferredoxin-NADP+ reductase complexes with its protein partners. C. Gómez-Moreno; C. Marcuello; R. De Miguel; M. Medina; M. Martínez-Júlvez; A. Lostao. FLAVINS AND FLAVOPROTEINS 2011. 2013

  • Single molecule methods to study flavoproteins. Gómez-Moreno, Carlos; Lostao, Anabel. HANDBOOK OF FLAVOPROTEINS: COMPLEX FLAVOPROTEINS, DEHYDROGENASES AND PHYSICAL METHODS. 2013



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