Perfil (CV) del personal docente investigador

Gracia Lostao, Ana Isabel
Departamento: Bioquímica y Biología Molecular y Celular
Área: Bioquímica; Biofísica; Ciencia de Materiales; Nanobiología
Centro: Instituto de Nanociencia y Materiales de Aragón (INMA; CSIC-UZ)

Research Institute: INSTITUTO DE NANOCIENCIA Y MATERIALES DE ARAGÓN (INMA)
Grupo: E09_23R QUANTUM MATERIALS AND DEVICES
Categoría profesional: Investigador permanente ARAID
Teléfono fijo: 876555357
Teléfono móvil: 636371517
Correo electrónico: aglostao@unizar.es
ORCID: 0000-0001-7460-5916

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Artículos

  • Marcos Rubín-Osanz, Marina C. de Ory, Ignacio Gimeno, Wenzel Kersten, Marta Mas-Torrent, María C. Pallarés, Sebastián Roca-Jerat, David Rodriguez, Nerea González-Prato, J. Alejandro de Sousa, Lorenzo Tesi, Daniel Granados, Jaume Veciana, David Zueco, Anabel Lostao, Joerg Schmiedmayer, Inma Ratera, Joris Van Slageren, Núria Crivillers, Alicia Gomez, Fernando Luis. Optimizing magnetic coupling in lumped element superconducting resonators for molecular spin qubits. ARXIV. 2025. DOI: 10.48550/arXiv.2511.00857

  • Gimeno, Ignacio; Luis, Fernando; Marcuello, Carlos; Pallarés, Maria Carmen; Lostao, Anabel; Calero de Ory, Marina; Gomez, Alicia; Granados, Daniel; Tejedor, Inés; Natividad, Eva; Urtizberea, Ainhoa; Roubeau, Olivier. Localized nanoscale formation of vanadyl porphyrin 2D MOF nanosheets and their optimal coupling to lumped element superconducting resonators. JOURNAL OF PHYSICAL CHEMISTRY. C. 2024. DOI: 10.1021/acs.jpcc.4c07265

  • Repollés, Ana; Pallarés, María Carmen; Aguilà, David; Roubeau, Olivier; Velasco, Verónica; Gella, Diego; Barrios, Leoní A.; Martínez-Pérez, María José; Sesé, Javier; Drung, Dietmar; Martínez, Jesús Ignacio; Schurig, Thomas; Le Guennic, Boris; Lostao, Anabel; Aromí, Guillem; Luis, Fernando. Asymmetric [Dy2] molecules deposited into microSQUID susceptometers: in situ characterization of their magnetic integrity. NANOSCALE. 2024. DOI: 10.1039/d4nr03484h

  • Pele, Karinna Georgiana; Amaveda, Hippolyte; Mora, Mario; Marcuello, Carlos; Lostao, Anabel; Alamán-Díez, Pilar; Pérez-Huertas, Salvador; Pérez, María Ángeles; García-Aznar, José Manuel; García-Gareta, Elena. Hydrocolloids of egg white and gelatin as a platform for hydrogel-based tissue engineering. GELS. 2023. DOI: 10.3390/gels9060505

  • Lostao, Anabel; Lim, Keesiang; Pallarés, María Carmen; Ptak, Arkadiusz; Marcuello, Carlos. Recent advances in sensing the inter-biomolecular interactions at the nanoscale – A comprehensive review of AFM-based force spectroscopy. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2023. DOI: 10.1016/j.ijbiomac.2023.124089

  • Pérez-Domínguez, S. ; Caballero-Mancebo, S. ; Marcuello, C. ; Martínez-Júlvez, M. ; Medina, M. ; Gracia Lostao, A. Nanomechanical Study of Enzyme: Coenzyme Complexes: Bipartite Sites in Plastidic Ferredoxin-NADP+ Reductase for the Interaction with NADP+. ANTIOXIDANTS. 2022. DOI: 10.3390/antiox11030537

  • Novo, Nerea; Romero-Tamayo, Silvia; Marcuello, Carlos; Boneta, Sergio; Blasco-Machin, Irene; Velázquez-Campoy, Adrián; Villanueva, Raquel; Moreno-Loshuertos, Raquel; Lostao, Anabel; Medina, Milagros; Ferreira, Patricia. Beyond a platform protein for the degradosome assembly: the apoptosis-inducing factor as an efficient nuclease involved in chromatinolysis. PNAS NEXUS. 2022. DOI: 10.1093/pnasnexus/pgac312

  • Marcuello, C.; Miguel, R. De; Lostao, A. Molecular recognition of proteins through quantitative force maps at single molecule level. BIOMOLECULES. 2022. DOI: 10.3390/biom12040594

  • Marcuello, Carlos; Lostao, Anabel. Recent Progress in Molecular Recognition Imaging of Protein Systems at the Nanoscale Level. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2022. DOI: 10.3390/IECBM2022-13722

  • Gracia Lostao, Anabel; Medina, Milagros. Atomic Force Microscopy: Single-Molecule Imaging and Force Spectroscopy in the Study of Flavoproteins Ligand Binding and Reaction Mechanisms. METHODS IN MOLECULAR BIOLOGY. 2021. DOI: 10.1007/978-1-0716-1286-6_10

  • Marcuello C.; Frempong G.A.; Balsera M.; Medina M.; Lostao A. Atomic force microscopy to elicit conformational transitions of ferredoxin-dependent flavin thioredoxin reductases. ANTIOXIDANTS. 2021. DOI: 10.3390/antiox10091437

  • Lira-Navarrete E.; Pallarés M.C.; Castello F.; Ruedas-Rama M.J.; Orte A.; Gracia Lostao A.; Hurtado-Guerrero R. Protein o-fucosyltransferase 1 undergoes interdomain flexibility in solution. MOLECULES. 2021. DOI: 10.3390/molecules26082105

  • Gimeno, Ignacio; Kersten, Wenzel; Pallarés, María C.; Hermosilla, Pablo; Martínez-Pérez, María José; Jenkins, Mark D.; Angerer, Andreas; Sánchez-Azqueta, Carlos; Zueco, David; Majer, Johannes; Lostao, Anabel; Luis, Fernando. Enhanced Molecular Spin-Photon Coupling at Superconducting Nanoconstrictions. ACS NANO. 2020. DOI: 10.1021/acsnano.0c03167

  • de las Rivas, Matilde; Paul Daniel, Earnest James; Narimatsu, Yoshiki; Compañón, Ismael; Kato, Kentaro; Hermosilla, Pablo; Thureau, Aurélien; Ceballos-Laita, Laura; Coelho, Helena; Bernadó, Pau; Marcelo, Filipa; Hansen, Lars; Maeda, Ryota; Lostao, Anabel; Corzana, Francisco; Clausen, Henrik; Gerken, Thomas A.; Hurtado-Guerrero, Ramon. Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3. NATURE CHEMICAL BIOLOGY. 2020. DOI: 10.1038/s41589-019-0444-x

  • Sein-Echaluce, Violeta C.; Pallarés, María Carmen; Lostao, Anabel; Yruela, Inmaculada; Velázquez-Campoy, Adrián; Peleato, M. Luisa; Fillat, Maria F. Molecular basis for the integration of environmental signals by FurB from Anabaena sp. PCC 7120 . BIOCHEMICAL JOURNAL. 2018. DOI: 10.1042/BCJ20170692

  • Tapia-Rojo, Rafael; Marcuello, Carlos; Lostao, Anabel; Gómez-Moreno, Carlos; Mazo, Juan J.; Falo, Fernando. A physical picture for mechanical dissociation of biological complexes: From forces to free energies. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2017. DOI: 10.1039/c6cp07508h

  • Ceballos-Laita, L.; Marcuello, C.; Lostao, A.; Calvo-Begueria, L.; Velazquez-Campoy, A.; Bes, M.T.; Fillat, M.F.; Peleato, M.-L. Microcystin-LR Binds Iron, and Iron Promotes Self-Assembly. ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2017. DOI: 10.1021/acs.est.6b05939

  • Sebastián, María; Lira-Navarrete, Erandi; Serrano, Ana; Marcuello, Carlos; Velázquez-Campoy, Adrián; Lostao, Anabel; Hurtado-Guerrero, Ramón; Medina, Milagros; Martínez-Júlvez, Marta. The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2017. DOI: 10.1038/s41598-017-07716-5

  • Valero-González, J.; Leonhard-Melief, C.; Lira-Navarrete, E.; Jiménez-Osés, G.; Hernández-Ruiz, C.; Pallarés, M.C.; Yruela, I.; Vasudevan, D.; Lostao, A.; Corzana, F.; Takeuchi, H.; Haltiwanger, R.S.; Hurtado-Guerrero, R. A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2. NATURE CHEMICAL BIOLOGY. 2016. DOI: 10.1038/nchembio.2019

  • Serrano, A.;Sebastián, M.;Arilla-Luna, S.;Baquedano, S.;Pallarés, M. C.;Lostao, A.;Herguedas, B.;Velázquez-Campoy, A.;Martínez-Júlvez, M.;Medina, M. Quaternary organization in a bifunctional prokaryotic FAD synthetase: Involvement of an arginine at its adenylyltransferase module on the riboflavin kinase activity. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2015. DOI: 10.1016/j.bbapap.2015.03.005

  • Lira-Navarrete, E.; Rivas, M.de Las; Compañón, I.; Pallarés, M.C.; Kong, Y.; Iglesias-Fernández, J.; Bernardes, G.J.L.; Peregrina, J.M.; Rovira, C.; Bernadó, P.; Bruscolini, P.; Clausen, H.; Lostao, A.; Corzana, F.; Hurtado-Guerrero, R. Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation. NATURE COMMUNICATIONS. 2015. DOI: 10.1038/ncomms7937

  • Marcuello, C.; de Miguel, R.; Martínez-Júlvez, M.; Gómez-Moreno, C.; Lostao, A. Mechanostability of the Single-Electron-Transfer Complexes of Anabaena Ferredoxin-NADP+ Reductase. CHEMPHYSCHEM. 2015. DOI: 10.1002/cphc.201500534

  • Villanueva, R.; Ferreira, P.; Marcuello, C.; Usón, A.; Miramar, M. D.; Peleato, M. L.; Lostao, A.; Susin, S. A.; Medina, M. Key Residues Regulating the Reductase Activity of the Human Mitochondrial Apoptosis Inducing Factor. BIOCHEMISTRY. 2015. DOI: 10.1021/acs.biochem.5b00696

  • Marcuello, Carlos; de Miguel, Rocío; Martínez-Júlvez, Marta; Gómez-Moreno, Carlos; Lostao, Anabel. Inside Cover: Mechanostability of the Single-Electron-Transfer Complexes ofAnabaenaFerredoxin-NADP+Reductase (ChemPhysChem 152015). CHEMPHYSCHEM. 2015. DOI: 10.1002/cphc.201500840

  • Pallarés, M. C.; Marcuello, C.; Botello-Morte, L.; González, A.; Fillat, M. F.; Lostao, A. Sequential binding of FurA from Anabaena sp. PCC 7120 to iron boxes: Exploring regulation at the nanoscale. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2014. DOI: 10.1016/j.bbapap.2014.01.005

  • Moro, F.; de Miguel, R.; Jenkins, M.; Gómez-Moreno, C.; Sells, D.; Tuna, F.; Mcinnes, E. J. L.; Lostao, A.; Luis, F.; Van Slageren, J. Magnetic anisotropy of polycrystalline magnetoferritin investigated by SQUID and electron magnetic resonance. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS. 2014. DOI: 10.1016/j.jmmm.2014.02.053

  • Ferreira, P; Villanueva, R; Martínez-Júlvez, M; Herguedas, B; Marcuello, C; Fernandez-Silva, P; Cabon, L; Hermoso, J.A.; Lostao, A; Susin, S.A.; Medina, M. Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic Apoptosis Inducing Factor. BIOCHEMISTRY. 2014. DOI: 10.1021/bi500343r

  • Marcuello, C.; de Miguel, R.; Gomez-Moreno, C.; Lostao, A. Discrimination of protein receptors through quantitative adhesion force maps. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2013

  • Vega,S.; Neira,J. L.; Marcuello,C.; Lostao,A.; Abian,O.; Velazquez-Campoy,A. NS3 protease from hepatitis C virus: Biophysical studies on an intrinsically disordered protein domain. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2013. DOI: 10.3390/ijms140713282

  • Marcuello,C.;Arilla-Luna,S.;Medina,M.;Lostao,A. Detection of a quaternary organization into dimer of trimers of Corynebacterium ammoniagenes FAD synthetase at the single-molecule level and at the in cell level. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2013. DOI: 10.1016/j.bbapap.2012.12.013

  • Marcuello, C.; de Miguel, R.; Medina, M.; Martínez-Júlvez, M.; Gómez-Moreno, G.; Lostao, A. Nanomechanics of ferredoxin-NADP+ reductase complexes analyzed by AFM single-molecule force spectroscopy. FEBS JOURNAL. 2012

  • Lux, T.; Ballester, O.; Illa, J.; Jover Manas, G.; Lostao, A.; Martin-Mari, C.; Sanchez, F.; Rico, J.; Santorelli, R. A readout for electroluminescence TPCs based on avalanche photodiodes. IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD (1997). 2012. DOI: 10.1109/NSSMIC.2012.6551475

  • Marcuello, C.; Arilla-Luna, S.; Medina, M.; Lostao, A. Atomic force microscopy reveals a dimer of trimers organization in Corynebacterium ammoniagenes FAD synthetase FEBS JOURNAL. 2012

  • Marcuello, C.;de Miguel, R.;Gómez-Moreno, C.;Martínez-Júlvez, M.;Lostao, A. An efficient method for enzyme immobilization evidenced by atomic force microscopy. PROTEIN ENGINEERING DESIGN & SELECTION. 2012. DOI: 10.1093/protein/gzs086

  • Martínez-Pérez, M.-J.; Sesé, J; Luis, F.; Córdoba, R.; Drung, D.; Schurig, Th.; Bellido, E.; de Miguel, R.; Gomez-Moreno, C.; Lostao, A; Ruiz-Molina, D. Ultrasensitive broad band SQUID microsusceptometer for magnetic measurements at very low temperatures. IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY. 2011. DOI: 10.1109/TASC.2010.2082479

  • Martínez-Pérez, M. J.; Bellido,E.; de Miguel,R.; Sesé,J.; Lostao,A.; Gómez-Moreno,C.; Drung,D.; Schurig,T.; Ruiz-Molina,D.; Luis,F. Alternating current magnetic susceptibility of a molecular magnet submonolayer directly patterned onto a micro superconducting quantum interference device. APPLIED PHYSICS LETTERS. 2011. DOI: 10.1063/1.3609859

  • de Miguel, R; Martínez-Pérez, M.J.; Martínez-Júlvez, M; Fiddyment, S.; García-Otín, A.L.; Gómez-Moreno, C.; Luis, F.; Lostao A. Ferritin: nanotechnology at the service of the new biomedicine. FEBS JOURNAL. 2011

  • Lostao, A.; Peleato, M.L.; Gómez-Moreno, C.; Fillat, M.F. Oligomerization properties of FurA from the cyanobacterium Anabaena sp. PCC 7120: Direct visualization by in situ atomic force microscopy under different redox conditions. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2010. DOI: 10.1016/j.bbapap.2010.04.002

  • Bellido, E.; de Miguel, R.; Ruiz-Molina, D.; Lostao, A.; Maspoch, D. Controlling the number of proteins with dip-pen nanolithography. ADVANCED MATERIALS. 2010. DOI: 10.1002/adma.200902372

  • Martínez-Pérez, M.J.; de Miguel, R.; Carbonera, C.; Martínez-Júlvez, M.; Lostao, A.; Piquer, C.; Gómez-Moreno, C.; Bartolomé, J.; Luis, F. Size-dependent properties of magnetoferritin. NANOTECHNOLOGY. 2010. DOI: 10.1088/0957-4484/21/46/465707

  • Bellido, Elena;de Miguel, Rocío;Sese, Javier;Ruiz-Molina, Daniel;Lostao, Anabel;Maspoch, Daniel. Nanoscale Positioning of Inorganic Nanoparticles using Biological Ferritin Arrays Fabricated by Dip-Pen Nanolithography. SCANNING. 2010. DOI: 10.1002/sca.20162

  • Sotres, J.;Lostao, A.;Wildling, L.;Ebner, A.;Gomez-Moreno, C.;Gruber, H. J.;Hinterdorfer, P.;Baro, A. M. Unbinding Molecular Recognition Force Maps of Localized Single Receptor Molecules by Atomic Force Microscopy. CHEMPHYSCHEM. 2008

  • Sotres, J.; Lostao, A.; Gómez-Moreno, C.; Baró, A.M. Jumping mode AFM imaging of biomolecules in the repulsive electrical double layer. ULTRAMICROSCOPY. 2007. DOI: 10.1016/j.ultramic.2007.01.020

  • López-Llano, J.; Maldonado, S.; Bueno, M.; Lostao, A.; Ángeles-Jiménez, M.; Lillo, M.P.; Sancho, J. The long and short flavodoxins: I. The role of the differentiating loop in apoflavodoxin structure and FMN binding. JOURNAL OF BIOLOGICAL CHEMISTRY. 2004. DOI: 10.1074/jbc.M405792200

  • López-Llano, J.; Maldonado, S.; Jain, S.; Lostao, A.; Godoy-Ruiz, R.; Sanchez-Ruiz, J.M.; Cortijo, M.; Fernández-Recio, J.; Sancho, J. The long and short flavodoxins: II. The role of the differentiating loop in apoflavodoxin stability and folding mechanism. JOURNAL OF BIOLOGICAL CHEMISTRY. 2004. DOI: 10.1074/jbc.M405791200

  • Lostao, A.; Daoudi, F.; Irún, M.P.; Ramón, Á.; Fernández-Cabrera, C.; Romero, A.; Sancho, J. How FMN binds to Anabaena apoflavodoxin: A hydrophobic encounter at an open binding site. JOURNAL OF BIOLOGICAL CHEMISTRY. 2003. DOI: 10.1074/jbc.M301049200

  • Casaus, J.L.; Navarro, J.A.; Hervás, M.; Lostao, A.; de la Rosa, M.A.; Gómez-Moreno, C.; Sancho, J.; Medina, M. Anabaena sp. PCC 7119 flavodoxin as electron carrier from photosystem I to ferredoxin-NADP + reductase. Role of Trp 57 and Tyr 94. JOURNAL OF BIOLOGICAL CHEMISTRY. 2002. DOI: 10.1074/jbc.M112258200

  • Maldonado, S.; Irún, M.P.; Campos, L.A.; Rubio, J.A.; Luquita, A.; Lostao, A.; Wang, R.; Bertrand García-Moreno, E.; Sancho, J. Salt-induced stabilization of apoflavodoxin at neutral pH is mediated through cation-specific effects. PROTEIN SCIENCE. 2002. DOI: 10.1110/ps.2980102

  • Lostao, A.; El Harrous, M.; Daoudi, F.; Romero, A.; Parody-Morreale, A.; Sancho, J. Dissecting the energetics of the apoflavodoxin-FMN complex. JOURNAL OF BIOLOGICAL CHEMISTRY. 2000. DOI: 10.1074/jbc.275.13.9518

  • Medina, M.; Lostao, A.; Sancho, J.; Gómez-Moreno, C.; Cammack, R.; Alonso, P.J.; Martínez, J.I. Electron-nuclear double resonance and hyperfine sublevel correlation spectroscopic studies of flavodoxin mutants from Anabaena sp. PCC 7119. BIOPHYSICAL JOURNAL. 1999. DOI: 10.1016/S0006-3495(99)77017-7

  • Maldonado, S.; Lostao, A.; Irún, M.P.; Férnandez-Recio, J.; Genzor, C.G.; González, E.B.; Rubio, J.A.; Luquita, A.; Daoudi, F.; Sancho, J. Apoflavodoxin: Structure, stability, and FMN binding. BIOCHIMIE. 1998. DOI: 10.1016/S0300-9084(00)88876-8

  • Lostao, A.; Gómez-Moreno, C.; Mayhew, S.G.; Sancho, J. Differential stabilization of the three FMN redox forms by tyrosine 94 and tryptophan 57 in flavodoxin from Anabaena and its influence on the redox potentials. BIOCHEMISTRY. 1997. DOI: 10.1021/bi971384h

Comunicaciones

  • Postigo, Alejandro; Marcuello, Carlos; Verstraeten, William; Sarasa, Santiago; Walther, Tobias; Lostao, Anabel; Göpfrich, Kerstin; Barrio, Jesús Del; Hernández-Ainsa, Silvia. Folding and Functionalizing DNA Origami: A Versatile Approach Using a Reactive Polyamine. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2025. DOI: 10.1021/jacs.4c12637

  • Tapia-Rojo, R.; Marcuello, C.; Gómez-Moreno, C.; Lostao, A.; Mazo, J.J.; Falo, F. Characterizing the mechanical dissociation of biological complexes: from forces to free energies. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2015

Capítulos

  • Atomic Force Microscopy as a tool to understand the mechanostability of Ferredoxin-NADP+ reductase complexes with its protein partners. C. Gómez-Moreno; C. Marcuello; R. De Miguel; M. Medina; M. Martínez-Júlvez; A. Lostao. FLAVINS AND FLAVOPROTEINS 2011. 2013

  • Single molecule methods to study flavoproteins. Gómez-Moreno, Carlos; Lostao, Anabel. HANDBOOK OF FLAVOPROTEINS: COMPLEX FLAVOPROTEINS, DEHYDROGENASES AND PHYSICAL METHODS. 2013



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